Review
Dentistry, Oral Surgery & Medicine
Daniele Sorgatto Fae, Sibele Nascimento de Aquino, Francielle Silvestre Verner, Cleidiel Aparecido Araujo Lemos
Summary: This study aimed to evaluate and compare the risk of dental caries in HIV-infected and uninfected children and adolescents. Sixteen studies were included in the meta-analysis, which revealed that HIV-infected children and adolescents had a higher risk of dental caries in both primary and permanent dentitions.
Article
Medicine, General & Internal
Casey Lee McAtee, Joseph Lubega, Kristen Underbrink, Kristen Curry, Pavlos Msaouel, Martha Barrow, Eyal Muscal, Timothy Lotze, Poyyapakkam Srivaths, Lisa R. Forbes, Carl Allen, Brooke Bernhardt
Summary: Rituximab, a commonly used immunotherapy in pediatrics, is well tolerated among young people with few serious adverse events. However, infections are common, leading to a prolonged period of B cell count recovery often lasting for longer than a year. Further strategies to prevent infections following rituximab should be explored.
Review
Medicine, General & Internal
Asra Fazlollahi, Mahdi Zahmatyar, Mahta ZareDini, Behnam Golabi, Seyed Aria Nejadghaderi, Mark J. M. Sullman, Koroush Gharagozli, Ali-Asghar Kolahi, Saeid Safiri
Summary: This systematic review and meta-analysis investigated the frequency and risk of adverse events (AEs) in patients with epilepsy using cannabidiol (CBD). The study found that the use of CBD was associated with an increased risk of AEs. Additional studies are needed to determine the safe and effective CBD dosage for treating epilepsy.
Review
Pediatrics
Julie Jesson, Laura Saint -Lary, Marc Harris Dassi Tchoupa Revegue, John O'Rourke, Claire L. Townsend, Francoise Renaud, Martina Penazzato, Valeriane Leroy
Summary: Abacavir has been shown to be an effective and safe first-line treatment option for infants and children living with HIV, with rare toxic effects and manageable adverse reactions.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Review
Immunology
Hamidreza Kouhpayeh, Hossein Ansari
Summary: This study evaluated the safety and efficacy of COVID-19 vaccines. The results showed that mRNA vaccines are associated with a higher risk of adverse events following immunization. However, currently all types of vaccines still have greater benefits, and vaccination is highly recommended.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Luca Melnychuk, Sara Perlman-Arrow, Mayara Lisboa Bastos, Dick Menzies
Summary: This study aimed to investigate the incidence of adverse events (AE) associated with tuberculosis preventative therapy (TPT) regimens. The analysis included 175 publications and found that the incidence of AE was lower in pediatric populations compared to adults. Among adults, the 4-month rifampin regimen had the lowest incidence of AE.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Nutrition & Dietetics
Pengzhu Li, Nikolaus Alexander Haas, Robert Dalla-Pozza, Andre Jakob, Felix Sebastian Oberhoffer, Guido Mandilaras
Summary: This review investigates the adverse health events associated with energy drink (ED) consumption in children and adolescents. It found that ED intake may be associated with cardiovascular and neuropsychiatric health events in minors. Additional triggers and preexisting health conditions also play a critical role. To prevent future adverse events, it is important to educate children and adolescents about risk factors and responsible consumption behaviors.
Review
Pediatrics
Zhi-Juan Zhong, Pi-Mei Zheng, Hui-Hong Dou, Ji-Gan Wang
Summary: This study aimed to systematically analyze adverse events (AEs) in the treatment of spinal muscular atrophy (SMA) with Nusinersen in children and adolescents. The study found that Nusinersen-related AEs were rare and it effectively reduced common, serious, and fatal AEs in children and adolescents with SMA.
FRONTIERS IN PEDIATRICS
(2023)
Review
Endocrinology & Metabolism
Linghuan Wang, Binqi Li, He Zhao, Peixin Wu, Qingzhen Wu, Kang Chen, Yiming Mu
Summary: This systematic review and meta-analysis evaluated the incidence, evaluation, and management of interferon and endocrine side effects. The study found a higher incidence of hypothyroidism and hyperthyroidism in patients treated with interferon, particularly in combination with ribavirin.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Muhammad Zain Farooq, Sheeba Ba Aqeel, Prasanth Lingamaneni, Rayli Carolina Pichardo, Aleeza Jawed, Saad Khalid, Shristi Upadhyay Banskota, Pingfu Fu, Ankit Mangla
Summary: This meta-analysis study suggests that the overall risk of neurologic adverse events (NAEs) is lower with the use of immune checkpoint inhibitors (ICIs) compared to chemotherapy; however, the risk of NAEs is higher with ICI use compared to placebo.
Review
Gastroenterology & Hepatology
Suprabhat Giri, Babu P. Mohan, Vaneet Jearth, Aditya Kale, Sumaswi Angadi, Shivaraj Afzalpurkar, Sidharth Harindranath, Sridhar Sundaram
Summary: This meta-analysis analyzed the adverse events (AEs) associated with EUS-guided biliary drainage (BD) and found that despite a high clinical success rate, approximately one-seventh of the cases experienced AEs. However, the incidence of major AEs and mortality remained low.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Psychology, Multidisciplinary
Tatiana Matheus Pinto, Paulo Guirro Laurence, Cristiane Rufino Macedo, Elizeu Coutinho Macedo
Summary: This systematic review examined resilience-focused programs for children and adolescents, finding significant effectiveness in promoting resilience, especially among adolescents, with results continuing for up to 6 months. Further research is needed to analyze the different characteristics of programs and their outcomes.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Immunology
Juyue Zhou, Zhonghai Du, Jie Fu, Xiuxiu Yi
Summary: Cancer research has focused on prolonging the life of patients, and immune checkpoint inhibitors (ICIs) have shown good clinical efficacy but with severe adverse effects. Blood counts may serve as predictors of immune-related adverse events (irAEs) in cancer patients. This meta-analysis provides further evidence for the importance of blood counts in clinical practice.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Anesthesiology
Emilie Lambourg, Lesley Colvin, Greg Guthrie, Heather Walker, Samira Bell
Summary: This study conducted a systematic review and meta-analysis to evaluate the prevalence of analgesic use and the risk of analgesic-related adverse events in patients with chronic kidney disease (CKD). The results showed a high level of analgesic consumption and a significant association between analgesic use and adverse outcomes in CKD patients.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Review
Cardiac & Cardiovascular Systems
Zahra Pasdar, Lorenzo De Paola, Ben Carter, Tiberiu A. Pana, John F. Potter, Phyo K. Myint
Summary: Orthostatic hypertension (OHT) refers to a significant rise in blood pressure readings when standing. Our analysis found that systolic OHT (SOHT) is associated with an increased risk of death, heart and blood vessel disease, and stroke, while diastolic OHT is not linked to these outcomes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Laura Saint-Lary, Alpha Diallo, Laure-Amelie de Monteynard, Christelle Paul, Lucie Marchand, Roland Tubiana, Josiane Warszawski, Laurent Mandelbrot, Claire Rekacewicz, Ventzislava Petrov-Sanchez, Albert Faye, Jeanne Sibiude, Francois Dabis, Agnes Sommet, Valeriane Leroy
Summary: The study found that the use of protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) based regimens did not show significant association with adverse pregnancy outcomes, except for nucleoside reverse transcriptase inhibitor (NRTI) combinations. The number of integrase inhibitor (INI)-based combinations was too low to draw conclusions from.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Immunology
Julie Jesson, Siobhan Crichton, Matteo Quartagno, Marcel Yotebieng, Elaine J. Abrams, Kulkanya Chokephaibulkit, Sophie Le Coeur, Marie-Helene Ake-Assi, Kunjal Patel, Jorge Pinto, Mary Paul, Rachel Vreeman, Mary-Ann Davies, Jihane Ben-Farhat, Russell Van Dyke, Ali Judd, Lynne Mofenson, Marissa Vicari, George Seage, Linda-Gail Bekker, Shaffiq Essajee, Diana Gibb, Martina Penazzato, Intira Jeannie Collins, Kara Wools-Kaloustian, Amy Slogrove, Kate Powis, Paige Williams, Mogomotsi Matshaba, Lineo Thahane, Phoebe Nyasulu, Bhekumusa Lukhele, Lumumba Mwita, Adeodata Kekitiinwa-Rukyalekere, Sebastian Wanless, Tessa Goetghebuer, Claire Thorne, Josiane Warszawski, Luisa Galli, Annemarie M. C. van Rossum, Carlo Giaquinto, Magdalena Marczynska, Laura Marques, Filipa Prata, Luminita Ene, Lyuba Okhonskaya, Marisa Navarro, Antoinette Frick, Lars Naver, Christian Kahlert, Alla Volokha, Elizabeth Chappell, Jean William Pape, Vanessa Rouzier, Adias Marcelin, Regina Succi, Annette H. Sohn, Azar Kariminia, Andrew Edmonds, Patricia Lelo, Rita Lyamuya, Edith Apondi Ogalo, Francesca Akoth Odhiambo, Andreas D. Haas, Carolyn Bolton, Josephine Muhairwe, Hannock Tweya, Mariam Sylla, Marceline D'Almeida, Lorna Renner, Mark J. Abzug, James Oleske, Murli Purswani, Chloe Teasdale, Harriet Nuwagaba-Biribonwoha, Ruth Goodall, Valeriane Leroy
Summary: Adolescents living with HIV face various co-morbidities, including growth retardation and immunodeficiency. This study analyzed data from CIPHER global project and found that growth patterns differed by sex and region, while CD4 patterns were similar. Early diagnosis and timely treatment are crucial for improving growth and CD4 outcomes in adolescents with HIV.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Article
Health Policy & Services
Pierre-Julien Coulaud, Julie Jesson, Naseeb Bolduc, Olivier Ferlatte, Emily Jenkins, Karine Bertrand, Travis Salway, Marie Jauffret-Roustide, Rod Knight
Summary: This study found that young adults in Canada and France had significant unmet mental health needs during the COVID-19 pandemic. Factors such as gender and income loss due to the pandemic were associated with unmet mental health service needs. Additionally, participants from Quebec, those living in rural areas, and those who experienced ethno-racial discrimination had higher odds of reporting unmet needs for mental health services.
