Article
Geriatrics & Gerontology
Owoicho Adogwa, M. Cary Reid, Sai Chilakapati, Una E. Makris
Summary: Chronic musculoskeletal pain is a major cause of disability and functional impairment in older adults, with significant societal and personal costs. Managing chronic pain in older adults is challenging due to multiple comorbidities, concerns about treatment-related harm, and their beliefs about pain management. This narrative review presents data from high-quality clinical trials focusing on musculoskeletal pain management in older adults, highlighting insomnia as a contributor to knee osteoarthritis pain, digital and AI-driven behavioral interventions, and more efficient ways of delivering glucocorticoids for osteoarthritis. These selected studies have potential for scalability and meaningful impact in caring for older adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Meagan S. Kingren, Marlene E. Starr, Hiroshi Saito
Summary: The incidence and mortality rates of sepsis increase significantly with age, especially in older adults. However, there is currently a lack of effective therapeutic strategies targeting older patients with severe sepsis, despite ongoing research efforts. Further research using aged animal models with clinically relevant treatments is essential for future progress in this area.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Orthopedics
Melissa E. Hay, Denise M. Connelly
Summary: The study found that physical therapists go through five phases when creating and implementing exercise plans for older adults with chronic back pain, including listening to the patient's story, determining function, providing physical therapy care, supporting integration, and ultimately returning to life. These phases are part of a shared alliance between the therapist and patient, with a transfer of responsibility throughout treatment sessions aimed at achieving patient independence.
Article
Clinical Neurology
Arielle Vary-O'Neal, Sareh Miranzadeh, Nafisa Husein, Jayna Holroyd-Leduc, Tolulope T. T. Sajobi, Samuel Wiebe, Charles Deacon, Jose Francisco Tellez-Zenteno, Colin Bruce Josephson, Mark R. R. Keezer
Summary: This study aimed to investigate the relationship between frailty and seizure frequency and tolerability of antiseizure medications in older adults with epilepsy. The results showed that frailty was associated with decreased tolerability of antiseizure medications, but not with seizure frequency.
Article
Geriatrics & Gerontology
Elbert S. Huang, Jennifer Y. Liu, Kasia J. Lipska, Richard W. Grant, Neda Laiteerapong, Howard H. Moffet, L. Philip Schumm, Andrew J. Karter
Summary: This study identified three health status classes of older adults with diabetes based on prevalent comorbidities, and these classes were associated with significant differences in complication risks. These classes can provide guidance for population health management and personalized diabetes care.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Rehabilitation
Sean D. Rundell, Amol Karmarkar, Michael Nash, Kushang V. Patel
Summary: The study found that older adults with back pain who have multiple chronic conditions, especially arthritis, depression, and anxiety, are associated with poor physical functioning and an increased risk of falls over time.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Geriatrics & Gerontology
Christine Seel Ritchie, Kanan Patel, John Boscardin, Christine Miaskowski, Ana-Maria Vranceanu, Elizabeth Whitlock, Alexander Smith
Summary: This study aims to investigate the associations between persistent pain and physical function, cognitive function, and well-being in older adults. The results suggest that persistent pain contributes to declines in physical function and well-being, but not cognitive decline.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Katie de Luca, Sheilah Hogg-Johnson, Martha Funabashi, Silvano Mior, Simon D. French
Summary: This study analyzed data from two large observational studies in Australia and Canada, finding that one in seven chiropractic patients are over 65 years old, with nearly 60% presenting with back problems. Neck pain and lower limb issues were also common reasons for older adults seeking chiropractic care.
Article
Geriatrics & Gerontology
Sadaf Arefi Milani, Tyler R. Bell, Michael Crowe, Caitlin N. Pope, Brian Downer
Summary: This study aimed to evaluate the bidirectional association between pain interference and cognitive performance. The findings suggest that increased pain interference is associated with greater cognitive decline, while better baseline cognitive performance is related to lower pain interference at follow-up.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
R. Samper-Ternent, C. Gonzalez-Gonzalez, J. D. Zazueta, R. Wong
Summary: The prevalence of pain among older Mexican adults at the end-of-life is high, with factors such as sociodemographic characteristics, chronic diseases, number of medications, psychosocial factors, and functional status being associated with pain. These findings provide valuable information for policymakers and healthcare providers in Mexico to improve the quality of end-of-life care.
Review
Geriatrics & Gerontology
Anitha Saravanan, Louise Reagan, Ruby Rivera, Niharika Challa, Haalika Lankipalle, Vijay Ram Reddy Sareddy, Angela Starkweather
Summary: This scoping review identified a limited number of high-quality studies on non-pharmacological interventions for older adults with comorbid conditions and chronic pain in community settings. The studies lacked quantification and specific reporting of comorbidity indices and burden, and none of them measured changes in participant comorbidities and burden.
Article
Geriatrics & Gerontology
Yenisel Cruz-Almeida, Stephen Coombes, Marcelo Febo
Summary: NODDI imaging technique revealed lower neurite density and less geometric complexity in older adults with chronic musculoskeletal pain. The lower neurite density was associated with higher pain intensity and anatomical pain sites. Pain-by-sex differences in neurite density and geometric complexity were also observed.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Geriatrics & Gerontology
Yurun Cai, Suzanne G. Leveille, Ling Shi, Ping Chen, Tongjian You
Summary: The study found that chronic pain interference and pain distribution in older adults are associated with an increased risk of injurious falls, especially in women. Short-term moderate-to-severe pain also increases the risk of injurious falls in the subsequent month.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Psychology, Multidisciplinary
Olivia R. Noel, Daniel L. Segal, Katie L. Granier
Summary: This study examined the relationships between personality disorder features, Big Five personality traits, and interpersonal problems with anxiety. The results showed that anxiety was associated with PD features, aspects of Big Five personality traits, and interpersonal problems. PD features accounted for the most variance in anxiety symptoms, followed by interpersonal problems and Big Five personality traits. These findings suggest that these variables may play important roles in the development and maintenance of anxiety.
PSYCHOLOGICAL REPORTS
(2023)
Article
Psychology, Clinical
Andrew H. Rogers, Lorra Garey, Nicholas P. Allan, Michael J. Zvolensky
Summary: This study examined the impact of transdiagnostic psychosocial factors such as pain-related anxiety, anxiety sensitivity, emotion dysregulation, and distress tolerance on chronic pain and opioid outcomes. The results indicate that these factors have independent effects on pain and opioid outcomes, with pain-related anxiety most strongly related to pain intensity and interference, anxiety sensitivity related to opioid misuse, and emotion dysregulation related to all studied criterion variables.
BEHAVIOUR RESEARCH AND THERAPY
(2021)