Article
Infectious Diseases
Kevin Simon, Wolfgang Pier, Alex Kruettgen, Hans-Peter Horz
Summary: The combination of Sb-1 phage and oxacillin showed enhanced antibacterial effects against most S. aureus isolates, with rare antagonism observed. This heterologous antimicrobial pair provides a robust approach for controlling MRSA.
Article
Infectious Diseases
Sabrina Di Gregorio, Maria Sol Haim, Angela Maria Rosa Famiglietti, Jose Di Conza, Marta Mollerach
Summary: This study characterized isogenic strains of S. aureus with vancomycin resistance, both in vivo and in vitro, and found genetic changes associated with cell wall and phosphate metabolism, staphylococcal growth, and biofilm formation. These changes are not commonly associated with vancomycin resistance in S. aureus.
Article
Infectious Diseases
Elisabetta Buommino, Simona De Marino, Martina Sciarretta, Marialuisa Piccolo, Carmen Festa, Maria Valeria D'Auria
Summary: Oxadiazole compounds showed high efficacy against Gram-positive MRSA and were able to restore antibiotic activity, making them promising for the treatment of MRSA infections.
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Article
Biochemistry & Molecular Biology
Muhammad Mubashar Idrees, Khadija Saeed, Muhammad Akbar Shahid, Muhammad Akhtar, Khadija Qammar, Javariya Hassan, Tayyaba Khaliq, Ali Saeed
Summary: This cross-sectional study aimed to determine the prevalence of mecA and mecC genes among phenotypically identified MRSA and evaluate their effectiveness against different antibiotics. The results showed a high prevalence of mecA and mecC in MRSA samples, and penicillin and amoxicillin/clavulanic acid were ineffective against MRSA, while vancomycin, teicoplanin, and linezolid were the most effective drugs.
Article
Agriculture, Dairy & Animal Science
Pengfei Zhang, Xinyu Liu, Jie Zhang, Xueting Fu, Yangli Wan, Hu Pan, Congming Wu, Xin Wang
Summary: The study found that yak butter from Tibet, China, is contaminated with Staphylococcus aureus, including methicillin-resistant strains. The isolates carried various virulence genes, with blaZ being the most frequently detected resistance gene.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Infectious Diseases
Mingbiao Ma, Minjun Chu, Lvyan Tao, Jue Li, Xiaojuan Li, Hailin Huang, Kexuan Qu, Haiping Wang, Li Li, Tingyi Du
Summary: The study revealed a high detection rate of OS-MRSA in children's hospital, with the dominant molecular typing being ST59-SCCmec IV. The automated antimicrobial susceptibility test system has limited ability to identify OS-MRSA, therefore a combination of phenotypic analysis and molecular detection is recommended for better identification.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Microbiology
Shriram Patel, Abel A. Vlasblom, Koen M. Verstappen, Aldert L. Zomer, Ad C. Fluit, Malbert R. C. Rogers, Jaap A. Wagenaar, Marcus J. Claesson, Birgitta Duim
Summary: This study investigated the dynamics of the nasal microbiome of piglets over time, revealing an increase in richness and diversity as well as identifying coabundant groups of species strongly correlated with MRSA and S. aureus colonization.
Article
Veterinary Sciences
Asmita Shrestha, Rebanta Kumar Bhattarai, Himal Luitel, Surendra Karki, Hom Bahadur Basnet
Summary: This study identified a high prevalence of S. aureus-mediated subclinical mastitis in dairy herds in Chitwan, Nepal, with a small proportion being MRSA carrying a mecA gene. The contamination of milk by S. aureus, CoNS, and MRSA poses a public health risk due to their resistance to commonly used antibiotics. It is recommended to screen dairy herds for subclinical mastitis and treat animals based on antibiotic susceptibility tests to combat antimicrobial resistance. Future research should focus on exploring additional antibiotic resistance genes in Staphylococcus species beyond the mecA gene to ensure public health.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mark Hutchins, Richard A. Bovill, Peter J. Stephens, John A. Brazier, Helen M. I. Osborn
Summary: The increasing number of antibiotic-resistant bacteria poses a serious threat to global human health. This study examines the glycosylation of nadifloxacin to improve its solubility and finds that one glycoside derivative has the potential to be an effective antibacterial agent.
Review
Microbiology
Elena Mitevska, Britney Wong, Bas G. J. Surewaard, Craig N. Jenne
Summary: The prevalence of MRSA in Canada has been increasing since the early 1980s, with a steady rise in the 1990s and 2000s, especially among vulnerable populations. Studies have shown high susceptibility of MRSA to trimethoprim-sulfamethoxazole, but potentially variable resistance to other drugs.
Review
Veterinary Sciences
Shrijana Khanal, Sukolrat Boonyayatra, Nattakarn Awaiwanont
Summary: This study aimed to determine the overall prevalence and heterogeneity of MRSA in dairy cattle farms. The findings indicate that the prevalence of MRSA has been minimal and consistent over time, with higher rates in Asia and lower rates in South America. The year of publication and sample type were not significantly associated with MRSA prevalence.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori, Brian Conlon
Summary: Treatment with short electric pulses can enhance the effects of multiple antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). This combination therapy reduces the necessary antibiotic dosage and improves the efficacy of treating S. aureus infections such as skin and soft-tissue infections (SSTIs). SSTIs are accessible to physical intervention, making electric pulse co-treatment a potential option for wound and abscess debridement.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Nicholas M. Brown, Erwin M. Brown
Summary: The UK guidelines for MRSA infection treatment have been updated, incorporating new evidence and antibiotics for Gram-positive bacterial infections. However, the current literature review found a lack of strong evidence, resulting in a hybrid of varying degrees of evidence and expert opinion in the guidelines.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Hematology
Avani Shah, Parizad Patel, Keyur Patel, Binal Patel, Keyuri Jariwala, Preeti Sharma, Kanchan Mishra, Kanjaksha Ghosh
TRANSFUSION AND APHERESIS SCIENCE
(2020)
Letter
Rheumatology
Kanjaksha Ghosh
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, Research & Experimental
Salam Alkindi, Said S. Almufargi, Anil Pathare
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Multidisciplinary Sciences
Salam Alkindi, Ikhlas Al-Busaidi, Bushra Al-Salami, Samir Raniga, Anil Pathare, Samir K. Ballas
SCIENTIFIC REPORTS
(2020)
Article
Hematology
Avani Shah, Parizad Patel, Keyuri Jariwala, Farzin Qureshi, Kanchan Mishra, Sumit Bharadva, Kanjaksha Ghosh
Summary: There is a lack of data on the prevalence of rare blood group antigens among the blood donor population in South Gujarat due to the unavailability and high cost of antisera. This study used a PCR-based method to detect the presence of In-a and In-b antigens in regular voluntary blood donors. The frequency of In a antigen was found to be higher than Caucasians, lower than Iranians and Arabs, and comparable to Indians in Mumbai. This PCR-based method could be extremely helpful in creating a rare donor registry and screening blood donors on a large scale in the absence of antisera, particularly for low-frequency alleles like In-a.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Medicine, General & Internal
Naglaa Fawaz, Ismail Beshlawi, Alauldeen Alqasim, Mathew Zachariah, Roberta Russo, Immacolata Andolfo, Antonella Gambale, Anil Pathare, Achille Iolascon
Summary: We report a case of transfusion-dependent chronic anemia in a child, with clinical and laboratory features suggestive of a chronic nonspherocytic hemolytic anemia and bone marrow features suggestive of congenital dyserythropoietic anemia. However, DNA studies revealed a novel mutation in the PKLR gene responsible for pyruvate kinase deficiency as the underlying condition. Molecular investigations using targeted next-generation sequencing identified the patient as homozygous for a novel missense mutation, while both parents were heterozygous for the same mutation.
