Journal
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
Volume 10, Issue 5, Pages 468-484Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753465816654873
Keywords
lung disease; Notch1; Notch3; therapy; gamma-secretase
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Funding
- National Natural Science Foundation of China [81170036, 81370143]
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Notch signaling is an evolutionarily conserved cell-cell communication mechanism that plays a key role in lung homeostasis, injury and repair. The loss of regulation of Notch signaling, especially Notch1 and Notch3, has recently been linked to the pathogenesis of important lung diseases, in particular, chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis, pulmonary arterial hypertension (PAH), lung cancer and lung lesions in some congenital diseases. This review focuses on recent advances related to the mechanisms and the consequences of aberrant or absent Notch1/3 activity in the initiation and progression of lung diseases. Our increasing understanding of this signaling pathway offers great hope that manipulating Notch signaling may represent a promising alternative complementary therapeutic strategy in the future.
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