Article
Nutrition & Dietetics
Hong-Yeul Lee, Jung-Kyu Lee, Hye-Jin Kim, Dal-Lae Ju, Sang-Min Lee, Jinwoo Lee
Summary: Continuous enteral feeding has been shown to be more effective in achieving target nutrition, especially in patients receiving mechanical ventilation.
Article
Nutrition & Dietetics
Jun-Kwon Cha, Hyung-Sook Kim, Eun-Ji Kim, Eun-Sook Lee, Jae-Ho Lee, In-Ae Song
Summary: The initial nutritional delivery policy and route of nutrition delivery may have an impact on the clinical outcomes of patients with sepsis. Higher protein intake during the first week of sepsis onset is associated with lower in-hospital mortality, while higher energy intake is associated with lower 30-day mortality. Additionally, in patients with a high modified nutrition risk in the critically ill score, enteral feeding with supplemental parenteral nutrition is superior to other routes of nutrition delivery and is associated with lower mortality.
Article
Nutrition & Dietetics
Hiroyuki Ohbe, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
Summary: A comparison between large-bore sump tubes and small-bore feeding tubes in mechanically ventilated patients showed that patients in the small-bore feeding tube group had higher 28-day in-hospital mortality and prevalence of hospital-acquired pneumonia, suggesting that small-bore feeding tubes may not be associated with better clinical outcomes. Further studies are needed to understand the mechanisms behind these findings.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Montserrat Sierra-Colomina, Nagam Anna Yehia, Farhan Mahmood, Christopher Parshuram, Haifa Mtaweh
Summary: The utilization of noninvasive ventilation (NIV) in pediatric intensive care units (PICUs) to support children with respiratory failure has increased, but there is variation in the practice of initiating enteral nutrition (EN) due to safety concerns. This retrospective study found that early enteral feeding in children on NIV was associated with a lower rate of respiratory complications and shorter ICU stays.
Article
Critical Care Medicine
Ricard Mellado-Artigas, Carlos Ferrando, Frederic Martino, Agathe Delbove, Bruno L. Ferreyro, Cedric Darreau, Sophie Jacquier, Laurent Brochard, Nicolas Lerolle
Summary: This study evaluated the effect of early intubation on septic shock patients and found that early intubation did not improve outcomes in terms of in-hospital mortality, intensive care, and hospital length of stay. There were no significant differences in ICU and hospital length of stay among groups, and sensitivity analyses confirmed the robustness of the findings.
Article
Nutrition & Dietetics
Omorogieva Ojo, Osarhumwese Osaretin Ojo, Qianqian Feng, Joshua Boateng, Xiaohua Wang, Joanne Brooke, Amanda Rodrigues Amorim Adegboye
Summary: This systematic review and meta-analysis evaluated the effects of enteral nutrition in critically ill patients with COVID-19. The results showed that early enteral nutrition significantly reduced the risk of mortality among these patients, while it did not significantly affect the length of hospital stay, length of ICU stay, and days on mechanical ventilation. Further studies are needed to examine the effect of early enteral nutrition in patients with COVID-19.
Article
Nutrition & Dietetics
Wen Xu, Ming Zhong, Tingting Pan, Hongping Qu, Erzhen Chen
Summary: This study found that gut microbiota and short-chain fatty acid levels are associated with enteral nutrition tolerance in critically ill patients. On the first day of enteral nutrition initiation, the tolerance group had higher microbiota diversity and operational taxonomic units than the intolerance group. On the third day, the genus Escherichia-Shigella was significantly elevated in the tolerance group. The levels of short-chain fatty acids decreased more significantly in the intolerance group.
Article
Nutrition & Dietetics
Judith Behnke, Vanessa Estreich, Frank Oehmke, Bernd Axel Neubauer, Anita Windhorst, Harald Ehrhardt
Summary: Nutritional supply is crucial for the growth and development of very-low-birthweight infants, and our study confirms the effectiveness of rapid enteral feeding in reducing long-term complications. Our findings show that the standardized protocol (STENA) for enteral feeding not only reduces the need for parenteral nutrition but also improves somatic growth and reduces the requirement for mechanical ventilation. Additionally, the benefits of STENA on head circumference persist until the age of 2 years.
Article
Medicine, General & Internal
Yuta Takahashi, Tomoyuki Morisawa, Hiroshi Okamoto, Nobuto Nakanishi, Noriko Matsumoto, Masakazu Saitoh, Tetsuya Takahashi, Toshiyuki Fujiwara
Summary: This study compared the incidence of diaphragm dysfunction and ICU-acquired weakness in patients with septic shock, with and without mechanical ventilation. The incidence of diaphragm dysfunction was higher than that of ICU-acquired weakness in patients with septic shock, regardless of the use of mechanical ventilation. Further studies are needed to assess the association between diaphragm dysfunction and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Yisong Cheng, Chaoyue Chen, Hao Yang, Min Fu, Xi Zhong, Bo Wang, Zhi Hu, Min He, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Qin Wu
Summary: This study compared the efficacy and safety of domperidone administered via the feeding tube versus intravenous metoclopramide in critically ill patients with EFI. The findings suggest that tube feeding domperidone was more effective in improving enteral nutrition delivery performance in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nutrition & Dietetics
Rachel Strahm, Manuel Weber, Reiner Wiest, Kai-Uwe Schmitt
Summary: This study examined the effects of early tube feeding compared to tube feeding after 24 hours on clinical parameters. Patients with percutaneous endoscopic gastrostomy (PEG) received tube feeding 4 hours after tube insertion following the updated ESPEN guidelines. An observational study analyzed whether the new scheme affected patient complaints, complications, or hospitalization duration. The study found that the new scheme did not impact patient complaints or complications, but it significantly reduced hospitalization duration.
