Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review

Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence

(2016) Philip J. Atherton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

(2016) Marlou L. Dirks et al.   DIABETES

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle

(2016) A. Vigelsø et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis

(2015) Haitham Abdulla et al.   DIABETOLOGIA

Not all disuse protocols are equal: new insight into the signalling pathways to muscle atrophy

(2015) Carlo Reggiani   JOURNAL OF PHYSIOLOGY-LONDON

Human skeletal muscle fibre contractile properties and proteomic profile: adaptations to 3 weeks of unilateral lower limb suspension and active recovery

(2015) Lorenza Brocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

Redox Characterization of Functioning Skeletal Muscle

(2015) Li Zuo et al.   Frontiers in Physiology

Neuromuscular electrical stimulation prevents muscle disuse atrophy during leg immobilization in humans

(2013) M. L. Dirks et al.   Acta Physiologica

Hibernation: The search for treatments to prevent disuse-induced skeletal muscle atrophy

(2013) Sue C. Bodine   EXPERIMENTAL NEUROLOGY

The regulation of muscle protein turnover in diabetes

(2013) Biruh Workeneh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of muscle protein synthesis and the effects of catabolic states

(2013) Bradley S. Gordon et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Disuse Impairs the Muscle Protein Synthetic Response to Protein Ingestion in Healthy Men

(2013) Benjamin T. Wall et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle

(2013) C. Suetta et al.   JOURNAL OF PHYSIOLOGY-LONDON

Quadriceps Strength, Quadriceps Power, and Gait Speed in Older U.S. Adults with Diabetes Mellitus: Results from the National Health and Nutrition Examination Survey, 1999-2002

(2013) Rita Rastogi Kalyani et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Patients With Type 2 Diabetes Show a Greater Decline in Muscle Mass, Muscle Strength, and Functional Capacity With Aging

(2013) Marika Leenders et al.   Journal of the American Medical Directors Association

Reduced Satellite Cell Numbers with Spinal Cord Injury and Aging in Humans

(2013) LEX B. VERDIJK et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Neuromuscular electrical stimulation increases muscle protein synthesis in elderly type 2 diabetic men

(2012) Benjamin T. Wall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

(2012) Micah J. Drummond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative stress and disuse muscle atrophy

(2012) Scott K. Powers et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance

(2012) Rasmus S. Biensø et al.   DIABETES

Role of Muscle Mass and Muscle Quality in the Association Between Diabetes and Gait Speed

(2012) S. Volpato et al.   DIABETES CARE

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Heterogeneous atrophy occurs within individual lower limb muscles during 60 days of bed rest

(2012) Tanja Miokovic et al.   JOURNAL OF APPLIED PHYSIOLOGY

The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms

(2012) Lorenza Brocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men

(2012) Tyler A. Churchward-Venne et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscle protein synthesis in response to nutrition and exercise

(2012) P. J. Atherton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

(2012) Amanda R Martins et al.   Lipids in Health and Disease

Mechanisms responsible for disuse muscle atrophy: Potential role of protein provision and exercise as countermeasures

(2012) Joanne E. Mallinson et al.   NUTRITION

Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism

(2012) Tyler A Churchward-Venne et al.   Nutrition & Metabolism

Aging Affects the Transcriptional Regulation of Human Skeletal Muscle Disuse Atrophy

(2012) Charlotte Suetta et al.   PLoS One

Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise

(2011) D. W. West et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mechanistic Links Between Oxidative Stress and Disuse Muscle Atrophy

(2011) Scott K. Powers et al.   ANTIOXIDANTS & REDOX SIGNALING

Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991–2011)

(2011) K. J. Hackney et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy

(2011) Kisuk Min et al.   JOURNAL OF APPLIED PHYSIOLOGY

A longitudinal MRI study of muscle atrophy during lower leg immobilization following ankle fracture

(2011) Maria Psatha et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Redox homeostasis, oxidative stress and disuse muscle atrophy

(2011) Maria Antonietta Pellegrino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle

(2011) Scott K. Powers et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of Genes that Elicit Disuse Muscle Atrophy via the Transcription Factors p50 and Bcl-3

(2011) Chia-Ling Wu et al.   PLoS One

Skeletal muscle loss: cachexia, sarcopenia, and inactivity

(2010) William J Evans   AMERICAN JOURNAL OF CLINICAL NUTRITION

Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy

(2010) Elisa I. Glover et al.   Applied Physiology Nutrition and Metabolism

Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism

(2010) Jared M Dickinson et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Autophagy in skeletal muscle

(2010) Marco Sandri   FEBS LETTERS

Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans

(2010) Kimberly A. Reich et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining

(2010) Lars Hvid et al.   JOURNAL OF APPLIED PHYSIOLOGY

Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres

(2010) R. H. Fitts et al.   JOURNAL OF PHYSIOLOGY-LONDON

Facts, noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy

(2010) M. J. Rennie et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia

(2010) Nathan A Stephens et al.   Genome Medicine

Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

(2009) Emilie A Wilkes et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Protein and energy metabolism in type 1 diabetes

(2009) Sadie L. Hebert et al.   CLINICAL NUTRITION

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes

(2009) S. W. Park et al.   DIABETES CARE

Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production

(2009) Andreas N. Kavazis et al.   FREE RADICAL BIOLOGY AND MEDICINE

A transient antioxidant stress response accompanies the onset of disuse atrophy in human skeletal muscle

(2009) Luciano Dalla Libera et al.   JOURNAL OF APPLIED PHYSIOLOGY

Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity

(2009) T. B. Symons et al.   JOURNAL OF APPLIED PHYSIOLOGY

Alterations of protein turnover underlying disuse atrophy in human skeletal muscle

(2009) S. M. Phillips et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human muscle protein synthesis and breakdown during and after exercise

(2009) Vinod Kumar et al.   JOURNAL OF APPLIED PHYSIOLOGY

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

(2009) Nava Bashan et al.   PHYSIOLOGICAL REVIEWS

Inverse association between insulin resistance and gait speed in nondiabetic older men: results from the U.S. National Health and Nutrition Examination Survey (NHANES) 1999-2002

(2009) Chen-Ko Kuo et al.   BMC Geriatrics

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

(2008) P. L. Greenhaff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Signal transduction pathways that regulate muscle growth

(2008) Henning Wackerhage et al.   Essays in Biochemistry

Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit

(2008) Naomi Brooks et al.   JOURNAL OF APPLIED PHYSIOLOGY

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

(2008) Elisa I. Glover et al.   JOURNAL OF PHYSIOLOGY-LONDON

Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle

(2008) Sarah B. Wilkinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

(2008) John Papaconstantinou   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Human soleus single muscle fiber function with exercise or nutrition countermeasures during 60 days of bed rest

(2007) Scott Trappe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY