Article
Endocrinology & Metabolism
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The level of gestational weight gain (GWG) during pregnancy is associated with adverse pregnancy outcomes in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT). Low GWG below recommended levels frequently occurs in GDM women without increased risk for adverse outcomes. Excessive GWG is associated with increased risk for neonatal hypoglycemia and worse metabolic profile postpartum in GDM women, and with higher rates of instrumental delivery and larger infants in NGT women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Aiqi Yin, Fuying Tian, Xiaoxia Wu, Yixuan Chen, Kan Liu, Jianing Tong, Xiaonian Guan, Huafan Zhang, Linlin Wu, Jianmin Niu
Summary: This study evaluated the effect of weight gain in different trimesters on the risk of gestational diabetes mellitus (GDM). The results showed that insufficient weight gain in early pregnancy and excessive weight gain in middle pregnancy were associated with an increased risk of GDM. Strict control of weight gain in early pregnancy and sufficient nutrition in middle pregnancy are necessary.
CHINESE MEDICAL JOURNAL
(2022)
Article
Obstetrics & Gynecology
Huiling Xu, Jennifer A. Hutcheon, Xingrong Liu, Olof Stephansson, Sven Cnattingius, Elizabeth Arkema, Kari Johansson
Summary: This study investigated the association between gestational weight gain in early pregnancy and before diagnosis and the risk of gestational diabetes mellitus (GDM). The results showed that higher weight gain before diagnosis was associated with increased risk of GDM in all BMI groups, except for obese class III. Additionally, higher weight gain in early pregnancy was associated with increased risk of GDM in overweight women, while lower weight gain was associated with reduced risk of GDM in obese women. The findings suggest that obese women may benefit from lower weight gain, especially in early pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Endocrinology & Metabolism
Xiaoqin Luo, Jiayi Gao, Zhangya He, Jing Ji, Wanyu Zhang, Pei Wu, Xiaoxiao Guo, Dan Cao, Zhangrui Xu, Chao Li, Yang Mi
Summary: This study investigated the appropriate range of gestational weight gain (GWG) in gestational diabetes mellitus (GDM) women and found that a stricter GWG range can prevent adverse pregnancy outcomes better than the recommendation of the US Institute of Medicine (IOM).
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Environmental Sciences
Andrea L. Deierlein, Haotian Wu, Allan C. Just, Allison J. Kupsco, Joseph M. Braun, Emily Oken, Diana C. Soria-Contreras, Alejandra Cantoral, Ma Luisa Pizano, Nia McRae, Martha M. Tellez-Rojo, Robert O. Wright, Andrea A. Baccarelli
Summary: The study found that prenatal exposure to phthalates was negatively associated with gestational weight gain and positively associated with long-term changes in maternal weight. Further investigation is needed to understand how phthalates influence body composition and whether they contribute to the development of obesity and other cardiometabolic diseases in women.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Qiuhong Zhang, Chee Shin Lee, Lixia Zhang, Qi Wu, Yunyan Chen, Danqing Chen, Lu Qi, Zhaoxia Liang
Summary: Different factors, such as advanced age and high pre-pregnancy BMI, contribute to elevated HbA1c levels in pregnant women with GDM. Monitoring and controlling blood glucose levels have shown effectiveness in reducing adverse pregnancy outcomes, especially in cases of excessive GWG.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Xiao-guang Yin, Peng Wang, Mei-ting Zhou, De-qin Li, Rui-xue Tao, Fang-biao Tao, Yang Wang, Peng Zhu
Summary: The timing of gestational diabetes mellitus (GDM) diagnosis and gestational weight gains (GWG) during pregnancy are associated with the growth trajectory of children from perinatal to early childhood. GDM diagnosed before 26 weeks increases the risk of fetal overgrowth and higher birth weight, as well as higher BMI peak within 48 months. Maternal early GDM diagnosis and excessive gestational weight gains have additive impacts on offspring overgrowth, with higher levels of hsCRP observed in the early EGWG group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Ksawery Golawski, Wojciech Giermaziak, Michal Ciebiera, Cezary Wojtyla