COMMUNITY MENTAL HEALTH JOURNAL
(2023)
Review
Obstetrics & Gynecology
Laura Saint-Lary, Justine Benevent, Christine Damase-Michel, Christophe Vayssiere, Valeriane Leroy, Agnes Sommet
Summary: In this study, the researchers conducted a systematic review on the adverse perinatal outcomes associated with prenatal exposure to protease inhibitors (PI) based antiretroviral therapy (ART) compared with non-nucleoside reverse transcriptase inhibitors (NNRTI) based ART. The findings showed no significant association between prenatal exposure to PIs and most adverse perinatal outcomes, except for a significantly increased risk of very small for gestational age (VSGA).
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Immunology
Caitlin M. Dugdale, Ogochukwu Ufio, Christopher Alba, Sallie R. Permar, Lynda Stranix-Chibanda, Coleen K. Cunningham, Genevieve G. Fouda, Landon Myer, Milton C. Weinstein, Valeriane Leroy, Elizabeth J. McFarland, Kenneth A. Freedberg, Andrea L. Ciaranello
Summary: Infant HIV prophylaxis with broadly neutralizing anti-HIV antibodies (bNAbs) could be a cost-effective intervention to reduce vertical HIV transmission in sub-Saharan African settings, according to a cost-effectiveness analysis. The study estimated the potential clinical impact and cost-effectiveness of hypothetical bNAb prophylaxis programs for HIV-exposed children in Cote d'Ivoire, South Africa, and Zimbabwe and found that bNAb prophylaxis would significantly reduce infant HIV incidence.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)
Article
Immunology
Siobhan Crichton, Julie Jesson, Marie-Helene Ake-Assi, Erik Belfrage, Mary-Ann Davies, Jorge Pinto, Chloe Teasdale, Nguyen Van Lam, Rachel Vreeman, Mary Paul, Paige William, Marcel Yotebieng, Valeriane Leroy, Ruth Goodall, Elaine Abrams, Russell Van Dyke, Ali Judd, Marissa Vicari, Intira Jeannie Collins, Kara Wools-Kaloustian, Kunjal Patel, Amy Slogrove, Kathleen M. Powis, Mogomotsi Matshaba, Lineo Thahane, Phoebe Nyasulu, Bhekumusa Lukhele, Lumumba Mwita, Adeodata Kekitiinwa-Rukyalekere, Tessa Goetghebuer, Claire Thorne, Josiane Warszawski, Elena Chiappini, Annemarie van Rossum, Magdalena Marczynska, Laura Marques, Filipa Prata, Luminita Ene, Liubov Okhonskaya, Marisa Navarro, Maria Mendez, Paolo Paioni, Sophie Le Coeur, Alla Volokha, Jean William Pape, Vanessa Rouzier, Adias Marcelin, Kulkanya Chokephaibulkit, Annette H. Sohn, Azar Kariminia, Andrew Edmonds, Patricia Lelo, Francesca Akoth Odhiambo, Andreas D. Haas, Carolyn Bolton, Mariam Sylla, Lehila Bagnan Tossa, Lorna Renner, Mark J. Abzug, James Oleske, Murli Purswani, Elaine Chadwick
Summary: This study aimed to describe pubertal growth spurts among adolescents with perinatally acquired HIV on antiretroviral therapy. The study found that older age at ART initiation and lower height-for-age z-scores were associated with delayed and less intense growth spurts. Longer-term follow-up is important for understanding the impact of delayed growth.
