Article
Ophthalmology
Nimra Ghani, Jahnvi Bansal, Abhishek Naidu, Khurram M. Chaudhary
Summary: This study analyzed the postoperative movement of the electrode array in five patients with retinal degenerative diseases who underwent retinal prosthesis implantation. The results showed a statistically significant downward rotation of the retinal prosthesis over a two-year period. Therefore, it is important to consider this movement when designing retinal implants.
Article
Neurosciences
Ezgi Yucel, Roksana Sadeghi, Arathy Kartha, Sandra Rocio Montezuma, Gislin Dagnelie, Ariel Rokem, Geoffrey M. Boynton, Ione Fine, Michael Beyeler
Summary: This article discusses two main obstacles in the development of epiretinal prosthesis technology and provides insights into the causes of high current amplitude thresholds and poor spatial resolution in the Argus II epiretinal implant.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Ophthalmology
Marie-Noelle Delyfer, David Gaucher, Saddek Mohand-Said, Pierre-Olivier Barale, Fouzia Rezaigua-Studer, Sarah Ayello-Scheer, Helene Dollfus, Jessy D. Dorn, Jean-Francois Korobelnik, Jose-Alain Sahel
Summary: The study evaluated the long-term outcomes of the Argus II Retinal Prosthesis on patients with end-stage retinitis pigmentosa, focusing on its functional visual benefit in daily activities. Results showed positive impacts on functional vision and well-being, with improvement in daily tasks and standardized visual assessments for over 70% of subjects. The system was found to be safe and effective, with only two serious adverse events observed.
ACTA OPHTHALMOLOGICA
(2021)
Editorial Material
Optics
Dierck Hillmann
Summary: Optical coherence tomography (OCT) is an important technology in ophthalmic diagnostics, allowing for high-resolution three-dimensional visualization of retinal structural changes. Recent developments have led to smaller and more cost-effective OCT systems, expanding its potential use cases in various industries and medical applications.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Article
Computer Science, Information Systems
Simon Schurer-Waldheim, Philipp Seebock, Hrvoje Bogunovic, Bianca S. Gerendas, Ursula Schmidt-Erfurth
Summary: In this study, the PRE U-net was introduced as a novel approach for fully automated fovea centralis detection. By concatenating spatial location information and training a deep network, the PRE U-net significantly outperformed existing methods in localization. This research is of great importance for clinical practice.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Biology
Barbara Parolini, Matteo Ripa, Rino Frisina, Veronika Matello, Lorenzo Motta
Summary: This study describes the advantages and feasibility of microscope-integrated intraoperative optical coherence tomography (i-OCT) in managing various vitreoretinal diseases in a real-life setting. The results showed that i-OCT was a useful diagnostic exam for all cases and significantly influenced surgical management.
Article
Medicine, General & Internal
Paola Triggianese, Matteo Di Marino, Carolina Nesi, Elisabetta Greco, Stella Modica, Maria Sole Chimenti, Paola Conigliaro, Raffaele Mancino, Carlo Nucci, Massimo Cesareo
Summary: This study utilized SD-OCT and OCT-A to explore retinal abnormalities in a specific group of type I HAE patients, revealing thicker retinal nerve fiber layer and optic nerve head thickness, as well as decreased capillary density in both superficial and deep regions compared to healthy controls. These findings suggest the potential utility of SD-OCT/OCT-A for comprehensive care of individuals with HAE.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Archana A. Nair, Rebecca Liebenthal, Shefali Sood, Grant L. Hom, Marc E. Ohlhausen, Thais F. Conti, Carolina C. S. Valentim, Hiroshi Ishikawa, Gadi Wollstein, Joel S. Schuman, Rishi P. Singh, Yasha S. Modi
