Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging

Reflections on the role of senescence during development and aging

(2016) F. Triana-Martínez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Age and muscle strength mediate the age-related biomechanical plasticity of gait

(2016) Tibor Hortobágyi et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors

(2016) Carlos Campos et al.   Expert Review of Neurotherapeutics

Long-Term Effects of Individually Tailored Physical Training and Activity on Physical Function, Well-Being and Cognition in Scandinavian Nursing Home Residents: A Randomized Controlled Trial

(2016) Kerstin Frändin et al.   GERONTOLOGY

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor  B-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning

(2016) R. Neidl et al.   JOURNAL OF NEUROSCIENCE

Use of Elderly Allografts in Liver Transplantation

(2016) Flavio Paterno et al.   TRANSPLANTATION

Exergame and Balance Training Modulate Prefrontal Brain Activity during Walking and Enhance Executive Function in Older Adults

(2016) Patrick Eggenberger et al.   Frontiers in Aging Neuroscience

Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors

(2016) Carlos Campos et al.   Expert Review of Neurotherapeutics

Telomere regulation during ageing and tumorigenesis of the grey mouse lemur

(2015) Delphine Trochet et al.   BIOCHIMIE

Multifunctional cytomegalovirus (CMV)-specific CD8+T cells are not restricted by telomere-related senescence in young or old adults

(2015) Natalie E. Riddell et al.   IMMUNOLOGY

CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+T Cells

(2015) Judith Leitner et al.   JOURNAL OF IMMUNOLOGY

Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans

(2015) Axel Ronald Schulz et al.   JOURNAL OF IMMUNOLOGY

T cell metabolic reprogramming and plasticity

(2015) Maria Slack et al.   MOLECULAR IMMUNOLOGY

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

Human-specific derived alleles ofCD33and other genes protect against postreproductive cognitive decline

(2015) Flavio Schwarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic evidence for the evolution of human postmenopausal longevity

(2015) Kristen Hawkes   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive Resilience to Apolipoprotein E ε4

(2015) Allison R. Kaup et al.   JAMA Neurology

Satellite cells in human skeletal muscle plasticity

(2015) Tim Snijders et al.   Frontiers in Physiology

Physical Activity Is Linked to Greater Moment-To-Moment Variability in Spontaneous Brain Activity in Older Adults

(2015) Agnieszka Z. Burzynska et al.   PLoS One

The Red Queen's long race: human adaptation to pathogen pressure

(2014) Katherine J Siddle et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

T cells and their cytokines in persistent stimulation of the immune system

(2014) Hassen Kared et al.   CURRENT OPINION IN IMMUNOLOGY

Cellular signaling in the aging immune system

(2014) Tamas Fulop et al.   CURRENT OPINION IN IMMUNOLOGY

Effect of age and CMV on NK cell subpopulations

(2014) Carmen Campos et al.   EXPERIMENTAL GERONTOLOGY

Increased numbers and functional activity of CD56+T cells in healthy cytomegalovirus positive subjects

(2014) Mazen Almehmadi et al.   IMMUNOLOGY

The Ontogeny and Fate of NK Cells Marked by Permanent DNA Rearrangements

(2014) K. Pilbeam et al.   JOURNAL OF IMMUNOLOGY

Induction of CD56 and TCR-Independent Activation of T Cells with Aging

(2014) B. H. Lemster et al.   JOURNAL OF IMMUNOLOGY

Cognitive Function in the Prefrailty and Frailty Syndrome

(2014) Deirdre A. Robertson et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

(2014) T. Kobilo et al.   LEARNING & MEMORY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging

(2014) Sulggi A. Lee et al.   PLoS One

Autonomous Stimulation of Cancer Cell Plasticity by the Human NKG2D Lymphocyte Receptor Coexpressed with Its Ligands on Cancer Cells

(2014) Xin Cai et al.   PLoS One

Tim-3 expression on peripheral monocytes and CD3+CD16/CD56+natural killer-like T cells in patients with chronic hepatitis B

