Review
Geriatrics & Gerontology
D. Scott Kehler, Jovana Milic, Giovanni Guaraldi, Tamas Fulop, Julian Falutz
Summary: This paper discusses the clinical and scientific aspects of frailty in older people living with HIV, highlighting its impact on healthcare and adverse outcomes. Frailty negatively affects the clinical status of PLWH and increases their risk of adverse outcomes, affecting quality of life and health-span. Identifying and managing related risk factors can help mitigate the development of frailty.
Review
Nutrition & Dietetics
Wassim Gana, Arnaud De Luca, Camille Debacq, Fanny Poitau, Pierre Poupin, Amal Aidoud, Bertrand Fougere
Summary: Vitamin deficiencies have a significant impact on healthy aging, especially in high-income countries. Malnutrition plays a key role in the development of frailty, aging, and sarcopenia, with poor nutritional status being a major cause of geriatric morbidity and mortality. Further research programs focusing on nutritional interventions are needed to reduce deficiencies in older populations and decrease the risk of frailty and sarcopenia.
Review
Health Care Sciences & Services
Alan J. Sinclair, Ahmed H. Abdelhafiz
Summary: Multimorbidity and frailty are common in older people with diabetes and are associated with adverse outcomes, including increased healthcare utilization, disability risk, and mortality risk. Mental health disorders may enhance the risk of adverse outcomes related to multimorbidity. Comprehensive diabetes management, including screening and management of mental health disorders, is necessary.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Yuki Kato, Kouji Izumi, Atsushi Mizokami
Summary: The decline in testosterone is associated with sarcopenia and frailty, and testosterone replacement therapy has been shown to improve muscle mass and strength.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Darren G. Candow, Scott C. Forbes, Ben Kirk, Gustavo Duque
Summary: Sarcopenia, characterized by age-related reduction in muscle mass, strength, and physical performance, is associated with various age-related health conditions. Creatine supplementation, especially when combined with resistance training, shows promising effects on muscle, bone, and fat mass, as well as strength and physical performance in healthy older adults. However, more research is needed on the efficacy of creatine supplementation in older adults with specific conditions like osteoporosis and sarcopenic obesity.
Review
Cell Biology
Helio Jose Coelho-Junior, Riccardo Calvani, Matteo Tosato, Francesco Landi, Anna Picca, Emanuele Marzetti
Summary: The study found that a protein intake higher than the recommended dietary allowance is cross-sectionally associated with better physical performance and greater muscle strength in older adults. However, over time, a high consumption of proteins does not seem to prevent decline in physical function.
AGEING RESEARCH REVIEWS
(2022)
Article
Geriatrics & Gerontology
Kinda Ibrahim, Mark A. Mullee, Natalie Cox, Cynthia Russell, Mark Baxter, Simon Tilley, Guiqing Lily Yao, Shihua Zhu, Helen C. Roberts
Summary: This study assessed the feasibility of assessing sarcopenia and frailty among older people attending fracture clinics. The results showed that SARC-F and PRISMA-7 are recommended for use in fracture clinics to screen for sarcopenia and frailty, and Comprehensive Geriatric Assessment (CGA) led to positive interventions for participants.
Article
Geriatrics & Gerontology
Alejandro Alvarez-Bustos, Jose Antonio Carnicero-Carreno, Betty Davies, Francisco Javier Garcia-Garcia, Fernando Rodriguez-Artalejo, Leocadio Rodriguez-Manas, Cristina Alonso-Bouzon
Summary: Frailty and sarcopenia are age-associated syndromes that are often linked to functional decline and mortality. This study examined the role of sarcopenia in modulating transitions within frailty status, finding that sarcopenia impacted frailty transitions but did not affect the risk of death associated with frailty.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Gert-Jan van der Putten, Cees de Baat
Summary: The oral health of older individuals can deteriorate rapidly due to various systemic health factors. These factors include adverse reactions to medications, such as hyposalivation caused by certain medications, as well as frailty, disability, sarcopenia, care dependency, and limited access to professional oral healthcare. A comprehensive approach involving effective communication between oral healthcare providers, other healthcare providers, and informal caregivers is necessary to prevent rapid deterioration of oral health. Oral healthcare providers have a responsibility to advocate for the importance of maintaining adequate oral health and raise awareness of the serious consequences of weakened oral health.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Gulistan Bahat, S. Ozkok, C. Kilic, M. A. Karan
Summary: The study found that SARC-F >= 1 can be used with high sensitivity for screening frailty, while SARC-F >= 4 can be used with high specificity for diagnosing frailty. SARC-F may be utilized for evaluating frailty in routine geriatric practice, showing potential clinical applicability for screening and assessment of frailty.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Endocrinology & Metabolism
Assaf Buch, Arie Ben-Yehuda, Vanessa Rouach, Andrea B. Maier, Yona Greenman, Elena Izkhakov, Naftali Stern, Roy Eldor
Summary: In older adults with type 2 diabetes, there is high agreement between DSMF-BIA and DXA in measuring muscle mass, supporting the use of DSMF-BIA as an alternative method for assessing body composition.