Article
Critical Care Medicine
Yuetian Yu, Cheng Zhu, Yucai Hong, Lin Chen, Zhiping Huang, Jiancang Zhou, Xin Tian, Dadong Liu, Bo Ren, Cao Zhang, Caibao Hu, Xinan Wang, Rui Yin, Yuan Gao, Zhongheng Zhang
Summary: In a multicentre, open-label trial, adults with septic shock were randomly assigned to receive usual care or anisodamine. There was no significant difference in hospital mortality or ventilator-free days between the usual care and anisodamine groups, but the treated group had significantly lower serum lactate levels and were less likely to need vasopressors.
Article
Nursing
Weiqin Zhang, Wenguang Zhou, Yue Kong, Qi Li, Xiaoqiong Huang, Binbin Zhao, Honghong Su, Silu Chen, Xianying Shen, Zhaojun Qiu
Summary: This study aimed to evaluate the impact of abdominal massage on enteral feeding tolerance in mechanically ventilated patients. The results showed that abdominal massage can effectively reduce the incidence of gastric retention, abdominal distension, aspiration, gastric residual volume, and abdominal circumference in mechanically ventilated patients, but not the incidence of vomiting, reflux, and diarrhea.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Medicine, General & Internal
Wen-jun Liu, Jun Zhong, Jing-chao Luo, Ji-li Zheng, Jie-fei Ma, Min-jie Ju, Ying Su, Kai Liu, Guo-wei Tu, Zhe Luo
Summary: Patients with cardiogenic shock after cardiac surgery had a high proportion of early EN intolerance, leading to longer mechanical ventilation time, longer ICU stay, and higher infection rates. No significant correlation was identified between EN tolerance and the dose of vasoactive drugs.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Maria Rosaria Marchili, Antonella Diamanti, Valeria Zanna, Giulia Spina, Cristina Mascolo, Marco Roversi, Benedetta Guarnieri, Gianluca Mirra, Giulia Testa, Umberto Raucci, Antonino Reale, Alberto Villani
Summary: Nutritional rehabilitation with naso-gastric feeding (NGF) is crucial for weight restoration in hospitalized anorexia nervosa (AN) patients. Patients treated with NGF have a lower BMI on admission and discharge, longer hospital stay, and a longer time to relapse compared to patients without NGF. Early NGF intervention is associated with a shorter length of hospitalization and facilitates faster recovery.
Article
Nutrition & Dietetics
Jayshil J. Patel, Michelle Kozeniecki, William J. Peppard, Sarah R. Peppard, Stephanie Zellner-Jones, Jeanette Graf, Aniko Szabo, Daren K. Heyland
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2020)
Article
Surgery
Savo Bou Zein Eddine, Kaitlin Cooper-Johnson, Forrest Ericksen, Carolyn C. Brookes, William J. Peppard, Sara L. Revolinski, Thomas W. Carver
JOURNAL OF SURGICAL RESEARCH
(2020)
Letter
Pharmacology & Pharmacy
Chris Carter, Kevin D. Betthauser, William J. Peppard
ANNALS OF PHARMACOTHERAPY
(2020)
Article
Critical Care Medicine
Rahul Nanchal, Ram Subramanian, Constantine J. Karvellas, Steven M. Hollenberg, William J. Peppard, Kai Singbartl, Jonathon Truwit, Ali H. Al-Khafaji, Alley J. Killian, Mustafa Alquraini, Khalil Alshammari, Fayez Alshamsi, Emilie Belley-Cote, Rodrigo Cartin-Ceba, Joanna C. Dionne, Dragos M. Galusca, David T. Huang, Robert C. Hyzy, Mats Junek, Prem Kandiah, Gagan Kumar, Rebecca L. Morgan, Peter E. Morris, Jody C. Olson, Rita Sieracki, Randolph Steadman, Beth Taylor, Waleed Alhazzani
CRITICAL CARE MEDICINE
(2020)
Article
Critical Care Medicine
Rahul Nanchal, Ram Subramanian, Constantine J. Karvellas, Steven M. Hollenberg, William J. Peppard, Kai Singbartl, Jonathon Truwit, Ali H. Al-Khafaji, Alley J. Killian, Mustafa Alquraini, Khalil Alshammari, Fayez Alshamsi, Emilie Belley-Cote, Rodrigo Cartin-Ceba, Joanna C. Dionne, Dragos M. Galusca, David T. Huang, Robert C. Hyzy, Mats Junek, Prem Kandiah, Gagan Kumar, Rebecca L. Morgan, Peter E. Morris, Jody C. Olson, Rita Sieracki, Randolph Steadman, Beth Taylor, Waleed Alhazzani
CRITICAL CARE MEDICINE
(2020)
Article
Otorhinolaryngology
Spencer Joseph Laehn, John Anthony LoGuidice, Patrick Christian Hettinger, Lisa Egner Rein, William John Peppard
Summary: In free flap transfers to the head and neck, the incidence of complications postoperatively was lower in the light sedation group compared to the deep sedation group.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Pharmacology & Pharmacy
Mary M. O'Keefe, Thomas W. Carver, David J. Herrmann, Alyson Prom, Sara Hubbard, Lisa E. Rein, William J. Peppard
Summary: This study evaluated the effectiveness of a BMI-based enoxaparin prophylaxis dosing protocol in achieving target anti-Xa concentrations in trauma patients. The study found that the rate of achieving target anti-Xa concentrations was suboptimal and further improvement is needed. The correlation between enoxaparin dose per EBV and anti-Xa concentrations was higher compared to dose per TBW and BMI.
