Article
Infectious Diseases
Ling Yang, Yu Fu, Si Li, Chang Liu, Donghua Liu
Summary: By detecting TP DNA and CXCL13 concentration in the cerebrospinal fluid (CSF) of HIV-negative syphilis patients, this study provides evidence for the diagnosis and treatment of neurosyphilis (NS). CSF CXCL13 levels may be a useful marker to distinguish NS from non-NS syphilis.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Public, Environmental & Occupational Health
Zheng-Xiang Gao, Yu Gou, Xiao-Qin Liu, Lei-Wen Peng
Summary: With the increasing rate of latent syphilis infection, the clinical manifestations of neurosyphilis have become more diverse. Cerebrospinal fluid testing plays an important role in the diagnosis of neurosyphilis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Immunology
Matthew M. Hamill, Khalil G. Ghanem, Susan Tuddenham
Summary: We reviewed the key concepts of diagnosis, treatment, and follow-up of neurosyphilis. We discussed the epidemiology of syphilis in the US, focusing on affected populations and estimating the burden of neurosyphilis. We described the clinical features, significance of asymptomatic neurosyphilis, indications for cerebrospinal fluid examination, performance characteristics of different assays, and future biomarkers and imaging.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Jia Zhou, Hanlin Zhang, Keyun Tang, Runzhu Liu, Jun Li
Summary: This review article provides an overview of recent advances in neurosyphilis, including epidemiology, clinical manifestations, laboratory findings, diagnosis, treatment, and more. The increase in neurosyphilis incidence is mainly attributed to the expansion of men who have sex with men and the infection of human immunodeficiency virus. Exploring biomarkers of neurosyphilis may help uncover its pathogenesis.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
Romain Salle, Philippe A. Grange, Guillaume Ollagnier, Nadjet Benhaddou, Ugo Heller, Nicolas Dupin
Summary: This study evaluated different molecular and serological assays used in neurosyphilis (NS) diagnosis and found that there is no "gold standard" method. Molecular techniques have excellent specificity but lack sufficient diagnostic performance. A combination of clinical and biological parameters, combining PCR and serology in cerebrospinal fluid (CSF), is a feasible approach for NS diagnosis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Immunology
Christina M. Marra, Clare L. Maxwell, Sharon K. Sahi, Lauren C. Tantalo, Shelia B. Dunaway, Sheila A. Lukehart
Summary: Previous syphilis was found to attenuate the manifestations of subsequent T. pallidum infection, with reduced detection of the pathogen in blood and cerebrospinal fluid, as well as a decreased risk of neurosyphilis in individuals with a history of syphilis.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Ramona Andreea Codreanu Balaban, Any Axelerad, Daniela Musat, Anabella Cristiana Cioabla, Alina Zorina Stuparu, Silviu Docu Axelerad, Lavinia Florenta Muja
Summary: In recent decades, it was believed that syphilis and its complications, including neurological damage, could be controlled through proper epidemiological management. However, changes in socio-economic factors and the issue of antibiotic resistance have brought it back to the attention of clinicians. This study presents cases of three male patients from different backgrounds and occupations who were diagnosed with neurosyphilis, highlighting the potential complications and benefits of targeted therapy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Immunology
Chenyan Yuan, Wei Xu, Chenggui Zhao, Wei Gao, Guoqiu Wu
Summary: This study reports the detection of T. phagedenis sequence in the cerebrospinal fluid of a patient, which is the first report of its kind. The patient was diagnosed with neurosyphilis, and T. phagedenis was identified as the sole microorganism in the cerebrospinal fluid through metagenomic sequencing. The patient's symptoms did not improve after a round of benzathine penicillin therapy, but resolved after treatment with penicillin G sodium.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Xiaoli Zhou, Shengkun Peng, Tiange Song, Dandan Tie, Xiaoyan Tao, Li Jiang, Jie Zhang
Summary: The rapid and accurate identification of pathogenic agents is crucial for the diagnosis and treatment of intractable diseases like neurosyphilis. Using mNGS technology, Treponema pallidum was detected for the first time in patients with ocular involvement, highlighting the importance of this method for the diagnosis and differential diagnosis of neurosyphilis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Clinical Neurology
Min Shi, Danqing Luo, Zhaoying Li, Man Li, Shuoguo Jin, Dongdong Yang, Jun Guo, Guo Chen
Summary: Neurosyphilis could coexist with anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). This case report presents a patient with neurosyphilis manifested as optic neuritis with positive MOG antibody. Treatment improved the patient's visual acuity but not visual field and color vision.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Marija Djukic, Helmut Eiffert, Peter Lange, Ioanna Giotaki, Jana Seele, Roland Nau
Summary: This study found that approximately 1% of geriatric patients with cognitive decline or neuropathy have antibodies against Treponema pallidum in their serum, indicating a need for further diagnostic testing and potential antibiotic therapy.
Article
Medicine, General & Internal
Spencer J. Glenn, Saba Haq, Keshav Poddar, Leigh Hunter
Summary: Neurosyphilis, caused by systemic infection, presents as neurological deficits and typically progresses slowly over many years. It is rare in developed countries where antibiotics are available. Patients, like the one in this report, often respond well to treatment with antibiotics even in later stages.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Infectious Diseases
Nicolo Girometti, Muhammad H. Junejo, Diarmuid Nugent, Alan McOwan, Gary Whitlock
Summary: This study compared outcomes of patients diagnosed with early neurosyphilis and treated with doxycycline or procaine G penicillin. The results showed similar rates of clinical and serological response and seroreversion in the groups treated with procaine G penicillin versus doxycycline. A randomized controlled trial is needed to establish the effectiveness of doxycycline in the treatment of early neurosyphilis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Immunology
Noah Kojima, Kelika A. Konda, Jeffrey D. Klausner
Summary: Efforts to develop a syphilis vaccine have been ongoing for nearly a century, but significant progress has yet to be made. In recent years, however, advances in understanding the outer membrane proteins (OMPs) of the syphilis pathogen have led to increased efforts in vaccine development. While current vaccine formulations have shown partial protection in animal models, there are still important knowledge gaps to be addressed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhenzhou Luo, Yi Ding, Jun Yuan, Lishan Tian, Li Zhang, Qiuhong Wu, Jinsong Mou
Summary: The study found that a higher percentage of early syphilis patients achieved serological cure two years after treatment. The results indicated that syphilis stage and baseline serum titer were crucial factors associated with serological cure.
Article
Engineering, Electrical & Electronic
Zhaohao Zhang, Fan Zhang, Yadong Zhang, Gaobo Xu, Zhenhua Wu, Qingzhu Zhang, Yongliang Li, Huaxiang Yin, Jun Luo, Wenwu Wang, Tianchun Ye
Summary: This Letter proposes a 1M-based TCAM with an ultradense 4F(2) cell area on a single reconfigurable TiN/HZO/IGZO/TiN FE diode. The FE diodes were designed with reconfigured P-N, N-P, and ohmic like junctions for '0', '1', and 'X' storage states, respectively. The memory device showed great potential in area-efficient artificial intelligence processors with typical TCAM functions and a maximum driving on/off ratio of approximately 500.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Jialin Yang, Wenhan Zhou, Chuyao Chen, Jingwen Zhang, Hengze Qu, Yuxi Ji, Li Tao, Zhenhua Wu, Haibo Zeng, Shengli Zhang
Summary: Semiconductors are being considered as potential alternatives to silicon for channels in next-generation electronic devices. The study investigates the electronic and ballistic transport properties of 2-D SiP2, which exhibits anisotropy in both geometric structures and electronic properties. The research demonstrates that SiP2 field-effect transistors (FETs) with underlap configuration and gate lengths of 5-12 nm can meet the goals of International Technology Roadmap for Semiconductors (ITRS) and International Roadmap for Devices and Systems (IRDS), with excellent performance in terms of on-state current, delay time, and power dissipation. The study highlights the great potential of 2-D SiP2 for future competitive electronic devices.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jielong Li, Diwei Liu, Ruizhe Ren, Chuanhong Xiao, Zongjun Shi, Tao Zhao, Min Hu, Yanyu Wei, Zhaoyun Duan, Yubin Gong, Zhenhua Wu
Summary: In this study, a novel improvement on ladder line structure called longitudinally slotted structure is proposed, which increases the cross-sectional area of the electron beam and effective interaction area, thereby significantly improving the output power. The dispersion characteristics and field distribution of the slotted structure are analyzed through numerical and simulation calculations, and the optimal parameters are determined. A 94-GHz 2-D slotted structure EIO is designed and compared with the ladder line, it shows a 52.5% increase in cavity characteristic impedance $\textit{R}$ / $\textit{Q}$ and a 21.1% increase in output power. This new structure is expected to provide a new idea for power enhancement in millimeter-wave and terahertz EIOs.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Optics
Jiang-Tao Liu, Yuan Zhang, Xunming Cai, Jinbao Huang, Kun Luo, Hongxu Li, Dejian Zhang, Zhenhua Wu
Summary: Computational ghost imaging can be used to display the characteristics of digital data, especially periodicity. The use of optical imaging methods for analyzing binary data has unique advantages, particularly in anti-interference. Computational ghost imaging enables robust analysis and imaging of binarized signals, even in the presence of strong noise, random amplitude, and phase changes, making it highly valuable in fields such as big data analysis, meteorology, astronomy, economics, and more.
