Article
Cardiac & Cardiovascular Systems
Sara Rovai, Alessandra Magini, Marco Cittar, Marco Mase, Cosimo Carriere, Mauro Contini, Carlo Vignati, Gianfranco Sinagra, Piergiuseppe Agostoni
Summary: The presence of a double threshold was identified in healthy subjects, which does not affect peak exercise performance but is associated with delayed hyperventilation induced by acidosis.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Sport Sciences
Francesca Anselmi, Luna Cavigli, Antonio Pagliaro, Serafina Valente, Francesca Valentini, Matteo Cameli, Marta Focardi, Nicola Mochi, Paul Dendale, Dominique Hansen, Marco Bonifazi, Martin Halle, Flavio D'Ascenzi
Summary: The study found that the recommended exercise intensity definition based on percentages of peak HR and peak VO2 may misclassify the effective exercise intensity. Using a ventilatory threshold-based approach may be more suitable for defining an appropriate level of exercise intensity, especially in cardiac patients.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Biochemistry & Molecular Biology
Patricia Dias, Isaura Tavares, Sara Fonseca, Daniel Humberto Pozza
Summary: The study proposes a new, reproducible, and less time-consuming thermal QST protocol to help characterize and monitor pain. The QST outcomes were compared between healthy and chronic pain subjects, revealing higher pain sensitivity and hyperalgesia in the chronic pain group.
Review
Health Care Sciences & Services
Stefanos Karanasios, Ioannis Lignos, Kosmas Kouvaras, Maria Moutzouri, George Gioftsos
Summary: Low-intensity exercise with blood flow restriction (LIE-BFR) has been proposed as an effective intervention to increase pain threshold. However, there is still a lack of systematic reviews on this topic. This study aimed to evaluate the effect of LIE-BFR on pain threshold compared to other interventions and explore how different applications may influence hypoalgesic response. Based on the included randomized controlled trials, LIE-BFR was found to significantly increase pain threshold compared to conventional exercise. However, further research is needed to examine its effectiveness in patients with pain symptoms.
Review
Clinical Neurology
Michael A. Wewege, Matthew D. Jones
Summary: Based on the analysis of multiple studies, aerobic exercise induces a large reduction in pain for healthy individuals, while dynamic resistance exercise induces a small reduction, and isometric exercise does not induce any reduction in pain. In individuals with chronic musculoskeletal pain, isometric exercise also does not induce a reduction in pain. Further research is needed to explore the effects of aerobic and dynamic resistance exercise on chronic musculoskeletal pain.
Article
Engineering, Biomedical
Ali Asghar Zarei, Armita Faghani Jadidi, Eugen Romulus Lontis, Winnie Jensen
Summary: TENS has been reported to alleviate pain by cortical inhibition, and high-frequency TENS intervention significantly suppresses cortical activity and reduces the intensity and area size of perceived sensations.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Health Care Sciences & Services
Stefanos Karanasios, Alexia Sozeri, George A. Koumantakis, George Gioftsos
Summary: This study aimed to compare the hypoalgesic effects of elbow flexion low-load resistance exercise and high-load resistance exercise on healthy individuals. The results showed that both low-load and high-load resistance exercise significantly reduced pain threshold, indicating a decrease in pain sensitivity. Furthermore, changes in blood pressure and perceived exertion did not mediate the changes in pain threshold.
Review
Anatomy & Morphology
Laura Josephine Bubenzer, Lena Konsolke, Elena Enax-Krumova, Frederic Eberhardt, Martin Tegenthoff, Oliver Hoeffken, Oezuem Simal Oezguel
Summary: This systematic review compared and summarized the study results of pain-related evoked potentials with concentric surface electrodes (PREP with CE) in healthy subjects and patients, and identified possible influencing factors. The results showed that patients with polyneuropathies had consistent PREP results, while findings in other patient groups and healthy subjects were more heterogeneous. Factors such as age, height, and emotions were found to have an influence on the results, which should be considered in further studies. More systematic research is needed to analyze PREP results based on individual and disease-specific factors and develop optimal normative values.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Integrative & Complementary Medicine
Yu-Chen Lee, Cheng-Hao Tu, Hsin-Yi Chung, Sih-Ting Luo, Yu-Ting Chu, Iona J. MacDonald, Peddanna Kotha, Chien-Chen Huang, Hsien-Yuan Lane, Jaung-Geng Lin, Yi-Hung Chen
Summary: This pilot study aimed to investigate whether the histamine H1 receptor antagonist dexchlorpheniramine (DCPA) can facilitate electroacupuncture (EA) analgesia in healthy human subjects. The results showed that subjects in the high-dose DCPA group had a significantly higher pain threshold elevation after EA, indicating that 4 mg of DCPA can enhance EA analgesia.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Chemistry, Analytical
Monica Albaladejo-Belmonte, Marta Tarazona-Motes, Francisco J. Nohales-Alfonso, Maria De-Arriba, Jose Alberola-Rubio, Javier Garcia-Casado
Summary: Chronic pelvic pain is closely associated with hypertonic dysfunction of the pelvic floor musculature, and surface electromyography can reveal alterations in pelvic floor muscle electrophysiology, providing clinicians with objective information for CPP diagnosis.
