The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling

(2015) M. Carrara et al.   EMBO JOURNAL

Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases

(2015) Erdi Sozen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The structure of the PERK kinase domain suggests the mechanism for its activation

(2011) Wenjun Cui et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Unfolded protein response in cancer: the Physician's perspective

(2011) Xuemei Li et al.   Journal of Hematology & Oncology

Client-Loading Conformation of the Hsp90 Molecular Chaperone Revealed in the Cryo-EM Structure of the Human Hsp90:Hop Complex

(2011) Daniel R. Southworth et al.   MOLECULAR CELL

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Versatility of Trigger Factor Interactions with Ribosome-Nascent Chain Complexes

(2010) Sathish Kumar Lakshmipathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of P58(IPK) TPR Fragment Reveals the Mechanism for its Molecular Chaperone Activity in UPR

(2010) Jiahui Tao et al.   JOURNAL OF MOLECULAR BIOLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of GADD153 induced by mechanical stress in cardiomyocytes

(2009) W. P. Cheng et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Substrate binding site flexibility of the small heat shock protein molecular chaperones

(2009) N. Jaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Cardiac Remodeling by Pravastatin Is Associated with Amelioration of Endoplasmic Reticulum Stress

(2008) Hui Zhao et al.   HYPERTENSION RESEARCH

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

(2008) InKi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY