Intratumoral accumulation of podoplanin-expressing lymph node stromal cells promote tumor growth through elimination of CD4+ tumor-infiltrating lymphocytes

TLS in Tumors: What Lies Within

(2016) Catherine Sautès-Fridman et al.   TRENDS IN IMMUNOLOGY

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma

(2015) Shinya Neri et al.   INTERNATIONAL JOURNAL OF CANCER

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma—An exclamation sign with a question mark

(2015) Guido Kroemer et al.   OncoImmunology

Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+T cell tolerance

(2014) Juan Dubrot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

(2014) Jillian L Astarita et al.   NATURE IMMUNOLOGY

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

(2014) Viviana Cremasco et al.   NATURE IMMUNOLOGY

Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells

(2014) A. E. Denton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis

(2014) A. L. Fletcher et al.   Science Translational Medicine

T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy

(2014) I. Melero et al.   Cancer Discovery

Lymphatic endothelial cells support tumor growth in breast cancer

(2014) Esak Lee et al.   Scientific Reports

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

(2014) Antonio P Baptista et al.   eLife

Characteristics of tertiary lymphoid structures in primary cancers

(2014) Jérémy Goc et al.   OncoImmunology

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

(2013) Qian Chai et al.   IMMUNITY

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility

(2013) Harini Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

CD44 Expressed on Cancer-Associated Fibroblasts Is a Functional Molecule Supporting the Stemness and Drug Resistance of Malignant Cancer Cells in the Tumor Microenvironment

(2013) Yumi Kinugasa et al.   STEM CELLS

Clinical Perspectives on Targeting of Myeloid Derived Suppressor Cells in the Treatment of Cancer

(2013) Yana G. Najjar et al.   Frontiers in Oncology

Lymphotoxin-β Receptor Signaling through NF-κB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells

(2012) Cécile Bénézech et al.   IMMUNITY

Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection

(2012) C. T. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?

(2012) Jane L. Messina et al.   Scientific Reports

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Targeting Regulatory T Cells in Cancer

(2011) W. L. Byrne et al.   CANCER RESEARCH

Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

(2011) L. de Chaisemartin et al.   CANCER RESEARCH

Splenic Stroma-Educated Regulatory Dendritic Cells Induce Apoptosis of Activated CD4 T Cells via Fas Ligand-Enhanced IFN-  and Nitric Oxide

(2011) X. Xu et al.   JOURNAL OF IMMUNOLOGY

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

(2011) Veronika Lukacs-Kornek et al.   NATURE IMMUNOLOGY

Fibroblastic Reticular Cells From Lymph Nodes Attenuate T Cell Expansion by Producing Nitric Oxide

(2011) Stefanie Siegert et al.   PLoS One

Reproducible Isolation of Lymph Node Stromal Cells Reveals Site-Dependent Differences in Fibroblastic Reticular Cells

(2011) Anne L. Fletcher et al.   Frontiers in Immunology

Tertiary Intratumor Lymphoid Tissue in Colo-Rectal Cancer

(2011) Francesca Bergomas et al.   Cancers

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

(2010) R. Bos et al.   CANCER RESEARCH

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

(2009) Linda Yip et al.   NATURE IMMUNOLOGY

Development of Secondary Lymphoid Organs

(2008) Troy D. Randall et al.   Annual Review of Immunology

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Direct Presentation of Antigen by Lymph Node Stromal Cells Protects Against CD8 T-Cell-Mediated Intestinal Autoimmunity

(2008) Fay C. Magnusson et al.   GASTROENTEROLOGY

Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures

(2008) Marie-Caroline Dieu-Nosjean et al.   JOURNAL OF CLINICAL ONCOLOGY

Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells

(2008) J. M. Gardner et al.   SCIENCE