Summary: This study utilized NIR-OCT to establish the position of the fovea centralis relative to the optic nerve in healthy individuals and found significant differences between the right and left eyes. It highlights the importance of preoperative and postoperative NIR-OCT scans for assessing true foveal ectopia.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Z. H. E. N. G. Y. U. DUAN, K. A. HUANG, Z. H. O. N. G. Z. H. O. U. LUO, K. E. MA, G. E. N. G. Y. U. A. N. WANG, X. I. A. O. D. O. N. G. HU, J. I. N. Z. E. ZHANG, X. I. A. O. L. I. N. G. LUO, Y. U. A. N. C. O. N. G. HUANG, G. A. N. G. J. U. N. LIU, X. I. A. O. Y. A. N. DING, P. E. N. G. XIAO, J. I. N. YUAN
Summary: We have developed a portable boom-type ophthalmic UHR-OCT system that can be used for high-resolution retinal examinations in pediatric, bedridden, and perioperative patients. The system integrates real-time iris display and automatic focusing, and has high mobility and stability.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Ophthalmology
Zitian Liu, Wenyong Huang, Zhenyu Wang, Ling Jin, Nathan Congdon, Yingfeng Zheng, Shida Chen, Yizhi Liu
Summary: This study demonstrates that the portable, self-imaging OCT is highly consistent with clinic-based SD-OCT in measuring CST and identifying most retinal lesions.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Stefan Steiner, Florian Schwarzhans, Sylvia Desissaire, Hemma Resch, Georg Fischer, Michael Pircher, Christoph K. Hitzenberger, Clemens Vass
Summary: This study used polarization-sensitive optical coherence tomography to investigate the birefringence of the circumpapillary retinal nerve fiber layer in early glaucoma. The results showed a reduction in birefringence in glaucomatous eyes, which may be indicative of changes in intracellular microtubules. Further longitudinal studies are needed to determine if birefringence changes occur before a decline in retinal nerve fiber layer thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Andrea Martinez-Lozano, Carolina Blanco-Angulo, Alberto Rodriguez-Martinez, Carlos G. Juan, Hector Garcia-Martinez, Jose M. Sabater-Navarro, Ernesto Avila-Navarro
Summary: This study demonstrates a radar-based microwave imaging system for detecting the brain-shift effect with minimal delay. The system estimates variations in the position and geometry of the brain to detect remarkable changes. Results show the potential of the system for intraoperative brain-shift detection.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Multidisciplinary
Shaolong Qi, Yajun Wang, Youliang Zhu, Xueyan Zhang, Xinyu Wang, Xinyang Yu, Kai Yang, Bing Bai, Yunxuan Feng, Jiaqi Lei, Kuo Zhang, Zhongyuan Lu, Shoujun Zhu, Jianshi Du, Guocan Yu
Summary: We have developed NIR-II fluorescent nanoprobes based on the isolated cage monodisperse strategy, which effectively inhibits stacking interactions and enhances the NIR-II imaging performance. Compared to ICG, the nanoformulations have reduced photobleaching and provide longer observation times, allowing high spatiotemporal resolution imaging of blood vessels and lymphatic system. The nanoprobes also enable accurate removal of sentinel lymph nodes and intuitive evaluation of lymphovenous anastomosis (LVA) through qualitative and quantitative NIR-II fluorescence signals, benefiting the innovation and promotion of LVA.
Article
Medicine, General & Internal
Yao Cai, Kate Grieve, Pedro Mece
Summary: This study thoroughly quantifies and characterizes the effects of retinal axial motion on high-resolution ophthalmic imaging devices, and finds that breath-holding can reduce large-and-slow drifts but increase small-and-fast fluctuations. By simulating a control loop, the study determines that a loop rate of 1.2 kHz is ideal for achieving 100% robust clinical retinal imaging.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Hedwig Sillen, Jan Van Looveren, Philip Plaeke, Luc Van Os, Marie-Jose Tassignon
