Article
Anesthesiology
Alba Chavarria-Miranda, Angel L. Guerrero, Blanca Talavera, Enrique Martinez-Pias, Javier Trigo-Lopez, Alvaro Sierra, David Garcia-Azorin
Summary: Linear headache may be a distinct headache syndrome, preventive treatment is often required, and the drug with the best response was onabotulinumtoxinA.
Review
Clinical Neurology
Maria-Luz Cuadrado
Summary: This article reviews the epidemiological and clinical features of nummular headache and epicrania fugax, proposed pathogenic mechanisms, and state-of-the-art management. Nummular headache and epicrania fugax are generally considered rare headache disorders, characterized by circumscribed head pain and moving paroxysms of pain, respectively. Diagnostic assessment requires careful examination and exclusion of underlying disorders, and treatment options include analgesics, anti-inflammatory drugs, botulinum toxin, and gabapentin.
Article
Clinical Neurology
Cristina Garcia-Iglesias, Ana Gonzalez-Celestino, Alvaro Sierra Mencia, Yesica Gonzalez Osorio, Andrea Recio Garcia, Cristina Martinez-Badillo, Ana Echavarria Iniguez, Berta Varona-Galan, David Garcia-Azorin, Angel Luis Guerrero-Peral
Summary: The long-term outcomes of nummular headache (NH) are generally positive, with a substantial number of patients experiencing inactive NH after a median follow-up period of 6.7 years. Preventive treatment is required by the majority of patients, but most of them respond well to the treatment. For patients with persistent symptoms, the frequency of headaches is lower.
Article
Clinical Neurology
Omeed Partovi, Amir Soheil Tolebeyan
Summary: This report shows that migraine patients may present with different olfactory hallucination manifestations, some occurring before headaches and some persisting. Due to the clinical significance, it is suggested that ICHD classify this phenomenon as a subtype of aura in the future, but further larger studies are needed to better assess its pathophysiology.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Roberta Messina, Cedric Gollion, Rune Hackert Christensen, Faisal Mohammad Amin
Summary: This review examines the use of fMRI to study the mechanisms of migraine. It finds that migraine attacks are associated with hypothalamic hyperexcitability and disruptions in the pain and central trigeminovascular pathways. The visual cortex also becomes hyperexcitable during the aura phase. Additionally, disruptions in the pontine, thalamic, sensorimotor, and visual networks are observed during the headache phase, while hypothalamic activity and connectivity normalize. The visual cortex remains hyperexcitable during the postdromal phase, and asymptomatic migraine patients also show functional alterations in pain and visual processing brain areas.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Etedal Ahmed A. Ibrahim, Ghada A. Mutaal Badri, Khabab Abbasher Hussien Mohamed Ahmed, Mohammed Eltahier Abdalla Omer
Summary: The study found that environmental conditions were the most common triggers of migraine headache among Sudanese patients, while Acetaminophen was the most commonly used drug for relieving migraine in this population. The majority of patients were female (80%), aged 26-35 years (56.9%), and a significant proportion were housewives (40%).
BRAIN AND BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Paola Tiberio, Alessandro Vigano, Mariya Boyanova Ilieva, Sebastiano Pindilli, Anna Bianchi, Alberto Zambelli, Armando Santoro, Rita De Sanctis
Summary: Numerous epidemiological studies have explored the potential link between migraine and breast cancer due to their association with female reproductive hormones. Current evidence suggests a protective role of migraine in breast cancer development, particularly in case-control studies. However, the inconsistency among studies and recent research challenging this concept indicate a more complex relationship between the two conditions. Further studies are needed to validate the protective role of migraine in breast cancer and identify the precise nature of this causal relationship.