Summary: Adequate weight gain during pregnancy is important for a healthy pregnancy, but excessive weight gain is associated with adverse pregnancy outcomes. Based on a Polish national survey of 10,319 women and 6930 children, excessive gestational weight gain is associated with higher birthweight, increased risk of birthweight over 4500 g, cesarean section/assisted delivery, pregnancy induced hypertension, hospitalization during pregnancy, and lower Apgar score in the first minute of neonate's life. However, there was no significant difference in premature rupture of membranes and labor inductions. Our study highlights the increased risk of adverse pregnancy outcomes with excessive gestational weight gain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tiange Sun, Fanhua Meng, Shufei Zang, Yue Li, Rui Zhang, Zhiyan Yu, Xinmei Huang, Fang Wang, Liwen Zhang, Jun Liu
Summary: This study found that insulin therapy for women with gestational diabetes was associated with a slight increase in maternal weight but a significant risk of increasing maternal blood pressure.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Multidisciplinary Sciences
Sara L. White, Dharmintra Pasupathy, Shahina Begum, Naveed Sattar, Scott M. Nelson, Paul Seed, Lucilla Poston
Summary: This study assessed the relationship between clinical risk factors, anthropometric measures of adiposity, and weight gain with the development of gestational diabetes mellitis (GDM) in pregnant women with obesity. The study found that age, previous GDM experience, and systolic blood pressure were early clinical risk factors, while subscapular skinfold thickness and neck circumference in the second trimester were positively associated with GDM. The study highlights the importance of modifiable factors before pregnancy in GDM prevention.
Article
Medicine, General & Internal
Teresa A. Hillier, Kathryn L. Pedula, Keith K. Ogasawara, Kimberly K. Vesco, Caryn E. S. Oshiro, Suzanne L. Lubarsky, Jan Van Marter
Summary: In this study comparing one-step screening with two-step screening for gestational diabetes mellitus, the one-step approach resulted in more diagnoses of gestational diabetes mellitus but did not have a significant impact on the incidence of adverse perinatal and maternal outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Obstetrics & Gynecology
Jiang-Feng Ke, Sheng Liu, Ri-Le Ge, Li Ma, Mei-Fang Li
Summary: In women with gestational diabetes mellitus (GDM), maternal pre-pregnancy body mass index (ppBMI) and gestational weight gain (GWG) are associated with adverse pregnancy outcomes (APOs). The study found that obese mothers and excessive GWG increase the risk of APOs, while inadequate GWG increases the risk of preterm birth.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Kamini Dangat, Sanjay Gupte, Girija Wagh, Sanjay Lalwani, Karuna Randhir, Shweta Madiwale, Hemlata Pisal, Vrushali Kadam, Shridevi Gundu, Nomita Chandhiok, Bharati Kulkarni, Sadhana Joshi, Caroline Fall, Harshpal Singh Sachdev
Summary: This study aimed to evaluate the trimester specific gestational weight gain (GWG) in Indian pregnant women and compare it with international and Indian reference data. The study found that Indian women had lower GWG compared to international standards, but higher GWG compared to Indian reference data. Maternal BMI, age, parity, hemoglobin concentrations, and height were found to be associated with GWG.
FRONTIERS IN MEDICINE
(2022)
Review
Nutrition & Dietetics
Shan Wu, Jiani Jin, Kai-Lun Hu, Yiqing Wu, Dan Zhang
Summary: This study aimed to evaluate the optimal intervention strategy to prevent gestational diabetes mellitus (GDM) and restrict gestational weight gain (GWG) among overweight/obese pregnant women. The results showed that PA and diet + PA interventions had a trend of preventing GDM, and interventions of diet, PA, and diet + PA were significant factors to restrict GWG. Overall, a combination of diet and physical activity intervention seemed to be the superior choice for both GDM prevention and excessive GWG.
