Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Erik van Zwet, Paul C. de Kruijff, Thijs W. van Harten, Ellis S. van Etten, Sanneke van Rooden, Louise van der Weerd, Mark A. van Buchem, Matthias J. P. van Osch, Steven M. Greenberg, Marianne A. A. van Walderveen, Gisela M. Terwindt, Marieke J. H. Wermer
Summary: Cortical calcifications are common in Dutch-type hereditary CAA (D-CAA) but rare in sporadic CAA. These calcifications are associated with the development of intracerebral hemorrhage (ICH) and may serve as a marker for advanced CAA. Additionally, there seems to be a link between cortical calcifications on computed tomography and the striped occipital cortex on 7T-magnetic resonance imaging.
Article
Endocrinology & Metabolism
Manon R. Schipper, Naomi Vlegels, Thijs W. van Harten, Ingeborg Rasing, Emma A. Koemans, Sabine Voigt, Alberto de Luca, Kanishk Kaushik, Ellis S. van Etten, Erik W. van Zwet, Gisela M. Terwindt, Geert Jan Biessels, Matthias J. P. van Osch, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: Cerebral Amyloid Angiopathy (CAA) is associated with vascular reactivity and microstructural white matter integrity loss in different disease stages of Dutch-type CAA. A lowered BOLD amplitude and delayed BOLD response are related to increased microstructural white matter integrity loss in D-CAA subjects, especially in the symptomatic stage. Further studies are needed to determine the causality of this relationship.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Simon Fandler-Hoefler, Thomas Gattringer, Christian Enzinger, David J. Werring
Summary: This study found that patients with probable CAA who were diagnosed using the Boston v2.0 criteria had a lower risk of ICH recurrence compared to those diagnosed using the v1.5 criteria.
Article
Clinical Neurology
Yuichiro Ii, Hidehiro Ishikawa, Akihiro Shindo, Hirofumi Matsuyama, Keita Matsuura, Kana Matsuda, Kimiko Yoshimaru, Masayuki Satoh, Ryota Kogue, Maki Umino, Masayuki Maeda, Hidekazu Tomimoto
Summary: The study found that the presence of CMIs with a high CAA-SVD score could be an indicator of more severe amyloid-associated vasculopathic changes in patients with probable CAA. CMIs were more frequently detected in the parietal and occipital lobes.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Kanishk Kaushik, Ellis S. van Etten, Bob Siegerink, L. Jaap Kappelle, Afina W. Lemstra, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Wilco C. Peul, Gisela M. Terwindt, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: We investigated the clinical profile, radiological features, and outcome of the presumed iatrogenic cause of cerebral amyloid angiopathy (CAA) in patients presenting with nonhereditary CAA under the age of 55.
Review
Clinical Neurology
Jhih-Yong Yang, Yung-Tsai Chu, Hsin-Hsi Tsai, Jiann-Shing Jeng
Summary: This study retrospectively described two cases of CAA-ri and investigated the longitudinal changes of amyloid PET. The results showed focal decreases in amyloid load after the inflammatory process. The study also revealed variable findings related to amyloid burden in post-inflammatory regions in previously reported cases of CAA-ri with available amyloid PET.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Emma A. Koemans, Sabine Voigt, Ingeborg Rasing, Thijs W. van Harten, Wilmar M. T. Jolink, Floris H. B. M. Schreuder, Erik W. van Zwet, Mark A. van Buchem, Matthias J. P. van Osch, Gisela M. Terwindt, Catharina J. M. Klijn, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: This study investigated the frequency of cerebellar superficial siderosis and its relation to hemorrhagic magnetic resonance imaging markers in patients with cerebral amyloid angiopathy (CAA). The study found that cerebellar superficial siderosis may be a novel marker for CAA.
Article
Clinical Neurology
Johannes M. Weller, Simon Jonas Enkirch, Christopher Bogs, Tim Bastian Braemswig, Milani Deb-Chatterji, Fee Keil, Christine Kindler, Sarah Maywald, Markus D. Schirmer, Sebastian Stosser, Laszlo Solymosi, Christian H. Nolte, Felix J. Bode, Gabor C. Petzold
Summary: Endovascular thrombectomy with or without thrombolysis seems beneficial for acute ischemic stroke patients with possible or probable CAA, but is associated with a worse functional outcome. Intravenous thrombolysis may improve the rate of good outcome in CAA patients.
