Gnaq and Gna11 in the Endothelin Signaling Pathway and Melanoma

Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice

(2015) J. L.-Y. Huang et al.   CANCER RESEARCH

Endothelin-1 protects human melanocytes from UV-induced DNA damage by activating JNK and p38 signalling pathways

(2015) Anne M. von Koschembahr et al.   EXPERIMENTAL DERMATOLOGY

Melanocyte UV resistance: Feelin' the endothelin

(2015) John A. D'Orazio   EXPERIMENTAL DERMATOLOGY

First-in-Human Proof-of-Concept Study: Intralesional Administration of BQ788, an Endothelin Receptor B Antagonist, to Melanoma Skin Metastases

(2015) J. Wouters et al.   ONCOLOGIST

Mutant GNAQ promotes cell viability and migration of uveal melanoma cells through the activation of Notch signaling

(2015) HONGLEI LIU et al.   ONCOLOGY REPORTS

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Gαq signalling: The new and the old

(2014) Guzmán Sánchez-Fernández et al.   CELLULAR SIGNALLING

Effect of Selumetinib vs Chemotherapy on Progression-Free Survival in Uveal Melanoma

(2014) Richard D. Carvajal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Akt and PI3K-dependent but CREB-independent upregulation of MCAM by endothelin-3 in human melanocytes

(2014) Brittny Williams et al.   MELANOMA RESEARCH

GNAQ and GNA11 mutations in uveal melanoma

(2014) Alexander N. Shoushtari et al.   MELANOMA RESEARCH

MAPK Pathway Inhibition Enhances the Efficacy of an Anti-Endothelin B Receptor Drug Conjugate by Inducing Target Expression in Melanoma

(2014) J. Asundi et al.   MOLECULAR CANCER THERAPEUTICS

Mutations in G Protein Encoding Genes and Chromosomal Alterations in Primary Leptomeningeal Melanocytic Neoplasms

(2014) Heidi V. N. Küsters-Vandevelde et al.   PATHOLOGY & ONCOLOGY RESEARCH

GPR87 Is an Overexpressed G-Protein Coupled Receptor in Squamous Cell Carcinoma of the Lung

(2013) Mathias Gugger et al.   DISEASE MARKERS

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations

(2013) X Chen et al.   ONCOGENE

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis

(2013) Stephen Hyter et al.   Pigment Cell & Melanoma Research

Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

(2012) W. Cruz-Munoz et al.   CANCER RESEARCH

Differential Effects of Neurofibromin Gene Dosage on Melanocyte Development

(2012) Mugdha Deo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells

(2012) Francesca Spinella et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF- B Pathways

(2012) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

GNA11andN-RASmutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system

(2012) M. Gessi et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Specifying and Sustaining Pigmentation Patterns in Domestic and Wild Cats

(2012) C. B. Kaelin et al.   SCIENCE

EDNRB gene variants and melanoma risk in two southern European populations

(2011) T. Spica et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest

(2011) I. Adameyko et al.   DEVELOPMENT

Regulators of G-Protein Signaling and Their G  Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

(2011) A. J. Kimple et al.   PHARMACOLOGICAL REVIEWS

A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken

(2011) Ben Dorshorst et al.   PLoS Genetics

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system

(2009) Heidi V. N. Küsters-Vandevelde et al.   ACTA NEUROPATHOLOGICA

Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin

(2009) Igor Adameyko et al.   CELL

Independent regulation of hair and skin color by two G protein-coupled pathways

(2009) Catherine D. Van Raamsdonk et al.   Pigment Cell & Melanoma Research

The fifth class of G  proteins

(2009) Y. Oka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation

(2009) J. H. C. Orth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation

(2008) Keiji Tanese et al.   AMERICAN JOURNAL OF PATHOLOGY

Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition

(2008) M. L. Harris et al.   DEVELOPMENT

Targeting of endothelin receptor-B to the neural crest

(2008) Noah R. Druckenbrod et al.   GENESIS

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE

Endothelin 3 Induces Skin Pigmentation in a Keratin-Driven Inducible Mouse Model

(2007) Roman J. Garcia et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY