Article
Medicine, General & Internal
Jeeyoung Kwak, You Hyun Lee, Kyung Tae Kang, Yu Cheol Kim
Summary: This retrospective study compared the effectiveness of intravitreal bevacizumab (IVB) injections alone and during cataract surgery in patients with diabetic macular edema. It found that in patients who underwent cataract surgery after IVB injection, there was a significant decrease in central subfield macular thickness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shivakumar K. Reddy, Abhijna R. Ballal, S. Shailaja, Raviraja N. Seetharam, Chandrashekar H. Raghu, Runali Sankhe, Kanthilatha Pai, Tenzin Tender, Mary Mathew, Annayya Aroor, Ashok K. Shetty, Shalini Adiga, Vasudha Devi, Manjunatha S. Muttigi, Dinesh Upadhya
Summary: Diabetic retinopathy (DR) is associated with various complications that lead to vision loss. Anti-VEGF therapy is used to reduce neovascularization and leakage, but requires frequent injections and may cause complications. This study found that MSC-sEVs loaded with bevacizumab can reduce the frequency of injections and sustain the beneficial effects for over two months, reducing VEGF levels and complications better than bevacizumab alone.
Article
Multidisciplinary Sciences
Luiz Guilherme Azevedo de Freitas, David Leonardo Cruvinel Isaac, Murilo Batista Abud, Alexandre Dantas Soares Quintas Segundo, Mariana Larissa Alvino Barros, Gabriela Caroline Monteiro de Albuquerque, Bruna Dantas Aires Guimaraes, Clarice Neuenschwander Lins de Morais, Marcos Pereira de Avila
Summary: This study aimed to analyze the concentrations of various cytokines in the aqueous humor of patients with diabetic macular edema and found significant changes in IL-6 and IL-8 levels during ranibizumab treatment, with VEGF showing a significant decrease at the end of the study. TNF, IL-1, IL-10, and IL-12 levels remained practically unchanged throughout the treatment process.
SCIENTIFIC REPORTS
(2021)
Article
Optics
Lyna Azzouz, Asad Durrani, Yunshu Zhou, Yannis M. Paulus
Summary: This study aims to investigate the impact of adjunct nondamaging focal laser therapy on the number of anti-vascular endothelial growth factor injections and visual acuity in patients with diabetic macular edema. The results indicate that adjunct focal macular laser therapy can significantly decrease the number of intravitreal injections required without compromising visual acuity or macular thickness.
Article
Medicine, General & Internal
Yoo-Ri Chung, Kyung Ho Lee, Kihwang Lee
Summary: This study compared the efficacy of three and five monthly loading regimens of intravitreal aflibercept injection for diabetic macular edema (DME) treatment. The results showed that the five-month loading regimen had better outcomes, reducing the rate of recurrence and improving the duration of treatment effectiveness.
MEDICINA-LITHUANIA
(2023)
Article
Ophthalmology
Farhad Fazel, Mohammad Malekahmadi, Awat Feizi, Behrooz Oliya, Mehdi Tavakoli, Mohammadreza Fazel
Summary: This study investigated the efficacy of combining suprachoroidal triamcinolone acetonide (SCTA) with intravitreal bevacizumab (IVB) in patients with center-involving diabetic macular edema (CI-DME). The results showed that the combination of SCTA and IVB had significant improvements in both visual acuity and retinal thickness, with no significant side effects observed.
Article
Endocrinology & Metabolism
Tsung-Cheng Hsieh, Guang-Hong Deng, Yung-Ching Chang, Fang-Ling Chang, Ming-Shan He
Summary: This study aimed to investigate optical coherence tomography (OCT) biomarkers of diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (anti-VEGF) therapy. The results showed that partially continuous inner segment-outer segment (IS-OS) layers were predictive of better response, while epiretinal membrane (ERM) was a significant predictor of poor response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Murat Okutucu, Huseyin Findik, Mehmet Gokhan Aslan, Medeni Arpa
Summary: In this study, it was found that intravitreal injections of BCZ significantly decreased serum VEGF levels in patients with diabetic macular edema, while leading to a significant upregulation in netrin-1 concentration.
Article
Ophthalmology
Abeer M. M. Khattab, Sherein M. M. Hagras, Nancy M. M. Lotfy
Summary: The aim of this study was to investigate whether treating diabetic macular edema (DME) before cataract surgery has superior effects compared to postoperative injections. The results showed no significant difference in macular edema and visual outcomes between preoperative and postoperative injections of anti-vascular endothelial growth factor (anti-VEGF). Therefore, preoperative control of DME may not be necessary in patients undergoing cataract surgery.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yunyan Hu, Yunkao Zeng, Jing Yang, Xiaomin Zeng, Dan Cao, Biqun Ou, Guanrong Zhang, Liang Zhang
Summary: This study investigated the changes in intraocular pressure after intravitreal injection of Conbercept and evaluated the associated risk factors. The results showed that intravitreal injection of Conbercept may cause a rapid spike in intraocular pressure, but is safe in the short term. Older age and shorter axial length are associated with higher intraocular pressure after injection.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Cameron D. Haydinger, Genevieve F. Oliver, Liam M. Ashander, Justine R. Smith
Summary: Diabetic retinopathy is a retinal disease associated with hyperglycemia in diabetes patients, affecting both the central and peripheral retina. Its major mechanism involves oxidative stress caused by elevated production of reactive oxygen species, which is particularly harmful to the retina due to its high metabolic activity. This review provides an overview of the role of oxidative stress in diabetic retinopathy, including the formation and effects of advanced glycation end-products, metabolic memory, and non-coding RNA, as well as potential therapeutic strategies.
Article
Ophthalmology
Justis P. Ehlers, Steven Yeh, Maureen G. Maguire, Justine R. Smith, Prithvi Mruthyunjaya, Nieraj Jain, Leo A. Kim, Christina Y. Weng, Christina J. Flaxel, Scott D. Schoenberger, Stephen J. Kim
Summary: Evidence review suggests that anti-VEGF agents and corticosteroids are effective treatments for diabetic macular edema, but corticosteroid therapy may lead to elevated intraocular pressure and cataract progression. Further research is needed to compare the efficacy of these therapies and individualized treatment choices are essential for optimal outcomes.
Article
Endocrinology & Metabolism
Karen Mulligan, Jaehong Kim, Bryan Tysinger, Jill Blim, Geoffrey Emerson, Philip J. Ferrone, Judy E. Kim, Seth Seabury, Paul Hahn
Summary: This study simulates economic outcomes for individuals with diabetic macular edema (DME) and finds that treatment significantly improves patients' vision, life expectancy, and quality of life, as well as positively affects employment and disability outcomes.
Article
Ophthalmology
Reza Mirshahi, Khalil Ghasemi Falavarjani, Saber Molaei, Abbas Habibi, Pasha Anvari, Maryam Ashraf Khorasani, Shahriar Ghasemizadeh, David Sarraf
Summary: The study found that after a single intravitreal injection of bevacizumab, diabetic patients with macular edema did not show significant changes in the retinal capillary plexus and vascular diameter, but the blood flow in the choriocapillaris improved significantly.
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2021)
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Letter
Neurosciences
Mohammad-Javad Eslami, Masoud Etemadifar, Mohammad Reza Khalili, Mahboobeh Faraidan-Esfahani, Hamidreza Jahanbani-Ardakani, Sara Ghorbani, Seyed-Hossein Abtahi
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Letter
Ophthalmology
R. Nourinia, S. Fekri, H. Nouri, S. -H. Abtahi
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2022)
Article
Ophthalmology
Ramin Nourinia, Parisa Nikzad, Mohammad Abolhosseini, Seyed-Mohamadmehdi Moshtaghion, Seyed-Hossein Abtahi
Summary: This study presents a new technique called RONA for internal limiting membrane peeling and shows its comparable success rate in closure of large full-thickness macular holes. The advantage of this technique is that there is no need to manipulate the macular hole edge or underlying tissues, and there is no need to worry about flap unfolding during the surgery.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Letter
Ophthalmology
Hamidreza Jahanbani Ardakani, Afshin Moliani, Sadaf Khorrami, Mohammad Reza Khalili, Seyed Hossein Abtahi
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Saeed Karimi, Hosein Nouri, Sahar Mahmoudinejad-Azar, Seyed-Hossein Abtahi
Summary: This article gathers and reviews the available knowledge on the implications of smoking and environmental tobacco smoke exposure in ocular disorders. Smoking is a modifiable risk factor in several ocular diseases, and ETS exposure is also associated with ocular complications. More education is needed for at-risk populations.
