Article
Cell Biology
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Summary: In this study, a mouse model of ACM was developed to investigate the dual role of genetics and external stressors in ACM progression. The findings suggest that cardiovascular stress is a key trigger for unmasking both electrical and structural phenotypes in ACM.
Article
Biochemistry & Molecular Biology
Kazuko Tajiri, Kyoko Imanaka-Yoshida, Yusuke Tsujimura, Kazuhiro Matsuo, Michiaki Hiroe, Kazutaka Aonuma, Masaki Ieda, Yasuhiro Yasutomi
Summary: The study introduces a novel mouse model of chronic myocarditis induced by rBCG-MyHC alpha, which resulted in similar symptoms to human DCM. This model may help identify the central pathophysiological and immunological processes involved in the progression to DCM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qing Kong, Jinping Gu, Ruohan Lu, Caihua Huang, Xiaomin Hu, Weifeng Wu, Donghai Lin
Summary: This study investigated the molecular mechanisms underlying the progression of viral myocarditis (VMC) into dilated cardiomyopathy (DCM) using mouse models and NMR-based metabonomic analyses. The results revealed distinct metabolic profiles and identified significant metabolites and disrupted metabolic pathways in different stages of VMC and DCM. Potential biomarkers for prognosis and diagnosis of heart diseases were also identified. This work lays the foundation for understanding the progression from acute VMC to DCM and has implications for the development of biomarkers.
Article
Biochemistry & Molecular Biology
Qing Kong, Jinping Gu, Ruohan Lu, Caihua Huang, Lili Chen, Weifeng Wu, Donghai Lin
Summary: In this study, metabolomic analysis of cardiac tissues was conducted to investigate the metabolic changes in different pathological stages of viral myocarditis. The results revealed distinct metabolic differences between the pathological groups and normal controls, and identified impaired metabolic pathways and potential cardiac biomarkers associated with these pathological stages.
Review
Cardiac & Cardiovascular Systems
Gary Tse, Ka Hou Christien Li, Chloe Kwong Yee Cheung, Konstantinos P. Letsas, Aishwarya Bhardwaj, Abhishek C. Sawant, Tong Liu, Gan-Xin Yan, Henggui Zhang, Kamalan Jeevaratnam, Nazish Sayed, Shuk Han Cheng, Wing Tak Wong
Summary: This review consolidates pre-clinical findings on the electrophysiological mechanisms underlying hypokalaemia-induced arrhythmogenicity, discussing triggers and substrates, as well as the characteristics of static and dynamic substrates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Lauren E. Parker, Ryan J. Kramer, Samantha Kaplan, Andrew P. Landstrom
Summary: Rare variants in the JPH2 gene are associated with various cardiac diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmias, and sudden cardiac death. This systematic review examines case reports and series describing patients with JPH2 variants and cardiac diseases. A total of 61 individuals with variant-positive were identified, with about 80% having some form of cardiac disease, including HCM, DCM, and arrhythmia/SCD. The analysis of the 24 probands showed that autosomal recessive loss-of-function variants are linked to severe, early onset DCM, while autosomal dominant missense variants are associated with a wider range of cardiac diseases.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Amy R. Kontorovich, Nihir Patel, Arden Moscati, Felix Richter, Inga Peter, Enkhsaikhan Purevjav, Simina Ramona Selejan, Ingrid Kindermann, Jeffrey A. Towbin, Michael Bohm, Karin Klingel, Bruce D. Gelb
Summary: Impairments in certain cardiac genes may increase the risk of myocarditis in children, as evidenced by more deleterious gene variants found in patients with acute myocarditis. Thirteen genes associated with cardiomyopathy or neuromuscular disorders with cardiac involvement were found to be implicated in the study.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Review
Cardiac & Cardiovascular Systems
Heinz-Peter Schultheiss, Christian Baumeier, Heiko Pietsch, C-Thomas Bock, Wolfgang Poller, Felicitas Escher
Summary: Infection of the heart muscle with cardiotropic viruses is a major cause of myocarditis and acute and chronic inflammatory cardiomyopathy, posing a significant public health issue globally. Advances in molecular genetic analysis of intramyocardial viruses have improved our understanding of the molecular pathogenesis and pathophysiology of viral infections of the heart muscle.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Paul Y. Lee, Hasan Garan, Elaine Y. Wan, Brian E. Scully, Angelo Biviano, Hirad Yarmohammadi