Article
Behavioral Sciences
Jun Seob Song, Yujiro Yamada, Ryo Kataoka, Vickie Wong, Robert W. Spitz, Zachary W. Bell, Jeremy P. Loenneke
Summary: A single bout of exercise can reduce pain sensitivity in healthy individuals, but exercise-induced hypoalgesia is often impaired in individuals with chronic pain. Existing literature suggests that training interventions may induce hypoalgesic adaptations, potentially driven by central nervous system and immune system factors, but further research is needed to understand the underlying mechanisms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Catherine Mailloux, Louis-David Beaulieu, Timothy H. Wideman, Hugo Masse-Alarie
Summary: This study investigated the reliability of PPT and TSP measurements at the low back and forearm in healthy participants, revealing that multiple measurements reduced errors and demonstrated excellent relative reliability.
Review
Cardiac & Cardiovascular Systems
Xiaowan Han, Tong Li, Yang Li, Jingjing Yang, Shiqi Chen, Xiangyu Zhu, Baofu Wang, Wenkun Cheng, Lei Wang, Ziwen Lu, Xiaoxiao Wu, Yangyang Jiang, Guozhong Pan, Mingjing Zhao
Summary: This study explored the relationship between exercise and circulating microparticles (CMPs) by reviewing 26 studies. It found that untrained subjects had increased levels of CMPs after a single bout of exercise, while trained subjects had lower levels, possibly due to their better ability to adapt to changes in hemodynamics and cellular function during exercise.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
So Yeon Lee, Joong Baek Kim, Jung Woong Lee, A. Mi Woo, Chang Jae Kim, Mee Young Chung, Ho Sik Moon
Summary: Pain, as a subjective sensation, is difficult to evaluate objectively. This study analyzed the correlation between the numeric rating scale (NRS) and objective pain measurement tools such as the current perception threshold (CPT), pain equivalent current (PEC), and quantified pain degree (QPD). The results showed significant correlations between NRS and CPT, as well as between NRS and QPD, suggesting that these objective measurements could be useful for estimating pain intensity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Gosuke Sato, Michihiro Osumi, Satoshi Nobusako, Shu Morioka
Summary: This study found that the combination of tDCS and AE can significantly alter the pressure pain threshold and induce a higher peak alpha frequency, with a more pronounced effect than tDCS or AE alone.
Article
Rheumatology
Mitchell T. Gibbs, Natalie M. Morrison, Matthew D. Jones, Danielle Burgess, Paul W. Marshall
Summary: This study examines the effectiveness of a modified fear hierarchy on measuring improvements in movement-associated fear in patients with chronic low back pain. The results demonstrate that reductions in movement-associated fear are conditional upon graded exposure, with different training methods leading to different improvements in specific movements.
MUSCULOSKELETAL CARE
(2023)
Review
Rehabilitation
Sally Casson, Matthew D. Jones, Joanne Cassar, Natalie Kwai, Andrew R. Lloyd, Benjamin K. Barry, Carolina X. Sandler
Summary: Activity pacing interventions are effective in reducing fatigue and psychological distress and improving physical function in people with chronic fatigue syndrome (CFS), particularly when individuals are encouraged to gradually increase activities.
DISABILITY AND REHABILITATION
(2023)
Review
Rheumatology
Adrian K. Ram, Simon J. Summers, John Booth, Mitchell T. Gibbs, Matthew D. Jones
Summary: This systematic review aimed to determine the effect of exercise intensity on outcomes in people with chronic low back pain. The review found that higher intensity exercise can reduce disability, but does not significantly improve pain and quality of life. The evidence quality was low, leading to uncertainty in the conclusions.
