Article
Respiratory System
Suhani Patel, Melanie D. Palmer, Claire Marie Nolan, Ruth Emily Barker, Jessica Anne Walsh, Stephanie C. Wynne, Sarah Elizabeth Jones, Harriet Shannon, Nicholas S. Hopkinson, Samantha Swee Chin Kon, Wei Gao, Matthew Maddocks, William D-C Man
Summary: In patients with COPD, pulmonary rehabilitation using minimal equipment produces clinically significant benefits in exercise capacity and health-related quality of life that are non-inferior to rehabilitation using specialist equipment. This study supports the provision of pulmonary rehabilitation using minimal exercise equipment in areas where access to specialist exercise equipment is limited.
Article
Immunology
Zuzanna Trzesniewska-Ofiara, Mariola Mendrycka, Andrzej Cudo, Magdalena Szmulik, Agnieszka Wozniak-Kosek
Summary: Microbiological diagnostics play a crucial role in controlling the spread of nosocomial infections. This study analyzes the incidence of nosocomial urinary tract infections among hospitalized patients and identifies the predominant etiological agents based on different clinical specimen collection methods. The findings reveal variations in the occurrence of multiple strains depending on the collection method.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Health Care Sciences & Services
Safwat Eldaabossi, Yasser Al-Ghoneimy, Ayman Ghoneim, Amgad Awad, Waheed Mahdi, Abdallah Farouk, Hesham Soliman, Hatem Kanany, Ahmad Antar, Yasser Gaber, Ahmed Shaarawy, Osama Nabawy, Moaz Atef, Sameh Nour, Ahmed Kabil
Summary: This study aimed to evaluate the value of the ARISCAT risk index in predicting pulmonary complications after thoracic surgery. The study found that the ARISCAT scoring system, lower FEV1%, longer ICU stay, and thoracotomy were significant predictors of postoperative complications.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Critical Care Medicine
C. Caleb Butts, Preston Miller, Andrew Nunn, Adam Nelson, Meagan Rosenberg, Orhan Yanmis, Martin Avery
Summary: The rib fracture triage pathway can reduce ICU and hospital resource utilization, decrease pulmonary complications, without increasing readmissions or mortality, and improve the likelihood of patients being discharged home for recovery, thus lowering healthcare costs.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Review
Physiology
Stine B. Nymand, Jacob P. Hartmann, Camilla Koch Ryrso, Ninna Struck Rossen, Regitse Hojgaard Christensen, Ulrik Winning Iepsen, Ronan M. G. Berg
Summary: COPD is considered irreversible, but the adult lung actually has regenerative potential inhibited by cellular senescence. High-intensity interval training may improve pulmonary gas exchange in COPD patients by disrupting cellular senescence and promoting the formation of new lung tissue.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Sebastian Rutkowski, Joren Buekers, Anna Rutkowska, Blazej Cieslik, Jan Szczegielniak
Summary: A study of 13 patients eligible for pulmonary rehabilitation found no significant difference in physical activity levels between training days and days off, as measured by the SenseWear armband. Using physical activity sensors may help motivate patients with COPD to be more active and improve health outcomes.
Article
Critical Care Medicine
Claire M. Nolan, Oliver Polgar, Susie J. Schofield, Suhani Patel, Ruth E. Barker, Jessica A. Walsh, Karen A. Ingram, Peter M. George, Philip L. Molyneaux, Toby M. Maher, William D-C Man
Summary: This study found that patients with IPF have similar completion rates and magnitude of response to pulmonary rehabilitation compared with a matched group of patients with COPD. In IPF, noncompletion of and nonresponse to pulmonary rehabilitation were associated with increased all-cause mortality.