Article
Endocrinology & Metabolism
Ning Wang, Yanqi Peng, Lu Wang, Lin Song, Bo Sun, Junxiang Wei, Ting Wang, Yang Mi, Wei Cui
Summary: The study aimed to analyze the risk factors for gestational diabetes mellitus (GDM) heterogeneity and its correlation with obesity. Results showed that GDM patients exhibit different glycemic physiology types, with specific obesity-related risk factors for the GDM-resistance subtype mediated by pre-pregnancy overweight/obesity and increased gestational weight gain in the first trimester.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Substance Abuse
Zeliha Donmez, Sakir Gica, Basak Unubol, M. Sinan Iyisoy, Huseyin Gulec
Summary: This study aims to determine changes in social cognition and other cognitive domains in ADHD comorbidity and investigate their moderating role in OUD. Findings suggest that changes in social environment/cognition are important in the follow-up/treatment of patients.
JOURNAL OF ETHNICITY IN SUBSTANCE ABUSE
(2021)
Article
Virology
Ahmet Cizmecioglu, Hilal Akay Cizmecioglu, Mevlut Hakan Goktepe, Ayca Emsen, Celalettin Korkmaz, Fatma Esenkaya Tasbent, Fatma Colkesen Consultant, Hasibe Artac
Summary: Elevated levels of acute-phase reactants and lymphopenia are indicative of disease severity in COVID-19. This study focused on investigating the role of apoptosis in lymphopenia in COVID-19 patients. Results showed an increase in apoptosis in B and T lymphocytes, particularly in severe cases, suggesting a potential association between lymphocyte apoptosis and disease severity in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Alison Weidner
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2021)
Article
Biochemistry & Molecular Biology
Esra Fidan, Z. Isik Solak Gormus, Ibrahim Kilinc, Mehmet Sinan Iyisoy, Niyazi Gormus
Summary: The study found that the combination of the antioxidant ion Mg+2 and the selective serotonin reuptake inhibitor sertraline has synergistic effects in the treatment of major depression and regulation of inotropic effect in the early postoperative period. However, this combined treatment may lead to shortened blood clotting time and significant decrease in blood lipids, as well as an increase in plasma enzymes, posing potential risks. Further studies are needed to evaluate the safety and efficacy of using magnesium combined with antidepressants for pre or post-operative depression.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Urology & Nephrology
Yasemin Coskun Yavuz, Nihal Cetin, Esma Menevse, Ahmet Cizmecioglu, Esin Celik, Zeynep Biyik, Can Sevinc, Serkan Yavuz, Muslu Kazim Korez, Lutfullah Altintepe
Summary: The study suggests that magnesium sulfate may have a nephrotoxicity-reducing effect on colistin, as it decreases urea and creatinine levels, reduces MDA levels, and improves renal tissue damage caused by colistin.
Article
Cardiac & Cardiovascular Systems
Yalcin Gunerhan, Mehmet Isik, Yuksel Dereli, Omer Tanyeli, Cengiz Kadiyoran, Mehmet Sinan Iyisoy, Niyazi Gormus
Summary: Volumetric changes in the aneurysm sac were evaluated in intact AAA patients following EVAR, showing a gradual decrease in total aneurysm volume, a temporary increase and subsequent decrease in thrombus-coated aneurysm wall volume, and a continuous decrease in patent lumen volume after 6, 12, and 24 months postoperatively.
CARDIOVASCULAR JOURNAL OF AFRICA
(2021)
Article
Immunology
Ahmet Cizmecioglu, Ayca Emsen, Sua Sumer, Dilek Ergun, Hilal Akay Cizmecioglu, Hatice Turk Dagi, Hasibe Artac
Summary: This study aimed to evaluate monocyte subsets and HLA-DR expressions in COVID-19 patients. The results showed that monocyte and HLA-DR expressions were decreased in COVID-19 patients compared with healthy controls. The expressions of CL and INT monocytes were further decreased in severe patients. NC monocytes were more affected in patients with different clinical features. These findings suggest that decreased monocyte HLA expressions may indicate immune suppression in severe COVID-19 patients.
