4.6 Article

Smartphone Operated Signal Transduction by Ion Nanogating (STING) Amplifier for Nanopore Sensors: Design and Analytical Application

Journal

ACS SENSORS
Volume 1, Issue 3, Pages 265-271

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acssensors.5b00289

Keywords

miniaturized sensing device; voltage-clamp; biosensor; point-of-care; nanopipette; ionic conductance; low noise; portable instrumentation

Funding

  1. National Institutes of Health [P01-35HG000205]
  2. National Institute of Neurological Disorders and Stroke [R21NS082927]

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In this report, we demonstrate a hand-held wireless voltage-clamp amplifier for current measurement of nanopore sensors. This amplifier interfaces a sensing probe and connects wirelessly with a computer or smartphone for the required stimulus input, data processing, and storage. To test the proposed signal transduction by ion nanogating (STING) wireless amplifier, in the current study the system was tested with a nano-pH sensor to measure pH of standard buffer solutions and the performance was compared against the commercial voltage-clamp amplifier. To the best of our knowledge, STING amplifier is the first miniaturized wireless voltage-clamp platform operated with a customized smart phone application (app).

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