Review
Oncology
Alessandro Isidori, Claudio Cerchione, Naval Daver, Courtney DiNardo, Guillermo Garcia-Manero, Marina Konopleva, Elias Jabbour, Farhad Ravandi, Tapan Kadia, Adolfo de la Fuente Burguera, Alessandra Romano, Federica Loscocco, Giuseppe Visani, Giovanni Martinelli, Hagop Kantarjian, Antonio Curti
Summary: Recent advances in understanding the pathogenesis of acute myeloid leukemia (AML) have accelerated the discovery of new drugs and innovative therapeutic approaches, with a particular focus on the role of the immune system in AML development. Efforts in immune therapy have shown promise in improving survival rates for AML patients by targeting leukemia stem cells and utilizing various modalities such as T cell therapy, checkpoint blockade, and leukemia vaccines.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Zheng Zhang, Qian Xu, Liang Huang
Summary: The immune system identifies and responds to foreign pathogens while distinguishing them from self-antigens in order to protect the human body. However, disruptions in self-tolerance can lead to an overactive immune system attacking healthy tissues and organs, resulting in autoimmune diseases. B cells and plasma cells play a significant role in the development and persistence of autoimmune diseases, both in an autoantibody-dependent and autoantibody-independent manner. Accumulating data suggests that therapies aimed at eliminating antibody-secreting cells, such as B cells or plasma cells, have shown effectiveness across a wide range of autoimmune diseases. Monoclonal antibodies (mAbs) are able to deplete B cell lineage or plasma cells through signaling disruption, complement-dependent cytotoxicity (CDC), and antibody-dependent cellular cytotoxicity (ADCC). Moreover, engineered-T cells equipped with chimeric antigen receptors (CARs) have been adapted from the field of hematological malignancies as a method to eliminate B cells or plasma cells. In this review, we provide an updated understanding of B cell depletion therapies in autoimmune diseases, reviewing the mechanisms, efficacy, safety, and applications of monoclonal antibodies and CAR-based immunotherapies, as well as discussing the strengths and weaknesses of these treatment options for patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Ke-Tao Jin, Bo Chen, Yu-Yao Liu, H. uan-Rong Lan, Jie-Ping Yan
Summary: Colorectal cancer is the third most common cancer globally with immunotherapy, including monoclonal antibodies and CAR-T cells, emerging as novel therapeutic approaches. Both monoclonal antibodies and CAR-T cells have beneficial anti-tumor effects on CRC by eliciting immune responses against tumor cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Virology
Jack M. Edwards, Behnaz Heydarchi, Georges Khoury, Natalia A. Salazar-Quiroz, Christopher A. Gonelli, Bruce Wines, P. Mark Hogarth, Anne B. Kristensen, Matthew S. Parsons, Damian F. J. Purcell
Summary: The study successfully enhanced the Fc-mediated effector functions of the bovine-human chimeric bNAb NC-Cow1 with an ultralong CDRH3, improving neutralization activity and cell potency against HIV-1 while maintaining envelope binding. This research is significant for the development of multifunctional anti-HIV antibodies and enhancing prevention of HIV-1 transmission.