CLINICAL CASE REPORTS
(2022)
Review
Hematology
Kanjaksha Ghosh, Kinjalka Ghosh
Summary: Monoclonal antibodies are increasingly used in hematology practice, either alone or in combination with other therapies, to improve outcomes in various hematological conditions. These antibodies have a wide range of applications in malignant and benign hematological diseases, as well as in different phases of stem cell transplantation. Advancements in protein engineering are rapidly improving the function of antibodies.
EXPERT REVIEW OF HEMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Kanjaksha Ghosh, Durjoy K. Shome, Bipin Kulkarni, Malay K. Ghosh, Kinjalka Ghosh
Summary: Bone marrow fibrosis is a significant structural change in the marrow that is not well understood in terms of its causes. This review consolidates the current understanding of marrow fibrosis, highlighting the complex interactions between growth factors, cytokines, chemokines, and hormones. The involvement of various cells, molecules, and genetic/epigenetic changes in the fibrosis process is also discussed.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Suryyani Deb, Mohammad Azharuddin, Sofia Ramstrom, Kanjaksha Ghosh, Santiswarup Singha, Thobias Romu, Hirak Kumar Patra
Summary: Arterial thrombosis is caused by platelet-mediated thrombus formation in blood vessels, leading to severe cardiovascular diseases. To better predict and treat arterial thrombosis, we have developed a nanoparticle platform that can simultaneously monitor and restrict thrombus growth. The platform works by inhibiting receptors on platelets and visualizing the thrombus status through magnetic resonance imaging.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Prashant P. Warang, Nikhil S. Shinde, Vinod D. Umare, Prajyot Deshmukh, Kanjaksha Ghosh, Manisha R. Madkaikar, Roshan B. Colah, Malay B. Mukherjee
Summary: This study evaluated the effects of fermented papaya preparation (FPP) on sickle cell patients, finding that it has the potential to reduce oxidative stress and protect red blood cell morphology. The analysis also revealed the presence of essential amino acids and vitamin D3 and derivatives in FPP.
Article
Biochemistry & Molecular Biology
Vinod Umare, Vandana Pradhan, Sneha Dadheech, Anjali Rajadhyaksha, Kanjaksha Ghosh, Anita Nadkarni
Article
Pathology
Sandhya Tamgadge, Treville Pereira, Sandeep Kale, Subraj Shetty, Avinash Tamgadge
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Rodrigo C. Menezes, Isabella B. B. Ferreira, Luciana Sobral, Stefania L. Garcia, Hugo N. Pustilnik, Mariana Araujo-Pereira, Bruno B. Andrade
Summary: This study aimed to identify the clinical features associated with viral pathogens responsible for severe lower respiratory tract infections (LRTI) in children. The study found that different viral agents have distinct associations with clinical features in children.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Ambrina Khatoon, Syed F. Hussain, Syed M. Shahid, Santosh Kumar Sidhwani, Salman Ahmed Khan, Omer Ahmed Shaikh, Abdulqadir J. Nashwan
Summary: Despite the increasing incidence of Staphylococcus aureus infection and dissemination in Pakistan, research on the epidemiology of different Staphylococcus aureus clones has been limited. This study used multilocus sequence typing (MLST) to analyze the epidemiology of Staphylococcus aureus in the area, finding high diversity of locally circulating clones defined by their geographic epidemiology.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Review
Public, Environmental & Occupational Health
Amir Khorram-Manesh, Krzysztof Goniewicz, Frederick M. Burkle Jr
Summary: This article discusses the management approach for globalized diseases in a globalized world. Through literature review and analysis, key focuses including data-driven decision-making, robust technology infrastructure, global cooperation, and ongoing public health education are identified. The weaknesses of current pandemic management systems are revealed, and recommendations for strengthening future pandemic management are provided.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Mst S. Munira, Yuta Okada, Hiroshi Nishiura
Summary: This study estimates the life expectancy at birth in Japan at the end of 2022 using death datasets from Aichi and Fukui prefectures. The results suggest that the impact of the pandemic on life expectancy was relatively small by the end of 2022.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
