Article
Medicine, General & Internal
Daniel Alberto Maldonado-Ortega, Gabriel Martinez-Castanon, Gabriela Palestino, Gabriela Navarro-Tovar, Carmen Gonzalez
Summary: This study evaluated the biological effects of AuNPs with different capping agents in an artery model and found that AuNPsCA exhibited contractile effects while AuNPsGA showed dilator effects. Moreover, the presence or absence of glycocalyx had different effects on the nitric oxide levels induced by AuNPsCA and AuNPsGA.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rocio Salsoso, Alfonso Mate, Fernando Toledo, Carmen M. Vazquez, Luis Sobrevia
Summary: Late-onset preeclampsia is associated with altered endothelial function in the fetoplacental vasculature, causing an imbalance in the L-arginine/NO signaling pathway and reducing umbilical vein dilation to insulin, which requires A(2B)AR activation in HUVECs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Anna Bartakova, Marie Novakova
Summary: Cardiovascular diseases are a major cause of death globally, often involving endothelial dysfunction. Plants contain biologically active substances that can affect the endothelium, potentially contributing to the development of cardiovascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Javier Palacios, Julio Benites, Gareth Owen, Pablo Morales, Mario Chiong, Chukwuemeka R. Nwokocha, Adrian Paredes, Fredi Cifuentes
Summary: This study showed that the naphthoquinone derivative Q7 has certain effects on vascular structure, influencing endothelial cell formation and vasomotion. Results also demonstrated that Q7 significantly inhibited phenylephrine-induced vascular rhythmic contractions, which were recovered by sodium nitroprusside.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Kristen J. Bubb, Owen Tang, Carmine Gentile, Seyed M. Moosavi, Thomas Hansen, Chia-Chi Liu, Belinda A. Di Bartolo, Gemma A. Figtree
Summary: FXYD1 plays a crucial role in protecting eNOS from oxidative stress and contributes to cardiovascular health; FXYD1 regulates oxidative dysregulation within caveolae where it is colocalized; In addition to impacting eNOS function, FXYD1 is closely associated with hypertension and diabetic vascular oxidative stress.
Article
Peripheral Vascular Disease
Carmine Savoia, Carolina De Ciuceis, Anna Paini, Raffaella Carletti, Emanuele Arrabito, Carmine Nicoletti, Paolo Mercantini, Cira Di Gioia, Allegra Battistoni, Sarassunta Ucci, Antonio Filippini, Enrico Agabiti Rosei, Massimo Volpe, Maria L. Muiesan, Damiano Rizzoni, Massimo Salvetti
Summary: In this study, chronic treatment with the direct renin inhibitor aliskiren significantly improved vascular function in both resistance and conduit arteries of type two diabetic and hypertensive patients. Aliskiren restored endothelial function and induced a more prompt peripheral vasodilation, possibly through increased production of nitric oxide via enhanced expression and function of the active phosphorylated form of endothelial nitric oxide synthase, compared to ramipril.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Karolini Zuqui Nunes, Fulvio Alexandre Scorza, Esper Abrao Cavalheiro, Dalton Valentim Vassallo
Summary: The authors investigated changes in vascular reactivity in rats following pilocarpine-induced status epilepticus. The results showed that epilepsy decreased the contractile responses of the aortic rings to phenylephrine. It was found that administration of L-NAME increased vascular reactivity, while administration of Catalase only decreased contractile responses in the rings of rats with epilepsy.
