Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Review
Clinical Neurology
Manal Nicolas-Jilwan, Max Wintermark
Summary: Recent advancements in computed tomography technology have reinforced the importance of perfusion computed tomography imaging in evaluating patients with acute ischemic stroke, especially in selecting patients for endovascular thrombectomy. Studies have shown the benefits of perfusion imaging in diagnosing patients with anterior circulation large vessel occlusion within 24 hours. This compelling data has led to an increased introduction of automated perfusion computed tomography imaging in routine evaluation of stroke patients.
Article
Chemistry, Multidisciplinary
Jian Wang, Qiangfei Su, Qiying Lv, Bo Cai, Xiakeerzhati Xiaohalati, Guobin Wang, Zheng Wang, Lin Wang
Summary: The study introduces a novel approach to stroke treatment by utilizing a nanotechnology-driven biosystem that generates oxygen through photosynthesis, rescuing neurons and treating stroke effectively. This innovative method combines microorganisms and nanotechnology to improve neuronal function recovery in stroke patients, showing promising results in cell-biological, biochemical, and animal-level behavioral data.
Review
Pharmacology & Pharmacy
Li Zhang, Yue Liu, Haiyan Huang, Hui Xie, Baozhu Zhang, Wujiong Xia, Bing Guo
Summary: Malignant brain tumors are a group of tumors with high invasiveness and destructiveness, and near-infrared optical imaging techniques show potential in the diagnosis and treatment of brain tumors due to their noninvasiveness, high resolution, and large penetration depth.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Engineering, Environmental
Feng Liu, Biao Huang, Tao Tang, Fanjie Wang, Ran Cui, Mingxi Zhang, Taolei Sun
Summary: Researchers developed a fluorescent nanozyme by doping Mn atoms into PbS/CdS quantum dots, which showed excellent antioxidant activity and could effectively scavenge ROS, thus providing neuroprotective effects for traumatic brain injury treatment. Additionally, the nanozyme exhibited exceptional NIR-IIb fluorescence performance, allowing for dynamic monitoring of the blood-brain barrier status to guide precise treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Zhuoran Ma, Feifei Wang, Weizhi Wang, Yeteng Zhong, Hongjie Dai
Summary: This study utilized artificial neural networks to transform fluorescence images in the shorter-wavelength NIR window to images resembling NIR-IIb window, achieving high signal-to-background ratio in vivo lymph node imaging with human-approved molecular probes. Translation of PD-L1 or EGFR imaging greatly enhanced tumor-to-normal tissue ratio and improved tumor margin localization, showcasing the potential of deep learning in enhancing noninvasive NIR imaging and microscopy. Deep learning equipped NIR imaging could facilitate basic biomedical research and clinical diagnostics and imaging-guided surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nanoscience & Nanotechnology
Yan Cheng, Airong Cheng, Yanlong Jia, Lin Yang, Yan Ning, Liang Xu, Yazhi Zhong, Zerui Zhuang, Jitian Guan, Xiaolei Zhang, Yan Lin, Teng Zhou, Xiusong Fan, Jianwu Li, Peng Liu, Gen Yan, Renhua Wu
Summary: The study developed a pH-sensitive theranostic nanoplatform for the precise delivery of rapamycin to ischemic brain tissues, enhancing therapeutic accuracy and enabling multimodal imaging for drug distribution monitoring. The nanoparticles showed good stability and biocompatibility, with the potential for neuroprotection in rats with transient middle cerebral artery occlusion (tMCAO). This pH-sensitive multifunctional nanoplatform could be a promising solution for the accurate in vivo imaging and treatment of acute ischemic stroke and other diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daan Peerlings, Edwin W. Bennink, Jan K. Dankbaar, Birgitta J. Velthuis, Bart W. Emmer, Jan W. Hoving, Charles B. L. M. Majoie, Henk A. Marquering, Henk van Voorst, Hugo W. A. M. de Jong
Summary: The study aimed to evaluate the variation in CT perfusion (CTP) imaging protocols among stroke centers and explore the potential for standardizing vendor software to harmonize CTP images. It found that CTP images varied significantly between different vendor software, while acquisition settings had minimal impact. Standardizing the estimation of ischemic regions helped to harmonize the images to a certain extent.
EUROPEAN RADIOLOGY
(2023)
Review
Neurosciences
Rachel Thomas, Samuel S. Shin, Ramani Balu
Summary: Acute brain injuries can lead to neurological worsening, further brain injury, and poor outcomes. Near-infrared spectroscopy (NIRS) shows potential as a bedside tool to monitor cerebrovascular physiology in critically ill patients with acute brain injury. NIRS can identify new brain injuries, measure intracranial pressure and cerebral autoregulation, and determine optimal blood pressure targets.
