Journal
CURRENT OPINION IN CHEMICAL ENGINEERING
Volume 14, Issue -, Pages 18-25Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coche.2016.07.005
Keywords
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Funding
- NSF [1553250, 1360867]
- DOE by the BioEnergy Science Center (BESC) [DE-AC05-000R22725]
- U.S. Department of Energy Bioenergy Research Center - Office of Biological and Environmental Research in the DOE Office of Science
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1553250] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1511881, 1360867] Funding Source: National Science Foundation
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Transforming biology into an engineering practice has great potential to shape the industrialization of biology that will drive rapid development of novel microbial manufacturing platforms. These platforms will be capable of producing a vast number of sustainable industrial chemicals at scale from alternative renewable feedstocks or wastes (e.g., biomass residues, biogas methane, syngas, CO2) without harming the environment. The challenge is to develop microbial platforms to produce targeted chemicals with high efficiency in a rapid, predictable, and reproducible fashion. This paper highlights recent progress in rational design of heterologous pathways for combinatorial biosynthesis of a large space of chemicals and modular cell design for rapid strain engineering.
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