Article
Clinical Neurology
E. A. Koemans, S. Voigt, I Rasing, W. M. T. Jolink, T. W. van Harten, J. van der Grond, S. van Rooden, F. H. B. M. Schreuder, W. M. Freeze, M. A. van Buchem, E. W. van Zwet, S. J. van Veluw, G. M. Terwindt, M. J. P. van Osch, C. J. M. Klijn, M. A. A. van Walderveen, M. J. H. Wermer
Summary: This study investigated the presence of striped occipital cortex and intragyral hemorrhage in sporadic CAA and non-sCAA intracerebral hemorrhage. The findings suggest that intragyral hemorrhages may be specific to CAA and related to advanced disease.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Neuroimaging
Nadieh Drenth, Jeroen van der Grond, Serge A. R. B. Rombouts, Mark A. van Buchem, Gisela M. Terwindt, Marieke J. H. Wermer, Jasmeer P. Chhatwal, M. Edip Gurol, Steven M. Greenberg, Sanneke van Rooden
Summary: The study found that patients with Dutch type hereditary CAA show diminished global brain functioning, particularly in symptomatic individuals. This suggests that the decreased brain connectivity may be considered a late consequence of the disease.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Andreas Charidimou, Gregoire Boulouis
Summary: This article conducted a meta-analysis to evaluate the value and accuracy of the Boston criteria in diagnosing probable sporadic cerebral amyloid angiopathy (CAA) patients. The results showed that the Boston criteria v.1.0 and v.1.5 have moderate-to-good diagnostic accuracy for probable CAA in symptomatic patients, with high specificity but low-to-moderate sensitivity.
Article
Clinical Neurology
Romella Durrani, Meng Wang, Emily Cox, Elisabeth Irving, Feryal Saad, Cheryl R. McCreary, Andrew E. Beaudin, Myrlene Gee, Krista Nelles, Tolulope T. Sajobi, Zahinoor Ismail, Richard Camicioli, Eric E. Smith
Summary: Neuroimaging biomarkers, including altered white matter diffusivity, cerebrovascular reactivity, and atrophy, are closely associated with cognitive dysfunction in cerebral amyloid angiopathy (CAA).
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Geriatrics & Gerontology
Yan Chang, Jiajin Liu, Liang Wang, Xin Li, Zhenjun Wang, Mu Lin, Wei Jin, Mingwei Zhu, Baixuan Xu
Summary: This study aimed to compare amyloid deposition in lobar cerebral microbleed (CMB) sites of cerebral amyloid angiopathy (CAA), Alzheimer's disease (AD), and cognitively normal healthy controls (NC), using an integrated C-11-Pittsburgh compound B (PIB) positron emission tomography (PET)/magnetic resonance (MR) approach. The results showed that the proposed method had a high accuracy in distinguishing CAA and AD patients, providing valuable insights into the pathogenesis of CMBs and the potential utility of PIB-PET/MR as a non-invasive diagnostic tool.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Raed A. Joundi, James A. King, Jillian Stang, Dana Nicol, Michael D. Hill, Moira K. Kapral, Eric E. Smith, Amy Y. X. Yu
Summary: This study validates the effectiveness of the Passive Surveillance Stroke Severity (PaSSV) Indicator using administrative datasets and clinical registries. The results suggest that PaSSV improves model discrimination for case fatality and home time outcomes in acute stroke patients.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Romella Durrani, Meng Wang, Emily Cox, Elisabeth Irving, Feryal Saad, Cheryl R. McCreary, Andrew E. Beaudin, Myrlene Gee, Krista Nelles, Tolulope T. Sajobi, Zahinoor Ismail, Richard Camicioli, Eric E. Smith
Summary: Neuroimaging biomarkers, including altered white matter diffusivity, cerebrovascular reactivity, and atrophy, are closely associated with cognitive dysfunction in cerebral amyloid angiopathy (CAA).
