Article
Audiology & Speech-Language Pathology
P. Roman-Naranjo, M. D. C. Moleon, I. Aran, A. Escalera-Balsera, A. Soto-Varela, D. Bachinger, M. Gomez-Finana, A. H. Eckhard, J. A. Lopez-Escamez
Summary: Rare variants in the MYO7A gene were found to be associated with familial Meniere's disease, with co-segregation of variants in other genes like CDH23, PCDH15, or ADGRV1. These genes may affect the structure of hair cell stereocilia in familial MD.
Review
Otorhinolaryngology
Jumah G. Ahmad, Kenny F. Lin
Summary: Meniere's disease is a disorder characterized by recurrent episodes of vertigo, hearing loss, tinnitus, and pressure in the ear. The debate regarding its pathogenesis and optimal management is ongoing, with conflicting evidence suggesting it could be either a primary disorder of the inner ear or a form of vestibular migraine. However, current evidence favors Meniere's disease as a disorder of the inner ear.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2023)
Article
Medicine, General & Internal
Maria-Del-Carmen Moleon, Estrella Martinez-Gomez, Marisa Flook, Andreina Peralta-Leal, Juan Antonio Gallego, Hortensia Sanchez-Gomez, Maria Alharilla Montilla-Ibanez, Emilio Dominguez-Duran, Andres Soto-Varela, Ismael Aran, Lidia Frejo, Jose A. Lopez-Escamez
Summary: Early-onset MD patients have a higher prevalence of migraine compared to late-onset patients, but migraine is not associated with cytokine profiles in MD patients. Levels of CCL18, CCL3, and CXCL4 were found to be different in patients with MD or migraine compared to controls.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yangming Leng, Ping Lei, Cen Chen, Yingzhao Liu, Kaijun Xia, Bo Liu
Summary: By measuring anatomical variables of the endolymphatic sac and duct using MRI, vestibular migraine can be differentiated from unilateral Meniere's disease. However, the diagnostic value of these variables is low and further research is needed.
FRONTIERS IN NEUROLOGY
(2022)
Review
Audiology & Speech-Language Pathology
Camilla Porto Campello, Cleidiel Aparecido Araujo Lemos, Wagner Teobaldo Lopes de Andrade, Luciana Pimentel Fernandes de Melo, Glaurea Regina de Santana Nunes, Hannalice Gottschalck Cavalcanti
Summary: This study highlights the association between migraine and tinnitus, as well as migraine and hearing loss. The majority of the studies indicate a high odds ratio and hazard ratio for these conditions. However, the limitation of this review is the small number of included studies, which calls for further research to confirm these associations.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2022)
Article
Clinical Neurology
Stefan Evers
Summary: Martin Luther reported experiencing headache and vertigo attacks. His headache attacks may be diagnosed as migraine, but further evidence is needed. His vertigo attacks may fulfill the criteria for Meniere's disease or vestibular migraine, but more information is required to confirm the diagnoses.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Jing-Yu Chen, Zhao-Qi Guo, Jun Wang, Dan Liu, E. Tian, Jia-Qi Guo, Wei-Jia Kong, Su-Lin Zhang
Summary: Meniere's disease is a vertigo disorder characterized by recurrent vertigo, fluctuating hearing loss, tinnitus, or ear fullness. It is important to accurately differentiate Meniere's disease from vestibular migraine for effective treatment. Advances in examination technologies have improved the diagnostic accuracy of differentiating vertigo diseases.
JOURNAL OF NEUROLOGY
(2023)
Article
Audiology & Speech-Language Pathology
James G. Naples, Drew Soda, Kahlil Rahman, Michael J. Ruckenstein, Kourosh Parham
Summary: This study evaluated the role of prestin and otolin-1 as biomarkers and found differences in their levels between Meniere's disease and vestibular migraine patients. Furthermore, prestin levels were correlated with word recognition scores in Meniere's disease patients, suggesting a potential role as a marker for inner ear function.