Summary: Intraoperative OCT imaging is an excellent tool for evaluating the VLI and demonstrating VLI dysgenesis during pediatric cataract surgery. VLI dysgenesis poses challenges for performing a calibrated PPCCC and may result in a defect in the anterior hyaloid membrane, leading to vitreous prolapse.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2021)
Article
Ophthalmology
Stanislao Rizzo, Pierre-Olivier Barale, Sarah Ayello-Scheer, Robert G. Devenyi, Marie-Noelle Delyfer, Jean-Francois Korobelnik, Aleksandra Rachitskaya, Alex Yuan, K. Thiran Jayasundera, David N. Zacks, James T. Handa, Sandra R. Montezuma, Dara Koozekanani, Paulo E. Stanga, Lyndon Da Cruz, Peter Walter, Albert J. Augustin, Marzio Chizzolini, Lisa C. Olmos de Koo, Allen C. Ho, Bernd Kirchhof, Paul Hahn, Lejla Vajzovic, Raymond Iezzi, David Gaucher, J. Fernando Arevalo, Ninel Z. Gregori, Salvatore Grisanti, Emin Ozmert, Young Hee Yoon, Gregg T. Kokame, Jennifer Lim, Peter Szurman, Eugene de Juan, Flavio A. Rezende, Joel Salzmann, Gisbert Richard, Suber S. Huang, Francesco Merlini, Uday Patel, Cynthia Cruz, Robert J. Greenberg, Sally Justus, Laura Cinelli, Mark S. Humayun
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Article
Biochemical Research Methods
Kristin Allan, Rose DiCicco, Michael Ramos, Kewal Asosingh, Alex Yuan
Article
Ophthalmology
Lucy T. Xu, Aleksandra Rachitskaya, Meghan J. DeBenedictis, James Bena, Shannon Morrison, Alex Yuan
Summary: The study revealed a positive correlation between array-retina distance and threshold measurements when measuring the entire array but not when using a faster measurement method of four corners and largest array-retina distance.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Genetics & Heredity
Madeline Williamson, Elias Traboulsi, Meghan DeBenedictis
OPHTHALMIC GENETICS
(2020)
Article
Genetics & Heredity
Meghan J. DeBenedictis, Yosef Gindzin, Enrico Glaab, Bela Anand-Apte
OPHTHALMIC GENETICS
(2020)
Article
Genetics & Heredity
Kevin Wang, Brittney Statler, Michael Ramos, Meghan J. DeBenedictis, Amy Babiuch, Alex Yuan, Elias I. Traboulsi
OPHTHALMIC GENETICS
(2020)
Article
Genetics & Heredity
Sydney Strait, Rebecca Loman, Lindsay Erickson, Meghan DeBenedictis
OPHTHALMIC GENETICS
(2020)
Article
Genetics & Heredity
H. Al-Hindi, M. Z. Chauhan, R. Sanders, H. Samarah, M. DeBenedictis, E. Traboulsi, S. H. Uwaydat
Summary: Patients with TULP1-related retinal dystrophy can exhibit a distinctive retinopathy characterized by a unique pattern of macular degeneration and periarteriolar vascular pigmentation.
OPHTHALMIC GENETICS
(2022)
Article
Ophthalmology
Rebecca M. Schur, Brendan L. Eck, Alex Yuan
Summary: LVAD interference in ERG waveforms can be successfully removed using simple digital filters. If post hoc data processing capabilities are unavailable, a large amount of interference can be removed by narrowing the acquisition bandwidth and averaging additional repeats of each stimulus response.
DOCUMENTA OPHTHALMOLOGICA
(2022)
Review
Genetics & Heredity
Sruthi Arepalli, Meghan M. DeBenedictis, Alex Yuan, Elias I. Traboulsi
Summary: This study reports three siblings with Knobloch syndrome. One patient was initially misdiagnosed as having a different retinal disease due to the absence of typical occipital scalp defects. The correct diagnosis was eventually made through molecular genetic testing.
OPHTHALMIC GENETICS
(2022)
Article
Genetics & Heredity
Madeline Beckman, Leanne Clevenger, Meghan J. J. DeBenedictis, Alex Yuan, Sumit Sharma
Summary: This case report describes a novel ocular phenotype associated with MFSD8 pathogenic variants causing macular dystrophy. The patient presented with central cone involvement without neurologic sequelae, which is different from the classic association of MFSD8 variants with neuronal ceroid lipofuscinosis. The findings suggest that MFSD8 pathogenic variants can result in a predominantly ocular phenotype with preserved neurologic function.
OPHTHALMIC GENETICS
(2023)
Article
Ophthalmology
Aleksandra Rachitskaya, Alex Yuan, Sara Davidson, Matthew Streicher, Meghan DeBenedictis, Anson B. Rosenfeldt, Jay Alberts
OPHTHALMOLOGY RETINA
(2020)