JOURNAL OF VIROLOGY
(2021)
Article
Oncology
Masato Karayama, Naoki Inui, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Kazuhiro Asada, Tomohiro Uto, Masato Fujii, Takashi Matsui, Shun Matsuura, Dai Hashimoto, Mikio Toyoshima, Masaki Ikeda, Hiroyuki Matsuda, Nao Inami, Yusuke Kaida, Satoshi Funayama, Shintaro Ichikawa, Satoshi Goshima, Takafumi Suda
Summary: This is a prospective trial investigating the treatment options for immune-related pneumonitis (irP) occurring after immune checkpoint inhibitors (ICIs) administration. The results showed that treatment with prednisolone demonstrated promising clinical benefit and manageable toxicity, suggesting it as a potential treatment option for irP.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Nicky A. Beelen, Merel R. Aberle, Virginia Bruno, Steven W. M. Olde Damink, Gerard M. J. Bos, Sander S. Rensen, Lotte Wieten
Summary: This study evaluated the cytotoxic potential of adoptive NK cells against pancreatic cancer organoids and found that ADCC-inducing antibodies can enhance NK cell anti-tumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Ali Bashiri Dezfouli, Mina Yazdi, Alan Graham Pockley, Mohammad Khosravi, Sebastian Kobold, Ernst Wagner, Gabriele Multhoff
Summary: In recent years, cell-based immunotherapies using Chimeric Antigen Receptors (CARs) have shown promise in cancer treatment, with CD19 CAR-engineered T cells being most commonly used for hematological malignancies. However, challenges in clinical applications include side effects like cytokine release syndrome, neurological symptoms, and off-target effects, necessitating the development of safer and more potent technologies. Natural Killer (NK) cells have emerged as a promising alternative, being capable of CAR engineering and exhibiting specialized lytic mechanisms against virally infected and cancer cells.
Review
Oncology
Kwong Yok Tsang, Massimo Fantini, Sharon A. Mavroukakis, Anjum Zaki, Christina M. Annunziata, Philip M. Arlen
Summary: This article describes a tumor-targeting monoclonal antibody called NEO-201, which can inhibit tumor growth through multiple mechanisms. NEO-201 kills tumor cells by engaging with immune cells through antibody-dependent cell-mediated cytotoxicity and complement dependent cytotoxicity, and it can also block interactions between tumor cells and other cells to enhance anti-cancer activity.
Review
Oncology
Melanie Gauthier, Caroline Laroye, Daniele Bensoussan, Cedric Boura, Veronique Decot
Summary: Monoclonal antibodies targeting tumors and the cooperation with NK cells play a crucial role in enhancing the efficacy of antibody therapy in cancer treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Su Yin Lim, Sara Alavi, Zizhen Ming, Elena Shklovskaya, Carina Fung, Ashleigh Stewart, Helen Rizos
Summary: Our study found that tumor necrosis factor alpha (TNF alpha) can influence the differentiation status and immune inhibition of melanoma cells, with different impacts on different melanoma cells. TNF alpha showed poor induction of antigen presentation molecules but readily induced the PD-L2 immune checkpoint in melanoma cells. Our results suggest that TNF alpha promotes dynamic changes in melanoma cells that may favor immunotherapy resistance.
Review
Chemistry, Multidisciplinary
Salma B. Abdelbaky, Mayar Tarek Ibrahim, Hebatallah Samy, Menatalla Mohamed, Hebatallah Mohamed, Mahmoud Mustafa, Moustafa M. Abdelaziz, M. Laird Forrest, Islam A. Khalil
Summary: Cancer immunotherapy has shown promise in eradicating cancer cells and overcoming multidrug resistance with fewer side effects compared to traditional cytotoxic therapies, utilizing agents such as checkpoint inhibitors and monoclonal antibodies to help immune cells target tumor cells. However, concerns remain around off-target side effects and poor pharmacokinetics in immunotherapeutics. Nanomedicine offers potential solutions by improving drug delivery, release control, and pharmacokinetic profiles, enhancing therapeutic outcomes and minimizing side effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Rim Trad, Walid Warda, Vincent Alcazer, Mathieu Neto da Rocha, Ana Berceanu, Clementine Nicod, Rafik Haderbache, Xavier Roussel, Yohan Desbrosses, Etienne Daguindau, Florain Renosi, Christophe Roumier, Lucie Bouquet, Sabeha Biichle, Melanie Guiot, Evan Seffar, Denis Caillot, Stephane Depil, Eric Robinet, Yahya Salma, Eric Deconinck, Marina Deschamps, Christophe Ferrand
Summary: This study identified IL-1RAP as a potential target for AML treatment, as it is overexpressed on the surface of leukemic stem cells (LSCs). The researchers demonstrated the effectiveness of IL-1RAP CAR T-cell therapy against AML cell lines and primary cells from patients, suggesting it as a promising strategy for AML treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Editorial Material
Immunology
Preston A. Humphries, Wan-Lin Lo
Summary: A new study reveals the differential binding manner of CTLA-4 to CD80 and CD86, which plays a crucial role in immune tolerance regulation.