Article
Health Care Sciences & Services
Il Hwan Lee, Hyunjae Yu, Seung-Su Ha, Gil Myeong Son, Ki Joon Park, Jae Jun Lee, Dong-Kyu Kim
Summary: Studies have shown a link between impaired hearing and vestibular function and the risk of dementia. This study examined the association between Meniere's disease (MD) and the risk of dementia using data from the South Korea National Health Insurance Service. The results indicated that late-onset MD is associated with an increased incidence of all-cause dementia, particularly Alzheimer's disease and vascular dementia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pediatrics
Davide Brotto, Marzia Ariano, Mose Sozzi, Roberta Cenedese, Eva Muraro, Flavia Sorrentino, Patrizia Trevisi
Summary: About 20% of children with congenital hearing loss have malformations of the inner ear. The morphology and function of the anterior part of the labyrinth have been extensively studied, as hearing loss can significantly impact a child's overall development. While a chance for hearing rehabilitation is now available for most of them, the anomalies range from lack of inner ear development to specific isolated structures. However, little is known about vestibular anomalies and dysfunctions in children with inner ear malformations.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Alexander A. Missner, James Dixon Johns, Shoujun Gu, Michael Hoa
Summary: Corticosteroids are the mainstay for inner ear diseases, but complete recovery rate remains low, suggesting a need for more effective treatment options. Differentially regulated genes expressed in SGN and SV cells may serve as potential druggable targets, with 42 candidate drugs identified for further exploration.
Article
Audiology & Speech-Language Pathology
Emilien Chebib, Audrey Maudoux, Charlotte Benoit, Sophie Bernard, Thierry Van den Abbeele, Natacha Teissier, Sylvette R. Wiener Vacher
Summary: This study investigated the impact of congenital cytomegalovirus infection on cochlear and vestibular function. The results showed that the vestibular part is more often impaired than the cochlear part, emphasizing the importance of evaluating both vestibular and auditory function in children infected with cytomegalovirus.
Article
Otorhinolaryngology
Kaitian Chen, Jincangjian Sun, Bixue Huang, Yue Liang, Min Liu, Xuan Wu
Summary: This study evaluated the lesional patterns in patients with presumed IEH from morphological and functional aspects. The results revealed differences in locations and lesional spectrums, indicating a possible pathomechanism for further exploration as a therapeutic target.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Jonathan Kil, E. Emily Harruff, Ryan J. Longenecker
Summary: The global impact of hearing loss and related auditory dysfunction, including tinnitus and hyperacusis, on human health is significant and growing, with research indicating that these conditions involve numerous genetic variations and molecular mechanisms. Investigational new drugs have been tested and repurposed in clinical trials, but there are currently no FDA-approved therapeutics for any auditory related indications.
Article
Clinical Neurology
Ricardo Wegmann-Vicuna, Raquel Manrique-Huarte, Diego Calavia-Gil, Eduardo Martin-Sanz, Pedro Marques, Nicolas Perez-Fernandez
Summary: The reduction in vestibulo-ocular reflex (VOR) gain measured with the video head-impulse test (vHIT) 1 month after the first intratympanic injection can predict the need for additional injections to control vertigo spells in patients with intractable Meniere's disease (MD). Single intratympanic treatment with gentamicin is effective and has limited impact on hearing in MD patients.
