Review
Biochemistry & Molecular Biology
Subrat Kumar Bhattamisra, Hui Min Koh, Shin Yean Lim, Hira Choudhury, Manisha Pandey
Summary: Catalpol isolated from Rehmannia glutinosa shows potent antioxidant properties and has been investigated for its effects on diabetes mellitus and its complications. The molecular pathways involved include promoting IRS-1/PI3K/AKT/GLUT2 activity, suppressing PEPCK and G6Pase expression in the liver, inducing myogenesis in skeletal muscles, and exerting antioxidant effects in the pancreas and liver. Catalpol also demonstrates neuroprotective, cardioprotective, and osteoblast stimulating effects, as well as potential in preventing neurodegeneration in the retina.
Review
Endocrinology & Metabolism
Yuyan Zhu, Xuan Xia, Qian He, Qing-Ao Xiao, Decheng Wang, Meirong Huang, Xiaolin Zhang
Summary: Neutrophil extracellular traps (NETs) are released by activated neutrophils and consist of antimicrobial proteins and DNA. NETosis, a form of neutrophilic cell death, plays a crucial role in diabetes and its complications. Increased levels of NETs in the blood of diabetic patients confirm the association between NETosis and complications such as impaired wound healing, retinopathy, and atherosclerosis. This article summarizes the mechanisms of NETosis and discusses potential therapeutic targets using small molecule compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Food Science & Technology
Susmita Barman, Krishnapura Srinivasan
Summary: Zinc plays a crucial role in the synthesis, storage, and secretion of insulin. Studies have shown that supplementing with zinc can reduce hyperglycemia, improve metabolic abnormalities and antioxidant status, and alleviate complications associated with diabetes. Additionally, zinc can also alleviate renal lesions, cataract, cardiovascular disease risk, and restore gastrointestinal health in experimental diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Medicine, Research & Experimental
Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sorine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jorgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O. Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C. W. Ma, Juliana C. N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Summary: Diabetic nephropathy (DN) is a polygenic disorder with poorly defined genome-wide methylation patterns. Methylation sequencing using leukocytes from a Finnish diabetes study identified differentially methylated genes associated with DN, which were further validated in independent T1D registries from Denmark, Hong Kong, and Thailand. Reduced DNA methylation at certain sites was connected with DN pathways related to insulin signaling, lipid metabolism, and fibrosis. Experimental observations in human renal cells, macrophages, and vascular endothelial cells supported the findings.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Emma Ooi, Katrina Nash, Lakshmi Rengarajan, Eka Melson, Lucretia Thomas, Agnes Johnson, Dengyi Zhou, Lucy Wallett, Sandip Ghosh, Parth Narendran, Punith Kempegowda
Summary: The study compared demographics, presentation, and management of diabetic ketoacidosis (DKA) in adults with type 1 and type 2 diabetes. It found that DKA in type 2 diabetes presents at an older age and with more ethnic minority representation, but the severity and duration of DKA are similar in both types, suggesting that the same clinical management approach is effective. Patients with type 2 diabetes had longer hospital stays.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Food Science & Technology
Pei Li, Biyu Lu, Jing Gong, Lin Li, Guoping Chen, Jiaxian Zhang, Yongda Chen, Xing Tian, Bo Han, Yake Guo, Zhiyong Xie, Qiongfeng Liao
Summary: This study found that chickpea extract can improve hyperglycemia, inflammatory state, organ functions, and relieve intestinal dysbiosis in diabetic rats. It restores amino acids degradation, bile acids metabolism, and carbohydrate metabolism as prebiotics to prevent diabetes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Fengtian Sun, Yuntong Sun, Feng Wu, Wenrong Xu, Hui Qian
Summary: This review introduces the novel cell-free strategy of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and their applications in the treatment of diabetes mellitus (DM) and diabetic complications. The major characteristics of MSC-EVs are summarized, and the recent advances in the use of engineered MSC-EVs for treating hyperglycemia-induced tissue damage are discussed. Additionally, the potential applications of engineered MSC-EVs in the therapy of DM-related diseases are presented, and the opportunities and challenges for clinical translation of MSC-EVs, particularly engineered MSC-EVs, are evaluated.
