Article
Dermatology
Jiyoon Lee, Karl R. Koehler
Summary: Culturing skin cells outside the body has long been essential to dermatological research, but artificial skin equivalents often lack the full complexity of native skin, especially in generating and maintaining skin appendages such as hair follicles and sweat glands.
EXPERIMENTAL DERMATOLOGY
(2021)
Editorial Material
Cell Biology
Renzhi Hou, Aliaksandr A. Astrowski, Maksim V. Plikus
Summary: The heightened ability of spiny mice to regenerate after injury is attributed to molecular changes in the Hippo-YAP pathway that protect wound fibroblasts from a persistent contractile state, as revealed in this issue of Developmental Cell.
DEVELOPMENTAL CELL
(2021)
Article
Cell & Tissue Engineering
Eva Maria Rico-Leo, Luis Francisco Lorenzo-Martin, Angel Carlos Roman, Xose Ramon Bustelo, Jaime Maria Merino, Pedro Maria Fernandez-Salguero
Summary: The aryl hydrocarbon receptor (AhR) plays a crucial role in skin regeneration and homeostasis by maintaining the identity of epidermal stem cells, making it a potential target for treating cutaneous pathologies.
Article
Dermatology
Wen-Yen Huang, Jin-Bon Hong, Michael Chang, Shih-Yi Wang, Shih-Fan Lai, Hsiung-Fei Chien, Sung-Jan Lin
Summary: The effects of cyclophosphamide on anagen hair follicles depend on dosage, with low dosages leading to dystrophy that can be self-repaired, while high dosages prematurely induce other growth stages. Analysis of cell dynamics revealed that apoptosis of central cells in hair bulbs is repairable, bulge stem cells remain unaffected, and basal cup cells can quickly replenish damaged cells and reconstruct structures.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Ranieri Cancedda, Maddalena Mastrogiacomo
Summary: Maintenance of tissue homeostasis and tissue regeneration are essential functions of adult stem cells. Transit-amplifying cells (TACs) play a crucial role in tissue development and regeneration by actively controlling the proliferation and differentiation of stem cells and their progeny. Autocrine and paracrine signals, as well as negative and positive feedback and feedforward mechanisms, are involved in these processes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiali Li, Bohao Zhao, Shuyu Yao, Yingying Dai, Xiyu Zhang, Naisu Yang, Zhiyuan Bao, Jiawei Cai, Yang Chen, Xinsheng Wu
Summary: This study found that exosomes derived from dermal papilla cells regulate hair follicle stem cell proliferation by stimulating LEF1, providing new insights into the regulatory mechanisms of hair follicle growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jingjing Wang, Yuheng Fu, Wenmao Huang, Ritusree Biswas, Avinanda Banerjee, Joshua A. Broussard, Zhihai Zhao, Dongmei Wang, Glen Bjerke, Srikala Raghavan, Jie Yan, Kathleen J. Green, Rui Yi
Summary: This study reveals that hair follicle stem cells (SCs) and hair germ (HG) progenitors have different mechanical properties, with SCs being stiff and resistant to size change, while HG progenitors are soft and periodically enlarge and contract. During hair follicle growth, HGs reduce contraction and more frequently enlarge, which is associated with weakening of the actomyosin network and nuclear YAP accumulation. miR-205 can reduce actomyosin contractility and activate hair regeneration in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Chinnavuth Vatanashevanopakorn, Thanutchaporn Sartyoungkul
Summary: Hair follicles are involved in a variety of functions and their formation and cycling require interaction between different cell types. Despite extensive research, generating functional human hair follicles for clinical use remains a challenge. Human pluripotent stem cells offer a promising unlimited cell source for generating hair follicle cells. This review discusses hair follicle morphogenesis, different cell sources for regeneration, and potential strategies using induced pluripotent stem cells for hair follicle bioengineering. Challenges and perspectives for using bioengineered hair follicles in treating hair loss disorders are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chao Zhang, YuanHong Li, Jie Qin, ChengQian Yu, Gang Ma, HongDuo Chen, XueGang Xu
Summary: In this study, it was found that injection of BMSC and MSC-CM led to the transition of telogen hair follicles to anagen hair follicles, and enhanced proliferation of HFSCs positive for Krt15 and Sox9 was observed. Proteomics analyses identified Krt25, Cpm, Stmn1, and Mb as potentially central players in hair follicle transition, suggesting they could be viable clinical targets for HL treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Xiaojiao Fan, Jing Chen, Yajun Zhang, Siyi Wang, Wenqian Zhong, Huipu Yuan, Xia Wu, Chaochen Wang, Yixin Zheng, Yuan Wei, Ying Xiao
Summary: This study clarified the mechanism by which Alpinetin (AP) promotes hair regeneration by activating HFSCs via Wnt signaling. These findings may contribute to the development of a new generation of pilatory that is more efficient and less cytotoxic for treating alopecia.
