Review
Biochemistry & Molecular Biology
Gabriela Bordeianu, Nina Filip, Andrei Cernomaz, Bogdan Veliceasa, Loredana Liliana Hurjui, Alin Constantin Pinzariu, Mihaela Pertea, Andreea Clim, Mihai Vasile Marinca, Ionela Lacramioara Serban
Summary: Despite advancements in prevention and clinical management, lung cancer remains a significant public health issue. Early diagnosis, accurate treatment, and the use of nanotechnology can improve lung cancer prognosis. This article provides a summary of current knowledge on the use of nanotechnology in lung cancer management, including diagnostic techniques and targeted drug delivery systems. It explores the potential impact of nanotechnology on lung cancer clinical prognosis.
Article
Multidisciplinary Sciences
Dimitris Kalliantas, Meletia Kallianta, Konstantinos Kordatos, Chaido Stefania Karagianni
Summary: This study focuses on the explanation of the structure and physicochemical properties of homeopathic ultra high diluted succussed medicinal products, revealing the creation of micro nanoparticles during preparation process and the differentiation in physicochemical properties between products from different origins. Through various tests and analysis, the characteristics and formation process of these products are unveiled.
Article
Biochemical Research Methods
Rohitas Deshmukh
Summary: Malaria is a life-threatening parasitic disease with drug resistance being a significant concern. Nanomedicine has shown promise in overcoming these limitations by utilizing nanomaterials to improve the efficacy of antimalarial drugs. This approach provides a more targeted and safer treatment option for malaria, potentially reducing side effects and increasing treatment efficiency.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2023)
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Pharmacology & Pharmacy
Hennie Marie Johnsen, Werner Filtvedt, Marianne Hiorth, Jo Klaveness
Summary: The medical use of hydrogen gas has gained attention in recent years. Researchers have investigated the use of silicon particles as nanocarriers to safely generate hydrogen. The results showed that cCVD silicon particles can efficiently generate hydrogen in physiological conditions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biology
Jorge A. Roacho-Perez, Elsa N. Garza-Trevino, Paulina Delgado-Gonzalez, Zuca G-Buentello, Juan Luis Delgado-Gallegos, Christian Chapa-Gonzalez, Margarita Sanchez-Dominguez, Celia N. Sanchez-Dominguez, Jose Francisco Islas
Summary: Pancreatic cancer is the most common lethal tumor in America, with limited treatment options and several side effects. Utilizing targeted nanoparticles as an alternative treatment for pancreatic cancer aims to reduce side effects and improve treatment outcomes by identifying and attacking cancer cells specifically.
Article
Chemistry, Multidisciplinary
Catia T. Perciani, Lewis Y. Liu, Lawrence Wood, Sonya A. MacParland
Summary: The use of engineered nanoparticles has shown promise in enhancing vaccine efficacy and host immune responses to viral and tumor antigens. By harnessing the properties of nanoparticles, it may be possible to overcome current obstacles in vaccinology and oncology.
Article
Environmental Sciences
Nelofer Jan, Neelofar Majeed, Muneeb Ahmad, Waseem Ahmad Lone, Riffat John
Summary: Nanoparticles are highly diverse in quality and sources of emission. The lack of rules and regulations has led to severe impacts on the environment and human health, with only a few studies assessing their toxic effects. Further research is needed to determine the actual impacts of nanoparticles on the environment and human health.