Article
Physiology
Tristan H. J. Lewis, Junqi Zhuo, Jacob X. Mcclellan, Paulina M. Getsy, Rita M. Ryan, Michael. J. Jenkins, Stephen J. Lewis
Summary: The blood supply to afferent cell bodies in the ipsilateral nodose and petrosal ganglia is provided by the left and right occipital arteries. The application of infrared (IR) light to modulate neural and other cell processes has been found to cause endothelium-dependent, nitric-oxide-mediated vasodilation in the occipital arteries of the rat. This ability of IR to generate rapid and sustained vasodilation may have important therapeutic implications for restoring or improving blood flow to targeted tissues.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Article
Physiology
Agnes Keszler, Brian Lindemer, Grant Broeckel, Dorothee Weihrauch, Yan Gao, Nicole L. Lohr
Summary: Nitric oxide-dependent vasodilation facilitated by 670 nm red light has been studied in an ex vivo murine model and in vivo mouse experiments. The results show that red light can promote vasodilation and increase blood flow by releasing a vasoactive nitric oxide precursor. This treatment may offer a simple home-based therapy for individuals with impaired blood flow in the leg in the future.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Seung Hyun Ahn, Gyujin Sim, Soonghee Chung, Ju-Tae Sohn
Summary: This study aimed to examine the effect of lipid emulsion on the vasodilation induced by a toxic dose of amlodipine in isolated rat aorta and elucidate its mechanism, with a particular focus on nitric oxide. The results showed that lipid emulsion enhanced amlodipine-induced vasodilation and inhibited amlodipine-induced cyclic guanosine monophosphate (cGMP) production. Additionally, lipid emulsion reversed the phosphorylation of eNOS induced by amlodipine. These findings suggest that lipid emulsion attenuates amlodipine-induced vasodilation through inhibiting nitric oxide release in isolated rat aorta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Sebastiano Sciarretta, Giacomo Frati, Flavio Di Nonno, Valentina Valenti, Michele Ciccarelli, Eleonora Venturini, Mariarosaria Scioli, Paola Di Pietro, Tommaso Bucci, Valentina Giudice, Marianna Storto, Bianca Serio, Annibale Alessandro Puca, Giuseppe Giugliano, Valentina Trimarco, Raffaele Izzo, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
Summary: In addition to well-known risk factors, cardiovascular events may also be associated with epigenetic and genetic alterations. This study found that the MTHFR C677T gene variant is related to increased cardiovascular risk. Interestingly, even with normal homocysteine levels, heterozygous carriers of this gene variant have an augmented risk of cardiovascular accidents, suggesting the presence of additional deregulated processes. The study suggests that targeting SIRT1 activation could be a new therapeutic strategy to control cardiovascular risk in MTHFR carriers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biology
Gabriela Maria da Silva, Mirelly Cunha da Silva, Deborah Victoria Gomes Nascimento, Ellen Mayara Lima Silva, Fabiola Furtado Fialho Gouvea, Luiz Gonzaga de Franca Lopes, Alice Valenca Araujo, Kelli Nogueira Ferraz Pereira, Thyago Moreira de Queiroz
Summary: Nitric oxide plays crucial physiological roles in the cardiovascular system, and its deficiency can lead to cardiovascular diseases such as hypertension. Nitric oxide donors are clinically beneficial in treating cardiovascular disorders by modulating oxidative stress and inflammation, particularly in conditions like hypertension. Novel NO donors, especially those containing metal ions, show promising potential in improving vascular function and treating hypertension.
Article
Pharmacology & Pharmacy
Samantha L. Saunders, Dana S. Hutchinson, Fiona C. Britton, Lu Liu, Irit Markus, Shaun L. Sandow, Timothy V. Murphy
Summary: The study demonstrated the presence of all three beta-adrenoceptor subtypes in the endothelium of rat cremaster muscle artery, with beta(3)-adrenoceptor mediated vasodilation only evident after blockade of beta(1/2)-adrenoceptors. Constitutive beta(1/2)-adrenoceptor activity inhibits beta(3)-adrenoceptor function in the endothelium of skeletal muscle resistance arteries.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski
Summary: Chronic hypoxia impairs vascular function through various mechanisms, including changes in mitochondrial respiration. Our study found that the hypoxia-mimetic agent CoCl2 reduces nitric oxide (NO) production, depletes intracellular ATP levels, and increases extracellular nucleotide and adenosine breakdown in endothelial cells (ECs). Supplementation of nucleotide precursors and inhibition of adenosine deaminase can restore ATP levels and protect endothelial function.
Article
Medicine, General & Internal
Ida Ayu Eka Widiastuti, Aryadi Arsyad, Irfan Idris, Ilhamjaya Patellongi, Hamsu Kadriyan, Gede Wira Buanayuda, Dian Puspita Sari, Rohadi Muhammad Rosyidi
Summary: The study revealed that TGF-beta 1 levels were lower in recreational cyclists compared to sedentary individuals, while lipid profiles were significantly better in cyclists than sedentary individuals. Regular physical exercise can lead to adaptations that suppress the activation of TGF-beta 1.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Health Care Sciences & Services
Riska Reviana, Andi Nilawati Usman, Indah Raya, Aliyah, Andi Dirpan, Aryadi Arsyad, Fendi Fendi
Summary: The study evaluated cocktail honey using the DPPH test method and found its weak antioxidant activity, suitable for women's reproductive health, especially during pre-conception.