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Geriatrics & Gerontology
Sophie Hu, Scott Patten, Anna Charlton, Karyn Fischer, Gordon Fick, Eric E. Smith, Zahinoor Ismail
Summary: This study compared the utility of MBI-C and NPI-Q in capturing non-cognitive symptoms in patients with subjective cognitive decline, mild cognitive impairment, and dementia. The results showed that both MBI-C and NPI-Q were effective in characterizing these symptoms, and MBI-C was able to capture non-cognitive symptoms across different cognitive stages.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Correction
Clinical Neurology
David J. Gladstone, M. Patrice Lindsay, James Douketis, Eric E. Smith, Dar Dowlatshahi, Theodore Wein, Aline Bourgoin, Jafna Cox, John B. Falconer, Brett R. Graham, Marilyn Labrie, Lena McDonald, Jennifer Mandzia, Daniel Ngui, Paul Pageau, Amanda Rodgerson, William Semchuk, Tammy Tebbutt, Carmen Tuchak, Stephen van Gaal, Karina Villaluna, Norine Foley, Shelagh Coutts, Anita Mountain, Gord Gubitz, Jacob A. Udell, Rebecca McGuff, Manraj K. S. Heran, Pascale Lavoie, Alexandre Y. Poppe
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Sabrina Adamo, Christopher Scott, Vincent Gaudet, Joel Ramirez, Walter Swardfager, Hugo Cogo-Moreira, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Min Su Kang, Jennifer S. Rabin, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the association between cerebrovascular burden and cognitive function, and found that the relationship was mainly mediated by localized neurodegeneration rather than amyloid beta deposition. The results suggest an amyloid-independent pathway through which vascular burden affects cognitive function.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Nicolas Raposo, Maria Clara Zanon Zotin, David J. Seiffge, Qi Li, Martina B. Goeldlin, Andreas Charidimou, Ashkan Shoamanesh, Hans Rolf Jager, Charlotte Cordonnier, Catharina Jm Klijn, Eric E. Smith, Steven M. Greenberg, David J. Werring, Anand Viswanathan
Summary: The study developed a new classification system called CLAS-ICH for subtyping intracerebral hemorrhage (ICH) based on recent advances in neuroimaging. The system assigns scores to each category to determine the underlying causes of ICH. The system was validated in two cohorts and demonstrated reliability and consistency.
ANNALS OF NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Raed A. Joundi, Amy Y. X. Yu, Eric E. Smith, Charlotte Zerna, Andrew M. Penn, Robert F. Balshaw, Kristine Votova, Maximilian B. Bibok, Melanie Penn, Viera Saly, Janka Hegedus, Shelagh B. Coutts
Summary: The relationship between the duration of transient neurological events and the presence of diffusion-weighted lesions varies depending on symptom type. For focal-only symptoms, there is a continuous increase in the probability of DWI lesion with longer duration, particularly in women. However, for nonfocal or mixed symptoms, the probability of DWI lesion remains constant regardless of duration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Shumei Man, Nicole Solomon, Brian Mac Grory, Brooke Alhanti, Ken Uchino, Jeffrey L. Saver, Eric E. Smith, Ying Xian, Deepak L. Bhatt, Lee H. Schwamm, Muhammad Shazam Hussain, Gregg C. Fonarow
Summary: Shorter door-to-needle times are associated with better long-term functional outcomes and lower mortality among older stroke patients treated with IVT only or IVT+EVT. These findings support efforts to accelerate thrombolytic administration in all eligible patients, including those receiving EVT.
Article
Health Care Sciences & Services
Meng Wang, Thierry Chekouo, Zahinoor Ismail, Nils D. Forkert, David B. Hogan, Aravind Ganesh, Richard Camicioli, Dallas Seitz, Michael J. Borrie, Ging-Yuek Robin Hsiung, Mario Masellis, Paige Moorhouse, Carmela Tartaglia, Eric E. Smith, Tolulope T. Sajobi
Summary: The study aimed to develop and validate a Bayesian risk prediction model combining research cohort data and expert knowledge to predict dementia progression in people with mild cognitive impairment (MCI). The results showed that adding expert knowledge did not improve the accuracy of the model in predicting dementia progression.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Neurosciences
Chih-Hao Chen, Mary Klir Khnaijer, Andrew E. Beaudin, Cheryl R. McCreary, Myrlene Gee, Feryal Saad, Richard Frayne, Zahinoor Ismail, G. Bruce Pike, Richard Camicioli, Eric E. Smith
Summary: In this study, researchers investigated whether cerebral amyloid angiopathy (CAA) is associated with subcortical atrophy. They found that CAA patients did not show substantial atrophy of subcortical volumes compared to Alzheimer's disease (AD) or healthy controls, except for the putamen. Differences in findings may be due to heterogeneity in CAA presenting syndromes or severity.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medical Informatics
Michelle Lu, Rachel E. Crooks, Diana F. Pricop, Emily Cox, Beatrice Anghelescu, Mark Hamilton, Davide Martino, Veronica Bruno, Colin B. Josephson, Scott Patten, Eric E. Smith, Pamela Roach
Summary: This study aimed to explore barriers and facilitators of virtual care from the perspective of neurological and psychiatric patients. One-on-one interviews were conducted remotely using telephone and online video teleconferencing, with a total of 57 participants. The study found that virtual care can increase accessibility and efficiency for patients and providers, indicating its potential for ongoing use in the delivery of clinical care. Patients perceived virtual care as an acceptable mode of healthcare delivery, but there remains a continued need for relationship-building between care providers and patients.