Review
Chemistry, Multidisciplinary
Sena Karaosmanoglu, Mengjiao Zhou, Bingyang Shi, Xiujuan Zhang, Gareth R. Williams, Xianfeng Chen
Summary: The clinical applications of many anti-cancer drugs are limited by their hydrophobic nature, leading to the development of carrier-based nanoparticles. However, these strategies often fail to efficiently encapsulate drugs and may cause toxicity problems in the long term. Therefore, elegantly designed strategies for carrier-free nanodrugs, including simple self-assembly and chemical modifications, are desired for high quality, stability, and performance.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Biomaterials
Hongsen Wang, Yu Wang, Zhaohui Zheng, Fang Yang, Xiaobin Ding, Aiguo Wu
Summary: In this study, four donor-acceptor compounds were synthesized to develop a multifunctional single molecule phototherapeutic agent with excellent fluorescence imaging, photothermal therapy, and photodynamic therapy. The compounds exhibited aggregation-induced emission characteristics and had long emission wavelengths, photostability, biocompatibility, photothermal stability, and singlet oxygen generation performance. The photothermal conversion efficiency of one of the compounds reached 84.5%. Cellular internalization and therapy demonstrated the compounds' good biocompatibility, excellent cell bioimaging, and cancer phototherapy capabilities in vitro.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biotechnology & Applied Microbiology
Lynn N. Jena, Lindsey A. Bennie, Emma M. McErlean, Sreekanth Pentlavalli, Kim Glass, James F. Burrows, Vicky L. Kett, Niamh E. Buckley, Jonathan A. Coulter, Nicholas J. Dunne, Helen O. McCarthy
Summary: A nano-formulation with the RALA peptide complexed with the N-BP, alendronate (ALN), demonstrated significant anticancer effects in GBM cells. The RALA/ALN NPs decreased colony formation, induced apoptosis and slowed spheroid growth in vitro, while also inhibiting prenylation. The lyophilisation of the NPs enhanced stability for potential scale-up and in vivo applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemical Research Methods
Junfeng Yao, Wen Sun, Zhongquan Jian, Qingqiang Wu, Xiaoli Wang
Summary: This paper proposes a novel model that incorporates complex relations of side effects into knowledge graph embeddings to predict the side effects of polypharmacy. Experimental results show that the model outperforms other methods in terms of performance.
Article
Microbiology
Snehal Patil, Murali Sastry, Atul Bharde
Summary: This study reports on the biological synthesis of plasmonic nanoparticles using bacterial metabolites. The researchers found that two metabolites obtained from a marine strain of Pseudomonas aeruginosa could rapidly produce gold and silver plasmonic nanoparticles. The morphology of the nanoparticles could be controlled by adjusting the concentration of the metabolites and the reaction time. The biologically obtained nanoparticles retained the metabolites on their surface and exhibited potent anticancer activities against metastatic lung cancer cells, indicating their potential for cancer nanomedicine.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiaohua Wang, Haiyue Lu, Baicheng Liao, Gen Li, Liyong Chen
Summary: In this study, a facile synthetic method for preparing LDH-based self-assembly structures via a metal ions-mediated zeolitic imidazolate framework-8 (ZIF-8) transformation process is proposed. The loading and release of small molecular weight drugs using hierarchical porous ZIF-8@LDHs core-shell structures and porous cages of LDHs (PC-LDHs) in drug delivery systems are studied. The results show that PC-LDHs outperform ZIF-8@LDHs core-shell structures in terms of drug delivery performance, indicating the decisive role of LDH nanosheets in the drug delivery process. This study provides the preliminary preparation for an LDH-based nanomedicine platform in the field of cancer therapy.