Article
Chemistry, Applied
Xue Qiao, Yang Li, Wumei Wang, Yuling Xiao, Tian Tian, Xiaobo Wang, Haibin Luo, Deliang Chen, Xianli Meng, Xiaodong Zeng, Xuechuan Hong
Summary: This study reports a near-infrared II (NIR-II) fluorophore HLX with a unique twisted donor-acceptor pi-architecture, which exhibits strong aggregation induced emission characteristics and high fluorescence quantum yield in the NIR-II window and near-infrared IIb (NIR-IIb) region. HLX dots achieved whole-body vascular imaging with superior clarity, and were utilized for NIR-IIb fluorescence imaging of ischemic stroke in animals to monitor the therapeutic efficacy of salidroside for the first time. The study further demonstrates the neuroprotective effects of salidroside against cerebral ischemic injury through promoting angiogenesis. The superior biocompatibility of HLX makes it a potential agent for imaging-guided therapy of ischemic stroke in the NIR-IIb region.
Article
Engineering, Biomedical
Shen-Jie Li, Fang Li, Na Kong, Jian-Ren Liu, Xingjun Zhu
Summary: This study introduces a temperature-responsive, near infrared (NIR) emissive lanthanide-doped nanoparticle for early diagnosis of ischemic stroke. The nanoparticles can not only judge the location and severity of cerebral ischemic injury, but also report the brain temperature variation in the ischemic area through a visualized way.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Neurosciences
Luca Menozzi, Wei Yang, Wuwei Feng, Junjie Yao
Summary: Photoacoustic imaging is a versatile imaging modality that can provide comprehensive information about biological tissues. This article reviews the scientific progress in using photoacoustic imaging to monitor cerebral blood vessel impairment and restoration after ischemic stroke, and discusses the technological barriers and challenges in translating this technology to a clinical tool for human strokes.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Ke Zhang, Fu-Rong Chen, Lidai Wang, Jinlian Hu
Summary: In this review, the advantages and various imaging technologies of near-infrared-II (NIR-II) bioimaging for deep brain imaging are discussed, along with the corresponding contrast agents. The applications of NIR-II bioimaging in visualizing cerebrovascular characteristics and monitoring pathology signals, as well as its potential for modulating brain structure and function, are outlined. Future perspectives for improving the clinical translation of NIR-II light are also proposed.
Article
Neurosciences
Yiming Jia, Hongyan Sun, Lulu Sun, Yinan Wang, Qingyun Xu, Yi Liu, Xinyue Chang, Yu He, Daoxia Guo, Mengyao Shi, Guo-Chong Chen, Jin Zheng, Yonghong Zhang, Zhengbao Zhu
Summary: In this study, a bidirectional two-sample Mendelian randomization analysis was conducted to explore the potential causal relationship between brain imaging-derived phenotypes (IDPs) and ischemic stroke. The results identified five IDPs associated with ischemic stroke and three IDPs associated with the risk of ischemic stroke, providing insights into the prediction and diagnosis of ischemic stroke using brain imaging.
Article
Biochemistry & Molecular Biology
Lei Meng, Bin Feng, Liming Luan, Zhihao Fang, Guangyu Zhao
Summary: The overexpression of MeCP2 can protect against ischemic brain injury by disrupting the FOXO3a/SPRY2/ZEB1 signaling axis. This finding provides new possibilities for the treatment of ischemic stroke.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Clinical Neurology
Meaghan Reid, Akinrinola O. Famuyide, Nils D. Forkert, Aron Sahand Talai, James W. Evans, Amith Sitaram, Moiz Hafeez, Mohamed Najm, Bijoy K. Menon, Andrew Demchuk, Mayank Goyal, Rani Gupta Sah, Christopher D. d'Esterre, Philip Barber
CLINICAL NEURORADIOLOGY
(2019)
Article
Clinical Neurology
F. Seker, J. Pfaff, S. Schoenenberger, C. Herweh, S. Nagel, P. A. Ringleb, M. Bendszus, M. A. Moehlenbruch
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Editorial Material