Article
Endocrinology & Metabolism
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The level of gestational weight gain (GWG) during pregnancy is associated with adverse pregnancy outcomes in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT). Low GWG below recommended levels frequently occurs in GDM women without increased risk for adverse outcomes. Excessive GWG is associated with increased risk for neonatal hypoglycemia and worse metabolic profile postpartum in GDM women, and with higher rates of instrumental delivery and larger infants in NGT women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Kim Sui Wan, Feisul Mustapha, Arunah Chandran, Shubash Shander Ganapathy, Nurhaliza Zakariah, Sivarajan Ramasamy, Gunenthira Rao Subbarao, Muhammad Fadhli Mohd Yusoff
Summary: Diabetes is a growing global health emergency. This study focuses on a 10-year retrospective cohort of type 2 diabetes patients in Malaysia, revealing suboptimal control of blood glucose, blood pressure, and lipid levels.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Cuihong Huang, Lifang Chen, Jiangtao Li, Juanjuan Ma, Jun Luo, Qian Lv, Jian Xiao, Pan Gao, Wen Chai, Xu Li, Ming Zhang, Fulan Hu, Dongsheng Hu, Pei Qin
Summary: Through a systematic review and meta-analysis, we found an association between mitochondrial DNA copy number and diabetes mellitus and metabolic syndrome. Lower copy numbers were associated with increased risk of diabetes mellitus and metabolic syndrome.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Immunology
Hong-Bin Lin, Feng-Xian Li, Jin-Yu Zhang, Zhi-Jian You, Shi-Yuan Xu, Wen-Bin Liang, Hong-Fei Zhang
Summary: Cerebral-cardiac syndrome (CCS) involves cardiac dysfunction following brain injuries, with ischemic stroke being a common cause. Diabetes may play a significant role in CCS by exacerbating systemic inflammation and contributing to cardiac pathological changes. The NLRP3 inflammasome is suggested to be a crucial link between diabetes, stroke, and CCS.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Milena Cioana, Jiawen Deng, Ajantha Nadarajah, Maggie Hou, Yuan Qiu, Sondra Song Jie Chen, Angelica Rivas, Parm Pal Toor, Laura Banfield, Lehana Thabane, Varun Chaudhary, M. Constantine Samaan
Summary: The global prevalence of diabetic retinopathy (DR) in pediatric patients with type 2 diabetes (T2D) is significant, especially after 5 years of diagnosis. Fundus photography is more sensitive than fundoscopy in detecting DR, making it the recommended method for early detection in pediatric patients. Annual screening starting from diagnosis is crucial for the timely detection and treatment of DR.
Article
Multidisciplinary Sciences
Jianwei Guo, Yun Wu, Xinlei Deng, Zifeng Liu, Lijin Chen, Yixiang Huang
Summary: The study aimed to explore the association between social determinants of health and the direct economic burden of Chinese middle-aged and elderly individuals living with diabetes. Various factors like rural-urban status, regional status, household personal consumption expenditures, and comorbidities were found to be crucial in influencing medical costs for people with diabetes.
Article
Endocrinology & Metabolism
Anitha Pitchika, Marcello Ricardo Paulista Markus, Sabine Schipf, Alexander Teumer, Sandra Van der Auwera, Matthias Nauck, Marcus Doerr, Stephan Felix, Hans Joergen Grabe, Henry Voelzke, Till Ittermann
Summary: The study aims to examine the association of different APOE alleles with T2DM and MetS, as well as the influence of hs-CRP on these associations. The results show that E4 carriers have a lower odds of developing T2DM, while both E2 and E4 carriers have higher odds of developing MetS. The association between E4 alleles and T2DM is moderately attenuated after adjusting for hs-CRP levels.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Review
Cell Biology
Chongxiang Xue, Keyu Chen, Zezheng Gao, Tingting Bao, Lishuo Dong, Linhua Zhao, Xiaolin Tong, Xiuyang Li
Summary: Diabetic vascular complications (DVCs), including macro- and micro- angiopathy, are major causes of mortality in patients with diabetes mellitus (DM), with endothelial dysfunction playing a key role in their pathogenesis. Hyperglycemia and lipid metabolism disorders contribute to endothelial dysfunction through various mechanisms, and targeting these common mechanisms may be effective in reducing the incidence of DVCs.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Patrice Marques, Elena Domingo, Arantxa Rubio, Sergio Martinez-Hervas, Juan F. Ascaso, Laura Piqueras, Jose T. Real, Maria-Jesus Sanz
Summary: Inhibiting PCSK9 function can impact systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions, enhancing T-regulatory cell activation, and reducing inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Peripheral Vascular Disease
Beatriz Moreno, Luisa Hueso, Rebeca Ortega, Esther Benito, Sergio Martinez-Hervas, Marta Peiro, Miguel Civera, Maria-Jesus Sanz, Laura Piqueras, Jose T. Real
Summary: The study analyzed the role of CXCR3 ligands on insulin resistance and endothelial dysfunction in obese patients. It found that CXCL10 and CXCL11 are associated with insulin resistance and enhance leukocyte endothelial arrest in obese subjects, suggesting that targeting CXCR3 signaling could be a new therapeutic approach for preventing obesity-associated cardiovascular co-morbidities.
MICROVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Jose Maria Mostaza, Xavier Pinto, Pedro Armario, Luis Masana, Jose T. Real, Pedro Valdivielso, Teresa Arrobas-Velilla, Ramon Baeza-Trinidad, Pilar Calmarza, Jesus Cebollada, M. Civera-Andres, J. I. Cuende Melero, J. L. Diaz-Diaz, J. Fernandez Pardo, C. Guijarro, C. Jerico, M. Laclaustra, C. Lahoz, J. Lopez-Miranda, S. Martinez-Hervas, O. Muniz-Grijalvo, J. A. Paramo, V. Pascual, J. Pedro-Botet, P. Perez-Martinez, N. Plana, J. Puzo, M. A. Sanchez Chaparro, L. Vila
Summary: The Spanish Society of Arteriosclerosis aims to contribute to the understanding, prevention, and treatment of vascular disease. Cardiovascular diseases are the leading cause of death in Spain, resulting in disability and high healthcare costs. Arteriosclerosis is a multifactorial disease, requiring a comprehensive approach to prevention that considers different associated risk factors. This document summarizes current knowledge, provides recommendations and procedures for patients with established cardiovascular disease or high vascular risk. It covers symptoms, signs, laboratory and imaging procedures, vascular risk estimation, diagnostic criteria, and treatment recommendations. Additionally, it includes aspects not commonly referenced in the literature, such as the organization of a vascular risk consultation.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2022)
Article
Endocrinology & Metabolism
Wan Chen Gu Hong, Jordi Ferri, Francisco Javier Ampudia-Blasco, Ramon Martin-Brufau, Marta Peiro, Esther Benito, Sergio Martinez-Hervas, Maria Jesus Sanz, Jose Tomas Real
Summary: This study analyzed the relationship between personality traits and blood glucose control in patients with type 1 diabetes mellitus (DM1). The study found that patients with poor blood glucose control had higher scores in feeling-guided, innovation-seeking, dissenting, submissive, and dissatisfied scales. The rebellious or non-conformist personality type was closely associated with poor blood glucose control.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Medicine, General & Internal
Sergio Martinez-Hervas, Maria M. Morales-Suarez-Varela, Irene Andres-Blasco, Francisco Lara-Hernandez, Isabel Peraita-Costa, Jose T. Real, Ana-Barbara Garcia-Garcia, F. Javier Chaves
Summary: The study developed a prediction model for type 2 diabetes based on FTGs, FPG, age, gender, and BMI values, which correctly classified 93.5% of individuals.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ana-Barbara Garcia-Garcia, Sergio Martinez-Hervas, Santiago Vernia, Carmen Ivorra, Ines Pulido, Juan-Carlos Martin-Escudero, Marta Casado, Julian Carretero, Jose T. Real, Felipe Javier Chaves
Summary: Patients with high cholesterol and glucose levels are at high risk for cardiovascular disease. This study found a mutation in the SREBF2 gene that may be associated with hypercholesterolemia and hyperglycemia.
