Review
Clinical Neurology
Tao Zou, Ping-Chuan Wang, Hao Chen, Xin-Min Feng, Hui-Hui Sun
Summary: This study aimed to evaluate the therapeutic effects of MIS-PCF and ACDF on unilateral cervical radiculopathy. The results showed that MIS-PCF had a significantly shorter postoperative hospitalization time compared to ACDF, and the operation time, complication/reoperation rate, and VAS-arm, VAS-neck, and NDI scores were comparable between the two methods. In North America, the average cost of MIS-PCF was lower than ACDF. Therefore, MIS-PCF can be an alternative to ACDF.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Arash Emami, Daniel Coban, Stuart Changoor, Conor Dunn, Nikhil Sahai, Kumar Sinha, Ki Soo Hwang, Michael Faloon
Summary: This retrospective study compared the effectiveness of MI-PCF and ACDF in treating unilateral cervical radiculopathy. The results showed that MI-PCF is a safe and effective alternative to ACDF, with similar short-term outcomes and advantages in preserving motion and avoiding fusion.
Article
Clinical Neurology
Michael M. Safaee, Diana Chang, John M. Hillman, Sumedh S. Shah, Harsh Wadhwa, Christopher P. Ames, Aaron J. Clark
Summary: ACDF procedures performed as same-day or overnight observation at a major academic center without a dedicated ASC showed no differences in perioperative complications, 30-day readmissions, or fusion at 12 months, with significant reductions in cost. This strategy can effectively utilize resources and establish viable outpatient spine practices at academic centers.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Rahul H. Jayaram, Peter Y. Joo, Michael J. Gouzoulis, Philip P. Ratnasamy, Dennis L. Caruana, Jonathan N. Grauer
Summary: This study compared the effects of single-level anterior cervical discectomy and fusion (ACDF) and posterior cervical foraminotomy (PCF) on perioperative adverse events and five-year revision rates. The study found that although PCF had worse outcomes in terms of adverse events, it had a lower readmission rate compared to ACDF.
Article
Medicine, General & Internal
Bartosz Godlewski, Adam Bebenek, Maciej Dominiak, Marcin Bochniak, Piotr Cieslik, Tomasz Pawelczyk
Summary: Surgical procedures for degenerative disease of the cervical spine often involve discectomy and interbody fixation. Evaluation of bone fusion is typically done using computed tomography (CT), but when CT evidence is not available, conventional radiographs can be used, with the bridging criterion being the most reliable.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ammad A. Baig, Alexander O. Aguirre, Mohamed A. R. Solimaan, Cathleen C. Kuo, Jaims Lim, Asham Khan, Ivette Chen, Kenneth Snyder, Elad I. Levy, Adnan H. Siddiqui, John Pollina, Jeffrey P. Mullin
Summary: In this study, the procedural success and outcomes of 1-2 level ACDF with and without cervical plating were compared, and similar effectiveness and outcomes were reported.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Alec W. Gibson, Abdullah H. Feroze, Madeline E. Greil, Margaret E. McGrath, Sananthan Sivakanthan, Gabrielle A. White-Dzuro, John R. Williams, Christopher C. Young, Christoph P. Hofstetter
Summary: This study compared the outcomes of patients with multilevel degenerative spine disease who underwent multilevel stand-alone ACDF with or without cellular allograft supplementation. Results showed that patients who received cellular allograft had higher fusion rates and greater improvement in functional outcomes after surgery.
NEUROSURGICAL FOCUS
(2021)
Review
Clinical Neurology
Andreas K. K. Demetriades, Georgios Mavrovounis, Moritz C. C. Deml, Kyaw Min Soe, Zorica Buser, Hans-Joerg Meisel
Summary: This study is a systematic review that aims to identify and present all available studies reporting on the costs of osteobiologics used in anterior cervical discectomy and fusion (ACDF). A total of 14 articles were included, one randomized controlled trial and 13 observational studies. Most studies reported on surgery-related costs, while only two studies reported the exact cost of the osteobiologic used.