Summary: This study aims to review the arrhythmogenic effects of common viruses and emphasizes the need for further research in this area.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Physiology
Weichao Li, Weihua Liu, Heng Li
Summary: The study aimed to assess the risk of postoperative ventricular arrhythmia (POVA) in patients undergoing cardiac surgery using preoperative electrocardiographic (ECG) markers and develop a risk predicting model. The results showed that ECG markers including J wave, Tpe >112.5 ms, and S-V1+R-V5 >35 mm were significantly associated with POVA. These findings are important for preoperative identification of high-/low-risk POVA patients and formulating appropriate treatment plans.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Anissa Souidi, Krzysztof Jagla
Summary: The Drosophila heart, a simpler version of vertebrate hearts, is a valuable model for studying mechanisms of cardiac aging, heart failure, and congenital heart diseases. Fast imaging technologies allow for characterizing heartbeat parameters and reproducing and analyzing human cardiac dysfunction in Drosophila, making it a powerful tool for fundamental and applied cardiac research. The genetic power and conservation of genes and pathways in Drosophila make it a key player in the field of cardiac research.
Article
Physiology
Yunpo Zhao, Joyce van de Leemput, Zhe Han
Summary: The Drosophila heart tube, although seemingly simple, possesses intricate anatomical complexity and highly specialized structures. Remarkably, the development of this organ in flies is similar to that of the early stages of mammalian heart development, and the underlying molecular-genetic mechanisms are conserved across species. With the added advantage of advanced genetic tools and various techniques to study structure and function in living organisms, Drosophila has become a valuable model system for understanding human heart development and diseases. This perspective emphasizes the similarities between fly and human hearts in terms of function and physiology, providing insights into the limitations in using flies and potential prospects for expanding the capabilities of Drosophila as a research model for studying human cardiac diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Vamsi Krishna Murthy Ginjupalli, Michael Cupelli, Jean-Baptiste Reisqs, Yvonne Sleiman, Nabil El-Sherif, Genevieve Gourdon, Jack Puymirat, Mohamed Chahine, Mohamed Boutjdir
Summary: Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes conduction abnormalities and arrhythmias in the heart. This study found that in a mouse model of DM1, there were reduced densities of sodium current, L-type calcium current, and transient outward potassium current, as well as changes in gating properties of L-type calcium channels, which may contribute to the observed ECG abnormalities. These findings suggest potential targeted therapeutics for DM1.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Maurits A. Sikking, Sophie L. V. M. Stroeks, Michiel T. H. M. Henkens, Max F. G. H. M. Venner, Xiaofei Li, Stephane R. B. Heymans, Mark R. Hazebroek, Job A. J. Verdonschot
Summary: Dilated cardiomyopathy (DCM) has a genetic cause in up to 40% of cases, and the presence of cardiac inflammation is associated with a younger disease onset in genetic DCM patients. However, cardiac inflammation does not increase the risk of mortality, heart failure hospitalization, or life-threatening arrhythmias. This suggests that myocarditis may be an exogeneous trigger for DCM in patients with a genetic susceptibility or that cardiac inflammation represents an early phase of the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Jiajia Tan, Jing Wei, Hongxiang Lu
Summary: sST2 is a predictor of poor outcomes and is involved in inflammatory response and fibrosis of myocarditis. Cellular senescence is an irreversible cell cycle arrest. Studies have shown that senescence of myofibroblasts can limit or reduce cardiac fibrosis. However, the molecular mechanism of sST2 regulating cellular senescence is still unclear.
Article
Endocrinology & Metabolism
Yan Hiu Athena Lee, Jeremy Man Ho Hui, Jeffrey Shi Kai Chan, Kang Liu, Edward C. Dee, Kenrick Ng, Pias Tang, Gary Tse, Chi Fai Ng
Summary: This study examined the associations between concurrent use of metformin and androgen deprivation therapy (ADT) and mortality risks in Asian, diabetic patients with prostate cancer (PCa). The results showed that the use of metformin concurrently with ADT was associated with lower risks of PCa-related mortality and all-cause mortality in these patients.