Article
Biochemistry & Molecular Biology
Francesco Bellanti, Domenica Mangieri, Giorgia di Bello, Aurelio Lo Buglio, Giuseppe Pannone, Maria Carmela Pedicillo, Alberto Fersini, Michal Dobrakowski, Aleksandra Kasperczyk, Slawomir Kasperczyk, Gianluigi Vendemiale
Summary: Redox homeostasis plays an important role in the modulation of stem cell fate. This study investigated the impact of redox modifications on the differentiation potential of a human hepatic progenitor cell line (HepaRG). The results reveal that both intra- and extracellular redox balance are crucial in determining the fate of HepaRG cells, highlighting the significance of redox status in pre-clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman, Yasuyuki Amoh
Summary: Hair-follicle-associated pluripotent (HAP) stem cells, located in hair follicles, can differentiate into multiple cell types, including neurons and cardiomyocytes. Studies have shown that HAP stem cells treated with neural-induction medium can differentiate into dopaminergic neurons, which may potentially help improve symptoms of Parkinson's disease in the future.
Article
Engineering, Biomedical
Mafalda Correia, Joana Lopes, Daniela Lopes, Ana Melero, Pooyan Makvandi, Francisco Veiga, Jorge F. J. Coelho, Ana C. Fonseca, Ana Claudia Paiva-Santos
Summary: This review discusses nanotechnology-based strategies for hair follicle (HF) regeneration, including controlled drug release and HF-specific targeting. In addition to traditional hair repair methods, wound-induced hair neogenesis (WIHN) has gained attention as a research focus. HF regeneration involves various modalities and technologies, including modulation of the hair cycle, stimulation of progenitor cells and signaling pathways, tissue engineering, WIHN, and gene therapy.
Review
Cell Biology
Min Yang, Tingting Weng, Wei Zhang, Manjia Zhang, Xiaojie He, Chunmao Han, Xingang Wang
Summary: Alopecia is a commonly seen issue affecting various age groups, with hair follicle regeneration considered as a strategy to address this problem. Non-coding RNAs, particularly microRNAs and long ncRNAs, play crucial regulatory roles in hair follicle development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Masahiro Fukuyama, Aki Tsukashima, Momoko Kimishima, Yoshimi Yamazaki, Hideyuki Okano, Manabu Ohyama
Summary: This study attempted to reproduce the anatomical relationship between the epithelial main body and the dermal papilla within hair follicles in vitro and evaluated how follicle characteristics were reproduced in constructs. Using hiPSC-derived cell composites, the study showed promising potential for regenerating hair follicle equivalents with in vitro hair inductive capacity, reducing the reliance on human tissue-derived trichogenic cell subsets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Sha Fu, Juan Wang, Xingwang Hu, Rong-rong Zhou, Yongming Fu, Daolin Tang, Rui Kang, Yan Huang, Lunquan Sun, Ning Li, Xue-Gong Fan
MOLECULAR ONCOLOGY
(2018)
Article
Cell Biology
Shaling Li, Huimin Gu, Yan Huang, Qian Peng, Rongrong Zhou, Panpan Yi, Ruochan Chen, Zebing Huang, Xingwang Hu, Yun Huang, Daolin Tang
Article
Cell Biology
Songman Yu, Ning Li, Zebing Huang, Ruochan Chen, Panpan Yi, Rui Kang, Daolin Tang, Xingwang Hu, Xuegong Fan
CELL DEATH & DISEASE
(2018)
Article
Cell Biology
Yajun Li, Yongming Fu, Xingwang Hu, Lunquan Sun, Daolin Tang, Ning Li, Fang Peng, Xue-gong Fan
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Zhenguo Liu, Yaqun Yu, Zebing Huang, Yi Kong, Xingwang Hu, Wei Xiao, Jun Quan, Xuegong Fan