GLOBAL SPINE JOURNAL
(2023)
Review
Pharmacology & Pharmacy
S. Sajith Kumar, Madhumitha Haridoss, Krishnamurthy Venkataraman, Bhavani Shankara Bagepally
Summary: This study found that Janus kinase inhibitors (JAK-i) are cost-effective as a second-line treatment for rheumatoid arthritis (RA) after csDMARD failure, but not cost-effective after csDMARD-TNF-a-i failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ali Darvishi, Mohsen Rezaei Hemami, Gita Shafiee, Rajabali Daroudi, Mahsa Mohseni, Farkhondeh Hosseini Shekarabi, Ramin Heshmat
Summary: The study compared four different strategies for sarcopenia screening in Iran and found that the European working group on sarcopenia in older people (EWGSOP) strategy was the most cost-effective.
Article
Medicine, General & Internal
Ryan Wing-Yuk Chan, Yung-Hsiao Chiang, Hsiu-Chen Lin, Chih-Yau Chang, Yi-Syue Tsou
Summary: Although several large-scale studies have investigated the surgical interventions for cervical spondylotic myelopathy (CSM), specifically multilevel anterior cervical discectomy and fusion (ACDF) and laminoplasty (LAMP), the optimal approach remains controversial. This study compared the postoperative complications of these two procedures and found that LAMP resulted in a higher frequency of surgical wound infections, longer hospital stays, and higher rates of unplanned reoperation. However, there were no significant differences in systemic complications and perioperative mortality between the two approaches.
Article
Clinical Neurology
Venkat Boddapati, Justin Mathew, Nathan J. Lee, Joel R. Peterson, Kyle L. McCormick, Joseph M. Lombardi, Zeeshan M. Sardar, Ronald A. Lehman, K. Daniel Riew
Summary: This study investigated the safety of outpatient three- and four-level ACDF. Outpatient multilevel ACDF is typically performed in younger and healthier patients, with three-level procedures being more common than four-level procedures. There was no observed increase in rates of total complications or readmissions in patients undergoing outpatient relative to inpatient surgery.
Article
Clinical Neurology
Yifei Deng, Beiyu Wang, Ying Hong, Yi Yang, Rong Xing, Xiaofei Wang, Hao Liu
Summary: This study aimed to reveal the common non-progressive bone loss phenomenon in anterior cervical diskectomy and fusion (ACDF) and explore its clinical and radiological outcomes. Retrospective analysis showed that 64.9% of Zero-P fusion implants and 55.2% of endplates had bone loss, which did not affect postoperative clinical outcomes and fusion rate but resulted in a higher incidence of subsidence.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Jiwon Park, Sang-Min Park, Dae-Woong Ham, Jae-Young Hong, Ho-Joong Kim, Jin S. Yeom
Summary: A study was conducted to evaluate the radiographic outcomes and clinical efficacy of using a CaO-SiO2-P2O5-B2O3 bioactive glass-ceramic (BGS-7) spacer for anterior cervical discectomy and fusion (ACDF) in treating cervical degenerative disorders. The study found that the BGS-7 spacer showed similar fusion rates and clinical outcomes as polyetheretherketone (PEEK) cages filled with hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) for ACDF surgery. These findings indicate that the BGS-7 spacer is a viable alternative for treating cervical degenerative disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Hyun Jun Jang, Kyung Hyun Kim, Jeong Yoon Park, Keun Su Kim, Yong Eun Cho, Dong Kyu Chin
Summary: This study found that in double-level ACDF procedures, the nonfusion rate was higher at the caudal fusion levels, especially at the lower endplates of the caudal fusion levels. There was no difference in radiological parameters and clinical outcomes between the fusion and pseudarthrosis groups.