Article
Health Care Sciences & Services
Ristiani, Aryadi Arsyad, Andi Nilawati Usman, Saidah Syamsuddin, Mardiana Ahmad, Andi Wardihan Sinrang
Summary: This review examines the use of aromatherapy in primary dysmenorrhea and finds that it effectively reduces pain intensity. Studies included a variety of research designs such as experiments and clinical trials, supporting aromatherapy as an effective alternative intervention for alleviating primary dysmenorrhea pain.
Article
Health Care Sciences & Services
A. Mustika Fadillah Rizki, Andi Nilawati Usman, Indah Raya, Aliyah, Andi Dirpan, Aryadi Arsyad, Fendi Fendi, Andi Sumidarti
Summary: The study examines the content and antioxidant activity of royal jelly, as well as its effectiveness in dealing with oxidative stress in preconception women. The results show that royal jelly can increase glutathione levels and inhibit lipid peroxidation enzyme.
Article
Health Care Sciences & Services
Asriani Tahir, Andi Wardihan Sinrang, Elizabet Catherine Jusuf, Saidah Syamsuddin, Stang, Aryadi Arsyad
Summary: This study aimed to analyze the influence of macronutrient intake, stress, and prostaglandin levels on adolescent dysmenorrhea incidence. The results showed that stress and prostaglandin levels significantly affect the occurrence of dysmenorrhea in adolescents. The study used observational analytic methods and multivariate analysis to draw this conclusion.
Article
Health Care Sciences & Services
Andi Nilawati Usman, Indah Raya, Riska Yasmin, Aliyah, Andi Dirpan, Aryadi Arsyad, Annisa Eka Permatasari, Andi Sumidarti, Nurrahmi Umami, Emmasitah
Summary: The study found that ginger honey supplementation significantly increased glutathione and estrogen levels, but did not affect cortisol levels. This suggests that ginger honey may have the potential to be used as a complementary therapy.
Article
Sport Sciences
Huldani Huldani, Ilhamjaya Pattelongi, Muhammad Nasrum Massi, Irfan Idris, Agussalim Bukhari, Andi Wardihan Sinrang, Aryadi Arsyad, Agung Dwi Wahyu Widodo, Harun Achmad, Burhanuddin Bahar
Summary: This study found significant differences in VO2 (max), HMGB1, IL6, and cortisol levels between basketball-trained students and untrained students following moderate-intensity aerobic exercise.
JOURNAL OF HUMAN SPORT AND EXERCISE
(2021)
Article
Nutrition & Dietetics
Aryadi Arsyad, Irfan Idris, Andi A. Rasyid, Rezky A. Usman, Kiki R. Faradillah, Wa Ode U. Latif, Zidni I. Lubis, Aminuddin Aminuddin, Ika Yustisia, Yulia Y. Djabir
JOURNAL OF NUTRITION AND METABOLISM
(2020)
Article
Nursing
Chandra Ariani Saputri, Isharyah Sunarno, Andi Nilawati Usman, Aryadi Arsyad, Irfan Idris
ENFERMERIA CLINICA
(2020)
Article
Nursing
Hairani Artika Manurung, Isharyah Sunarno, Andi Nilawati Usman, Irfan Idris, M. Aryadi Arsyad
ENFERMERIA CLINICA
(2020)
Article
Nursing
Heldayanti Sirenden, Isharyah Sunarno, M. Aryadi Arsyad, Irfan Idris
ENFERMERIA CLINICA
(2020)
Article
Nursing
Heldayanti Sirenden, Isharyah Sunarno, Andi Nilawati Usman, Irfan Idris, M. Aryadi Arsyad
ENFERMERIA CLINICA
(2020)
Article
Nursing
Sukmawati, Isharyah Sunarno, Andi Nilawati Usman, Irfan Idris, M. Ariyadi Arsyad
ENFERMERIA CLINICA
(2020)
Article
Nursing
Sukmawati Sukmawati, Isharyah Sunarno, M. Aryadi Arsyad, Irfan Idris
ENFERMERIA CLINICA
(2020)
Article
Oncology
Aryadi Arsyad, Elke Sokoya, Geoffrey P. Dobson
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2018)