Article
Pharmacology & Pharmacy
Maria Gabriela Villamizar-Sarmiento, Juan Guerrero, Ignacio Moreno-Villoslada, Felipe A. Oyarzun-Ampuero
Summary: This study investigates the efficient association and controlled release of HALMD in polymeric nanoparticles, emphasizing the role of drug self-association tendency and aromatic-aromatic interaction with the polymer. The results show that lower cac values lead to stronger binding to the polymer, impacting the formation of NPs and drug release profiles. These findings highlight the importance of rational design for efficient drug delivery systems.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Daniel Emmanuel Ekpo, Parker Elijah Joshua, Arome Solomon Odiba, Okwesilieze Fred Chiletugo Nwodo
Summary: The flavonoid-rich fraction of Lasianthera africana leaves showed significant antioxidant, hepatoprotective, and curative effects in a carbon tetrachloride-induced hepatotoxicity rat model. LAFRF reduced lipid peroxidation levels, liver enzyme activities, increased antioxidant status, and improved hepatic histo-architecture in pre- and post-treated rats, indicating its potential for future drug development.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Cell Biology
Janet Olayemi Olugbodi, Keren Samaila, Bashir Lawal, Oluchukwu Ogechukwu Anunobi, Roua S. Baty, Omotayo Babatunde Ilesanmi, Gaber El-Saber Batiha
Summary: Ischemia-reperfusion injury can lead to testicular damage and infertility, and this study showed that Proxeed Plus has anti-inflammatory and antioxidant effects against testicular assault.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Yanjun Wu, Xiangxing Zhu, Arome Solomon Odiba, Zisheng Lin, Jiancong Wen, Daoyuan Gong, Jing Liang, Shuguang Wu, Ganqiu Lan
Summary: This study aimed to investigate the liver transcriptome of Kunming mice induced with diabetes by either streptozotocin (STZ) or non-STZ. The results showed that a high-fat, high-carbohydrate diet combined with a low dose of STZ effectively induced diabetes in Kunming mice despite abnormal gene expression in the liver. Genes differentially expressed were related to metabolism mediated by p53.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Nkwachukwu Oziamara Okoro, Arome Solomon Odiba, Patience Ogoamaka Osadebe, Edwin Ogechukwu Omeje, Guiyan Liao, Wenxia Fang, Cheng Jin, Bin Wang
Summary: Plants and their products, whether in the form of herbs or functional foods, are rich in bioactive phytochemicals that have medicinal, culinary, and nutraceutical applications. These bioactive compounds have been found to possess antioxidant, anti-inflammatory, anti-carcinogenic, and antimicrobial properties, among others, which can improve health quality in humans and animals. Efforts to discover and study these bioactive compounds have been intensified using the Caenorhabditis elegans aging model, revealing common aging and longevity pathways shared between C. elegans and humans.
Article
Biochemistry & Molecular Biology
Arome Solomon Odiba, Chiemekam Samuel Ezechukwu, Guiyan Liao, Siqiao Li, Zhongliang Chen, Xihui Liu, Wenxia Fang, Cheng Jin, Bin Wang
Summary: This study demonstrates the essential role of C. elegans NSE-4 in genome maintenance and DNA repair, particularly in maintaining chromosomal structure and repairing chemically induced DNA damage. Additionally, NSE-4 is involved in inter-sister repair during meiosis and is crucial for the localization of NSE-1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Christian Chijioke Amah, Parker Elijah Joshua, Daniel Emmanuel Ekpo, Jacob Ikechukwu Okoro, Rita Onyekachukwu Asomadu, Ursula Chidimma Obelenwa, Arome Solomon Odiba
Summary: This study demonstrated the antidiabetic potential of the ethyl acetate fraction of Fagara zanthoxyloides root-bark, providing scientific basis for its traditional use in treating diabetes and its complications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Infectious Diseases
Arome Solomon Odiba, Olanrewaju Ayodeji Durojaye, Ifeoma Maureen Ezeonu, Anthony Christian Mgbeahuruike, Bennett Chima Nwanguma
Summary: Resistance to antifungal drugs for treating Candida infections remains a major concern globally. This study identified new molecular adaptations of Candida isolates that explain their resistance to the drug fluconazole.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi
Summary: This study investigated the immunomodulatory effects of aqueous seed extract of Datura stramonium L. (ASEDS) on Wistar rats. The results showed that ASEDS could improve immune cell counts, immunoglobulin synthesis, high-density lipoprotein concentration, and antioxidant status of rats.