Article
Physics, Condensed Matter
Jiayi Chen, Zhen Wang, Zhenhua Wu, Xiaojing Li
Summary: We investigate the electronic and optical properties of different stacked configurations of bilayer black phosphorus quantum dots. Our results show that the energy levels are influenced by the stacking configurations. The AC-stacked and unsymmetrical AB-stacked black phosphorus bilayers enhance optical transitions and realize dark-to-bright transitions in the absorption spectra. The coupling strength of edge states differs between configurations, providing a feasible approach to modulating the electronic and optical properties of bilayer black phosphorus.
SOLID STATE COMMUNICATIONS
(2023)
Article
Geochemistry & Geophysics
Baiqiang Li, Taofa Zhou, Zhenzhen Wu, Yanick Blaise Ketchaya, Qicong Wang, Xiaoli Zhang, Jiangmin Du, Jonathan Atuquaye Quaye
Summary: This paper focuses on the controlling factor of the submember Ma5(5) dolostone reservoir in the western Ordos Basin. The main rock types, reservoir pores, physical properties, and pore structure characteristics of the reservoir were analyzed. The results show that there are two types of dolostone reservoirs in the submember Ma5(5), intercrystalline pore-type and dissolution pore-type, and their development is controlled by various geological factors such as lithofacies palaeogeography, diagenesis, and paleostructure.
Article
Engineering, Electrical & Electronic
Tao Song, Xu Qi, Taotao Mao, Chen Zhang, Jie Huang, Peisheng Liang, Aiqin Wang, Jiao Jiao, Na Yao, Kaichun Zhang, Xiaoqiuyan Zhang, Tao Zhao, Zhenhua Wu, Min Hu, Yanyu Wei, Yubin Gong, Wei Wang, Diwei Liu
Summary: Experimental investigations have been carried out on a 0.66-THz gyrotron, with the magnetic injection gun and the gyrotron beam-wave interaction cavity being designed and optimized. The gyrotron cavity incorporates a traditional three-section design. The experimental results demonstrate stable operation at the second cyclotron harmonic, with the gyrotron operating in the TE14,5 mode and a pulselength of 80 mu s. By adjusting the beam energy and magnetic field, the gyrotron achieves a maximum frequency of 656.95 GHz and an output power of 282 W. Additionally, the gyrotron can be used as a frequency-tunable source, with a tunable range of approximately 70 MHz. This gyrotron is specifically designed for irradiating THz waves on living bodies.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jielong Li, Zhenhua Wu, Diwei Liu, Wei Wang, Tao Zhao, Renbin Zhong, Zongjun Shi, Kaichun Zhang, Zhaoyun Duan, Yanyu Wei, Yubin Gong, Shenggang Liu, Min Hu
Summary: A novel high-frequency structure was proposed, which involved vertically placing four conventional ladder-line slow wave structures to form a four-sheet-beam orthogonal interconnection structure. The simulation results showed the achievement of an output power of over 500 W for a 0.22-THz wave with four sheet beams at 16.6 kV and each current of 0.8 A. This structure provides an alternative for the development of terahertz EIOs.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jiali Huo, Zhaohao Zhang, Yadong Zhang, Fan Zhang, Gangping Yan, Guoliang Tian, Haoqing Xu, Guohui Zhan, Gaobo Xu, Qingzhu Zhang, Huaxiang Yin, Zhenhua Wu
Summary: In this work, ferroelectric field effect transistors (FeFETs) are demonstrated by integrating the ferroelectric Hf0.5Zr0.5O2 (HZO) gate insulator and 2-D ferroelectric semiconductor alpha-In2Se3 channel. These FeFETs feature enhanced large memory windows (MWs) and ultrahigh-speed. The results show that FeFETs have considerable potential in ultra-fast nonvolatile memory (NVM) applications.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Cell & Tissue Engineering
Zhenhua Wu, Jie Geng, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Zhigang Guo
Summary: This research demonstrates that miR-125b-5p reduces the level of F2RL2 by inhibiting the activation of NFAT2 pathway, which ultimately reduces damage and inflammation in cardiogenic vascular endothelial cells, potentially offering a new treatment approach for myocardial infarction.