CELL DEATH & DISEASE
(2019)
Article
Pharmacology & Pharmacy
Songman Yu, Ning Li, Juan Wang, Yongming Fu, Yan Huang, Panpan Yi, Ruochan Chen, Daolin Tang, Xingwang Hu, Xuegong Fan
CLINICAL THERAPEUTICS
(2020)
Article
Biotechnology & Applied Microbiology
Shanshan Lu, Minhui Dai, Xingwang Hu, Hong Yi, Yiya Zhang
Summary: This study developed and validated an ion channel signature for prognostic prediction of hepatocellular carcinoma (HCC), identifying 35 differential expressed ion channel genes (DEChannelGs) in HCC. The novel ion channel risk model was shown to be an independent prognostic factor and associated with the immune microenvironment in HCC, particularly with ANO10 and CLCN2 being up-regulated and related to poor prognosis.
Article
Dermatology
H. Xie, L. Zhou, F. Liu, J. Long, S. Yan, Y. Xie, X. Hu, J. Li
Summary: Short-term UVA exposure induces autophagy and upregulates AQP3, while long-term UVA exposure inhibits autophagy, AQP3, and triggers senescence. AQP3 controls skin fibroblast photoageing by regulating autophagy, making it a potential target for future interventions against skin ageing.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Genetics & Heredity
Shenglan Cai, Xingwang Hu, Ruochan Chen, Yiya Zhang
Summary: A total of 64 immune-related eRNAs were identified in HCC, among which 14 were associated with overall survival. The constructed IReRS was correlated with poor survival and served as an independent prognostic biomarker for HCC. Additionally, IReRS was found to be correlated with infiltrating immune cells, including CD8(+) T cells and M0 macrophages.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Xing-Wang Hu, Xiang-Min Li, Ai-Min Wang, Yong-Ming Fu, Fang-Jie Zhang, Feng Zeng, Li-Ping Cao, Hui Long, Ying-Hui Xiong, Ji Xu, Jia Li
Summary: This study found that caffeine can mitigate acute liver injury by increasing the expression of NEDD4L and inhibiting the expression of GRP78, thus protecting liver cells.
INFLAMMATION RESEARCH
(2022)
Article
Oncology
Zhangya Pu, Jinghua Liu, Zelong Liu, Fang Peng, Yuanyuan Zhu, Xiaofang Wang, Jiayan He, Panpan Yi, Xingwang Hu, Xuegong Fan, Jiang Chen
Summary: This study constructed a novel prognostic nomogram model for predicting the survival probability of individual hepatocellular carcinoma (HCC) patients and determined an immune-related prognostic gene signature. These findings may have important implications for future HCC treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ying-Hui Xiong, Xue-Gong Fan, Ya-Yu Chen, Yan Huang, Jun Quan, Pan-Pan Yi, Mei-Fang Xiao, Ze-Bing Huang, Xing-Wang Hu
Summary: This study compared three commonly used EVs isolation kits for isolating EVs from HepG2 cell culture medium. The results showed that the total amount of microRNA isolated from EVs using the EI kit was higher and had a higher quality of high-throughput sequencing data compared to the other two kits.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Zhangya Pu, Jiang Chen, Fang Peng, Zhiping Ruan, Yuanyuan Zhu, Xiaofang Wang, Yan Huang, Panpan Yi, Yayu Chen, Jun Quan, Zebing Huang, Zelong Liu, Xingwang Hu
Summary: This study conducted the largest population-based study to describe the clinicopathologic characteristics of patients with HMVT and established and validated prognostic nomograms that accurately predicted 1-, 3-, and 5-year OS and CSS.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Jia Li, Yongming Fu, Xingwang Hu, Yinghui Xiong