Endocrinology & Metabolism
Marcelo Rocha, Ashutosh P. Jadhav, Tudor G. Jovin
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Clinical Neurology
Mayank Goyal, Mohammed Almekhlafi, Diederik W. Dippel, Bruce C. V. Campbell, Keith Muir, Andrew M. Demchuk, Serge Bracard, Antoni Davalos, Francis Guillemin, Tudor G. Jovin, Bijoy K. Menon, Peter J. Mitchell, Scott Brown, Philip White, Charles B. L. M. Majoie, Jeffrey L. Saver, Michael D. Hill
Article
Clinical Neurology
Angel Chamorro, Scott Brown, Sergio Amaro, Michael D. Hill, Keith W. Muir, Diederik W. J. Dippel, Wim van Zwam, Ken Butcher, Gary A. Ford, Heleen M. den Hertog, Peter J. Mitchell, Andrew M. Demchuk, Charles B. L. M. Majoie, Serge Bracard, Igor Sibon, Ashutosh P. Jadhav, Blanca Lara-Rodriguez, Aad van der Lugt, Elizabeth Osei, Arturo Renu, Sebastien Richard, David Rodriguez-Luna, Geoffrey A. Donnan, Anand Dixit, Mohammed Almekhlafi, Sandrine Deltour, Jonathan Epstein, Benoit Guillon, Serge Bakchine, Meritxell Gomis, Richard du Mesnil de Rochemont, Demetrius Lopes, Vivek Reddy, Gernot Rudel, Yvo B. W. E. M. Roos, Alain Bonafe, Hans-Christoph Diener, Olvert A. Berkhemer, Geoffrey C. Cloud, Stephen M. Davis, Robert van Oostenbrugge, Francis Guillemin, Mayank Goyal, Bruce C. V. Campbell, Bijoy K. Menon
Article
Cardiac & Cardiovascular Systems
Moa Simonsson, Henric Winell, Henrik Olsson, Karolina Szummer, Joakim Alfredsson, Marlous Hall, Tatendashe B. Dondo, Chris P. Gale, Tomas Jernberg
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Clinical Neurology
Romain Bourcier, Mayank Goyal, David S. Liebeskind, Keith W. Muir, Hubert Desal, Adnan H. Siddiqui, Diederik W. J. Dippel, Charles B. Majoie, Wim H. van Zwam, Tudor G. Jovin, Elad I. Levy, Peter J. Mitchell, Olvert A. Berkhemer, Stephen M. Davis, Linad Derraz, Geoffrey A. Donnan, Andrew M. Demchuk, Robert J. van Oostenbrugge, Michael Kelly, Yvo B. Roos, Reza Jahan, Aad van der Lugt, Marieke Sprengers, Stephane Velasco, Geert J. Lycklama A. Nijeholt, Wagih Ben Hassen, Paul Burns, Scott Brown, Emmanuel Chabert, Timo Krings, Hana Chloe, Christian Weimar, Bruce C. V. Campbell, Gary A. Ford, Marc Ribo, Phil White, Geoffrey C. Cloud, Luis San Roman, Antoni Davalos, Olivier Naggara, Michael D. Hill, Serge Bracard
Review
Biotechnology & Applied Microbiology
Aubrey M. Demchuk, Trushar R. Patel
BIOTECHNOLOGY ADVANCES
(2020)
Article
Neurosciences
Aubrey M. Demchuk, Sutherland T. Dube, Lilia Mesina, Bruce L. McNaughton
NEUROSCIENCE LETTERS
(2020)
Article
Clinical Neurology
Rohit Bhatia, P. N. Sylaja, M. V. Padma Srivastava, Snigdha Komakula, Thomas Iype, Rajsrinivas Parthasarathy, Dheeraj Khurana, Vibhor Pardasani, Vijaya Pamidimukkala, S. Kumaravelu, Jeyaraj Pandian, Suman Kushwaha, Debashish Chowdhury, Salil Gupta, Srijithesh P. Rajendran, Rajshekar Reddy, Jayanta Roy, Arvind Sharma, Vivek Nambiar, Nirendra Kumar Rai, Ashish Datt Upadhyay, Sathish Parkipandla, Mamta Bhushan Singh, Deepti Vibha, Venugopalan Y. Vishnu, Roopa Rajan, Anu Gupta, Awadh Kishore Pandit, Ayush Agarwal, Shailesh B. Gaikwad, Ajay Garg, Leve Joseph, Sapna Erat Sreedharan, Sritheja Reddy, Krishna Sreela, Dileep Ramachandran, Githin Benoy George, Praveen Panicker, M. K. Suresh, Vipul Gupta, Sucharita Ray, Vikas Suri, Chirag Ahuja, Kamal Kajal, Vivek Lal, Rakesh K. Singh, Harsh Oza, Hiral Halani, Srinivasareddy Sanivarapu, Rajeshwar Sahonta, Ashish Duggal, Prashant Dixit, Girish Baburao Kulkarni, A. V. R. Taallapalli, Mamta Parmar, Vamsi Chalasani, Manshi Kashyap, Biswamohan Misra, Sudheer Pachipala, P. M. Yogeesh, Manish Salunkhe, Pranjal Gupta