Article
Medicine, General & Internal
Ahmet Cizmecioglu, Dilek Tezcan, Selda Hakbilen, Sema Yilmaz
Summary: This study found that CRT is significantly prolonged in patients with SSc, and in patients with pathological NFC, CRT results are also prolonged and accompanied by higher pulmonary artery pressure levels. Therefore, evaluating CRT with NFC positivity may predict pulmonary progression in patients with SSc, especially in dSSc patients.
KONURALP TIP DERGISI
(2022)
Article
Cardiac & Cardiovascular Systems
Betul Kozanhan, Tolga Semerkant, Hidir Esme, Ahmet Canitez, Mehmet Sinan Iyisoy
Summary: This study evaluates the efficacy of rhomboid intercostal and subserratus plane (RISS) block for postoperative pain relief after thoracic surgeries. The results show that continuous RISS block reduces postoperative pain scores, decreases opioid consumption, improves pulmonary function, and increases patient satisfaction.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Hilal Akay Cizmecioglu, Mevlut Hakan Goktepe, Ahmet Cizmecioglu
Summary: This study found that diabetic patients have a high level of awareness of disease complications, with the awareness being highest for ocular-related complications and lowest for neuropathy. Increased education levels can improve awareness of combined drug use, but may decrease adherence. Doctors play a significant role in raising awareness of disease complications.
KONURALP TIP DERGISI
(2023)
Article
Ophthalmology
Gulfidan Bitirgen, Celalettin Korkmaz, Adil Zamani, Mehmet Sinan Iyisoy, Hurkan Kerimoglu, Rayaz A. Malik
Summary: This study aimed to investigate alterations in pupillary light reflex responses in COVID-19 subjects, especially those with long-COVID. The results showed that post-COVID-19 subjects had longer latency and shorter duration of pupil contraction, indicating parasympathetic dysfunction. Pupillary contraction duration was also reduced in long-COVID patients and correlated with the total score of the long-COVID questionnaire.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Urology & Nephrology
Ismail Baloglu, Halil Tonbul, Kultigin Turkmen, Nedim Selcuk, Mehmet Sinan Iyisoy
Summary: The study found a close relationship between KDRI/KDPI scores of donors and post-transplant creatinine levels in recipients, especially for those receiving kidneys from marginal donors. Therefore, evaluation of KDRI/KDPI scores may be necessary in assessing marginal donors.
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2021)
Article
Clinical Neurology
Sakir Gica, Ahsen Buyukavsar, M. Sinan Iyisoy, Huseyin Gulec
Summary: The study examined the psychometric properties of the Turkish version of QCAE in a Turkish population of 412 healthy volunteers. Results indicated good construct validity and reliability for the five-correlated factors model, but highlighted limitations in its use in the Cognitive Empathy and Affective Empathy sub-dimensions. The study supports the separate and total computation and interpretation of the 5 sub-dimensions of the Turkish version of QCAE.
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2021)
Article
Medicine, General & Internal
Osman Serhat Tokgoz, Figen Guney, Ahmet Kaya, Ahmet Bugrul, Esra Eruyar, Huseyin Buyukgol, Abdullah Seyithanoglu, Mehmet Sinan Iyisoy
Summary: This study found that lower TG and TG/HDL-C levels may be predictors of short-term mortality in patients with acute stroke. Lipid subgroups could play an important role in the clinical prognosis of patients with acute stroke.
MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL
(2021)
Meeting Abstract
Clinical Neurology
Okan Imre, Kursat Altinbas, Sedat Abusoglu, Ali Unlu