Article
Plant Sciences
Paula Schons Vieceli, Paulo Jose Lima Juiz, Pedro Santana Sales Lauria, Ricardo David Couto, Therezinha Coelho Barbosa Tomassini, Ivone Maria Ribeiro, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
Summary: Physalis angulata has been widely used in folk medicine for treating inflammatory conditions, including oral inflammatory diseases. The ethanolic extract of P. angulata showed protective effects in a murine model of chronic periodontitis, potentially through modulation of cytokines and inhibition of NF-?B transcriptional activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Vivian Cristina Noronha Novaes, Edilson Ervolino, Giovani Lopes Fernandes, Clara Possarle Cunha, Leticia Helena Theodoro, Valdir Gouveia Garcia, Juliano Milanezi de Almeida
Summary: Chemotherapy with antineoplastic agents 5-FU and CIS increased the intensity and duration of inflammation and compromised tissue repair by reducing cellular and vascular turnover. The more severe periodontal breakdown was caused by 5-FU.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Physiology
Rajendra P. Settem, Kiyonobu Honma, Sreedevi Chinthamani, Toshihisa Kawai, Ashu Sharma
Summary: Periodontitis is an inflammatory disease caused by bacteria, with dysregulated immune response playing a significant role in alveolar bone resorption. Specifically, activated B cells producing RANKL have been found to contribute significantly to alveolar bone loss in the presence of periodontal pathogens.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Ting-Yen Kuo, Ming-Chieh Hsieh, Chia-Dan Cheng, Ren-Yeong Huang, Thomas E. Van Dyke, Cheng-En Sung, Chen-Ying Wang, Yi-Shing Hsieh, Wan-Chien Cheng
Summary: This study aimed to evaluate the impact of chlorhexidine (CHX) gel on inflammation-induced periodontal tissue destruction, osteoclastogenesis, subgingival microbiota, and on the modulation of the RANKL/OPG as well as inflammatory mediators during bone remodeling in vivo. The results showed that CHX gel significantly reduced alveolar bone destruction, osteoclast number, and RANKL protein level. It also decreased inflammatory cell infiltration and the expression of inflammatory mediators COX-2 and iNOS. Evaluation of the subgingival microbiota revealed changes in rats with CHX gel treatment.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Pengfei Zhao, Aimin Xu, Wai Keung Leung
Summary: Obesity and periodontitis are common health concerns with negative relationships. Obesity leads to bone metabolic disorders and increased risks of periodontitis and alveolar bone loss. This review summarizes the clinical changes in periodontium and the biological interlinks in obesity-associated bone remodeling. The potential mechanism underlying obesity-enhanced alveolar bone loss is also discussed, providing practical considerations for managing periodontal disease in obese patients.
Article
Plant Sciences
Zhengxiang Xia, Qin Li, Zhongyan Tang
Summary: This study investigated the efficacy and pharmaceutical mechanism of action of the Chinese herbal formula Ermiao Wan (EMW) against periodontitis. Results showed that EMW could prevent alveolar bone loss and inhibit inflammation, potentially through regulating the PI3K/AKT and NF-Kappa B/MAPK signal pathways. Therefore, EMW could be a potential therapy for periodontitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Chufang Liao, Shanshan Liang, Yining Wang, Ting Zhong, Xiangning Liu
Summary: Sclerostin, the protein product of the SOST gene, has inhibitory effects on bone formation. Recent studies have found its expression in various functional cell types in oral tissues and its involvement in the development of oral diseases. Further research is needed to explore the potential therapeutic implications of sclerostin in the field of dentistry.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
P. Tegelberg, T. Tervonen, M. Knuuttila, T. Saxlin, P. Ylostalo
Summary: This study aimed to investigate the association between long-term obesity, long-term central obesity, weight gain and alveolar bone loss. A sub-population of the Northern Finland Birth Cohort 1966 was categorized based on BMI and waist circumference at ages 31 and 46. The results showed that the associations of long-term obesity and weight gain with alveolar bone loss were stronger in smokers and males who passed on to higher BMI and waist circumference categories.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Genetics & Heredity
Yanan Yang, Lingxia Wang, Haibing Zhang, Lijun Luo
Summary: MLKL-mediated necroptosis plays a significant role in the pathogenesis of periodontitis, as evidenced by increased expression of MLKL in gingival tissues of patients with periodontitis and the impact of Mlkl deficiency on the development of the disease. These findings highlight the importance of necroptosis in inflammatory responses in periodontitis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Cell Biology
Hua Liu, Yingjie Xu, Qi Cui, Ning Liu, Fuhang Chu, Beibei Cong, Yingtao Wu
Summary: The study found that psoralen can reduce alveolar bone loss in rats with periodontitis, promote the secretion of anti-inflammatory factor IL-10, decrease the level of pro-inflammatory factor TNF-alpha, and reduce the RANKL/OPG ratio.