(2014) Y.-H. Rong et al.   TISSUE ANTIGENS

Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly

(2014) Sandra Barral et al.   JAMA Neurology

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Thymic rejuvenation and aging

(2013) Melissa S Ventevogel et al.   CURRENT OPINION IN IMMUNOLOGY

The Epidemiology of Longevity and Exceptional Survival

(2013) A. B. Newman et al.   EPIDEMIOLOGIC REVIEWS

Benefits of Physical Exercise on the Aging Brain: The Role of the Prefrontal Cortex

(2013) Marika Berchicci et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Exceptional memory performance in the Long Life Family Study

(2013) Sandra Barral et al.   NEUROBIOLOGY OF AGING

Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment

(2013) Francis E Lotrich et al.   NEUROPSYCHOPHARMACOLOGY

Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells

(2013) A El-Gazzar et al.   ONCOGENE

The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity

(2013) N. Miskov-Zivanov et al.   Science Signaling

Donor Characteristics That Are Associated With Survival in Liver Transplant Recipients Older Than 70 Years With Grafts

(2013) J.-M. Álamo et al.   TRANSPLANTATION PROCEEDINGS

The distinct role of T cell costimulation in antiviral immunity

(2013) Suzanne PM Welten et al.   Current Opinion in Virology

Promoting physical activity for elders with compromised function: the Lifestyle Interventions and Independence for Elders (LIFE) Study physical activity intervention

(2013) W. Jack Rejeski et al.   Clinical Interventions in Aging

Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells

(2012) Bo Pei et al.   Annals of the New York Academy of Sciences

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Persistent accumulation of interferon-γ-producing CD8+CD56+ T cells in blood from patients with coronary artery disease

(2012) Ida Bergström et al.   ATHEROSCLEROSIS

High Levels of Costimulatory Receptors OX40 and 4-1BB Characterize CD4 + CD28 null T Cells in Patients With Acute Coronary Syndrome

(2012) Ingrid E. Dumitriu et al.   CIRCULATION RESEARCH

Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types

(2012) J. L. Kubinak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Immunological hurdles of ageing: Indispensable research of the human model

(2011) Abbe N. Vallejo   AGEING RESEARCH REVIEWS

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

(2011) A. Pievani et al.   BLOOD

Role of increased CD8/CD28null T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease

(2011) G. Hodge et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults

(2011) Sean X. Leng et al.   EXPERIMENTAL GERONTOLOGY

Virus stimulation of human mast cells results in the recruitment of CD56+ T cells by a mechanism dependent on CCR5 ligands

(2011) Sarah M. McAlpine et al.   FASEB JOURNAL

Age is not a contraindication for orthotopic liver transplantation: a single institution experience with recipients older than 75 years

(2011) C. Burcin Taner et al.   Hepatology International

Gait Speed and Survival in Older Adults

(2011) Stephanie Studenski   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Selective T Cell Expansion during Aging of CD8 Memory Repertoires to Influenza Revealed by Modeling

(2011) Y. N. Naumov et al.   JOURNAL OF IMMUNOLOGY

Polyfunctional T Cells Accumulate in Large Human Cytomegalovirus-Specific T Cell Responses

(2011) R. Lachmann et al.   JOURNAL OF VIROLOGY

A Physiologic Index of Comorbidity: Relationship to Mortality and Disability

(2011) A. B. Newman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Myosin Heavy Chain Plasticity in Aging Skeletal Muscle With Aerobic Exercise Training

(2011) A. R. Konopka et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Voluntary Wheel Running Reverses Age-Induced Changes in Hippocampal Gene Expression

(2011) Rachel A. Kohman et al.   PLoS One

NK-Like T Cells and Plasma Cytokines, but Not Anti-Viral Serology, Define Immune Fingerprints of Resilience and Mild Disability in Exceptional Aging

(2011) Abbe N. Vallejo et al.   PLoS One

Advanced Donor Age Alone Is Not a Risk Factor for Graft Survival in Kidney Transplantation

(2011) T. Karatzas et al.   TRANSPLANTATION PROCEEDINGS

Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans

(2011) Xin Zhou et al.   VACCINE

Genetic Diversity in Cytokines Associated with Immune Variation and Resistance to Multiple Pathogens in a Natural Rodent Population

(2011) Andrew K. Turner et al.   PLoS Genetics

Impact of age on T cell signaling: A general defect or specific alterations?