ACTA NEUROCHIRURGICA
(2022)
Review
Clinical Neurology
Joshua Kurian, Mark N. Pernik, Jeffrey Traylor, William H. Hicks, Mohamad El Shami, Kalil G. Abdullah
Summary: This study reviewed articles describing cortical mapping for tumor resection in the past 20 years and evaluated the contribution of awake versus asleep cortical mapping to postoperative neurological deficits. The findings showed similar rates of transient and permanent neurological deficits between awake and asleep cortical mapping groups.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Oncology
Kalil G. Abdullah, Cylaina E. Bird, Joseph D. Buehler, Lauren C. Gattie, Milan R. Savani, Alex C. Sternisha, Yi Xiao, Michael M. Levitt, William H. Hicks, Wenhao Li, Denise M. O. Ramirez, Toral Patel, Tomas Garzon-Muvdi, Samuel Barnett, Gao Zhang, David M. Ashley, Kimmo J. Hatanpaa, Timothy E. Richardson, Samuel K. McBrayer
Summary: An optimized protocol was developed to establish organoids from LGG primary tissue samples, producing the first suite of these models. Patient-derived organoids recapitulated key biological features of their respective parental tumor specimens, demonstrating fidelity and potential for preclinical studies and personalized treatment assessments.
Article
Oncology
Shiyou Wei, Delong Yin, Shengnan Yu, Xiang Lin, Milan R. Savani, Kuang Du, Yin Ku, Di Wu, Shasha Li, Hao Liu, Meng Tian, Yaohui Chen, Michelle Bowie, Seethalakshmi Hariharan, Matthew Waitkus, Stephen T. Keir, Eric T. Sugarman, Rebecca A. Deek, Marilyne Labrie, Mustafa Khasraw, Yiling Lu, Gordon B. Mills, Meenhard Herlyn, Kongming Wu, Lunxu Liu, Zhi Wei, Keith T. Flaherty, Kalil Abdullah, Gao Zhang, David M. Ashley
Summary: This study aimed to investigate the antitumor activity and mechanisms of a mitochondrial-localized HSP90 inhibitor, Gamitrinib, in multiple glioma models. The results showed that Gamitrinib inhibited cell proliferation, induced apoptosis and delayed tumor growth in glioma cell lines and animal models. Integrated analysis revealed that Gamitrinib acted by suppressing mitochondrial biogenesis and tumor bioenergetics, and activating related pathways.
CLINICAL CANCER RESEARCH
(2022)
Article
Neurosciences
Yan Liu, Adwait Amod Sathe, Kalil G. Abdullah, Samuel K. McBrayer, Steven H. Adams, Andrew J. Brenner, Kimmo J. Hatanpaa, Mariano S. Viapiano, Chao Xing, Jamie M. Walker, Timothy E. Richardson
Summary: This study used global methylation profiling to identify the presence/absence of chromosomal instability (CIN) in IDH-mutant astrocytomas. It was found that IDH-mutant astrocytomas with evidence of CIN have distinct characteristics and worse clinical outcomes compared to chromosomally stable counterparts.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Cell Biology
Gao Guo, Ke Gong, Nicole Beckley, Yue Zhang, Xiaoyao Yang, Rati Chkheidze, Kimmo J. Hatanpaa, Tomas Garzon-Muvdi, Prasad Koduru, Arifa Nayab, Jennifer Jenks, Adwait Amod Sathe, Yan Liu, Chao Xing, Shwu-Yuan Wu, Cheng-Ming Chiang, Bipasha Mukherjee, Sandeep Burma, Bryan Wohlfeld, Toral Patel, Bruce Mickey, Kalil Abdullah, Michael Youssef, Edward Pan, David E. Gerber, Shulan Tian, Jann N. Sarkaria, Samuel K. McBrayer, Dawen Zhao, Amyn A. Habib
Summary: In this study, the authors discovered a new tumor-suppressive function of EGFR in EGFR-amplified glioblastomas. They found that the level of EGFR ligands can shift the role of EGFR from an oncogene to a tumor suppressor, influencing the prognosis of the disease. Increasing the level of EGFR ligands can activate the tumor-suppressive function of EGFR, resulting in inhibited tumor growth and invasion.