NUTRITION & DIABETES
(2022)
Review
Cell Biology
Helena Maia Almeida, Amanda Sardeli, Jessica Conway, Niharika Arora Duggal, Claudia Regina Cavaglieri
Summary: The present meta-analysis found no evidence of differences in intestinal microbiota diversity between frail and non-frail older adults. However, the primary studies revealed differences in the relative abundance of bacterial phyla, families, genera, and species between the frail and non-frail groups.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, General & Internal
Yanxia Lu, Wee Shiong Lim, Xia Jin, Ma Schwe Zin Nyunt, Tamas Fulop, Qi Gao, Su Chi Lim, Anis Larbi, Tze Pin Ng
Summary: Dysregulated insulin secretion may play an important role in age-related and diabetes-related sarcopenia.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yukihiro Inoguchi, Toyoshi Inoguchi, Tomoaki Eto, Mitsunori Masakado, Satoru Suehiro, Teruaki Yamauchi, Fumio Umeda
Summary: The study suggests that serum indirect bilirubin levels may be associated with decreased skeletal muscle mass in older male patients with type 2 diabetes.
Article
Nutrition & Dietetics
Ke-Vin Chang, Wei-Ting Wu, Lan-Rong Chen, Hsin- Wang, Tyng-Guey Wang, Der-Sheng Han
Summary: This study found a positive correlation between decreased tongue pressure and an increased risk of malnutrition in community-dwelling older individuals. Older people with suboptimal tongue pressure may need to undergo a thorough assessment of their nutritional status and swallowing function for early identification of subclinical malnutrition and dysphagia.
Article
Pharmacology & Pharmacy
Karen Schneck, Lai San Tham, Ali Ertekin, Jesus Reviriego
JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Endocrinology & Metabolism
Luis Alberto Vazquez, Eva Calvo-Bonacho, Jesus Reviriego, Teresa Garcia-Margallo, Elena Caveda, Albert Goday
Review
Endocrinology & Metabolism
Irene Romera, Ana Cebrian-Cuenca, Fernando Alvarez-Guisasola, Fernando Gomez-Peralta, Jesus Reviriego
Review
Endocrinology & Metabolism
Mercedes Nunez, Silvia Diaz, Tatiana Dilla, Jesus Reviriego, Antonio Perez
Article
Medicine, General & Internal
Julio Lopez-Bastida, Juan Pedro Lopez-Siguero, Juan Oliva-Moreno, Luis Alberto Vazquez, Isaac Aranda-Reneo, Jesus Reviriego, Tatiana Dilla, Magaly Perez-Nieves
CURRENT MEDICAL RESEARCH AND OPINION
(2019)
Article
Endocrinology & Metabolism
Raffaella Gentilella, Irene Romera, Claudia Nicolay, Raffaella Buzzetti, Luis Alberto Vazquez, Giorgio Sesti
Article
Endocrinology & Metabolism
Raffaella Gentilella, Giorgio Sesti, Luis Vazquez, Helene Sapin, Victoria Reed, Irene Romera, Paolo Pozzilli
DIABETES OBESITY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Irene Romera, Silvia Diaz, Antoni Sicras-Mainar, Flora Lopez-Simarro, Tatiana Dilla, Esther Artime, Jesus Reviriego
Article
Medicine, General & Internal
Silvia Diaz-Cerezo, Irene Romera, Antoni Sicras-Mainar, Flora Lopez-Simarro, Tatiana Dilla, Esther Artime, Jesus Reviriego
CURRENT MEDICAL RESEARCH AND OPINION
(2020)
Article
Endocrinology & Metabolism
Irene Romera, Ignacio Conget, Luis Alberto Vazquez, Raffaella Gentilella, Jeremie Lebrec, Esteban Jodar, Jesus Reviriego
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2020)
Article
Medicine, Research & Experimental
Natalia Duque, Esther Artime, Irene Romera, Jeremie Lebrec, Silvia Diaz, Miriam Rubio, Antoni Sicras-Mainar, Enrique Carretero-Anibarro, Xavier Mundet, Juan J. Gorgojo-Martinez, Jesus Reviriego
Summary: In real-world practice, patients with type 2 diabetes mellitus receiving insulin glargine U300 required higher insulin doses at 6, 12, and 18 months compared to those receiving insulin glargine U100, despite similar reductions in HbA1c levels.
ADVANCES IN THERAPY
(2021)
Article
Endocrinology & Metabolism
F. Javier Ampudia-Blasco, Esther Artime, Silvia Diaz, Miriam Rubio, Jesus Reviriego, Beth Mitchell, Beatrice Osumili, Mark Peyrot, Robin Pokrzywinski, Erik Spaepen, Frank Snoek
Summary: The majority of severe hypoglycaemic events among people with insulin-treated diabetes occur at home, with the most common cause being eating less than planned. Carbohydrate intake is the most common action taken during these events, while glucagon use is low. Feelings of fear, unpreparedness, and helplessness are reported by a significant portion of individuals during such events.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2021)
Article
Medicine, General & Internal
David Ruiz, Miguel Santibanez, Bernardo Alio Lavin, Ana Berja, Coral Montalban, Luis Alberto Vazquez
Summary: The study aimed to investigate the evolution of mitochondrially derived peptides (MDPs) and their relationship with changes in insulin sensitivity in pregnant women during early stages of pregnancy. The levels of MDPs (humanin and MOTSc) were found to significantly decrease from the first to the second trimesters. The study also revealed a significant association between changes in MOTSc levels and insulin resistance, suggesting its involvement in the increase of insulin resistance during early pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
