Article
Endocrinology & Metabolism
Thanh D. Hoang, Gregory S. Schmidt, Tuan D. Nguyen, Francois O. Tuamokumo, Mohamed K. M. Shakir
Summary: In patients with primary hyperparathyroidism, BMI is strongly correlated with bone mineral density and the probability of osteoporosis. Other parameters such as alkaline phosphatase, ionized calcium, and vitamin D are also significantly correlated with bone density.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Jessica Costa-Guda, Kristin Corrado, Justin Bellizzi, Elizabeth Saria, Kirsten Saucier, Miriam Guemes-Aragon, Guntas Kakar, Madison Rose, Melanie Pascal, Cynthia Alander, Sanjay M. Mallya, Andrew Arnold
Summary: This study found that vitamin D deficiency may not increase the incidence of parathyroid tumors, but it may accelerate the growth of existing tumors.
Article
Medicine, Research & Experimental
Richard H. Law, Katherine A. Larrabee, Andrew J. Stefan, Daniel L. Quan, Edward L. Peterson, Michael C. Singer
Summary: This study aimed to compare the cure rates of patients with normohormonal primary hyperparathyroidism (NHHPT) and classical primary hyperparathyroidism (PHPT). The results showed that achieving an 80% or more reduction in intraoperative parathyroid hormone (IOPTH) levels from baseline predicts a high likelihood of cure in NHHPT patients, similar to classical PHPT patients.
Article
Cardiac & Cardiovascular Systems
Maria Pilar Lopez-Diez, Aitor Alquezar-Arbe, Javier Jacob, Pere Llorens, Lluis Llauger, Pablo Herrero, Victor Gil, Julio Nunez, Francisco Javier Martin-Sanchez, Oscar Miro
Summary: This study investigated whether the existence of heart failure units (HFU) and link nurse units (LNU) in the hospital improve short-term outcomes of acute heart failure (AHF) episodes. The results showed that the complete development of these follow-up units was not associated with 30-day mortality but was associated with less prolonged hospitalization and fewer post-discharge adverse events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Urology & Nephrology
Huimin Chen, Wenkai Ren, Zhanhui Gao, Ming Zeng, Shaowen Tang, Fangyan Xu, Yaoyu Huang, Lina Zhang, Ying Cui, Guang Yang, Hanyang Qian, Wenbin Zhou, Chun Ouyang, Xueyan Gao, Jing Zhang, Yujie Xiao, Baiqiao Zhao, Jing Wang, Anning Bian, Fan Li, Huiting Wan, Wei Gao, Xiaoyun Wang, Changying Xing, Xiaoming Zha, Ningning Wang
Summary: This study found correlations between plasma (1-84) PTH levels and heart rate variability (HRV) in CKD5 patients, with improved HRV related to decreased levels of (1-84) PTH and (7-84) PTH after PTX. No antagonistic effects of (1-84) PTH and (7-84) PTH on HRV were observed in CKD5 patients.
Article
Endocrinology & Metabolism
Anda Mihaela Naciu, Gaia Tabacco, Stefania Falcone, Giosue Giordano Incognito, Iacopo Chiodini, Daria Maggi, Claudio Pedone, Diana Lelli, John P. Bilezikian, Nicola Napoli, Silvia Manfrini, Roberto Cesareo, Andrea Palermo
Summary: The study found that TBS values did not differ significantly among NHPT patients, PHPT patients, and control group, but LS Z-score adjusted for TBS can predict moderate to severe vertebral fractures in PHPT patients. However, LS Z-score*TBS cannot accurately predict overall vertebral fractures in NHPT patients, but it has high accuracy in predicting moderate to severe fractures.
ENDOCRINE PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Yuta Seko, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Masayuki Shiba, Erika Yamamoto, Yusuke Yoshikawa, Yugo Yamashita, Takeshi Kitai, Ryoji Taniguchi, Moritake Iguchi, Kazuya Nagao, Toshikazu Jinnai, Akihiro Komasa, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura
Summary: Elderly patients with multiple comorbidities are more likely to develop newly diagnosed infections after admission for acute heart failure, which is associated with higher in-hospital and post-discharge mortality in patients with acute heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Otorhinolaryngology
Rodrigo Casanueva, Fernando Lopez, Andres Coca-Pelaz, Jose L. Llorente, Juan P. Rodrigo
Summary: Positive preoperative localization studies support that MIVAP is a safe and effective technique for surgical treatment of pHPT due to a parathyroid adenoma, with a success rate exceeding 95% and a low complication rate. This study involved 167 patients treated in a tertiary hospital between 2007 and 2019, with an average surgical duration of 61 minutes and hospital stay of 1.8 days.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, General & Internal
Lourdes Vicent, Jose Guerra, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Luis Martinez Dolz, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Juan Delgado, Francisco Fernandez-Aviles, Manuel Martinez-Selles
Summary: This study aimed to investigate the impact of ischemic etiology on prognosis among men and women with heart failure. The results showed that ischemic etiology was not directly associated with mortality in HF patients, but was related to previous readmissions and chronic obstructive pulmonary disease in men, and diabetes in women in ischemic HF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Tatiana Fedorova, Karen Hagglund, Abdelkader Hawasli
Summary: Normohormonal Primary Hyperparathyroidism (NPHPT) is rare and often diagnosed in later stages. More than 50% of cases require exploration of all four glands. A drop in intra-operative PTH below 30 pg/ml can be considered indicative of successful surgery.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Magdalena Basinska-Lewandowska, Andrzej Lewinski, Krzysztof C. Lewandowski, Elzbieta Skowronska-Jozwiak
Summary: This study found that elevated PTH concentrations in the setting of normocalcemia in spring are more likely to be caused by 25OHD deficiency rather than nPHPT, while increased PTH concentrations in autumn are more likely to reflect nPHPT.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yumiko Kawakubo Ichihara, Yasuyuki Shiraishi, Shun Kohsaka, Shintaro Nakano, Yuji Nagatomo, Tomohiko Ono, Makoto Takei, Munehisa Sakamoto, Atsushi Mizuno, Mitsunobu Kitamura, Nozomi Niimi, Takashi Kohno, Tsutomu Yoshikawa
Summary: This study found that patients with behavioral precipitant factors (PFs) had a higher risk of heart failure rehospitalization, despite having a lower risk of in-hospital death.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fazal Wahab Khan, Benish Fatima, Brian D. Lahr, Kevin L. Greason, Hartzell Schaff, Joseph A. Dearani, Richard C. Daly, John M. Stulak, Juan A. Crestanello
Summary: This study investigated the prevalence of preoperative hyponatremia and its impact on short-term and long-term outcomes after cardiac surgery. The results showed that preoperative hyponatremia was associated with increased risk of operative mortality, long-term mortality, prolonged length of stay, renal failure, prolonged ventilation use, and stroke or transient ischemic attack. Severity of hyponatremia was also linked to higher risk for death and postoperative complications.