NATURE CELL BIOLOGY
(2022)
Review
Neurosciences
Timothy E. Richardson, Jamie M. Walker, Kalil G. Abdullah, Samuel K. McBrayer, Mariano S. Viapiano, Zarmeen M. Mussa, Nadejda M. Tsankova, Matija Snuderl, Kimmo J. Hatanpaa
Summary: Chromosomal instability (CIN) is a fundamental property of cancer and a key mechanism of tumorigenesis and progression. It is found in various cancers and is associated with poor clinical outcomes. However, there have been relatively few studies on this process, mainly due to the difficulty of measuring it clinically.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Clinical Neurology
Cylaina E. Bird, Jeffrey I. Traylor, Zachary D. Johnson, Jun Kim, Jack Raisanen, Babu G. Welch, Kalil G. Abdullah
Summary: Intraosseous hemangiomas are rare benign tumors that can invade the outer table of the skull but typically spare the inner layer and intracranial structures. Surgical resection is the standard treatment, with proper reconstruction critical for cosmetic outcomes. En bloc or piecemeal resection may be necessary depending on the extent of involvement.
JOURNAL OF NEUROLOGICAL SURGERY REPORTS
(2022)
Article
Oncology
Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, Joyce H. Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy B. Cameron, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y. R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin, Samuel K. McBrayer
Summary: This study found that IDH1-mutant glioma cells are hypersensitive to drugs targeting enzymes in the de novo pyrimidine nucleotide synthesis pathway. They also showed that a brain-penetrant DHODH inhibitor exhibits monotherapy efficacy against IDH-mutant gliomas, based on experiments using a genetically engineered mouse model and patient-derived models.
Review
Oncology
Diana D. Shi, Soummitra Anand, Kalil G. Abdullah, Samuel K. McBrayer
Summary: This article summarizes the current understanding of how IDH mutations influence DNA damage in glioma and discusses the clinical implications of these findings.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Joseph D. Buehler, Cylaina E. Bird, Milan R. Savani, Lauren C. Gattie, William H. Hicks, Michael M. Levitt, Mohamad El Shami, Kimmo J. Hatanpaa, Timothy E. Richardson, Samuel K. McBrayer, Kalil G. Abdullah
Summary: The researchers established a set of 3-dimensional patient-derived glioma organoids and developed a new algorithm to evaluate organoid viability. They found correlations between the new algorithm and traditional markers of cell viability, providing a quantitative measurement of organoid viability.
CANCER INFORMATICS
(2022)
Meeting Abstract
Oncology
Mohamad El Shami, Milan Savani, Lauren Gattie, William Hicks, Timothy Richardson, Samuel McBrayer, Kalil Abdullah
Meeting Abstract
Clinical Neurology
Timothy Richardson, Steven Adams, Kimmo Hatanpaa, Andrea Gilbert, Samuel McBrayer, Kalil Abdullah, Andrew Brenner, Jamie Walker
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Neda Wick, Changhong Xing, Yanel De Los Santos, Kalil Abdullah, Michael Youssef, Elena Daoud, Jack Raisanen, Kimmo Hatanpaa
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell & Tissue Engineering
William H. Hicks, Cylaina E. Bird, Lauren C. Gattie, Mohamad El Shami, Jeffrey Traylor, Diana D. Shi, Samuel K. McBrayer, Kalil G. Abdullah
Summary: Personalized cancer therapy requires accurate cancer models, and patient-derived organoids offer a promising approach. These organoids retain the heterogeneity of tumors and demonstrate similar therapeutic responsiveness, making them useful for drug screening and treatment selection.
CURRENT STEM CELL REPORTS
(2022)
Meeting Abstract
Oncology
D. D. Shi, A. C. Wang, W. Gao, J. Khanal, M. M. Levitt, R. B. Jennings, S. Signoretti, Q. D. Nguyen, J. E. Endress, M. Xu, S. Gradl, A. Sutter, M. Jeffers, A. Janzer, D. P. Cahill, K. G. Abdullah, K. L. Ligon, I. S. Harris, W. G. Kaelin, S. K. McBrayer
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)