(2010) Anis Larbi et al.   AGEING RESEARCH REVIEWS

Human NK cells display major phenotypic and functional changes over the life span

(2010) Magali Le Garff-Tavernier et al.   AGING CELL

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset

(2010) S. Lopez-Verges et al.   BLOOD

Cytomegalovirus Seroprevalence in the United States: The National Health and Nutrition Examination Surveys, 1988–2004

(2010) Sheri Lewis Bate et al.   CLINICAL INFECTIOUS DISEASES

Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation

(2010) F. Gomez-Pinilla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Human cytomegalovirus-specific CD8+ T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects

(2010) Diana L. Wallace et al.   IMMUNOLOGY

Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein (CETP) Gene With Memory Decline and Incidence of Dementia

(2010) Amy E. Sanders   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NKG2D Initiates Caspase-Mediated CD3  Degradation and Lymphocyte Receptor Impairments Associated with Human Cancer and Autoimmune Disease

(2010) N. Hanaoka et al.   JOURNAL OF IMMUNOLOGY

Long-Term Retention of Older Adults in the Cardiovascular Health Study: Implications for Studies of the Oldest Old

(2010) Elsa S. Strotmeyer et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Psychomotor Speed and Functional Brain MRI 2 Years After Completing a Physical Activity Treatment

(2010) Caterina Rosano et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study

(2010) K. I. Erickson et al.   NEUROLOGY

Clinical and immunologic predictors of influenza illness among vaccinated older adults

(2010) Zainab Shahid et al.   VACCINE

Plasticity of brain networks in a randomized intervention trial of exercise training in older adults

(2010) Voss   Frontiers in Aging Neuroscience

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4

(2009) D. Scott-Algara et al.   BLOOD

Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells

(2009) G. Li et al.   BLOOD

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD

Cytosolic PLA2is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

(2009) Fangming Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Normally occurring NKG2D+CD4+T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

(2009) Zhenpeng Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Varicella‐Zoster Virus–Specific Immune Responses to Herpes Zoster in Elderly Participants in a Trial of a Clinically Effective Zoster Vaccine

(2009) Adriana Weinberg et al.   JOURNAL OF INFECTIOUS DISEASES

Decreased ERK and JNK signaling contribute to gene overexpression in “senescent” CD4+CD28- T cells through epigenetic mechanisms

(2009) Yingxuan Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Long-Term Function in an Older Cohort—The Cardiovascular Health Study All Stars Study

(2009) Anne B. Newman et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Evidence for Neurocognitive Plasticity in At-Risk Older Adults: The Experience Corps Program

(2009) M. C. Carlson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

(2009) Peter D. Adams   MOLECULAR CELL

Executive control function, brain activation and white matter hyperintensities in older adults

(2009) Vijay K. Venkatraman et al.   NEUROIMAGE

Older Age and a Reduced Likelihood of 2009 H1N1 Virus Infection

(2009) David N. Fisman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Memory T cells need CD28 costimulation to remember

(2009) Alina C. Boesteanu et al.   SEMINARS IN IMMUNOLOGY

Genes encoding longevity: from model organisms to humans

(2008) Maris Kuningas et al.   AGING CELL

Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors

(2008) D. I. Zonios et al.   BLOOD

Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis

(2008) Dorin Capraru et al.   CLINICAL IMMUNOLOGY

Varicella‐Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine

(2008) M. J. Levin et al.   JOURNAL OF INFECTIOUS DISEASES

Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells

(2008) Guangjin Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetic polymorphism in long-lived people: Cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity

(2008) Massimiliano Bonafè et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exceptional longevity does not result in excessive levels of disability

(2008) K. Christensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA