Article
Biochemistry & Molecular Biology
Wei Ou, Yu Liang, Yu Qing, Wei Wu, Maodi Xie, Yabing Zhang, Yarong Zhang, Liwei Ji, Haiyang Yu, Tao Li
Summary: The study revealed that hypoxic acclimation (HA) can alleviate cardiac ischemia-reperfusion (I/R) injury by enhancing antioxidative capacity through activation of glucose metabolism, particularly by upregulating the enzyme G6PDH. This cardioprotective effect highlights the potential of HA as a promising strategy against I/R injury, suggesting that O-GlcNAc modification of G6PDH could be a therapeutic target for ischemic heart disease.
Article
Endocrinology & Metabolism
Li Zhang, Lin Jin, Jialiang Guo, Kai Bao, Jinglue Hu, Yingze Zhang, Zhiyong Hou, Liping Zhang
Summary: The study demonstrated that CIHH treatment improves fracture healing, increases bone mineral density, and enhances bone strength through the activation of HIF-1 alpha and bone production-related genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alejandro Gonzalez-Candia, Alejandro A. Candia, Adolfo Paz, Fuad Mobarec, Rodrigo Urbina-Varela, Andrea del Campo, Emilio A. Herrera, Rodrigo L. Castillo
Summary: This study aims to investigate the response of cardiac function in a rat model to intermittent hypobaric hypoxia (IHH) exposure. The results demonstrate that IHH exposure improves cardiac function and reduces oxidative stress levels.
Article
Orthopedics
Zhang Ruixia, Liu Chuanchuan, Guan Lu, Ma Shuang, Zhu Qiang, Tian Xiaofang, Ba Yinggui
Summary: The study found that under low-temperature and low-oxygen conditions, the body weight of rats decreased and affected lipid levels in the serum, while reducing the activity of fatty acid metabolism factors and increasing the activity of lipid metabolism-related enzymes. In addition, hypothermia and hypoxia also affect skeletal muscle morphology, and AMPK/PGC-1 alpha can regulate skeletal muscle cell proliferation.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Medicine, Research & Experimental
Hao Tian, Xiaoshuai Zhao, Yuxi Zhang, Zhongyuan Xia
Summary: Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases, and the mechanism involves multiple metabolic and signaling pathways. Glucose metabolism and lipid metabolism play important roles in regulating myocardial energy metabolism. This article focuses on the roles of glucose and lipid metabolism in myocardial ischemia-reperfusion injury and highlights the complex inter-regulatory relationship between them. Modulating the equilibrium between glucose and lipid metabolism could be a promising strategy for addressing myocardial ischemia-reperfusion injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Liuyang Tian, Zhilong Jia, Zhenguo Xu, Jinlong Shi, XiaoJing Zhao, Kunlun He
Summary: Oxygen metabolism is closely related to intestinal homeostasis. The hypobaric hypoxic environment of the plateau can cause intestinal diseases. Small intestine cells show changes in gene expression under hypobaric hypoxic conditions, with upregulation of metabolic and digestive pathways starting from the second week.
Article
Biochemistry & Molecular Biology
Tehila Dahan, Shahd Nassar, Olga Yajuk, Eliana Steinberg, Ofra Benny, Nathalie Abudi, Inbar Plaschkes, Hadar Benyamini, David Gozal, Rinat Abramovitch, Alex Gileles-Hillel
Summary: Obstructive sleep apnea (OSA) is a common disease associated with dyslipidemia, insulin resistance, and metabolic syndrome. Brown adipose tissue (BAT) is believed to affect systemic glucose tolerance through adaptive thermogenesis, while chronic hypoxia affects the function and metabolism of BAT. This study shows that chronic hypoxia leads to browning of BAT, but also tissue-specific and systemic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yanming Tian, Li Zhang, Xinqi Guo, Zheng Gao, Yi Zhang, Liping Zhang, Zhiyong Hou
Summary: In this study, chronic intermittent hypobaric hypoxia (CIHH) was found to protect against limb ischemic injury by promoting angiogenesis. CIHH increased contractile force, muscle fiber diameter, and reduced necrosis and fibrosis in ischemic muscle. Additionally, CIHH enhanced the density of CD31(+) and CD34(+) cells and upregulated angiogenesis-related genes in ischemic muscle.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zelin Chen, Xu Tan, Taotao Jin, Yu Wang, Linyong Dai, Gufang Shen, Can Zhang, Langfan Qu, Lei Long, Chongxing Shen, Xiaohui Cao, Jianwu Wang, Huijuan Li, Xiaofeng Yue, Chunmeng Shi
Summary: This study presents the potential of near infrared dye IR-780 for monitoring and protecting ischemic myocardium from injury. IR-780 selectively enters cardiomyocytes in at-risk heart tissues and can preconditon or administer timely to protect against cell death, myocardial remodeling, and heart failure induced by ischemia and oxidative stress. The dye binds to F0F1-ATP synthase in cardiomyocytes, decreases mitochondrial membrane potential, and slows down mitochondrial energy metabolism, leading to a quiescent mitochondria state and inhibition of mitochondrial permeability transition pore. Moderating mitochondrial function depression could be a targeted approach for developing cardioprotective reagents.
Article
Medicine, General & Internal
Shuo Li, Boqia Xie, Wenqian Zhang, Tong Li
Summary: In this study, the effects of dichloroacetate (DCA) on autophagy induction were investigated in a rat myocardial ischemia-reperfusion (I/R) injury model. DCA was found to decrease infarct size and arrhythmia scores, increase heart rate, left ventricular developed pressure, maximal rate of pressure rise, and coronary flow, and reduce the levels of serum creatine kinase, lactic dehydrogenase, and cardiac troponin I after I/R. DCA also regulated autophagy and glucose homeostasis to protect against I/R injury.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Yaqi Wan, Lu Huang, Yanmin Liu, Weizhong Ji, Changxing Li, Ri-li Ge
Summary: Intermittent hypobaric hypoxia preconditioning exerts neuroprotective effects in a rat stroke model, while persistent hypobaric hypoxia stimulation does not show significant neuroprotective effects. Intermittent hypoxic preconditioning for 6 hours/day for 10 days upregulates key proteins in clathrin-dependent endocytosis of neurons in the cortex.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Alejandro Gonzalez-Canadia, Alejandro A. Candia, Pamela Arias, Adolfo A. Paz, Emilio A. Herrera, Rodrigo L. Castillo
Summary: This study aimed to investigate the effects of chronic intermittent hypobaric hypoxia on cardiac and vascular response in adult rats simulating high-altitude working shifts. The results showed that chronic intermittent hypobaric hypoxia induced cardiac dysfunction and ventricular remodeling, increased collagen content in the right ventricle, and decreased antioxidant capacity in cardiac tissue. It also led to decreased contractile capacity and impaired vasodilation in carotid and femoral arteries. These findings highlight the importance of periodic cardiovascular evaluation in high-altitude workers.
Article
Multidisciplinary Sciences
Mehwish S. Bhatti, Ron D. Frostig
Summary: We have shown that sensory stimulation can protect against impending cortical ischemic stroke in a rat model. The activation of collaterals that allow for reperfusion of the ischemic area is a major mechanism underlying this protection. Additionally, we have found that the activation of astrocyte-neuron lactate shuttle (ANLS) is another important mechanism that complements collateral flow in the protection process.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
Garoa Santocildes, Gines Viscor, Teresa Pages, Sara Ramos-Romero, Josep Lluis Torres, Joan Ramon Torrella
Summary: The study found that intermittent exposure to hypobaric hypoxia and cold can have positive effects on body composition, hematological profiles, and muscle morphology and function. The rats exposed to both hypoxia and cold showed physiological adjustments such as increased brown adipose tissue weight and improved oxygen transport parameters in the blood.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Ursule Dumont, Stephane Sanchez, Cendrine Repond, Marie-Christine Beauvieux, Jean-Francois Chateil, Luc Pellerin, Anne-Karine Bouzier-Sore, Helene Roumes
Summary: Neonatal hypoxia-ischemia (nHI) is a major cause of death or disabilities in infants, with no pharmacological treatment currently available. Research has shown that supplementation of trans-resveratrol in pregnant rat females can significantly reduce brain lesions caused by nHI and alleviate long-term consequences.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Yan-Ming Tian, Yan Liu, Sheng Wang, Yi Dong, Tong Su, Hui-Jie Ma, Yi Zhang
Article
Pediatrics
Xinli Jiang, Huijie Ma, Chunguang Li, Yue Cao, Yan Wang, Yi Zhang, Yan Liu
PEDIATRIC RESEARCH
(2016)
Review
Pharmacology & Pharmacy
Meimei Tian, Yan Liu, Zhongji Zhi, Yukun Li
JOURNAL OF CLINICAL LIPIDOLOGY
(2017)
Article
Endocrinology & Metabolism
Yaru Zhou, Yu Yang, Yan Liu, Hengrui Chang, Kuanzhi Liu, Xiaojuan Zhang, Yanzhong Chang
CALCIFIED TISSUE INTERNATIONAL
(2019)
Article
Pediatrics
Yan Liu, Rick Havinga, Feike R. Van der Leij, Renze Boverhof, Pieter J. J. Sauer, Folkert Kuipers, Frans Stellaard
PEDIATRIC RESEARCH
(2008)
Article
Pediatrics
Yan Liu, Feike R. van der Leij
PEDIATRIC RESEARCH
(2011)
Article
Biochemistry & Molecular Biology
Yaru Zhou, Wenyue Wu, Zhifang Xu, Yan Liu, Hengrui Chang, Peng Yu, Xiaojuan Zhang, Yu Yang, Kuanzhi Liu, Yanzhong Chang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Food Science & Technology
Lei Ying, Liu Yan, Zhou Huimin, Li Min, Zhang Xiaojuan, Wang Zhanjian, Zhou Yaru
Summary: Iron overload has a significant impact on glucose metabolism, and tea polyphenols may help improve this impact. By regulating the expression of insulin receptor substrate 2 and glucose transporter 2, tea polyphenols can improve insulin sensitivity.
CYTA-JOURNAL OF FOOD
(2022)
Review
Biochemistry & Molecular Biology
Jing Xu, Min Li, Xinli Jiang, Yuling Wang, Huijie Ma, Yaru Zhou, Meimei Tian, Yan Liu
Summary: This review focuses on the role of oment-1 in diabetes, including its potential signaling pathways and the correlation between circulating oment-1 levels and diabetes and its complications. Studies have shown that oment-1 may exert its effects by inhibiting the NF-κB pathway and activating the Akt and AMPK-dependent pathways. Circulating oment-1 levels are negatively correlated with the occurrence of type 2 diabetes and some complications, and can be influenced by anti-diabetic therapies. Oment-1 could be a promising marker for screening and targeted therapy for diabetes and its complications, but further research is still needed.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Ophthalmology
Min Li, Meimei Tian, Xinli Jiang, Yan Liu, Yan Wang, Yukun Li
Summary: The study reveals that Gal-3 is involved in increased oxidative stress and inflammatory response in ARPE-19 cells under high glucose treatment, and knocking down Gal-3 can reduce these adverse effects.
CUTANEOUS AND OCULAR TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Yan Wang, Baoxin Li, Wei Zhang, Yan Liu, Peng Xue, Jianxia Ma, Yukun Li
Article
Physiology
Yan Liu, Harry van Goor, Rick Havinga, Julius F. W. Baller, Vincent W. Bloks, Feike R. van der Leij, Pieter J. J. Sauer, Folkert Kuipers, Gerjan Navis, Martin H. de Borst
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2008)
Article
Pediatrics
Yan Liu, Rick Havinga, Vincent W. Bloks, Juul F. Baller, Feike R. Van der Leij, Dirk-Jan Reijngoud, Pieter J. J. Sauer, Folkert Kuipers
PEDIATRIC RESEARCH
(2007)