Article
Zoology
Diana D. Moreno-Santillan, Carlos Machain-Williams, Georgina Hernandez-Montes, Jorge Ortega
Summary: This study focused on the major histocompatibility complex (MHC) of bats and discovered functional variants of MHC class I transcripts that may have adaptive functions through the analysis of five species from different families of New World bats.
JOURNAL OF MAMMALOGY
(2022)
Article
Medicine, Research & Experimental
Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen
Summary: This study proposes a novel therapeutic approach for SjS by blocking MHC class II I-Ag-7 antigen presentation in NOD mice. The results demonstrate that treating NOD mice with TATD or 8-Azaguanine can alleviate SjS symptoms and reduce the severity of the disease.
Article
Genetics & Heredity
Jerzy K. Kulski, Shingo Suzuki, Takashi Shiina
Summary: This study identifies and characterizes polymorphic human leukocyte antigen (HLA)-class II genes, MTCO3P1 pseudogene alleles, and indels of transposable elements linked to specific HLA-class II alleles. The research also reveals unique crossover sites between SNP-poor and SNP-rich genomic segments, with significant haplotype shuffling near putative recombination hotspots.
FRONTIERS IN GENETICS
(2021)
Article
Biology
Orsolya Vincze, Claire Loiseau, Mathieu Giraudeau
Summary: High MHC class I diversity is associated with significantly lower richness of haemosporidian parasites in birds, indicating more efficient protection against intracellular pathogens. However, these associations were only detected when MHC diversity was assessed using cloning, suggesting the need for further clarification on the use of different genotyping methods for MHC loci quantification.
Article
Pharmacology & Pharmacy
Natsumi Mizuno, Yoshiki Yanagawa
Summary: In this study, it was found that tofacitinib enhanced IFN-gamma-induced MHC II expression in macrophages by transcriptional regulation through induction of CIITA, while decreasing the expression of CD86.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ankur Saikia, Andries Hadeler, Pranathi Prasad, Martin Zacharias, Sebastian Springer
Summary: This study investigates the importance of peptide exchange in immunodominance and uncovers the mechanism of peptide exchange under low pH conditions. The results demonstrate that low pH triggers peptide exchange and provide insights into the individual steps of the exchange reaction.
Article
Immunology
Tereza Almeida, Yuko Ohta, Arnaud Gaigher, Antonio Munoz-Merida, Fabiana Neves, L. Filipe C. Castro, Andre M. Machado, Pedro J. Esteves, Ana Verissimo, Martin F. Flajnik
Summary: A new MHC lineage, UEA, has been identified in cartilaginous fish, particularly in sharks, but not in chimaeras or rays. UEA, along with the previously reported UCA lineage, shows unique characteristics with highly hydrophobic peptide-binding regions. UEA genes in sharks are MHC linked and fall into three sublineages with distinct features in the peptide-binding regions.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Katherine R. Martin, Katherine L. Mansfield, Anna E. Savage
Summary: Characterizing MHC genes' polymorphism is crucial for understanding vertebrates' immune response to disease. This study explores the immunogenetic variation in sea turtles afflicted by fibropapillomatosis, a global infectious tumour disease. Extensive variation and trans-species polymorphism were recovered in MHC class I genes among green and loggerhead sea turtles. Supertyping analysis identified three functional MHC supertypes corresponding to well-supported clades in the phylogeny. Positive selection at seven amino acid sites in the class I exon was observed. One allele weakly associated with a specific tumour texture was found, suggesting a potential link between MHC diversity and disease outcome. This study highlights the importance of evaluating genetic predictors of disease, including MHC and other functional markers, in sea turtles.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Multidisciplinary Sciences
Di Zhang, Kefang Liu, Dan Lu, Pengyan Wang, Qingxu Zhang, Peipei Liu, Yingze Zhao, Yan Chai, Jianxin Lyu, Jianxun Qi, William J. Liu
Summary: The study focuses on the use of heterologous beta(2)-microglobulin (beta(2)m) substitution to stabilize MHC I in mammals, providing methods for expression construct preparation, inclusion body purification, MHC complex refolding, protein thermostability determination, crystal screening, and structure determination.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Oncology
Adrianna Piatakova, Ingrid Polakova, Jana Smahelova, Shweta Dilip Johari, Jaroslav Nunvar, Michal Smahel
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment and their response to immunotherapy can vary depending on the expression of MHC-I molecules in the tumor. This study found that TAMs in tumors with distinct MHC-I expression levels show different immune reactions and cytotoxic capabilities. Consideration of these differences in TAMs is important for the development of effective cancer immunotherapies.
Article
Immunology
Karen Toledo-Stuardo, Carolina H. Ribeiro, Andrea Canals, Marcela Morales, Valentina Garate, Jose Rodriguez-Siza, Samantha Tello, Marco Bustamante, Ricardo Armisen, Douglas J. Matthies, Gerald Zapata-Torres, Patricio Gonzalez-Hormazabal, Maria Carmen Molina
Summary: This study revealed the association between MICA gene polymorphisms and susceptibility and prognosis of gastric cancer. Different MICA alleles were found to be significantly correlated with the risk and survival rates of gastric cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Huan Lan, Moritz Becker, Christian Freund
Summary: This review highlights the critical role of Tapasin (Tsn) in antigen processing and presentation by MHC-I molecules. It discusses recent findings on the mechanism of Tsn-mediated peptide loading and exchange, as well as the allosteric regulation of Tsn and MHC-I interaction. The review also covers the allotypic differences of MHC-I in relation to Tsn's editing and chaperoning function and discusses the evolutionary aspects of Tsn's mode of action and its impact on noncanonical MHC-I molecules.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Pediatrics
Ramesh Radhika, Milind S. Tullu, Sunil Karande, Umair Ahmed Bargir
Summary: Major Histocompatibility Complex (MHC) Class II deficiency is a rare autosomal recessive primary immunodeficiency caused by mutations in regulatory genes of MHC Class II proteins. This case report describes a 9-month-old girl presenting with repeated pneumonia, lymphocytopenia, and absence of HLA-DR expression on B cells, which led to the diagnosis of MHC Class II deficiency. Genetic analysis identified a homozygous mutation in the RFX-5 gene. Despite the patient's unfortunate outcome, the importance of prenatal diagnosis was emphasized to the parents.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Oyekunle J. Oladosu, Ishaku L. Haruna, Sibusiso A. Hadebe, Huitong Zhou, Jon G. H. Hickford
Summary: This study investigated the variability of the immune response-related gene BoLA-DQA1 in cattle from Nigeria and New Zealand. Ten alleles were identified using a PCR-SSCP approach, with two novel alleles reported for the first time through DNA sequencing. Overall, 12.60% of nucleotide positions analyzed were found to be variable.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Review
Immunology
Andy van Hateren, Tim Elliott
Summary: The selection of peptides presented by MHC-I molecules plays a crucial role in immune responses. The proteins tapasin and TAPBPR coordinate the peptide selection process, ensuring that MHC-I molecules acquire high-affinity-binding peptides. New structural analyses have provided insights into the mechanisms of tapasin's role within the peptide-loading complex and TAPBPR's ability to independently perform peptide editing. These structures reveal the intricate interactions between tapasin, TAPBPR, and MHC-I, as well as the complementary roles of calreticulin and ERp57 in achieving peptide editing.
CURRENT OPINION IN IMMUNOLOGY
(2023)