FRONTIERS IN NEUROLOGY
(2022)
Editorial Material
Neurosciences
Jose A. Lopez-Escamez, Arnaud Attye
JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION
(2023)
Letter
Infectious Diseases
Juan Riestra-Ayora, Maria Garrote-Garrote, Cristina Molina-Quiros, Eduardo Martin-Sanz
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Otorhinolaryngology
J. Yanes-Diaz, J. Riestra-Ayora, A. Rodriguez-Rivero, L. Yebra-Gonzalez, M. Chaure-Cordero, C. Vaduva, G. Monedero-Rodrigo, E. Martin-Sanz
Summary: This study investigated the demographics and clinical characteristics of benign parotid tumors, with a focus on the changing incidence of Warthin tumor in recent years. The results showed an increase in the proportion of Warthin tumor compared to pleomorphic adenoma, with higher prevalence in males, especially among patients with a history of smoking and older age at diagnosis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Medicine, General & Internal
Nicolas Perez-Fernandez, Sara Saez Coronado, Cristina Zulueta-Santos, Fernando Neria Serrano, Jorge Rey-Martinez, Melisa Blanco, Raquel Manrique-Huarte
Summary: Benign paroxysmal positional vertigo (BPPV) and bilateral vestibulopathy (BVL) are two distinct forms of vestibular disorder that can occur in the same patient. A retrospective review of patient data over a 15-year period found this coincidence in 23 patients, accounting for 0.4%. Sequential occurrence was more common (10/23) with BPPV diagnosed first, while simultaneous presentation occurred in 9/23 patients. A prospective study in BPPV patients found a slightly higher frequency of bilateral vestibular loss (6/405).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Juan Carlos Amor-Dorado, Eduardo Martin-Sanz, Virginia Franco-Gutierrez, Ana Urruticoechea-Arana, Ana M. Garcia-Arumi, Erwin Racines-Alava, Oscar Aleman-Lopez, Carmen P. Simeon-Aznar, Miguel A. Gonzalez-Gay
Summary: This study compared the audiovestibular function of patients with primary Raynaud's Phenomenon (RP) and secondary RP related to systemic sclerosis (SSc) with healthy controls. The results showed that patients with primary RP did not have any audiovestibular abnormalities, while some patients with secondary RP had hearing loss and balance disorders. Therefore, primary RP and secondary RP differ in terms of audiovestibular manifestations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Susana Marcos-Alonso, Cristina Nicole Almeida-Ayerve, Chiara Monopoli-Roca, Guillermo Salib Coronel-Touma, Sofia Pacheco-Lopez, Paula Pena-Navarro, Jose Manuel Serradilla-Lopez, Hortensia Sanchez-Gomez, Jose Luis Pardal-Refoyo, Angel Batuecas-Caletrio
Summary: This study analyzed 21 studies that met the inclusion criteria and found that the most common reasons for positive adherence to hearing aid use included higher degree of hearing loss, patient awareness of their condition, and daily life necessity. The most common causes for rejection were lack of perceived benefits or discomfort with the device. The meta-analysis results showed a prevalence of 0.623 (95% CI 0.531, 0.714) for patients who used their hearing aids. Both groups were highly heterogeneous (I2 = 99.31% in each group, p < 0.05). In conclusion, a significant proportion (38%) of patients do not use their hearing aids, and further homogeneous multicenter studies are needed to analyze the reasons for rejection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Mar Lamolda, Lidia Frejo, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez
Summary: Genetic sensorineural hearing loss and Meniere disease are associated with rare variations in the human genome. Human-induced pluripotent stem cells have emerged as cellular models to investigate the role of genetic and environmental factors in inner ear disorders. These models can facilitate a better understanding of the variants' role during differentiation and exploring strategies for restoring hearing and vestibular sensory epithelia as well as neurons.
Article
Neurosciences
Paula Pena Navarro, Sofia Pacheco Lopez, Cristina Nicole Almeida Ayerve, Susana Marcos Alonso, Jose Manuel Serradilla Lopez, Santiago Santa Cruz Ruiz, Jose Carlos Gomez Sanchez, Diego Kaski, Angel Batuecas Caletrio
Summary: This study aimed to investigate the treatment approach for horizontal canal cupulolithiasis (hc-BPPV-cu). The results showed that early specialist input allowed for early identification of central disorders, reduced symptom duration, decreased number of therapeutic maneuvers, and lower rates of multi-canal BPPV.
