Journal
ONCOIMMUNOLOGY
Volume 5, Issue 9, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2016.1213935
Keywords
Hyal-2+CD3-CD19-; Hyaluronidase Hyal-2; memory anticancer response; Z lymphocyte; Zfra
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Funding
- Department of Defense USA [DAMD17-03-1-0736, W81XWH-08-1-0682]
- National Health Research Institute, Taiwan, ROC [NHRI-EX99-9704BI]
- Department of Health, Taiwan, ROC [DOH101-TD-PB-111-TM010]
- Graduate/Postdoctoral Travel Award from the American Society for Biochemistry and Molecular Biology (ASBMB)
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When naive mice receive short Zfra peptides via tail vein injections, they develop lifetime resistance to growth of many cancer xenografts, due to activation of a novel spleen memory Hyal-2(+) CD3(-) CD19(-) Z lymphocyte. In vitro education of spleen cells with Zfra activates Z cell for conferring memory anticancer response in vivo.
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