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Medicine, General & Internal
Aldo Pezzuto, Giuseppe Tonini, Massimo Ciccozzi, Pierfilippo Crucitti, Michela D'Ascanio, Fiammetta Cosci, Antonella Tammaro, Antonella Di Sotto, Teresa Palermo, Elisabetta Carico, Alberto Ricci
Summary: The aim of this study was to determine the benefits of smoking cessation combined with a single inhaler triple therapy in patients with COPD. The study found that 51% of patients successfully quit smoking within a month, and these patients showed better outcomes after six months compared to those who continued smoking, including improvements in lung function and physical activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Hannah Whittaker, Clementine Nordon, Annalisa Rubino, Tamsin Morris, Yang Xu, Enrico De Nigris, Hana Mullerova, Jennifer K. Quint
Summary: This study investigated the association between lower respiratory tract infections (LRTIs) before chronic obstructive pulmonary disease (COPD) and future exacerbations and mortality. The results showed that increasing frequency and severity of LRTIs were associated with higher rates of subsequent exacerbations, as well as increased risk of all-cause and COPD-related mortality.
Article
Medicine, General & Internal
Ke-Hsin Ting, Yen-Ting Lu, Chung-Han Hsin, Chia-Yi Lee, Jing-Yang Huang, Shun-Fa Yang, Ming-Hong Hsieh
Summary: This retrospective study examined the association between the severity of coronary heart disease (CHD) and the development of chronic rhinosinusitis (CRS). The results showed that severe CHD treated with CABG was associated with a higher incidence of subsequent CRS, particularly among men.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Akihiro Shiroshita, Chisato Miyakoshi, Shunta Tsutsumi, Hiroshi Shiba, Chigusa Shirakawa, Kenya Sato, Shinya Matsushita, Yuya Kimura, Keisuke Tomii, Masahiro Ohgiya, Yuki Kataoka
Summary: This study aimed to evaluate whether the empirical use of anti-pseudomonal antibiotics can improve hospital stay length in patients with frequent COPD exacerbations. The results showed that the use of anti-pseudomonal antibiotics did not shorten hospital stay length.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Gaetan Deslee, Caroline Fabry-Vendrand, Nolwenn Poccardi, Gabriel Thabut, Caroline Eteve Pitsaer, Adrien Coriat, Charlotte Renaudat, Andrew Maguire, Thomas Pinto
Summary: This study evaluated the persistence of single inhaler triple therapy (SITT) compared with multiple inhaler triple therapy (MITT) in France. The results showed that SITT had higher persistence and most patients initiated with triple therapy had previous treatment with dual therapy and exacerbations.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Health Care Sciences & Services
Georgios S. Chatzopoulos, Ziou Jiang, Nicholas Marka, Larry F. Wolff
Summary: The study aimed to analyze the relationship between the extent, severity, and rate of progression of periodontitis and systemic diseases as well as smoking. The analysis of a large database showed that smokers were significantly associated with rapid progression of periodontitis (grade C), while gender, age, number of missing teeth, and number of tooth loss during supportive periodontal treatment were associated with disease characteristics.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Emile Ferrari, Etienne Fourrier, Florian Asarisi, Nathan Heme, Nassim Redjimi, Nathalie Berkane, Mohamed Labbaoui, Jean Philippe Breittmayer, Sok Sithikun Bun, Pamela Moceri, Fabien Squara
Summary: The severity of a first pulmonary embolism (PE) may be linked to a higher risk of recurrence, particularly if there is cardiac involvement. This finding could potentially become an important criterion for determining the duration of anticoagulant therapy after a PE, pending confirmation in a dedicated prospective trial.
Article
Critical Care Medicine
Bernardino Alcazar-Navarrete, Lucia Jamart, Joaquin Sanchez-Covisa, Monica Juarez, Ruth Graefenhain, Antoni Sicras-Mainar
Summary: This study found that COPD patients in Spain initiating SITT had improved persistence, reduced exacerbations, and lower healthcare resource utilization compared to those initiating MITT. SITT was also associated with lower all-cause mortality risk.
Article
Medicine, General & Internal
Haresh Selvaskandan, Katherine L. Hull, Sherna Adenwalla, Safa Ahmed, Maria-Cristina Cusu, Matthew Graham-Brown, Laura Gray, Matt Hall, Rizwan Hamer, Ammar Kanbar, Hemali Kanji, Mark Lambie, Han Sean Lee, Khalid Mahdi, Rupert Major, James F. Medcalf, Sushiladevi Natarajan, Boavojuvie Oseya, Stephanie Stringer, Matthew Tabinor, James Burton
Summary: The incidence of severe COVID-19 is high among patients on haemodialysis, with strong evidence of an association between socioeconomic deprivation and COVID-19 severity. Other risk factors that apply to the general population may not apply to this cohort.
Article
Infectious Diseases
I. Russel Lee, Tun-Linn Thein, Li Wei Ang, Ying Ding, Jonathan J. Lim, Chwee Fang Bok, Shilpa Mukherjee, Christina Titin, Shirin Kalimuddin, Sophia Archuleta, David C. Lye
Summary: A retrospective study comparing IV cefazolin and IV ceftriaxone treatment in Klebsiella pneumoniae bacteraemia patients did not show a significant difference in 28-day all-cause mortality rates. This suggests that cefazolin may be a potential alternative treatment to ceftriaxone for antibiotic-susceptible K. pneumoniae bacteraemia.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Biing-Ru Wu, Ding-Han Chen, Wei-Chih Liao, Wen-Chao Ho, Ming-Chien Yin, Cheng-Li Lin, Chia-Hui Chou, Yi-Hao Peng
Summary: This study found a significant association between statin therapy and a reduced risk of viral infection in patients with hyperlipidemia, regardless of age, gender, and treatment duration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yuanyuan Wang, Jens H. Bos, Catharina C. M. Schuiling-Veninga, H. Marike Boezen, Job F. M. van Boven, Bob Wilffert, Eelko Hak
Summary: The study found that there was a lower incidence of NPAEs among general population using varenicline compared to nicotine replacement therapy, while there was no significant difference in NPAEs incidence between COPD patients using varenicline and NRT.
Article
Psychiatry
Joanne Salas, Wenjin Wang, Paula P. Schnurr, Beth E. Cohen, Kenneth E. Freedland, Allan S. Jaffe, Patrick J. Lustman, Matthew Friedman, Jeffrey F. Scherrer
Summary: Patients with comorbid PTSD and T2D have a higher risk of microvascular complications compared to those with T2D alone. However, they have a lower risk of mortality due to increased healthcare utilization and earlier detection of chronic diseases. PTSD screening may be necessary for patients with T2D.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Medicine, General & Internal
Nick Jovanoski, Xin Chen, Ursula Becker, Kelly Zalocusky, Devika Chawla, Larry Tsai, Michelle Borm, Margaret Neighbors, Vincent Yau
Summary: This retrospective cohort study used a large electronic health record database to identify potential risk factors for adverse long-term outcomes associated with COVID-19. Patients with severe COVID-19 were found to have an increased risk of new clinical conditions up to 6 months after hospital discharge. The study suggests that strategies to prevent COVID-19 progression may help minimize the occurrence of these conditions.
Article
Respiratory System
Hannah Whittaker, Kieran J. Rothnie, Jennifer K. Quint
Summary: Identifying factors associated with causes of death in patients with chronic obstructive pulmonary disease (COPD) can help target therapies to reduce mortality. The study found that airflow limitation, COPD classification, exacerbation frequency and severity, and COPD phenotype were associated with all-cause mortality.