Letter
Respiratory System
Katarina Zeder, Alexander Avian, Gerhard Bachmaier, Philipp Douschan, Vasile Foris, Teresa Sassmann, Natascha Troester, Luka Brcic, Michael Fuchsjaeger, Leigh Matthew Marsh, Bradley A. Maron, Horst Olschewski, Gabor Kovacs
Summary: The study demonstrated that PVR >5 WU is the strongest independent haemodynamic predictor of mortality in COPD patients, identifying those with severe pulmonary vascular disease.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Editorial Material
Respiratory System
Ruth E. Barker, Samantha S. C. Kon, Stuart F. Clarke, Jenni Wenneberg, Claire M. Nolan, Suhani Patel, Jessica A. Walsh, Oliver Polgar, Matthew Maddocks, Morag Farquhar, Nicholas S. Hopkinson, Derek Bell, Jadwiga A. Wedzicha, William D-C. Man
Summary: Pulmonary rehabilitation following hospitalisation for AECOPD is beneficial for patients' exercise capacity and quality of life. This study suggests that COPD discharge bundles delivered by PR practitioners can significantly increase the referral and uptake of post-hospitalisation PR. Closer integration between hospital and PR services may help improve the rates of post-hospitalisation PR referral and uptake.
Article
Critical Care Medicine
Charles R. Esther, Wanda K. O'Neal, Wayne H. Anderson, Mehmet Kesimer, Agathe Ceppe, Claire M. Doerschuk, Neil E. Alexis, Annette T. Hastie, R. Graham Barr, Russell P. Bowler, J. Michael Wells, Elizabeth C. Oelsner, Alejandro P. Comellas, Yohannes Tesfaigzi, Victor Kim, Laura M. Paulin, Christopher B. Cooper, MeiLan K. Han, Yvonne J. Huang, Wassim W. Labaki, Jeffrey L. Curtis, Richard C. Boucher
Summary: This study identified altered physiologic pathways associated with COPD airway pathophysiologic features through the analysis of sputum samples. Several biomarkers were found to be correlated with disease severity and predicted exacerbations in COPD patients.
Review
Pharmacology & Pharmacy
Z. Lahmar, E. Ahmed, A. Fort, I. Vachier, A. Bourdin, A. Bergougnoux
Summary: COPD is a chronic airway disease that affects millions of people worldwide and is ranked as the third leading cause of death. Genetic susceptibility, environmental factors, and the combined effects of these factors play important roles in the development of COPD. The Hedgehog signaling pathway and its inhibitor HHIP are potential targets for therapeutic interventions in COPD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Mauro Maniscalco, Debora Paris, Paola Cuomo, Salvatore Fuschillo, Pasquale Ambrosino, Annabella Tramice, Letizia Palomba, Andrea Motta
Summary: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and a single strategy of pulmonary rehabilitation (PR) may not achieve the desired outcomes for all patients. This study used nuclear magnetic resonance (NMR) profiling of exhaled breath condensate (EBC) and multivariate statistical analysis to investigate the relationship between biomarkers and clinical parameters in COPD patients undergoing PR. The results showed that the metabolic COPD phenotype evolves during PR, and methanol metabolite could serve as a useful biomarker for monitoring personalized outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marilisa Schiwek, Simon M. F. Triphan, Juergen Biederer, Oliver Weinheimer, Monika Eichinger, Claus F. Vogelmeier, Rudolf A. Joerres, Hans-Ulrich Kauczor, Claus P. Heussel, Philip Konietzke, Oyunbileg von Stackelberg, Frank Risse, Bertram J. Jobst, Mark O. Wielpuetz
Summary: QDP computed using DCE-MRI showed strong correlations with MRI perfusion score and CT PRM indices, particularly with Otsu's method. It is associated with established markers of disease severity and may be a useful tool for future clinical studies in COPD.
EUROPEAN RADIOLOGY
(2022)
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Respiratory System
Khushboo Goel, Nicholas Egersdorf, Amar Gill, Danting Cao, Scott D. Collum, Soma S. Jyothula, Howard J. Huang, Maor Sauler, Patty J. Lee, Susan Majka, Harry Karmouty-Quintana, Irina Petrache
Summary: This study investigated the remodeling of pulmonary blood vessels in COPD-PH patients and found that remodeling of small and microvascular pulmonary blood vessels is associated with the development of COPD and COPD-PH. Decreased expression of miR126 and reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in COPD and COPD-PH.