Article
Biochemistry & Molecular Biology
Su-Jin Kim, Se Hui Lee, Binh Do Quang, Thanh-Tam Tran, Young-Gwon Kim, Jun Ko, Weon-Young Choi, Sun Young Lee, Je-Hwang Ryu
Summary: This study verified the protective effects of Avenanthramide-C (Avn-C) on periodontal inflammation and alveolar bone erosion. Avn-C treatment decreased the expression of catabolic factors and ameliorated alveolar bone erosion. The inhibitory effects of Avn-C were mediated by the ERK, NF-κB, p38 MAPK, and JNK signaling pathways.
MOLECULES AND CELLS
(2023)
Review
Pharmacology & Pharmacy
Putri Ayu Jayusman, Nurrul Shaqinah Nasruddin, Badiah Baharin, Nurul Izzah Ibrahim, Haryati Ahmad Hairi, Ahmad Nazrun Shuid
Summary: Osteoporosis and periodontitis are often seen in postmenopausal women and are related to systemic bone loss and alveolar bone loss. Phytoestrogens, which are plant-based estrogen-like compounds, have been widely studied for the treatment of menopause-related symptoms, but there is limited research on their effect on alveolar bone in postmenopausal osteoporosis. Further studies are needed to explore the therapeutic effects of phytoestrogens on bone protection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Turan Emre Kuzu, Kuebra Ozturk, Cem A. Gurgan, Arzu Yay, Ozge Goktepe, Alpdogan Kantarci
Summary: Objective: This study aimed to investigate the potential anti-inflammatory effect of paeoniflorin (Pae) on diabetic periodontitis and its impact on bone loss.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Immunology
Xueying Ma, Xin Chen, Zhonghua Duan, Yuqiong Wu, Jiaen Shu, Pei Wu, Yiguo Zhao, Xu Wang, Yuhua Wang
Summary: Circadian rhythm disruption (CRD) promotes the inflammatory response of macrophages, and the role of macrophages in periodontitis remains unclear. The study found that CRD increased infiltration and activation of macrophages, and the key regulator Kdm6a may be involved in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sara Alrumaih, Nouf Alshibani, Lamees Alssum, Fahad A. Alshehri, Mohammed A. Almayrifi, Mohammed Almayouf, Ali Alrahlah, Leonel S. J. Bautista
Summary: This study aimed to investigate the effect of RvE1 on bone regeneration in Wistar rats with critical-size defects. The results showed that the combination of RvE1 and bovine bone graft significantly enhanced bone regeneration.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zheng Wang, Yanan Zhang, Yijia Yin, Jiang Liu, Peiran Li, Yuxi Zhao, Ding Bai, Hang Zhao, Xianglong Han, Qianming Chen
Summary: In this study, a high-strength and injectable supramolecular hydrogel was successfully fabricated by constructing a multi-hydrogen-bonding system. The hydrogel exhibited excellent biocompatibility and antibacterial activity, and showed improved bone healing compared to natural healing and commercial gelatin sponge.
ADVANCED MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yiruo He, Yangyang Wang, Xinghai Wang, Jiangyue Wang, Ding Bai, Yongwen Guo
Summary: This case report presents the successful nonsurgical treatment of a 20-year-old male patient with hyperdivergent skeletal Class III malocclusion. Using miniscrews and other auxiliary tools, proper occlusion and improved facial profile were achieved.
ANGLE ORTHODONTIST
(2022)
Review
Cell & Tissue Engineering
Lingyi Huang, Zizhuo Zheng, Ding Bai, Xianglong Han
Summary: This article summarizes the biological characteristics of stem cells from human exfoliated deciduous teeth (SHEDs) and their potential role in the prevention and treatment of neurological diseases and injuries.
CURRENT STEM CELL RESEARCH & THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ye Tian, Gao Huang, Xiang Xiang, Ning Wang, Wenyu Dai, Jiajun Chen, Rui Shu, Ding Bai, Hui Xu
Summary: This study identified the key parameter for the positioning of anterior teeth in 45 degrees angled smiles through 3-dimensional facial image processing and geometric analysis. It provides an important reference for esthetic assessment and establishes esthetic ranges for different observers.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Endocrinology & Metabolism
Zhongyu Liu, Yijia Yin, Zheng Wang, Liang Xie, Peng Deng, Donghui Wang, Ning Ji, Hang Zhao, Xianglong Han, Qianming Chen, Chun-Hsi Chung, Ding Bai, Xuefeng Zhao
Summary: Fibrous dysplasia (FD) is a rare bone disease caused by GNAS mutation, and there is currently no cure available. Inhibition of RANKL expression has been identified as a potential therapy for FD. This study evaluated the effects of a small-molecule RANKL inhibitor (A52676293) on a transgenic FD mouse model, and found that it effectively suppressed osteoclastogenesis and halted FD progression. The results suggest that RANKL inhibition could be an effective treatment for FD.
Article
Biochemistry & Molecular Biology
Yiruo He, Ye Tian, Wenjie Zhang, Xinghai Wang, Xue Yang, Bin Li, Liming Ge, Ding Bai, Defu Li
Summary: The oxidized sodium alginate (OSA) collagen heterogeneous bilayer barrier membrane with well-controlled pore size presents a significant improvement in promoting osteogenesis and enhancing barrier function, showing important implications for bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Jiangyue Wang, Sa Cha, Qing Zhao, Ding Bai
Summary: This systematic review aimed to explore the diagnostic accuracy of CBCT and ultrasound for gingival thickness measurement. The results showed no significant difference between CBCT measurement and transgingival probing in both anterior and posterior dentition. A moderate correlation was observed between CBCT and transgingival probing, while a weak correlation was found between ultrasound measurement and transgingival probing.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2022)
Article
Engineering, Biomedical
Yi Deng, Jiacheng Shi, Yau Kei Chan, Ding Bai, Rui Shu, Xiuyuan Shi, Yunfei Li, Limei Li, Xiao Yang, Weizhong Yang
Summary: In this study, a heterostructured coating was created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multiple mechanisms and effectively kills bacteria through photothermal/photodynamic effects and photo-induced accelerated ion release. The results confirmed the excellent osteogenicity and osseointegration of the heterostructured orthopedic implant, as well as its photoswitchable disinfection controlled by NIR light.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yipeng Wang, Peiqi Wang, Xiang Xiang, Hui Xu, Yuting Tang, Yumeng Zhou, Ding Bai, Chaoran Xue
Summary: The study proposed a standardized protocol for 3D-printed splints and assessed the precision of splints with different occlusal coverage depths. Results showed that deviations were more evident in the vertical dimension and pitch rotation, increasing as the occlusal coverage depth increased. Splints with 2-mm and 3-mm occlusal coverage depths are recommended for precision relative to clinical acceptability.
Article
Cell Biology
Sa Cha, Jiangyue Wang, Sueng Min Lee, Zhen Tan, Qing Zhao, Ding Bai
Summary: Age-related bone loss and disease have a significant impact on the quality of life for the elderly population. This study explores the role of cellular circadian rhythms and miRNAs in regulating bone aging. It shows that miR-142-3p downregulates Bmal1, reducing the osteogenic potential of BMSCs, while Bmal1 promotes BMSCs osteogenesis by inhibiting YAP expression. Cell-based circadian therapy improves bone formation and turnover levels.
CELL DEATH DISCOVERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiaomeng Dong, Jie Feng, Bin Li, Ding Bai, Hui Xu
Summary: This study found that interleukin-33 (IL-33) inhibits osteoclastogenesis in the periodontal ligament (PDL) under orthodontic loading, partly through directly affecting osteoclast precursors and partly through cementoblast-mediated release of granulocyte-macrophage colony-stimulating factor (GM-CSF).
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Genetics & Heredity
Peiqi Wang, Xinghan Sun, Qiang Miao, Hao Mi, Minyuan Cao, Shan Zhao, Yiyi Wang, Yang Shu, Wei Li, Heng Xu, Ding Bai, Yan Zhang
Summary: This study investigated the genetic predispositions of aesthetic facial traits in the Chinese population. Several novel genetic associations were identified, and functional annotation and polygenic scores were used to understand the genetic basis of these traits.
FRONTIERS IN GENETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bin Li, Peiqi Wang, Hui Xu, Rui Gu, Xianglong Han, Ding Bai, Chaoran Xue
Summary: The study found that offset design influenced the accuracy of vertical bracket placement with GBDs, with TF being preferable to EF for GBDs due to smaller deviations in angulation and rotation. The differences between TF and EF also need to be considered in the design of other dental CAD/CAM devices.
JOURNAL OF OROFACIAL ORTHOPEDICS-FORTSCHRITTE DER KIEFERORTHOPADIE
(2022)
Article
Chemistry, Multidisciplinary
Bin Li, Rui Shu, Wenyu Dai, Fan Yang, Hui Xu, Xiuyuan Shi, Yunfei Li, Ding Bai, Weizhong Yang, Yi Deng
Summary: The study presents a bioheterojunction-engineered orthopedic implant that addresses the challenges of infection and high glucose levels in diabetic patients. The engineered implant uses a combination of bioheterojunctions and chemical reactions to kill bacteria and promote bone integration. In vivo experiments confirm the effectiveness of the implant in eliminating biofilm and promoting vascularization for improved osseointegration.
Article
Dentistry, Oral Surgery & Medicine
Peiqi Wang, Hui Xu, Rui Gu, Liwei Zhu, Ding Bai, Chaoran Xue
Summary: This study introduces a noninvasive and efficient protocol for integrating the digitized maxillary dentition with a 3D facial photo. By using a modified CAD/CAM facebow, this protocol generates 3D fused images with colored faces and high-resolution dentitions. The protocol shows high integration accuracy and reproducibility, providing accurate and reproducible results.