Article
Clinical Neurology
Cinzia Cavestro, Giancarlo Prandi, Matteo Manildo, Sabina Martini, Corrado Genovesi, Alberto Premoli, Flavio Fraire, Loris Neri, Silvia Mandrino, Marcella Ferrero, Eugenia Rota
Summary: This study aimed to investigate the association between HP infection and headache, particularly migraine. The results showed no significant association between HP infection and migraine, but a significant association between HP infection and headache frequency.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Jawad H. Butt, Heidi S. Eddelien, Christina Kruuse
Summary: Sildenafil induces aura and migraine-like headache in patients with migraine with aura, supporting the dissociation between the aura and the headache phase.
Review
Medicine, General & Internal
Eliseo Barral, Elisa Martins Silva, David Garcia-Azorin, Michele Viana, Francesca Puledda
Summary: Migraine is a common and severe primary headache disorder characterized by pain and various non-painful symptoms, including visual phenomena. This review focuses on two visual disorders associated with migraine: visual aura and visual snow syndrome (VSS). Visual aura presents as transient positive and negative visual symptoms before, during, or outside of a migraine attack. VSS is a newly recognized phenomenon that is comorbid with migraine. The review discusses clinical features, pathophysiological mechanisms, differential diagnoses, and treatment options for these disorders, aiming to assist clinicians and researchers in recognizing these visual phenomena commonly seen in patients with underlying migraine biology.
Article
Medicine, General & Internal
Seung Jae Kim, Hye Jeong Lee, Sue Hyun Lee, Soomi Cho, Kyung Min Kim, Min Kyung Chu
Summary: The aim of this study was to investigate the prevalence and impact of visual aura (VA) in non-migraine headaches and its comparison with migraine headaches. The results showed that non-migraine headache patients with VA had more severe symptoms. These findings can enhance the understanding and management of individuals with non-migraine headaches.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Yu-Chien Tsao, Yen-Feng Wang, Jong-Ling Fuh, Wei-Ta Chen, Kuan-Lin Lai, Hung-Yu Liu, Shuu-Jiun Wang, Shih-Pin Chen
Summary: This study investigated the clinical correlates of visual symptoms in patients with migraine. The presence of non-aura transient visual disturbance was found to be associated with higher migraine-related disability and a higher risk of chronic migraine than typical migraine aura in migraine patients.
Article
Medicine, General & Internal
Pierfrancesco Lapolla, Placido Bruzzaniti, Giuseppa Zancana, Antonella Stoppacciaro, Michela Relucenti, Rui Chen, Xiaobo Li, Andrea Mingoli, Alessandro Frati, Pietro Familiari
Summary: We reported a rare case of lipomatous meningioma presenting with a migraine with visual aura as the first clinical symptom. Surgery dramatically improved the symptoms and quality of life.
Article
Clinical Neurology
Arife Cimen Atalar, Aynur Ozge, Bengi Gul Turk, Esme Ekizoglu, Duygu Kurt Gok, Betul Baykan, Semih Ayta, Fusun Ferda Erdogan, Seher Naz Yeni, Bahar Tasdelen, Sibel K. Velioglu
Summary: In this study, the diagnostic gaps in the diagnosis of comorbid migraine without aura (MwoA) in patients with idiopathic/genetic epilepsy (I/GE) were disclosed using a zone concept. Longer headache duration, throbbing pain, increase of pain by physical activity, photophobia and/or phonophobia, presence of vertigo/dizziness, osmophobia, and higher VAS scores were found to be the main associated factors for the comorbid MwoA diagnosis in patients with I/GEs.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Andreas Vinther Thomsen, Oula Puonti, David Gaist, Kirsten Ohm Kyvik, Kristoffer Madsen, Axel Thielscher, Hartwig Roman Siebner, Messoud Ashina, Anders Hougaard
Summary: In this study, we compared the distances between visual cortical areas and overlying dura mater in female patients with migraine aura without headache and female patients with migraine aura with headache. The results showed no significant differences in distances or volumes between the two groups. Therefore, we conclude that there may not be a direct connection between migraine aura and headache.