Article
Cardiac & Cardiovascular Systems
Beizheng Xu, Yueying Wang, Gary Tse, Jiayi Chen, Guangping Li, Panagiotis Korantzopoulos, Tong Liu
Summary: This systematic review and meta-analysis found that radiation therapy (RT) may increase the acute and long-term risks for patients with cardiac implantable electronic devices (CIEDs) such as pacemakers and implantable cardioverter-defibrillators. The risk of device malfunction was higher for implantable cardioverter-defibrillator (ICD) than pacemakers, and higher with radiation using beam energy ≥ 10 MV and neutron-generating RT. Risk stratification is needed for patients with cancer receiving RT and have CIEDs.
Article
Cardiac & Cardiovascular Systems
Xinxin Zhang, Yuxi Sun, Yunlong Zhang, Ning Wang, Qiuyan Sha, Songqi Yu, Xin Lv, Zijie Ding, Yanli Zhang, Gary Tse, Ying Liu
Summary: This study suggests that the combined use of neurohormonal antagonists in patients with HFmrEF can significantly reduce the occurrence of rehospitalization and death.
Article
Oncology
Jeffrey Shi Kai Chan, Yan Hiu Athena Lee, Jeremy Man Ho Hui, Kang Liu, Edward Christopher Dee, Kenrick Ng, Tong Liu, Gary Tse, Chi Fai Ng
Summary: Our study examined the impact of cardiovascular comorbidities on adverse cardiovascular outcomes in prostate cancer patients treated with androgen deprivation therapy (ADT). We analyzed data from Hong Kong patients with prostate cancer who received ADT and found that the presence of heart failure, myocardial infarction, arrhythmia, or a combination of these comorbidities was associated with increased cardiovascular risks. The number of major cardiovascular comorbidities had a prognostic impact, indicating its importance over the specific type of comorbidity.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Cardiac & Cardiovascular Systems
Ying Liu, Yi Zheng, Gary Tse, George Bazoukis, Konstantinos Letsas, Christos Goudis, Panagiotis Korantzopoulos, Guangping Li, Tong Liu
Summary: This systematic review and meta-analysis aimed to explore the relationship between sick sinus syndrome (SSS) and atrial fibrillation (AF) and compare different therapy strategies for patients with SSS and AF. Results showed that SSS was associated with a higher risk of new-onset AF. Catheter ablation was found to be more effective than pacemaker therapy in reducing the risk of AF recurrence, AF progression, mortality, stroke, and heart failure hospitalization. Different pacing strategies for SSS were also compared, with VVI/VVIR showing a higher risk of new-onset AF compared to DDD/DDDR. AAI/AAIR had a higher risk of all-cause mortality but a lower risk of cardiac death compared to DDD/DDDR. Right atrial septum pacing showed similar risks of new-onset AF or AF recurrence compared to right atrial appendage pacing. The meta-analysis emphasized the importance of avoiding high ventricular pacing percentages in SSS patients to reduce AF burden and mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Hematology
Xiaogang Zhu, Zhenhua Wang, Markus W. Ferrari, Katharina Ferrari-Kuehne, David H. Hsi, Gary Tse, Quanzhong Zhou, Haifeng Liang, Yuhui Zhang, Jian Zhang
Summary: Infective endocarditis (IE) carries a high risk of vascular complications, which are correlated with increased mortality. The use of anticoagulation in IE patients remains controversial and challenging. An appropriate anticoagulation strategy is crucial for improving outcomes and requires a good understanding of the indication, timing, and regimen of anticoagulation in IE.