Article
Pharmacology & Pharmacy
William J. Peppard, Sarah R. Peppard, Joel T. Feih, Andy K. Kim, Steve J. Obenberger, Ashley F. Mulvey, Bi Qing Teng, Ruta Brazauskas, Kate O. Pape, Gabrielle A. Gibson, Amy L. Dzierba, Paul P. Dobesh
Summary: The study aimed to identify characteristics associated with critical care pharmacists that make them targets of unsolicited invitations to publish. The results indicated a strong correlation between the number of previous PubMed-indexed publications and the likelihood of critical care pharmacists receiving unsolicited publication invitations.
JOURNAL OF PHARMACY PRACTICE
(2023)
Article
Medicine, General & Internal
Joseph Zenga, Samantha Atkinson, Tina Yen, Becky Massey, Michael Stadler, Jennifer Bruening, William Peppard, Michael Reuben, Michael Hayward, Brian Mesich, Blake Buchan, Nathan Ledeboer, Joyce L. Sanchez, Raphael Fraser, Chien-Wei Lin, Mary L. Holtz, Musaddiq Awan, Stuart J. Wong, Sidharth V. Puram, Nita Salzman
Summary: The study aimed to evaluate the safety and efficacy of a topical mucosal antiseptic bundle in preventing surgical site infection (SSI) in head and neck cancer surgery. The results showed that the antiseptic bundle significantly reduced oral bacterial colonization and was associated with a low rate of SSI. Microbiome analysis revealed a correlation between pre-operative oral bacteria and SSI.
Article
Surgery
Katherine Tyson, Basil S. Karam, William J. Peppard, Rachel Morris, Patrick Murphy, Anuoluwapo Elegbede, Mary Schroeder, Lewis Somberg, Colleen M. Trevino
Summary: A comprehensive guideline on opioid prescribing successfully reduced morphine milligram equivalents for trauma patients and improved compliance with recommendations from the Centers for Disease Control and Prevention.
Article
Surgery
Stephanie Tchen, Rootvij Bhatt, William Peppard, Aniko Szabo, Huaying Dong, Rachel Morris, Colleen M. Trevino
Summary: This study aimed to describe the relationship between opioid use and opioid-related adverse effects in emergency laparotomies and identify the appropriate dose reductions for clinically beneficial outcomes. The results showed significant associations between opioid dose and clinical outcomes such as pain scores, time to first bowel movement, and nasogastric tube duration.
Article
Pharmacology & Pharmacy
Keaton S. S. Smetana, Alexander H. H. Flannery, Payal K. K. Gurnani, William J. J. Peppard, Megan A. A. Van Berkel Patel, Cara Joyce, Megan A. A. Rech
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
William Peppard, Holly Sheldon, Sarah Endrizzi, Rebekah Walker, Gwynne Kirchen, Alexis Schrang, Sneha Nagavally, Leonard Egede
Summary: This study investigated opioid prescription inequity between Black and White patients treated by F&MCW. The results showed that Black patients had higher prescription numbers and daily dose compared to White patients, but the significance decreased and was lost when adjusted for patient demographics and comorbidities.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2022)
Article
Pharmacology & Pharmacy
Kathryn M. O'Brien, Melissa E. Badowski, Anna S. Bartoo, William J. Peppard, Kerry Schwarz, Abigail R. Sharpe, Jennifer Austin Szwak
Summary: Despite institutional financial and educational support, the most commonly reported barriers to conducting pharmacy research were time, funding, and knowledge or experience of staff pharmacists. The survey also highlighted that a majority of research projects in pharmacy departments were driven by postgraduate residents.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Kirsten Elena Wallskog, Stacy Lauderdale, William J. Peppard, Craig Kirkwood, Stacy Taylor, Susan Johnston
Summary: The survey revealed that most hospitals have i.v. APAP on formulary for perioperative use, but with restrictions. Differences in i.v. APAP formulary practices between academic medical centers and non-academic medical centers warrant further consideration.