Article
Microbiology
Sayed Usman, Chao Du, Qijian Qin, Arome Solomon Odiba, Rui He, Bin Wang, Cheng Jin, Wenxia Fang
Summary: Aspergillus flavus is a common fungal pathogen that causes invasive aspergillosis in humans and produces highly carcinogenic mycotoxins in postharvest crops. The study reveals that phosphomannose isomerase (PMI) plays an important role in the growth, conidiation, stress responses, and pathogenicity of A. flavus, suggesting it as a potential target for combating infection and controlling aflatoxin contamination caused by A. flavus.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Yuchen Sun, Jin Xie, Lihua Tang, Arome Solomon Odiba, Yanlu Chen, Wenxia Fang, Xiaogang Wu, Bin Wang
Summary: Plant parasitic nematodes (PPNs) are difficult to control due to their destructiveness and resistance to existing pesticides. Conventional chemical nematicides are toxic and harmful to the environment. Therefore, the screening of nematicidal microbial resources and the identification of natural products are important for environmentally friendly control. In this study, a strain called DT10 was isolated from moss samples and identified as Streptomyces sp. The compound spectinabilin was isolated from DT10 and showed high nematicidal activity on Caenorhabditis elegans. Spectinabilin exhibited a different mode of action compared to currently used nematicidal drugs. These findings suggest that spectinabilin has potential as a biological nematicide.
Article
Multidisciplinary Sciences
Olanrewaju Ayodeji Durojaye, Nkwachukwu Oziamara Okoro, Arome Solomon Odiba, Bennett Chima Nwanguma
Summary: SARS-CoV-2 infection has caused millions of deaths worldwide and severely impacted economies. Developing effective therapeutics against the virus is a top priority. Many existing drugs have limitations, and research is focused on discovering broad-spectrum antivirals that target conserved pathways.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Kei Yamaya, Bin Wang, Nadin Memar, Arome Solomon Odiba, Alexander Woglar, Anton Gartner, Anne M. Villeneuve
Summary: RAD54 family DNA translocases, together with RAD51 recombinases, play a role in maintaining genome stability. Studying the functions of RAD54 paralogs RAD-54.L and RAD-54.B in Caenorhabditis elegans during meiotic prophase reveals their distinct contributions to the dynamics of RAD-51 association with DNA and meiotic double-strand break repair. RAD-54.L is essential for RAD-51 removal from meiotic double-strand break sites, while RAD-54.B prevents excessive accumulation of RAD-51 on unbroken DNA. This study provides insights into the division of labor among RAD-54 paralogs in promoting efficient homologous recombination and preventing deleterious effects of unproductive RAD-51 association.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Nutrition & Dietetics
Nkwachukwu Oziamara Okoro, Arome Solomon Odiba, Qi Yu, Bin He, Guiyan Liao, Cheng Jin, Wenxia Fang, Bin Wang
Summary: Dendrobium officinale, a widely used medicinal herb, has gained attention for its polysaccharide content and its potential medicinal properties. In this study, the anti-aging potential of polysaccharides extracted from D. officinale grown in different environments was investigated using Caenorhabditis elegans as a model. The findings showed that greenhouse-grown D. officinale polysaccharides had the optimal effect of extending lifespan and enhancing stress resistance. These results provide valuable information for the cultivation and medicinal applications of D. officinale.
Article
Biology
Edeke Affiong Asuquo, Okwesilieze Fred Chiletugo Nwodo, Anosike Chioma Assumpta, Uchendu Nene Orizu, Okoro Nkwachukwu Oziamara, Odiba Arome Solomon
Summary: Eggplant and African eggplant have the potential to combat obesity by inhibiting the expression levels of the FTO gene in high-fat diet-induced obese animals, while also showing therapeutic effects on obesity-related injuries.
OPEN LIFE SCIENCES
(2022)
Article
Genetics & Heredity
Olanrewaju Ayodeji Durojaye, Nkwachukwu Oziamara Okoro, Arome Solomon Odiba
Summary: This study characterized a poorly understood coronavirus accessory protein, revealing high similarity between SARS-CoV-2 and previously characterized proteins. The generated protein model was of good quality, supporting future in vitro and in vivo experiments to devise therapeutics against the virus. Phylogenetic analysis confirmed the relationship between SARS-CoV-2 and other related coronaviruses.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2021)
