Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 3, Issue 10, Pages 819-823Publisher
WILEY-BLACKWELL
DOI: 10.1002/acn3.342
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Funding
- National Institute of Child Health and Human Development [R21HD075327]
- NIH National Center for Medical Rehabilitation Research T32 Neuromuscular Plasticity Training Program [T32HDO43730]
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We examined the impact of expiratory muscle strength training on maximum expiratory pressure, cough spirometry, and disease progression in a 71-year-old male with amyotrophic lateral sclerosis. Maximum expiratory pressure declined 9% over an 8-week sham training period, but subsequently improved by 102% following 8 weeks of expiratory muscle strength training. Improvements in cough spirometry and mitigated disease progression were also observed post expiratory muscle strength training. Improvements in maximum expiratory pressures were maintained 6 months following expiratory muscle strength training and were 79% higher than baseline data obtained 301 days prior. In this spinal-onset amyotrophic lateral sclerosis patient, respiratory training improved subglottic air pressure generation and sequential cough generation.
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