ANNALS OF THORACIC SURGERY
(2021)
Article
Endocrinology & Metabolism
Magalie Haissaguerre, Estelle Louiset, Christofer C. Juhlin, Adam Stenman, Christophe Laurent, Helene Trouette, Herve Lefebvre, Antoine Tabarin
Summary: We present a case of paraneoplastic hyperparathyroidism caused by an oncocytic adrenocortical carcinoma. The tumor secreted parathyroid hormone (PTH) and increased estradiol, leading to gynecomastia and hypogonadism. Immunohistochemistry studies confirmed the abnormal PTH expression and identified two subtypes of tumor cells, with one exclusively producing PTH.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Karsten Keller, Lukas Hobohm, Mir A. Ostad, Sebastian Goebel, Mareike Lankeit, Stavros Konstantinides, Thomas Muenzel, Philip Wenzel
Summary: An analysis of the German nationwide inpatient sample from 2005 to 2016 found that hospitalizations for heart failure increased during this period, while the inhospital case fatality rate and major adverse cardiovascular and cerebrovascular event rate decreased. Independent predictors of inhospital death included age 70 years and older and a diagnosis of cancer.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Clinical Neurology
Weijia Li, Jiyoung Seo, Damianos G. Kokkinidis, Leonidas Palaiodimos, Sanjana Nagraj, Eleni Korompoki, Haralambos Milionis, Wolfram Doehner, Gregory Y. H. Lip, George Ntaios
Summary: The use of oral anticoagulation therapy in patients with heart failure and sinus rhythm can reduce the occurrence of stroke, but it also increases the risk of major bleeding. Rivaroxaban has a better effect in preventing stroke, but it is also associated with a higher risk of bleeding. There were no significant differences between the use of oral anticoagulants and the control group in terms of myocardial infarction, all-cause mortality, and hospitalization for heart failure.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Cardiac & Cardiovascular Systems
Stefan D. Anker, Muhammad Shahzeb Khan, Javed Butler, Anne Pernille Ofstad, Barbara Peil, Egon Pfarr, Wolfram Doehner, Naveed Sattar, Andrew J. S. Coats, Gerasimos Filippatos, Joao Pedro Ferreira, Faiez Zannad, Stuart Pocock, Milton Packer
Summary: In this study, the relationship between baseline BMI, weight loss, and the effects of empagliflozin on heart failure patients with reduced ejection fraction (HFrEF) were analyzed. The study found that the benefits of empagliflozin were consistent across all BMI categories, and weight loss was associated with increased risk of all-cause mortality regardless of treatment group.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Roberto F. E. Pedretti, Dominique Hansen, Marco Ambrosetti, Maria Back, Thomas Berger, Mariana Cordeiro Ferreira, Veronique Cornelissen, Constantinos H. Davos, Wolfram Doehner, Carmen de Pablo Y. Zarzosa, Ines Frederix, Andrea Greco, Donata Kurpas, Matthias Michal, Elena Osto, Susanne Pedersen, Rita Esmeralda Salvador, Maria Simonenko, Patrizia Steca, David R. Thompson, Matthias Wilhelm, Ana Abreu
Summary: Optimal patient adherence to treatment is crucial for successful secondary prevention of cardiovascular disease (CVD). However, unsatisfactory adherence rates have been consistently observed for CVD risk factors and treatment. This consensus document provides a modern reappraisal of adherence to optimal treatment and offers simple, practical, and feasible suggestions to achieve this goal in the clinical setting, focusing on evidence-based concepts.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Andrew Sindone, Wolfram Doehner, Josep Comin-Colet
Summary: Intravenous iron-carbohydrate complex supplementation has a positive effect on heart failure patients, reducing hospitalization rates and improving functional and exercise capacity.