Summary: The study found that during the COVID-19 pandemic in 2020, there were delays and reductions in the diagnosis, treatment, and management of stroke patients, but overall, the proportion of patients with good outcomes was similar to 2019.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Jeyaraj Durai Pandian, Shweta Jain Verma, Deepti Arora, Meenakshi Sharma, Rupinder Dhaliwal, Himani Khatter, Rahul Huilgol, P. N. Sylaja, Aneesh Dhasan, Vishnu Renjith, Abhishek Pathak, Aparna Pai, Arvind Sharma, Anand Vaishnav, Biman Ray, Dheeraj Khurana, Gaurav Mittal, Girish Kulkarni, Ivy Sebastian, Jayanta Roy, Somasundaram Kumaravelu, Lydia John, Mahesh Kate, M. V. Srivastava, Madhusudhan Byadarahalli Kempegowda, Nomal Borah, Neetu Ramrakhiani, Nirendra Rai, Pawan Ojha, Rohit Bhatia, Rupjyoti Das, Sachin Sureshbabu, Shaikh Afshan Jabeen, Sanjeev Bhoi, Sanjith Aaron, Prabhakaran Sarma, Aralikatte Onkarappa Saroja, Sherly Abraham, Sudhir Sharma, Sulena Sulena, Sankar Gorthi, Sundarachary Nagarjunakonda, Sunil Narayan, Thomas Mathew, Tina George, Pamidimukkala Vijaya, Vikram Huded, Vivek Nambiar, Y. Muralidhar Reddy
Summary: The INSTRuCT project in India aims to establish a state-of-the-art stroke clinical trial network and conduct relevant trials. Through expert meetings, the scope of the network was defined and established stroke centers with clinical trial experience were included. The project has successfully initiated trials like SPRINT and RESTORE, with plans for more in the future.
Editorial Material
Clinical Neurology
K. P. Vinayan, Vivek Nambiar, Vaishakh Anand
Summary: Ischemic stroke is a common cause of acute neurological symptoms in children, but its clinical presentation is not well-defined. Acute thrombolysis, although rarely used in children, has shown good results in case reports. However, there is a lack of clinical studies and randomized controlled trials in children, hindering the development of guidelines and recommendations for this age group. More research is needed to establish evidence-based guidelines for the acute management of ischemic strokes in children.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2022)
Article
Hematology
Ann Maria Tony, Vivek Vinod, Vivek Nambiar, Sajitha Krishnan, Lalitha Biswas
Summary: In this case-control study, the prevalence of hereditary thrombophilic risk factors and environmental risk factors in VTE patients from Kerala, India was analyzed. The study found a high prevalence of the PAI-1 4G/5G polymorphism among the VTE patients, which could be a potential biomarker for assessing VTE risk, particularly among the Indian population.
Article
Clinical Neurology
Sruthi Sasikumar, Jino Vincent, Siby Gopinath, Vivek Nambiar, Saraf Udit Umesh, Sudheeran Kannoth, Dayana Antony, Annamma Mathai, Anandkumar Anandakuttan
Summary: This retrospective study analyzed 23 LGI1 antibody-positive patients and identified three cases with Faciobrachio-crural dystonic seizures (FBCDS) accompanied by asymmetrical parkinsonian features. Immunotherapy successfully relieved FBCDS and completely resolved extrapyramidal symptoms in all patients.
ACTA NEUROLOGICA BELGICA
(2022)
Article
Clinical Neurology
Rohit Bhatia, M. V. Padma Srivastava, P. N. Sylaja, Snigdha Komakula, Ashish Upadhyay, Vibhor Pardasani, Thomas Iype, Rajsrinivas Parthasarathy, Rajshekhar Reddy, Suman Kushwaha, Jayanta Roy, P. Satish, Anjan Trikha, Naveet Wig, Lalit Dhar, Deepti Vibha, Venugopalan Y. Vishnu, Awadh Kishore Pandit, Anu Gupta, A. Elavarasi, Ayush Agarwal, Vipul Gupta, Rakesh K. Singh, Harsh Oza, Hiral Halani, Dileep Ramachandran, Githin B. George, Praveen Panicker, M. K. Suresh, S. Kumaravelu, Dheeraj Khurana, Srijithesh P. Rajendran, Vijaya Pamidimukkala, Salil Gupta, Jeyaraj D. Pandian, Debashish Chowdhury, Nirendra K. Rai, Arvind Sharma, Vivek K. Nambiar
Summary: The study compared clinical features and outcomes of stroke patients with and without COVID-19, finding that patients with COVID-19 had higher stroke severity, increased in-hospital complications and mortality rates, and higher mortality at 3 months. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and baseline stroke severity were independent predictors of mortality.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2021)