Review
Immunology
John O'Rourke, Claire L. Townsend, Edith Milanzi, Intira Jeannie Collins, Hannah Castro, Ali Judd, Marissa Vicari, Julie Jesson, Valeriane Leroy, Martina Penazzato, Francoise Renaud
Summary: This systematic review assessed the efficacy and safety of TAF in infants, children, and adolescents living with HIV. The results showed that TAF-containing regimens can effectively suppress viral replication and have good safety profiles over 24-48 weeks of treatment. However, further research is needed to evaluate the long-term efficacy and safety, including the impact on weight and metabolic changes, in children and adolescents.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)
Article
Medicine, General & Internal
Rachel C. Vreeman, Constantin T. Yiannoutsos, Nik Khairulddin Nik Yusoff, C. William Wester, Andrew Edmonds, Susan Ofner, Mary-Ann Davies, Valeriane Leroy, Pagakrong Lumbiganon, Regina Celia de Menezes Succi, Christella Twizere, Steven Brown, Carolyn Bolton-Moore, Ounoo Elom Takassi, Michael Scanlon, Roxanne Martin, Kara Wools-Kaloustian, IeDEA
Summary: This study aims to assess the access children with HIV have to comprehensive HIV care services, evaluate the implementation and scale-up of services, and explore whether access to these services influences retention in care. A cross-sectional survey was conducted in 174 IeDEA sites in 32 countries, and a comprehensiveness score based on WHO's essential services was developed to categorize sites. The findings suggest that meeting recommendations for comprehensive HIV services should remain a global priority.
Article
Public, Environmental & Occupational Health
Pierre-julien Coulaud, Travis Salway, Julie Jesson, Naseeb Bolduc, Olivier Ferlatte, Karine Bertrand, Annabel Desgrees du Lou, Emily Jenkins, Marie Jauffret-Roustide, Rod Knight
Summary: This study investigated the moderating effect of financial support from government or family/friends on the association between income loss and depression among young adults. The results showed that receiving financial support from family/friends can alleviate the impact of income loss on depression, while receiving financial support from the government does not have this effect.
SSM-POPULATION HEALTH
(2023)
Article
Hematology
Aldiouma Guindo, Zenab Cisse, Ibrahima Keita, Sophie Desmonde, Yeya dit Sadio Sarro, Boubacari A. Toure, Mohamed Ag Baraika, Oumarou Tessougue, Pierre Guindo, Moussa Coulibaly, Oumar Traore, Niagale Sylla, Mahamadou Diassana, Amaguire Saye, Valentina Picot, Emilie Lauressergues, Valeriane Leroy
Summary: This study assessed the acceptability and diagnostic performances of two rapid diagnostic tests for sickle cell disease (SCD) newborn screening in Mali. The results showed that both tests had reliable diagnostic performances to exclude SCD-free newborns and identify SCD carriers. The study suggests that this strategy could be implemented in large-scale newborn screening programs.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
John Humphrey, Elizabeth Nagel, James G. Carlucci, Andrew Edmonds, Aarti Kinikar, Kim Anderson, Valeriane Leroy, Daisy Machado, Dwight E. Yin, Marco Tulio Luque, Madeleine Amorissani-Folquet, Safari Mbewe, Tulathip Suwanlerk, Athanase Munyaneza, Rena C. Patel, Beverly Musick, Lisa Abuogi, Kara Wools-Kaloustian
Summary: The WHO recommends integrating HIV services with maternal and child health services to improve care for women living with HIV and their children. A survey of 202 HIV treatment sites in 40 countries found varying levels of integration, with higher proportions in Southern and East Africa. Further research is needed to understand the impact of integration on maternal and child health outcomes.
FRONTIERS IN GLOBAL WOMENS HEALTH
(2023)
Meeting Abstract
Immunology
C. Alba, S. Malhotra, S. Horsfall, M. Barnhart, K. Chapman, C. K. Cunningham, P. Fast, G. G. Fouda, K. A. Freedberg, L. Ghazaryan, V. Leroy, C. Mann, M. M. McCluskey, E. J. McFarland, V. Muturi-Kioi, S. R. Permar, D. Sok, L. Stranix-Chibanda, M. C. Weinstein, A. L. Ciaranello, C. M. Dugdale
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
L. Saint-Lary, I. Lacroix, V. Leroy, A. Sommet
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)