MUSCULOSKELETAL CARE
(2023)
Review
Orthopedics
Yannick L. Gilanyi, Michael A. Wewege, Brishna Shah, Aidan G. Cashin, Christopher M. Williams, Simon R. E. Davidson, James H. Mcauley, Matthew D. Jones
Summary: Exercise has been found to increase pain self-efficacy in adults with nonspecific chronic low back pain, based on a systematic review and meta-analysis of randomized controlled trials. However, further research is needed to confirm this effect and investigate its potential significance.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2023)
Review
Orthopedics
Jack J. Devonshire, Michael A. Wewege, Harrison J. Hansford, Hasibe A. Odemis, Benedict M. Wand, Matthew D. Jones, James H. Mcauley
Summary: This study evaluated the effectiveness of cognitive functional therapy (CFT) for adults with chronic low back pain (LBP) through a systematic review and meta-analysis. Fifteen randomized controlled trials were included, and the results showed that CFT was not more effective than other common interventions in reducing pain and disability. The effectiveness of CFT remains highly uncertain and further high-quality studies are needed to confirm these findings.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2023)
Article
Sport Sciences
Ricardo N. O. Mesquita, Christopher Latella, Cassio V. Ruas, Kazunori Nosaka, Janet L. Taylor
Summary: The study compared different formulas used to estimate muscle contraction velocity (Vc) assessed by tensiomyography. The reliability, required minimum number of trials, proportional bias, and effects of joint angle were investigated. The results showed that formulas 1 (0-2 mm of displacement) and 5 (normalized to 10-90% of maximal displacement) had higher reliability. A minimum of 6-7 trials was required for reliable estimates. The study also found that Vc was faster at shorter muscle lengths for all formulas except formula 5. Different formulas should not be used interchangeably and more precise nomenclature is needed to describe the information obtained from each formula.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Rheumatology
Elise E. Drum, Alexandre Kovats, Matthew D. Jones, Sarah Dennis, Justine Naylor, Kathryn Mills, Jeanette M. Thom
Summary: This study aimed to investigate the perceptions of knee crepitus and its impact on exercise behaviors among individuals with osteoarthritis. The findings suggest that most participants were not concerned about knee crepitus, but it did influence their exercise habits and movements. Providing guidance and support to individuals with concerns about knee crepitus may help them feel more confident in exercising for joint health benefits.
MUSCULOSKELETAL CARE
(2023)
Article
Neurosciences
Ricardo N. O. Mesquita, Janet L. Taylor, Gabriel S. Trajano, Ales Holobar, Basilio A. M. Goncalves, Anthony J. Blazevich
Summary: The study aimed to investigate whether jaw clenching and mental stress facilitate the activation of persistent inward currents (PICs) in human motoneurons. The results showed that PIC activation significantly increased during jaw clenching and in some cases of mental stress.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Matthew D. Jones, Sally M. Casson, Benjamin K. Barry, Sophie H. Li, Trinidad Valenzuela, Joanne Cassar, Camillo Lamanna, Andrew R. Lloyd, Carolina X. Sandler
Summary: eLearning has been shown to increase knowledge and confidence among allied health professionals in managing patients with medically unexplained chronic fatigue states.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Orthopedics
Mitchell T. Gibbs, Jill A. Hayden, Aidan G. Cashin, Brishna Shah, Yannick L. Gilanyi, Andrew Natoli, Grant Holmes, Rachel Ogilvie, Amanda D. Hagstrom, James H. McAuley, Paul W. Marshall, Matthew D. Jones
Summary: This study aimed to estimate the proportion of exercise interventions tested in clinical trials for chronic low back pain (CLBP) that meet the World Health Organisation's (WHO) physical activity guidelines. A secondary analysis of the 2021 Cochrane review of exercise therapy for CLBP was performed, and the results showed that few interventions meet the WHO guidelines, indicating a lack of broader impact on health outcomes.
Review
Medicine, General & Internal
Harrison J. Hansford, Aidan G. Cashin, Matthew D. Jones, Sonja A. Swanson, Nazrul Islam, Susan R. G. Douglas, Rodrigo R. N. Rizzo, Jack J. Devonshire, Sam A. Williams, Issa J. Dahabreh, Barbra A. Dickerman, Matthias Egger, Xabier Garcia-Albeniz, Robert M. Golub, Sara Lodi, Margarita Moreno-Betancur, Sallie-Anne Pearson, Sebastian Schneeweiss, Jonathan A. C. Sterne, Melissa K. Sharp, Elizabeth A. Stuart, Miguel A. Hernan, Hopin Lee, James H. Mcauley
Summary: The reporting of observational studies that aim to emulate a target trial is inconsistent, and the development of a reporting guideline may improve the quality of reporting.
Article
Rheumatology
Mitchell T. Gibbs, Theo Last, Paul Marshall, Matthew D. Jones
Summary: Practitioners' attitudes and beliefs towards chronic low back pain influence their treatment choices, with higher biomedical beliefs being associated with specific exercise and manual therapy, while higher biopsychosocial beliefs are related to general exercise and cognitive behavioral therapy.
MUSCULOSKELETAL CARE
(2023)
Article
Multidisciplinary Sciences
Claire V. Burley, Anne-Nicole Casey, Matthew D. Jones, Kemi E. Wright, Belinda J. Parmenter
Summary: This meta-analysis examined nonpharmacological interventions for pain and depression in people with osteoarthritis. The results showed significant effects of movement meditation, multimodal interventions, and psychological therapy in reducing pain. Resistance exercise and aerobic exercise alone did not improve pain. For depressive symptoms, movement meditation and multimodal interventions had significant effects.
SCIENTIFIC REPORTS
(2023)
Review
Anesthesiology
Adrian Ram, John Booth, Jeanette M. Thom, Mitchell T. Gibbs, Matthew D. Jones
Summary: The findings of this systematic review and meta-analysis suggest that there is no short-term association between changes in pain knowledge after pain science education and treatment outcomes in people with chronic pain.
CLINICAL JOURNAL OF PAIN
(2023)