Article
Oncology
Ihor Arkhypov, Feyza Gul Ozbay Kurt, Rebekka Bitsch, Daniel Novak, Vera Petrova, Samantha Lasser, Thomas Hielscher, Christopher Groth, Alisa Lepper, Xiaoying Hu, Wei Li, Jochen Utikal, Peter Altevogt, Viktor Umansky
Summary: Soluble HSP90 alpha can convert monocytes into MDSC, which inhibits the antitumor function of T and NK cells. Higher levels of HSP90 alpha in plasma of patients with melanoma are associated with increased PD-L1 expression on MDSC and shorter PFS after ICI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Heejin Lim, Taewoo Yang, Wongeun Lee, Sung-Gyoo Park
Summary: The study demonstrates that MDSCs are a source of MFGE8, which plays a role in tumor metastasis. TME positively regulates MFGE8 production by MDSCs through TGF-beta, suggesting MFGE8 as an important effector molecule for MDSCs to promote tumor metastasis.
Article
Immunology
Jiajun Chen, Shiqi Cai, Renjie Li, Jie Xie, Fan Yang, Tao Liu
Summary: This study found that MDSCs play an important role in sepsis-induced immune dysfunction. Inhibiting COX-2 may be a promising therapy for MDSCs-induced immunosuppression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Binita Chakraborty, Jovita Byemerwa, Jonathan Shepherd, Corinne N. Haines, Robert Baldi, Weida Gong, Wen Liu, Debarati Mukherjee, Sandeep Artham, Felicia Lim, Yeeun Bae, Olivia Brueckner, Kendall Tavares, Suzanne E. Wardell, Brent A. Hanks, Charles M. Perou, Ching-Yi Chang, Donald P. McDonnell
Summary: Research has shown that estrogen signaling through the estrogen receptor plays a significant role in melanoma growth by affecting intratumoral macrophage function, CD8+ T cell activity, and ICB resistance. Targeting estrogen signaling within myeloid cells could potentially reverse immune suppression and enhance the efficacy of ICB in melanoma patients.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Yoshiaki Nagatani, Yohei Funakoshi, Hirotaka Suto, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Kimihiro Yamashita, Hironobu Minami
Summary: MDSC are divided into M-MDSC, G-MDSC, and I-MDSC subsets, with M-MDSC and G-MDSC suppressing T cell activation while I-MDSC has no suppressive effect. High levels of IL-1RA and arginase were detected in M-MDSC and G-MDSC cultures, with no inhibitory molecules found in I-MDSC cultures. The population of functional MDSC was significantly increased in cancer patients compared to healthy donors.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Veronica Huber, Lorenza Di Guardo, Luca Lalli, Daniele Giardiello, Agata Cova, Paola Squarcina, Paola Frati, Anna Maria Di Giacomo, Lorenzo Pilla, Marcella Tazzari, Chiara Camisaschi, Flavio Arienti, Chiara Castelli, Monica Rodolfo, Valeria Beretta, Massimo Di Nicola, Michele Maio, Michele Del Vecchio, Filippo de Braud, Luigi Mariani, Licia Rivoltini
Summary: A multistep downsizing process identified a myeloid index score (MIS) composed of four cell subsets that stratified melanoma patients based on prognosis. The MIS serves as a simple blood biomarker in real-life oncology, aiding in tailoring therapeutic choices.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Andrea Gaissler, Jonas Bochem, Janine Spreuer, Shannon Ottmann, Alexander Martens, Teresa Amaral, Nikolaus Benjamin Wagner, Manfred Claassen, Friedegund Meier, Patrick Terheyden, Claus Garbe, Thomas Eigentler, Benjamin Weide, Graham Pawelec, Kilian Wistuba-Hamprecht
Summary: This study investigated potential cellular biomarkers in patients with stage IV M1c melanoma undergoing immune checkpoint blockade (ICB). It was found that elevated baseline monocytic MDSC frequencies were associated with poorer outcomes, but a subgroup of patients with rapidly decreasing MDSC frequencies during therapy showed better prognosis, suggesting an imperfect correlation between high baseline MDSCs and patient outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Guohui Qin, Shasha Liu, Li Yang, Weina Yu, Yi Zhang
Summary: Variation in myeloid cell differentiation is common in tumors, inflammation, autoimmune diseases, and metabolic diseases. Single-cell sequencing reveals the differentiation trajectory of myeloid cells in COVID-19 patients. Targeting myeloid cell-derived cytokines or checkpoints is crucial in developing therapeutic strategies for severe COVID-19 patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Chun I. Yu, Jan Martinek, Te-Chia Wu, Kyung In Kim, Joshy George, Elaheh Ahmadzadeh, Rick Maser, Florentina Marches, Patrick Metang, Pierre Authie, Vanessa K. P. Oliveira, Victor G. Wang, Jeffrey H. Chuang, Paul Robson, Jacques Banchereau, Karolina Palucka
Summary: Metastasis of melanoma significantly worsens prognosis; the CD33+CD11b+CD117+ myeloid cells could serve as a potential biomarker and therapeutic target for metastatic melanoma.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Iosif Papafragkos, Efrosyni Markaki, Christina Kalpadakis, Panayotis Verginis
Summary: Myeloid-derived suppressor cells (MDSCs) are potent regulators of the immune system, playing a role in cancer but their specific contribution to lymphomas remains unclear. This review focuses on MDSCs in lymphomas, discussing literature and lessons learned from animal models, and highlights future research directions and challenges in understanding the immune system complexities in malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Juliette Ferrant, Faustine Lhomme, Simon Le Gallou, Jonathan M. Irish, Mikael Roussel