RESPIRATORY RESEARCH
(2022)
Article
Surgery
Melissa Medina, Shannon R. Foiles, Matilde Francois, Carl Asche, Jinma Ren, Dale K. Mueller, Richard C. Anderson
AMERICAN JOURNAL OF SURGERY
(2019)
Article
Medicine, General & Internal
Minchul Kim, William Tillis, Preeti Patel, Rachael M. Davis, Carl Asche
CURRENT MEDICAL RESEARCH AND OPINION
(2019)
Article
Economics
Carl Asche, Simon Dagenais, Amiee Kang, Jinma Ren, Brian T. Maurer
JOURNAL OF MEDICAL ECONOMICS
(2019)
Article
Multidisciplinary Sciences
Jinma Ren, Kirk Moberg, Heidi Scuffham, Dongming Guan, Carl V. Asche
Article
Health Care Sciences & Services
Jinma Ren, Carl V. Asche, Yaping Shou, Aaron Galaznik
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Jinma Ren, Marisa Ascencio, Tommaso Raimondi, Edward C. Rainville, Reuben M. Valenzuela, Carl Asche
CLINICAL THERAPEUTICS
(2019)
Article
Cardiac & Cardiovascular Systems
Jay Nitin Patel, Mansoor Ahmad, Minchul Kim, Sandeep Banga, Carl Asche, Marco Barzallo, Sudhir Mungee
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Article
Economics
Katarzyna Kolasa, W. Ken Redekop, Alexander Berler, Vladimir Zah, Carl Asche
Article
Public, Environmental & Occupational Health
Carl Asche, Karriem Watson, Meredith Greer Baumgartner, Joanna Buscemi, Marian Fitzgibbon, Melissa Simon, Robert Winn, Candace Henley, Joanne Glenn, Susan Hong
Summary: Financial toxicity, as a result of cancer diagnosis, can lead to depletion of assets and financial insolvency for patients in a short period of time. Despite a majority of Americans wanting to discuss care costs with their healthcare providers, only a small percentage actually engage in these conversations, potentially resulting in patients forgoing necessary care.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2021)
Article
Medicine, General & Internal
Daniel Rhon, Minchul Kim, Carl Asche, Stephen C. Allison, Chris S. Allen, Gail D. Deyle
Summary: Physical therapy and intra-articular glucocorticoid injection are initial treatment options for knee osteoarthritis, and a study found that physical therapy was more cost-effective compared to glucocorticoid injections.
Article
Economics
Anita Burrell, Zsombor Zrubka, Annette Champion, Vladimir Zah, Laura Vinuesa, Anke-Peggy Holtorf, Rossella Di Bidino, Jagadeswara Rao Earla, Joanna Entwistle, Artem Tarasovic Boltyenkov, George Braileanu, Katarzyna Kolasa, Jessica Roydhouse, Carl Asche
Summary: This study reviewed definitions of digital health and examined their relevance to health outcomes research. The results showed that while there are existing seminal definitions, they have been adapted over time and new definitions have emerged. However, there is still considerable overlap between the four umbrella terms in terms of their characteristics.
Article
Public, Environmental & Occupational Health
Larisa A. Burke, Alana D. Steffen, Sandeep Kataria, Karriem S. Watson, Robert A. Winn, Damilola Oyaluade, Barbara Williams, Cherdsak Duangchan, Carl Asche, Alicia K. Matthews
Summary: The purpose of this study was to examine the association between cigarette use and smoking-related health conditions by race/ethnicity among diverse and low-income patients at a federally qualified health center (FQHC). The results showed that patients with higher smoking rates were more likely to have various health problems, and there were differences in the associations between smoking status and health conditions among different race/ethnicity. Therefore, resources for documenting smoking status and offering cessation services should be increased in FQHCs to promote health equity for lower income populations.
Article
Economics
Margaret Holtz, Nick Liao, Jennifer H. Lin, Carl V. Asche
Summary: This study compared the economic outcomes and incidence of hypotension associated with the use of liposomal bupivacaine (LB) and traditional epidural analgesia for abdominal surgery. The results showed that LB was associated with economic benefits and reduced incidence of postsurgical hypotension and vasopressor use, compared to epidural analgesia.
JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH
(2022)
Article
Rheumatology
J. Ren, A. T. Masi, J. C. Aldag, C. V. Asche
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2020)
Article
Pharmacology & Pharmacy
Edward C. Rainville, Carl Asche, Jinma Ren, MinChul Kim, Lucas Walker, B. Ted Maurer, Daniel R. Knolhoff, Kyle M. Shick