Article
Oncology
Tongqing Xue, Xiang Zhao, Kun Zhao, Yan Lu, Juan Yao, Xianguo Ji
Summary: In addition to traditional treatment strategies, immunotherapy has emerged as a new approach for lung cancer treatment. The goal of immunotherapy is to stimulate the immune system to fight against cancer using various methods including therapeutic vaccines, monoclonal antibodies, immune checkpoint inhibitors, and T-cell therapy. CAR-T cell therapy, which genetically modifies T-cells to recognize and eliminate tumor cells expressing certain antigens, has shown promising results in lung tumors. This review summarizes different immunotherapy approaches for lung cancer and discusses the structure of CAR-T cells and potential targets in designing CAR-T cells for lung cancer.
CURRENT PROBLEMS IN CANCER
(2022)
Review
Medicine, Research & Experimental
Qing Wang, Xindi Zhang, Weijun Wei, Min Cao
Summary: Despite advances in cancer treatment, lung cancer remains a leading cause of cancer mortality. Immunotherapies using immune checkpoint inhibitors have shown promise in treating lung cancer. ImmunoPET, utilizing radiolabeled monoclonal antibodies or antibody derivatives as tracers, offers advantages over traditional PET imaging in lung cancer detection, diagnosis, staging, risk stratification, treatment guidance, and recurrence monitoring. ImmunoPET holds potential for patient stratification and response evaluation in immunotherapy. This review summarizes the value of immunoPET in imaging lung cancers and optimizing immunotherapy in NSCLC.
MOLECULAR PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Vikash Kumar, Ankita Behl, Rumaisha Shoaib, Mohammad Abid, Maxim Shevtsov, Shailja Singh
Summary: In this review, we summarize the information on prefoldin family members in archaea and humans, and analyze the unexplored subunits of Plasmodium falciparum (Pf). By comparing with the homologs in archaea and H. sapiens, we enhance the understanding of the functions, structure, and substrate binding mechanism of Pf prefoldin. Our review also highlights the importance of certain PfPFD subunits in malaria parasite biology, as well as their up-regulation during different stages of the parasite life cycle.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Materials Science, Multidisciplinary
Evgeniy V. Orekhov, Andrey Yu. Arbenin, Elena G. Zemtsova, Darya N. Sokolova, Alexandra N. Ponomareva, Maxim A. Shevtsov, Natalia M. Yudintceva, Vladimir M. Smirnov
Summary: Modern materials science is actively developing methods for creating structures with specific ordering. Template synthesis is a widely-used approach, where the structure is ordered based on a template shape. In this study, a template electrochemical method was used to synthesize calcium hydroxyapatite (HAp) coatings, replicating a planar template texture during deposition. The developed approach has potential applications in obtaining micro-ordered hydroxyapatite structures on bone implants, improving their biomedical characteristics.
Article
Medicine, General & Internal
Tatyana Bukkieva, Maria Pospelova, Aleksandr Efimtsev, Olga Fionik, Tatyana Alekseeva, Konstantin Samochernych, Elena Gorbunova, Varvara Krasnikova, Albina Makhanova, Anatoliy Levchuk, Gennadiy Trufanov, Stephanie Combs, Maxim Shevtsov
Summary: Neurological and psychiatric disorders are commonly observed in breast cancer survivors, leading to changes in the functional connectivity of the default mode network. This study used rs-fMRI to assess these changes and found significant differences in the functional connectivity compared to a control group. These alterations were associated with decreased quality of life in the patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yang Zhou, Rui Liu, Maxim Shevtsov, Huile Gao
Summary: Imaging techniques, especially those using nanosystems with size-tunable features, are becoming popular for research and clinical diagnostics. These nanosystems with sufficient contrast and high resolution allow better monitoring of disease progression, targeted delivery, and therapy. The size of the nanosystems significantly impacts their imaging performance, and both large and small nanosystems have their own advantages.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Kamil Gareev, Ruslana Tagaeva, Danila Bobkov, Natalia Yudintceva, Daria Goncharova, Stephanie E. Combs, Artem Ten, Konstantin Samochernych, Maxim Shevtsov
Summary: Nanocarriers have shown potential in translational oncology, but their practical application in living organisms is hindered by physiological barriers. This review focuses on approaches to enhance the translocation of nanoparticles across blood-tissue barriers and accumulate in tumors. These approaches include the functionalization of particle surfaces with cell-penetrating peptides and the use of chemical agents or physical methods to increase barrier permeability.