Article
Otorhinolaryngology
Susana Marcos Alonso, Nicole Almeida Ayerve, Chiara Monopoli Roca, Guillermo Coronel Touma, Juan Carlos del Pozo de Dios, Hortensia Sanchez Gomez, Santiago Santa Cruz Ruiz, Angel Batuecas Caletrio
Summary: This study found that the slow-phase velocity (SPV) of skull vibration-induced nystagmus (SVIN) may be more sensitive than the video head impulse test (vHIT) in identifying the recovery of vestibular function following intratympanic gentamicin (ITG) treatment. This is the first study to illustrate the link between a reduction in SPV and the likelihood of vertigo episodes in patients with Meniere disease (MD) who have been treated with ITG.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Juan Manuel Espinosa-Sanchez, Alex Gomez-Marin, Fernando de Castro
Summary: The origins of cybernetics can be traced back to two influential papers published in 1943. The first paper established the concept of purposeful behavior being controlled by negative feedback, while the second paper proposed the idea of interconnected neurons acting as logical operators. These ideas caught the attention of von Neumann, who was working on the development of the first stored-program computer. Subsequent meetings were held between 1946 and 1953 to further explore these concepts. The contribution of Spanish neurophysiologist Rafael Lorente de No in the early days of cybernetics is noteworthy, as he not only participated in key conferences but also provided the first neurobiological demonstration of a feedback loop.
Review
Medicine, General & Internal
Roberto Teggi, Anna Del Poggio, Iacopo Cangiano, Alessandro Nobile, Omar Gatti, Mario Bussi
Summary: This study reviewed literature to investigate cochlear and vestibular symptoms in patients with herpes zoster oticus (HZO). The findings showed a high percentage of HZO cases with cochlear and vestibular symptoms, including hearing loss and vertigo. There is still debate about whether the damage is localized in the inferior/superior vestibular nerves and cochlear nerves or directly in the inner ear.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Guillermo Salib Coronel-Touma, Chiara Monopoli-Roca, Cristina Nicole Almeida-Ayerve, Susana Marcos-Alonso, Diana Gomez de la Torre-Morales, Jose Serradilla-Lopez, Santiago Santa Cruz-Ruiz, Angel Batuecas-Caletrio, Hortensia Sanchez-Gomez
Summary: This study analyzed the influence of age and cardiovascular risk factors on the evolution of vestibular neuritis. The results showed that CVRFs do not independently affect VOR gain in VN patients' follow-ups. However, age significantly impacts VOR gain in VN and could be modulated by gender and hypertension.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Audiology & Speech-Language Pathology
Roberto Teggi, Bruno Colombo, Iacopo Cangiano, Omar Gatti, Mario Bussi, Massimo Filippi
Summary: Meniere's disease and vestibular migraine (VM) are two common inner ear disorders. Recurrent Vestibular Symptoms-Not Otherwise Specified (RVS-NOS) refers to patients who experience recurring episodes of vertigo but do not fulfill the criteria for either disease. This study aimed to compare RVS-NOS with VM in terms of clinical history, bedside examination, and family history. The findings showed similarities between the two disorders, including age of onset, duration of attacks, motion sickness, and family history. However, some aspects suggest that RVS-NOS may be a heterogeneous disorder.
AUDIOLOGY RESEARCH
(2023)
Article
Audiology & Speech-Language Pathology
Daniela Caldirola, Claudia Carminati, Silvia Dacco, Massimiliano Grassi, Giampaolo Perna, Roberto Teggi
Summary: In this open-pilot intervention study, we evaluated the feasibility, acceptability, and potential clinical usefulness of balance rehabilitation with peripheral visual stimulation (BR-PVS) in patients with panic disorder and agoraphobia. After the BR-PVS intervention, improvements were observed in postural control, panic-agoraphobic symptoms, and dizziness. These findings suggest that balance evaluation and BR-PVS may be beneficial for patients with residual agoraphobia.
AUDIOLOGY RESEARCH
(2023)
Article
Otorhinolaryngology
Melissa Blanco Pareja, Gloria Liano Esteso, Victor Suarez-Vega, Raquel Manrique-Huarte, Pablo Dominguez, Nicolas Perez-Fernandez
Summary: This study retrospectively reviewed the data of 10 patients with suspected inner ear hemorrhage and evaluated the lesional patterns from radiological and functional aspects. The results showed that only a portion of patients with sensorineural hearing loss had a correlation between MRI findings and dysfunction in the inner ear. Therefore, specific MRI sequences should be requested to rule out inner ear hemorrhage in patients with sensorineural hearing loss.
ACTA OTO-LARYNGOLOGICA
(2023)