THROMBOSIS RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Jeffrey Shi Kai Chan, Danish Iltaf Satti, Edward Christopher Dee, Garima Sharma, Salim S. Virani, Tong Liu, Gary Tse
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jeffrey Shi Kai Chan, Dawnie Ho Hei Lau, Emma King, Leonardo Roever, Tong Liu, Yuki Ka Ling Shum, Kenrick Ng, Edward Christopher Dee, Ana Ciobanu, George Bazoukis, Elham Mahmoudi, Danish Iltaf Satti, Kamalan Jeevaratnam, Adrian Baranchuk, Gary Tse, Cardiovasc Analyt Grp
Summary: This article introduces a virtual international medical research mentoring organization, which has successfully trained 63 members from 14 different countries in academic medicine through the use of virtual platforms and multi-level mentoring approach. The members have published over 100 peer-reviewed research and review articles and won 13 research prizes. This accessible and distributed model is viable and efficient, catering to the needs of contemporary healthcare, and others should consider building similar models to improve medical research mentoring globally.
Article
Cardiac & Cardiovascular Systems
Xiaoyan Liu, Lidong Huang, Gary Tse, Tong Liu, Jingjin Che
Summary: This study retrospectively analyzed the efficacy and safety of LCZ696 in patients with CHF and ESRD on dialysis. The results showed that LCZ696 treatment group had significantly lower rate of HF rehospitalization, delayed occurrence of HF rehospitalization, and longer survival time. Therefore, LCZ696 is effective and safe in CHF patients with ESRD on dialysis.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sharen Lee, Cheuk To Skylar Chung, Danny Radford, Oscar Hou In Chou, Teddy Tai Loy Lee, Zita Man Wai Ng, Leonardo Roever, Rajesh Rajan, George Bazoukis, Konstantinos P. P. Letsas, Shaoying Zeng, Fang Zhou Liu, Wing Tak Wong, Tong Liu, Gary Tse
Summary: This study found that there are differences in health care resource utilization and costs between patients with Brugada syndrome (BrS) and congenital long QT syndrome (LQTS). BrS patients have lower total costs but higher costs for Accident and Emergency (A & E) and general outpatient services, while they have lower costs for inpatient stay and specialist outpatient services compared to LQTS patients.
CLINICAL CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Gary Tse, Quinncy Lee, Oscar Hou In Chou, Cheuk To Chung, Sharen Lee, Jeffrey Shi Kai Chan, Guoliang Li, Narinder Kaur, Leonardo Roever, Haipeng Liu, Tong Liu, Jiandong Zhou
Summary: Routinely collected electronic health records (EHRs) data provide valuable information for epidemiological studies, and the use of big data and artificial intelligence (AI) has rapidly increased in Hong Kong since 2015. The advantages of big data include generalizability, simultaneous determination of multiple outcomes, ease of cross-validation, analysis of numerous variables, analysis of static and dynamic variables, capturing non-linear and latent interactions, and enhancing prediction models with AI approaches.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Nursing
Shyla Gupta, Sebastian Garcia-Zamora, Jorge Juarez-Lloclla, Juan Farina, Melanie Foisy, Laura Pulido, Victoria Ramos, Franco Merschon, Josefina B. Parodi, Maria Elena Sanchez, Ana Munera, Daniel Piskorz, Daniel Jose Pineiro, Gary Tse, Ricardo Lopez-Santi, Adrian Baranchuk
Summary: During the COVID-19 pandemic in Latin America, nurses were particularly vulnerable to workplace violence, experiencing higher rates of aggression and cognitive symptoms and lower rates of complaints compared to other healthcare providers.
JOURNAL OF ADVANCED NURSING
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Ronald Nam, Gary Tse
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Oncology
Yan Hiu Athena Lee, Jeremy Man Ho Hui, Chi Ho Leung, Christopher Tze Wei Tsang, Kyle Hui, Pias Tang, Jeffrey Shi Kai Chan, Edward Christopher Dee, Kenrick Ng, Sean McBride, Paul L. Nguyen, Gary Tse, Chi Fai Ng
Summary: This study compared the risks of major adverse cardiovascular events (MACE) between enzalutamide and abiraterone in prostate cancer patients, and found that enzalutamide users had lower cardiovascular risks.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Letter
Medicine, General & Internal
Jeffrey Shi Kai Chan, Oscar Hou In Chou, Teddy Tai Loy Lee, Yan Hiu Athena Lee, Raymond Ngai Chiu Chan, Edward Christopher Dee, Kenrick Ng, Tong Liu, Gary Tse
JOURNAL OF INTERNAL MEDICINE
(2023)