Article
Chemistry, Multidisciplinary
Vyacheslav Ryzhov, Vladimir Deriglazov, Denis Grouzdev, Veronika Koziaeva, Igor Kiselev, Ivan Larionov, Kamil Gareev, Nikita Sitkov, Tatiana Zimina, Yaroslav Marchenko, Maxim Shevtsov
Summary: The magnetic parameters of magnetosomes inside bacteria of different strains were studied. The samples were stored for different lengths of time and analyzed using various spectroscopic techniques. The results showed the presence of magnetosomes with different magnetic properties and variations in the spectral peaks between new and old samples.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Zhiyuan Wu, Stefan Stangl, Alicia Hernandez-Schnelzer, Fei Wang, Morteza Hasanzadeh Kafshgari, Ali Bashiri Dezfouli, Gabriele Multhoff
Summary: This study found that the use of novel Fe3O4-Au nanoparticles fused with Hsp70-specific peptide TPP can enhance the radiosensitivity of triple-negative breast cancer cells by activating G2/M checkpoint arrest and increasing ROS production, leading to DNA double-strand breaks and apoptotic cell death.
Review
Oncology
Peter Vaupel, Helmut Piazena, Markus Notter, Andreas R. Thomsen, Anca-L. Grosu, Felix Scholkmann, Alan Graham Pockley, Gabriele Multhoff
Summary: Mild hyperthermia (mHT) has significant effects on tumor oxygenation, which enhances the efficacy of radiotherapy, chemotherapy, and immunotherapy. The underlying mechanisms and the extent of these effects are not fully understood. This review discusses the biological mechanisms induced by mHT that are relevant to radio-oncology and immunotherapy.
Article
Biochemistry & Molecular Biology
Seyer Safi, Luis Messner, Merten Kliebisch, Linn Eggert, Ceyra Ceylangil, Philipp Lennartz, Benedict Jefferies, Henriette Klein, Moritz Schirren, Michael Dommasch, Dominik Lobinger, Gabriele Multhoff
Summary: By measuring circulating Hsp70 levels and lymphocyte immunophenotype using ELISA and multiparameter flow cytometry, respectively, this study identified a predictive biomarker signature for lung cancer patients. The study found that Hsp70 levels increased with tumor stage and metastatic disease, and started to rise early in patients with recurrence. The results suggest that circulating Hsp70 concentrations have the potential to distinguish lung cancer from metastatic disease and predict advanced tumor stage and early recurrence.
Review
Pharmacology & Pharmacy
Boris Nikolaev, Ludmila Yakovleva, Viacheslav Fedorov, Hanmei Li, Huile Gao, Maxim Shevtsov
Summary: Nano- and microemulsions, colloidal systems widely used in biomedicine, have important applications in various fields such as wound healing, cosmetology, drug development, and oncology. The stability of these systems depends on the balance of molecular interactions between nanodomains. Microemulsions, as a colloidal form, play a crucial role in stability due to their thermodynamic stability and low surface energy. This review examines the theory, methods of obtaining, and structure analysis of nano- and microemulsions. It also summarizes the main studies in wound healing and cancer therapy using emulsions, highlighting future prospects in this area.