REGENERATIVE MEDICINE
(2023)
Article
Oncology
Zhe Gong, Yanqiu Zhang, Yue Yang, Yanan Yang, Jieyun Zhang, Yixuan Wang, Liqin Zhao, Nuoya Yu, Zhenhua Wu, Weijian Guo
Summary: Long noncoding RNAs (lncRNAs) have been recently found to play a key role in various types of cancer. In this study, we identified a lncRNA LINC01094 that is associated with the metastasis of gastric cancer (GC) through next-generation sequencing. High expression of LINC01094 is linked to advanced T and N stages and poor prognosis in GC patients. We demonstrated that LINC01094 promotes the proliferation and metastasis of GC both in vitro and in vivo. Furthermore, we discovered that LINC01094 interacts with AZGP1, leading to downregulation of PTEN expression and activation of the AKT pathway.
Proceedings Paper
Engineering, Electrical & Electronic
Na Li, Shihui Qiu, Zhenhua Wu, Hongju Mao
Summary: With the widespread use of assisted reproduction technology, there is still room for improvement in cell cryopreservation, especially for rare cells. This study introduces a cryopreservation system composed of pico-liter-volume droplets, which offers advantages such as single cell manipulation, high throughput, easy handleability, great performance, and customizability to optimize reagent formula for individual responses.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Shihui Qiu, Na Li, Zhenhua Wu, Jianlong Zhao, Hongju Mao
Summary: This platform enables the isolation of tumor cells from WBCs and performs fluorescence in situ hybridization (FISH) in a single chip. The platform offers several advantages: (1) Precise cell isolation based on differences in cell size and protein biomarkers; (2) In situ analysis prevents contamination; (3) Single-cell level FISH analysis for CTCs is achieved; (4) Reagent and time savings; (5) Low costs and automation prospects. Hence, the platform holds potential for single-cell level FISH assays.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Article
Mathematics, Applied
Zhen Wu, Bing Xie, Zhiyong Yu
Summary: This paper discusses the Sobolev type weak solutions of a certain class of second order quasilinear parabolic partial differential equations (PDEs). It provides a probabilistic interpretation for the weak solutions by using a family of coupled forward-backward stochastic differential equations (FBSDEs) that satisfy the monotonous assumption. The existence of weak solutions is proven based on the classical solutions of a family of PDEs approximating the weak solutions of the quasilinear PDEs. The uniqueness of the weak solutions is obtained through the principle of norm equivalence linking FBSDEs and PDEs.
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS
(2023)
Article
Acoustics
Deshi Meng, Lijun Li, Zhenhua Wu
Summary: This study presents the design and experimental validation of acoustic metamaterials with ventilation and broadband asymmetric absorption. An asymmetric absorbing cell (AAC) consisting of detuned Helmholtz resonators connected by sound channels achieves near-perfect sound absorption from the left port, while maintaining a ventilation ratio of 40%. Parallel three-cell asymmetric absorber (PTAA) formed by paralleling three AACs exhibits broadband asymmetric absorption. Additionally, a multi-asymmetric absorber (MAA) with a frequency range of 1000 Hz to 1750 Hz and air circulation capability is designed and fabricated using 3D printing technology.
JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL
(2023)