HEALTH AND TECHNOLOGY
(2023)
Article
Clinical Neurology
Inaara M. Ebrahim, Maryam Ghahremani, Richard Camicioli, Eric E. Smith, Zahinoor Ismail
Summary: Affective dysregulation in older adults without dementia is associated with a higher risk of developing dementia and should be considered in clinical assessments.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Raed A. Joundi, James King, Jillian Stang, Dana Nicol, Michael D. Hill, Hude Quan, Peter Faris, Amy Y. X. Yu, Moira K. Kapral, Eric E. Smith
Summary: The study aimed to explore whether the association between co-morbidity and mortality after acute stroke is influenced by stroke type, age, sex, or time since stroke. A province-wide population-based study in Alberta, Canada was conducted using linked administrative databases. The results showed a stronger association between severe co-morbidity and mortality in younger age groups and the subacute phase after stroke.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Emma A. Koemans, Jasmeer P. Chhatwal, Susanne J. van Veluw, Ellis S. van Etten, Matthias J. P. van Osch, Marianne A. A. van Walderveen, Hamid R. Sohrabi, Mariel G. Kozberg, Zahra Shirzadi, Gisela M. Terwindt, Mark A. van Buchem, Eric E. Smith, David J. Werring, Ralph N. Martins, Marieke J. H. Wermer, Steven M. Greenberg
Summary: Cerebral amyloid angiopathy, a common age-related small vessel pathology, is associated with intracerebral haemorrhage and cognitive impairment. By studying individuals with different forms of the disease and using mouse models, researchers have identified key stages in the progression of cerebral amyloid angiopathy, which may help in developing interventions for this and other cerebral small vessel diseases.
Review
Clinical Neurology
Marco Duering, Geert Jan Biessels, Amy Brodtmann, Christopher Chen, Charlotte Cordonnier, Frank-Erik de Leeuw, Stephanie Debette, Richard Frayne, Eric Jouvent, Natalia S. Rost, Annemieke ter Telgte, Rustam Al-Shahi Salman, Walter H. Backes, Hee-Joon Bae, Rosalind Brown, Hugues Chabriat, Alberto De Luca, Charles deCarli, Anna Dewenter, Fergus N. Doubal, Michael Ewers, Thalia S. Field, Aravind Ganesh, Steven Greenberg, Karl G. Helmer, Saima Hilal, Angela C. C. Jochems, Hanna Jokinen, Hugo Kuijf, Bonnie Y. K. Lam, Jessica Lebenberg, Bradley J. MacIntosh, Pauline Maillard, Vincent C. T. Mok, Leonardo Pantoni, Salvatore Rudilosso, Claudia L. Satizabal, Markus D. Schirmer, Reinhold Schmidt, Colin Smith, Julie Staals, Michael J. Thrippleton, Susanne J. van Veluw, Prashanthi Vemuri, Yilong Wang, David Werring, Marialuisa Zedde, Rufus O. Akinyemi, Oscar H. Del Brutto, Hugh S. Markus, Yi-Cheng Zhu, Eric E. Smith, Martin Dichgans, Joanna M. Wardlaw
Summary: Cerebral small vessel disease (SVD) is a common age-related condition that can cause stroke, cognitive decline, neurobehavioral symptoms, and functional impairment. STRIVE-1 classified and standardized the various visible features of SVD on structural MRI, but new information and imaging techniques have emerged since then. Quantitative imaging biomarkers and machine learning methods offer a more comprehensive understanding of the impact of SVD on the brain and can serve as intermediary outcomes in clinical trials and routine practice.