Article
Biochemistry & Molecular Biology
Alexia Xanthopoulos, Ann-Kathrin Samt, Christiane Guder, Nicholas Taylor, Erika Roberts, Hannah Herf, Verena Messner, Anskar Trill, Katharina Larissa Kreszentia Holzmann, Marion Kiechle, Vanadin Seifert-Klauss, Sebastian Zschaeck, Imke Schatka, Robert Tauber, Robert Schmidt, Katrin Enste, Alan Graham Pockley, Dominik Lobinger, Gabriele Multhoff
Summary: Hsp70 is overexpressed in many tumors and selectively presented on the plasma membrane of tumor cells. It can be considered a universal tumor biomarker. Circulating levels of Hsp70 can serve as a predictive biomarker for therapeutic failure in early-stage tumors and as a target for the isolation of circulating tumor cells in different tumor diseases.
Article
Pathology
Samvel Tonyan, Maria Pospelova, Varvara Krasnikova, Olga Fionik, Tatyana Alekseeva, Konstantin Samochernykh, Nataliya Ivanova, Tatyana Vavilova, Elena Vasilieva, Albina Makhanova, Aleksandra Nikolaeva, Tatyana Bukkieva, Stephanie Combs, Maxim Shevtsov
Summary: Peripheral nervous system (PNS) damage is a common complication of breast cancer (BC) treatment, affecting 60-80% of survivors. This study measured the levels of brain-derived neurotrophic factor (BDNF), galectin-3 (Gal-3), and neurotrophin-3 (NT-3) in the blood serum of BC patients to investigate their potential as biomarkers for PNS damage. The results showed that NT-3 levels were significantly higher in BC patients compared to healthy volunteers, suggesting NT-3 could be a potential biomarker for PNS damage in BC patients.
Article
Pathology
Alexandra Nikolaeva, Maria Pospelova, Varvara Krasnikova, Albina Makhanova, Samvel Tonyan, Yurii Krasnopeev, Evgeniya Kayumova, Elena Vasilieva, Aleksandr Efimtsev, Anatoliy Levchuk, Gennadiy Trufanov, Mark Voynov, Maxim Shevtsov
Summary: Vestibulo-atactic syndrome (VAS), a complication of breast cancer treatment, significantly impacts patients' quality of life. This study found that the levels of ICAM-1, PECAM-1, NSE, and NR-2-ab in the blood serum of VAS patients were associated with brain connectome data obtained from fMRI studies. The elevated biomarker levels indicate damage to CNS neurons and endothelial cells, which is related to changes in brain connectivity in this group of patients.
Article
Engineering, Biomedical
Denis Nazarov, Ilya Ezhov, Natalia Yudintceva, Maxim Shevtsov, Aida Rudakova, Vladimir Kalganov, Vladimir Tolmachev, Yuliya Zharova, Oleksiy Lutakov, Ludmila Kraeva, Elizaveta Rogacheva, Maxim Maximov
Summary: The combination of titania nanofilms and silver nanoparticles is a promising material for titanium implant coatings, exhibiting antibacterial activity and osseointegration-induced properties. In this study, TiO2 nanolayer/Ag NP structures were successfully prepared on titanium disks using atomic layer deposition. The samples showed high antibacterial activity, differentiation in the osteogenic direction, and non-cytotoxicity, indicating the success of the combining of TiO2 and Ag to produce a multifunctional biocompatible and bactericidal material.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Pathology
Maria Pospelova, Varvara Krasnikova, Olga Fionik, Tatyana Alekseeva, Konstantin Samochernykh, Nataliya Ivanova, Nikita Trofimov, Tatyana Vavilova, Elena Vasilieva, Mariya Topuzova, Alexandra Chaykovskaya, Albina Makhanova, Tatyana Bukkieva, Evgeniya Kayumova, Stephanie Combs, Maxim Shevtsov
Summary: This study measured ICAM-1 and PECAM-1 serum levels in breast cancer patients after treatment and found that these biomarkers were significantly higher. The elevated levels could be associated with neurological complications.