CUTANEOUS AND OCULAR TOXICOLOGY
(2023)
Article
Ophthalmology
S. Karimi, H. Nikkhah, H. Nafisi, H. Nouri, I. Ansari, S. Barkhordari, S. Samnejad, S. -H. Abtahi
Summary: This randomized clinical trial compared the efficacy of intravitreal bevacizumab (IVB) and oral acetazolamide (OA) combination therapy with IVB monotherapy in patients with macular edema secondary to retinal vein occlusion (RVO). The results showed that both regimens were effective in improving visual acuity and reducing macular thickness, but combination therapy did not provide additional short-term benefits.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2023)
Review
Ophthalmology
Seyed-Hossein Abtahi, Ramin Nourinia, Mehdi Mazloumi, Hosein Nouri, J. Fernando Arevalo, Hamid Ahmadieh
Summary: This article reviews the current knowledge on the pathophysiology and risk factors of paracentral acute middle maculopathy (PAMM), the vasculature and blood flow of the middle and inner retinas, and the vulnerability of the middle retina in vaso-occlusive disorders. The inner nuclear layer (INL) is easily affected by retinal hypoperfusion and ischemia, leading to skip PAMM lesions and fern-like appearance. The progression of INL infarction can result in diffuse globular PAMM and transmural infarction of the middle and inner retinas, resembling an ischemic cascade.
SURVEY OF OPHTHALMOLOGY
(2023)
Review
Clinical Neurology
Seyed-Hossein Abtahi, Fatemeh Esfahanian, Mojtaba Akbari, Peyman Roomizadeh, Sina Neshat
Summary: The aim of this study was to quantify and comprehend the variance in the prevalence of headaches among medical students at the global and regional levels. A comprehensive search approach yielded 79 relevant studies. The results showed that the prevalence of headaches among medical students is higher than that of the general population of the same age, and higher stressors and overwork may contribute to this condition.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Ophthalmology
Ramin Nourinia, Seyed Mohammadjavad Mashhadi, Seyed-Hossein Abtahi, Hosein Nouri
Summary: The study aimed to investigate the association between retinal vein occlusion (RVO) and evidence of previous, unnoticed inner nuclear layer (INL) infarction in the fellow eye. The results showed a higher prevalence of INL lesions in the fellow eye of hypertension patients with RVO compared to those without RVO. These INL lesions may serve as early markers of increased RVO risk in individuals with hypertension.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Editorial Material
Ophthalmology
Hosein Nouri, Reza Nasri, Seyed-Hossein Abtahi
Summary: Optical coherence tomography angiography (OCTA) provides non-invasive visual and quantitative data on retinal microvasculature. However, there are considerable inter-device differences in OCTA data due to variations in technical specifications. Unsupervised deep image-to-image translation techniques, such as Cycle-GANs and DDPMs, can address this issue.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Ophthalmology
Saeed Karimi, Homayoun Nikkhah, Amir Mohammadzadeh, Alireza Ramezani, Iman Ansari, Hosein Nouri, Seyed-Hossein Abtahi
Summary: To assess the additional risk of acute endophthalmitis after intravitreal injections associated with face masks during the COVID-19 pandemic, a retrospective study was conducted comparing cases during the pre-COVID era (March 1st, 2013 to October 31st, 2019) and the COVID era (March 1st, 2020 to April 1st, 2021) of intravitreal bevacizumab (IVB) injections. The incidence of post-IVB endophthalmitis was compared between the two eras and found to be statistically similar, suggesting that the use of face masks does not increase the risk of post-IVB endophthalmitis.
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2023)
Letter
Ophthalmology
Mahmoud Dehghan, Ramin Nourinia, Sahba Fekri, Seyed-Hossein Abtahi
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2022)
Article
Ophthalmology
Sahba Fekri, Masoud Soheilian, Sepehr Roozdar, Seyed-Hossein Abtahi, Hosein Nouri
Summary: This study aimed to investigate the effect of correcting vitamin D deficiency on the treatment outcome of DME patients. The results showed that correcting vitamin D deficiency, in addition to intravitreal bevacizumab (IVB) injections, may improve visual acuity and central macular thickness (CMT) in these patients. However, the beneficial effect may be delayed by several months.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Medicine, Research & Experimental
Maryam Khalili, Hamid Rahimi Hajiabadi, Mojtaba Akbari, Rana Saleh, Bahram Nasr Esfahani, Sharareh Moghim
Summary: This study developed a fast and accurate multiplex RT-PCR method for screening viruses that cause acute meningitis/meningoencephalitis in children. The method demonstrated high precision in clinical samples and showed similar sensitivity to the traditional monoplex PCR method.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2022)