Article
Endocrinology & Metabolism
Jordi Ferri, Juncal Martinez-Ibanez, Liria Terradez, Ester Savall, Sergio Martinez-Hervas, Maria Cristina Oller, Rosario Lorente, Juan Francisco Ascaso, Jose Tomas Real
Summary: The aim of this study was to investigate the etiology of Cushing's disease (CD) in patients without pituitary adenoma detected by MRI but requiring catheterization of the inferior petrosal sinus (CIPS). The study found that 20% of the patients had corticotroph cell hyperplasia as the cause of CD.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Peripheral Vascular Disease
Susana Martin-Vano, Alejandra Miralles-Abella, Pascual Castano, Gema Hurtado-Genoves, Maria Aguilar-Ballester, Andrea Herrero-Cervera, Angela Vinue, Sergio Martinez-Hervas, Herminia Gonzalez-Navarro
Summary: This study explores the involvement of the tumor necrosis factor superfamily (TNFSF) ligands in the gene expression signature associated with vascular smooth muscle cell plasticity. The results indicate that these ligands play a crucial role in maintaining the identity of vascular smooth muscle cells and preventing them from acquiring a genetic expression signature compatible with functional cellular plasticity.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2023)
Review
Nutrition & Dietetics
Elena Jimenez-Marti, Gema Hurtado-Genoves, Maria Aguilar-Ballester, Sergio Martinez-Hervas, Herminia Gonzalez-Navarro
Summary: The increasing prevalence of obesity and type 2 diabetes is causing a socioeconomic burden, particularly in the form of cardiovascular disease. Metabolic surgery, which improves the action of preproglucagon-derived hormones, shows promise beyond traditional dietary restrictions and weight loss. This review explores the complexities of these hormones and their analogues, particularly the use of dual and triagonists, and discusses their potential for treating cardiovascular disease.
Letter
Endocrinology & Metabolism
Antonio Perez Perez, Emilio Ortega Martinez de Victoria, Francisco Arrieta Blanco, Assumpta Caixas Pedragos, Estefania Santos Mazo, Pablo Fernandez-Catalina, Sergio Martinez-Hervas, Jose Antonio Lopez-Medina, Lorena Suarez-Gutierrez, Juan Ramon Urgeles Planelles, Sonia Gatell Menchen, Francisco Tinahones Madueno
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Endocrinology & Metabolism
Ana Palanca, F. Javier Ampudia-Blasco, Jose Miguel Calderon, Inmaculada Sauri, Sergio Martinez-Hervas, Jose Luis Trillo, Josep Redon, Jose T. Real
Summary: The study aimed to assess the impact of GLP-1RA treatment in obese adults with type 2 diabetes and compare it with other glucose-lowering agents. The results showed that GLP-1RA users had lower persistence but higher medication adherence. Within 2 years, persistent GLP-1RA users showed better reduction in HbA1c. However, therapeutic inertia was observed in the study population.
Article
Nutrition & Dietetics
Blanca Alabadi, Miguel Civera, Adrian De la Rosa, Sergio Martinez-Hervas, Mari Carmen Gomez-Cabrera, Jose T. Real
Summary: Body composition changes during aging, particularly loss of lean mass, can contribute to the development of age-associated diseases such as type 2 diabetes (T2D). T2D is also associated with increased oxidative stress (OS) that negatively affects skeletal muscle. This study aimed to investigate the differences in clinical and nutritional parameters, disease control, and OS in older patients with T2D based on their amount of lean mass. The findings indicate that older women with low fat-free mass and muscle mass have poorer T2D metabolic control, and those with low muscle mass exhibit higher levels of OS. Thus, low lean mass in geriatric T2D patients is associated with worse glycemic control and increased OS.
Meeting Abstract
Peripheral Vascular Disease
Olga Martinez-Arroyo, Ana Ortega, Elena Solaz, Fernando Martinez, Sergio Martinez-Hervas, Josep Redon, Raquel Cortes
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Aguilar Ballester, S. Martin-Vano, A. Abella Miralles, G. Hurtado Genoves, A. Herrero-Cervera, A. M. Taberner Cortes, A. Vinue, S. Martinez-Hervas, H. Gonzalez-Navarro
Meeting Abstract
Cardiac & Cardiovascular Systems
G. Hurtado Genoves, S. Martin-Vano, A. Herrero-Cervera, M. Aguilar-Ballester, A. Vinue, A. M. Taberner Cortes, S. Martinez-Hervas, H. Gonzalez-Navarro