Summary: The study reviews the phenotypic and functional description of the circulating monocytic lineage in B cell lymphomas, providing initial insights into the heterogeneity of these cell populations and highlighting the potential of circulating myeloid regulatory cells as diagnostic and prognostic biomarkers in B-cell lymphomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jingshan Cai, Yudan Cui, Jun Yang, Shengjun Wang
Summary: MDSCs play a crucial role in tumor immunity, closely linked to tumor EMT and possessing unique functions in an immunosuppressive environment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Biochemical Research Methods
Samuel E. Norton, Julia K. H. Leman, Tiffany Khong, Andrew Spencer, Barbara de St Groth, Helen M. McGuire, Roslyn A. Kemp
BMC BIOINFORMATICS
(2020)
Review
Immunology
Luis Munoz-Erazo, Janet L. Rhodes, Valentine C. Marion, Roslyn A. Kemp
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Endocrinology & Metabolism
Sebastian Aberg, Jim Mann, Silke Neumann, Alastair B. Ross, Andrew N. Reynolds
Review
Oncology
Matthew J. Woodall, Silke Neumann, Katrin Campbell, Sharon T. Pattison, Sarah L. Young
Article
Pharmacology & Pharmacy
Milda Naciute, Virginia Niemi, Roslyn A. Kemp, Sarah Hook
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Review
Cell Biology
Felix M. D. Marsh-Wakefield, Andrew J. Mitchell, Samuel E. Norton, Thomas Myles Ashhurst, Julia K. H. Leman, Joanna M. Roberts, Jessica E. Harte, Helen M. McGuire, Roslyn A. Kemp
Summary: High-dimensional cytometry represents a new exciting era in immunology research, requiring a shift in users' thinking towards experimental design and data analysis to maximize data quality.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Spectroscopy
Chima Robert, Julia Tsiampali, Sara J. Fraser-Miller, Silke Neumann, Donata Maciaczyk, Sarah L. Young, Jaroslaw Maciaczyk, Keith C. Gordon
Summary: Raman spectroscopy combined with chemometrics was used to distinguish the phenotype of T-cells and monocytes incubated with media conditioned by glioblastoma stem-cells, showing different molecular backgrounds. Different clusters were formed based on EMT activator ZEB1 or CD73 inhibition, and discriminatory analysis using LDA and SVM yielded sensitivities and specificities of over 70% and 67% respectively. Flow cytometric analysis revealed the influence of TCMs on cytokine profile of T-cells and monocytes, indicating the potential of Raman spectroscopy in tracking immune cell phenotypes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Silke Neumann, Katrin Campbell, Matthew J. Woodall, Meghan Evans, Andrew N. Clarkson, Sarah L. Young
Summary: Obesity can affect the immune system and tumor growth in mice, with obese mice showing differences in immune cell populations and tumor growth rate compared to lean mice. This study suggests a potential link between obesity-induced immune changes and cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Milda Naciute, Tamara Kiwitt, Roslyn A. Kemp, Sarah Hook
Summary: The study found that bacteria biohybrid-based vaccine delivery systems have the potential to enhance immune stimulation and may be used for treating colorectal cancer. Experiments demonstrated that emulsion and liposome biohybrid vaccines have high therapeutic potential, promoting CD8(+) T cell infiltration and inhibiting tumor growth.
Article
Biotechnology & Applied Microbiology
Gemma L. Laws, John D. F. Hale, Roslyn A. Kemp
Summary: This study found that consumption of S. salivarius BLIS K12 led to increased levels of IL-8 at 24 hours, an increase in Tregs frequency 7 days after probiotic consumption, and higher IL-10 concentrations at 7 days compared to 24 hours after consumption. There was no difference in the frequency and activation of CD4(+), CD8(+), B cells and NK cells. Interestingly, there was an increase in IL-12 7 days after the consumption of S. salivarius BLIS K12.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Biology
Paulo C. M. Urbano, Hamish C. K. Angus, Safina Gadeock, Michael Schultz, Roslyn A. Kemp
Summary: This study aimed to develop a standardized protocol for human intestinal organoid (hIO) generation across multiple centers, resulting in a consistent biobank of hIOs from diverse patients. The use of a refined media containing insulin-like growth factor (IGF)-1 and fibroblast growth factor (FGF)-2 enabled successful expansion of TC and SC hIOs from healthy donors.
BMC RESEARCH NOTES
(2022)
Article
Immunology
Nicholas J. Shields, Estelle M. Peyroux, Katrin Campbell, Sunali Mehta, Adele G. Woolley, Claudio Counoupas, Silke Neumann, Sarah L. Young
Summary: Proteases released from dying cells can degrade antigens and generate proteolytic intermediates that enhance immune cell responses.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Hamish Ck Angus, Paulo Cm Urbano, Gemma A. Laws, Shijun Fan, Safina Gadeock, Michael Schultz, Grant Butt, Andrew J. Highton, Roslyn A. Kemp
Summary: This study developed a new autologous colonic monolayer model to study the complexity of CD, revealing impaired epithelial integrity in monolayers derived from CD donors compared to non-IBD donors, with higher variability in CD donors.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Hamish C. K. Angus, A. Grant Butt, Michael Schultz, Roslyn A. Kemp
FRONTIERS IN MEDICINE
(2020)
Article
Medicine, Research & Experimental
Virginia Niemi, Douglas Gaskarth, Roslyn A. Kemp
LABORATORY ANIMAL RESEARCH
(2020)