Article
Cardiac & Cardiovascular Systems
Peter Carson, John R. Teerlink, Michel Komajda, Inder Anand, Stefan D. Anker, Javed Butler, Wolfram Doehner, Joao Pedro Ferreira, Gerasimos Filippatos, Markus Haass, Alan Miller, Steen Pehrson, Stuart J. Pocock, Sven Schnaidt, Janet M. Schnee, Faiez Zannad, Milton Packer
Summary: There is limited published information on outcome adjudication in heart failure (HF). In this study, the authors compared investigator reports (IRs) to a Clinical Events Committee (CEC) and found that IRs can be an alternative to CEC with similar accuracy and faster event accumulation. They also suggest broadening the definition of hospitalization for heart failure (HHF) to include for or with worsening disease.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Hoffmann, Sabine Hanss, Monika Kraus, Jens Schaller, Christian Schaefer, Dana Stahl, Stefan D. Anker, Gabriele Anton, Thomas Bahls, Stefan Blankenberg, Arne Blumentritt, Leif-Hendrik Boldt, Steffen Cordes, Steffen Desch, Wolfram Doehner, Marcus Doerr, Frank Edelmann, Ingo Eitel, Matthias Endres, Stefan Engelhardt, Jeanette Erdmann, Katharina Eulenburg, Volkmar Falk, Stephan B. Felix, Derk Frank, Thomas Franke, Norbert Frey, Tim Friede, Lars Geidel, Lisa Germans, Ulrich Grabmaier, Martin Halle, Joerg Hausleiter, Vera Jakobi, Ahmad-Fawad Jebran, Alexander Jobs, Stefan Kaeaeb, Mahir Karakas, Hugo A. Katus, Alexandra Klatt, Christoph Knosalla, Joachim Krebser, Ulf Landmesser, Mahsa Lee, Kristin Lehnert, Stephanie Lesser, Katrin Leyh, Roberto Lorbeer, Stephanie Mach-Kolb, Benjamin Meder, Eike Nagel, Christian H. Nolte, Abdul S. Parwani, Astrid Petersmann, Miriam Puls, Henriette Rau, Maximilian Reiser, Otto Rienhoff, Tabea Scharfe, Mario Schattschneider, Heiko Scheel, Renate B. Schnabel, Andreas Schuster, Boris Schmitt, Tim Seidler, Moritz Seiffert, Barbara-Elisabeth Staehli, Adriane Stas, Thomas J. Stocker, Lukas von Stuelpnagel, Holger Thiele, Rolf Wachter, Reza Wakili, Tanja Weis, Kerstin Weitmann, Heinz-Erich Wichmann, Philipp Wild, Tanja Zeller, Wolfgang Hoffmann, Elisabeth Maria Zeisberg, Wolfram-Hubertus Zimmermann, Dagmar Krefting, Titus Kuehne, Annette Peters, Gerd Hasenfuss, Steffen Massberg, Thomas Sommer, Stefanie Dimmeler, Thomas Eschenhagen, Matthias Nauck
Summary: The German Centre for Cardiovascular Research (DZHK) aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics for people with cardiovascular disease. The DZHK designed a research platform to standardize data and sample collections across all studies and ensure compliance with legal regulations and FAIR principles. The platform includes web-based and central units for data management, as well as a Public Open Data strategy to enable interdisciplinary use of data and samples.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mareike S. Poetsch, Sandra Palus, Sophie Van Linthout, Stephan von Haehling, Wolfram Doehner, Andrew J. S. Coats, Stefan D. Anker, Jochen Springer
Summary: This study compared the effects of different doses of ACM-001 and other cardiac drugs on cardiac mass and function in tumor-induced cachexia rats. The results showed that 3 mg/kg/day ACM-001 reduced weight loss and attenuated lean mass wasting, while improving cardiac function.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Goran Loncar, Tania Garfias-Veitl, Miroslava Valentova, Mirela Vatic, Mitja Lainscak, Danilo Obradovic, Thomas Bernd Dschietzig, Wolfram Doehner, Ewa A. Jankowska, Stefan D. Anker, Stephan von Haehling
Summary: The aim of this study was to assess hip bone mineral density (BMD) in men with heart failure (HF). Dual energy X-ray absorptiometry was used to measure BMD in 141 male patients with HF. Patients with lower BMD were older, more likely to have sarcopenia, and had lower peak oxygen consumption compared to patients with higher BMD. Serum osteocalcin remained independently related to lower BMD in multivariate logistic regression analysis. Hip BMD and serum osteoprotegerin were independent predictors of impaired survival.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Multidisciplinary Sciences
Azadeh Shafieesabet, Nadja Jauert, Oliver Hartmann, Birte Arlt, Michael Joebges, Wolfram Doehner
Summary: The aim of this study was to investigate the prognostic value of bioactive adrenomedullin (bio-ADM) on outcomes after rehabilitation in stroke patients. The results showed that plasma bio-ADM levels were associated with 6-month all-cause mortality and composite outcomes. Elevated bio-ADM concentrations (> 70 pg/ml) were associated with higher rates of all-cause mortality and composite outcomes. Therefore, bio-ADM may be a suitable novel biomarker to assess the outcomes of patients in rehabilitation after acute stroke.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Simon Hellwig, Thomas Krause, Jan F. Scheitz, Juliane Herm, Ulrike Grittner, Nadja Jauert, Jochen B. Fiebach, Mario Kasner, Wolfram Doehner, Matthias Endres, Rolf Wachter, Thomas Elgeti, Christian H. Nolte, Karl Georg Haeusler
Summary: This study compared the rate of pathological findings in patients with acute ischemic stroke (AIS) between enhanced diagnostic workup and routine diagnostic care. The results showed that enhanced diagnostic workup yielded a higher rate of pathological findings and reduced the proportion of patients with cryptogenic stroke.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christoph Gertler, Nadja Jauert, Patrick Freyhardt, Miroslava Valentova, Sven Christopher Aland, Thula Cannon Walter-Rittel, Christina Unterberg-Buchwald, Marius Placzek, Virginia Ding-Reinelt, Tarek Bekfani, Wolfram Doehner, Gerd Hasenfuss, Bernd Hamm, Anja Sandek
Summary: This study analyzed the changes in iron signal and exercise capacity in chronic heart failure patients before and after intravenous iron therapy. The findings showed that patients with iron deficiency had lower iron content in the spleen, liver, and heart. After intravenous iron therapy, the iron content in the left ventricle, spleen, and liver increased. Improvement in exercise capacity was associated with an increase in hemoglobin levels after intravenous iron therapy.
Review
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Radoslaw Lenarczyk, Daniele Pastori, George Ntaios, Wolfram Doehner, Renate B. Schnabel
Summary: After an ischemic stroke, patients often experience cardiovascular complications known as stroke-heart syndrome. Managing these cardiovascular issues is crucial for life expectancy and quality of life, and requires a multidisciplinary approach involving healthcare professionals. Integrated care is key to improving outcomes for patients with stroke-heart syndrome, involving appropriate antithrombotic therapy, assessment of poststroke impairments, and management of cardiovascular risk factors and comorbidities.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Wolfram Doehner, Jelena Celutkiene, Mehmet Birhan Yilmaz, Andrew J. S. Coats
Summary: Heart failure (HF) can lead to cerebral injury, such as stroke, cognitive decline, dementia, and depressive disorders. The interaction between the heart and the central nervous system (CNS) is significant, with impaired cerebral functions contributing to myocardial injury and worsening of HF symptoms. However, this comorbidity is often overlooked in both diagnosis and treatment of HF. This article discusses the pathophysiological aspects of heart-CNS interactions in HF, including stroke, cognitive function, depressive disorder, and neurovegetative control.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Patrick Despang, Martin Schikora, Wolfram Doehner
Summary: Cardiovascular disease is a major cause of death globally, with high blood pressure and elevated LDL cholesterol being major modifiable risk factors. The polypill, a combination of different drugs in one tablet, has been shown to significantly improve patients' prognosis by reducing cardiovascular events. While previous trials have focused on risk factor control, recent trials have shown prognostic improvement in primary prevention and the SECURE trial has shown a reduction in cardiovascular events in secondary prevention.
Review
Nutrition & Dietetics
Stefan Zivkovic, Gorica Maric, Natasa Cvetinovic, Danijela Lepojevic-Stefanovic, Bojana Bozic Cvijan
Summary: Cardiovascular diseases (CVD) are the leading cause of death worldwide. Lipid-lowering agents used in the treatment of CVD may also have anti-inflammatory and immunomodulatory properties. This review aims to evaluate the anti-inflammatory properties of currently available lipid-lowering medications, dietary supplements, and novel drugs.