Article
Medicine, Research & Experimental
Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Yi
Summary: This study demonstrates that bergenin attenuates myocardial apoptosis and oxidative damage induced by MI/R through the SIRT1 signaling pathway. Bergenin significantly reduces cardiomyocyte apoptosis and ROS production, and improves cardiac function in vitro and in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Xin Su, Mingyang Zhou, Yingjian Li, Jianzhen Zhang, Na An, Fan Yang, Guoxia Zhang, Chao Yuan, Hengwen Chen, Hongjin Wu, Yanwei Xing
Summary: Patients with ischemic heart disease receiving reperfusion therapy are still at risk of left ventricular remodeling and heart failure. However, reperfusion itself can paradoxically lead to further cardiomyocyte death and dysfunction. Mitochondrial dysfunction and structural disorder play a crucial role in the development of ischemia/reperfusion (I/R) injury. This review summarizes the basic relationship and potential mechanisms of mitochondrial injury in I/R injury, and discusses natural products (NPs) that have shown therapeutic effects targeting mitochondria during I/R injury and related cellular signal transduction pathways. The study finds that these NPs mainly protect mitochondrial integrity and improve dysfunction, thus providing potential therapies for cardioprotection during I/R injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Plant Sciences
Haiyang Chen, Huifen Zhou, Jiehong Yang, Haitong Wan, Yu He
Summary: This study investigated the protective mechanism of Guhong injection (GHI) on myocardial ischemia/reperfusion (MI/R) injury. The results showed that GHI activated glutathione S-transferase P (GST P) to inhibit the ASK1-JNK/p38 pathway, thereby alleviating oxidative stress and apoptosis, and exerting cardioprotective effects.
Article
Environmental Sciences
Ying Liu, Yun Liu, Hong-Li Zhang, Fen-Fang Yu, Xiao-Rui Yin, Yan-Fang Zhao, Fei Ye, Xiang-Qi Wu
Summary: The study aimed to evaluate the cardioprotective effect of neoandrographolide on myocardial ischemia/reperfusion injury (I/R) models and found that Neo could alleviate myocardial I/R-induced damage by inhibiting inflammation and cell apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Rui-Ying Su, Wei-Yan Tai, Hong -Shan Yin, Xiao-Yong Geng
Summary: This study demonstrates that miR-432 plays an important role in myocardial ischemia/reperfusion (MI/R) injury. MiR-432 is upregulated in the heart following MI/R injury and its overexpression can decrease the infarct area and levels of serum CPK, while knockdown of miR-432 has the opposite effect. MiR-432 protects against MI/R injury by activating the beta-catenin/ HIF-1 alpha pathway and augmenting NRF2-mediated anti-oxidative stress.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Rui-Ying Su, Wei-Yan Tai, Hong -Shan Yin, Xiao-Yong Geng
Summary: This study demonstrates that miR-432 plays a crucial role in myocardial ischemia/reperfusion injury by activating the beta-catenin/HIF-1α pathway and enhancing NRF2-mediated anti-oxidative stress.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Immunology
Qihong Wu, Rong Xu, Kun Zhang, Ran Sun, Mengxi Yang, Kuan Li, Hanrui Liu, Yiyuan Xue, Huayan Xu, Yingkun Guo
Summary: This study comprehensively characterized the physiopathologic changes of myocardial injury after ischemia-reperfusion. It found that the early stage of reperfusion injury is mainly characterized by edema rather than inflammation, and suggested that edema may be a crucial factor contributing to myocardial injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Piotr Frydrychowski, Marcin Michalek, Iwona Bil-Lula, Elzbieta Chelmecka, Alina Kafel, Agnieszka Noszczyk-Nowak, Dominika Stygar
Summary: The study evaluated the cardioprotective effect of intracoronary administered aspirin on myocardial ischemia-reperfusion injury using an experimental animal model. The results showed that aspirin reduced oxidative stress levels in heart tissue and serum compared to the control group.
Article
Pharmacology & Pharmacy
Kai-yu Huang, Yong-wei Yu, Shuai Liu, Ying-ying Zhou, Jin-sheng Wang, Yang-pei Peng, Kang-ting Ji, Yang-jing Xue
Summary: The research shows that ASIV can alleviate myocardial I/R injury by regulating autophagy, and O-2(center dot-) plays a vital role in this process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chin-Feng Tsai, Hsing-Hui Su, Ke-Min Chen, Jiuan-Miaw Liao, Yi-Ting Yao, Yi-Hung Chen, Meilin Wang, Ya-Chun Chu, Yi-Hsin Wang, Shiang-Suo Huang
Summary: Paeonol has cardioprotective effects by regulating the crosstalk between apoptosis and autophagy, inhibiting apoptotic and autophagic cell death induced by myocardial ischemia/reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
L-Q Chen, W-S Wang, S-Q Li, J-H Liu
Summary: The study demonstrates that minocycline (MC) can reduce inflammation and oxidative stress levels in myocardial ischemia-reperfusion injury (MIRI) rat model or H9c2 cells, thereby inhibiting cardiomyocyte apoptosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yi-Shuai Zhang, Li-Qun Lu, Ya-Qian Jiang, Nian-Sheng Li, Xiu-Ju Luo, Jin-Wu Peng, Jun Peng
Summary: Allopurinol alleviated myocardial I/R oxidative injury by inhibiting the XO/VPO1 pathway, leading to decreased XO and VPO1-derived products in both rat heart and cardiac cell models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Binney Sharma, Avishek Roy, Trina Sengupta, Lal Chandra Vishwakarma, Anuraag Singh, Ritesh Netam, Tapas Chandra Nag, Nasreen Akhtar, Hruda Nanda Mallick
Summary: Sleep has an impact on both brain function and neuromuscular junction morphology and neurochemistry.
Article
Dentistry, Oral Surgery & Medicine
Bikash Chaurasia, Nitesh Tewari, Vijay Prakash Mathur, Tapas Chandra Nag, Subhash Chandra Yadav, Morankar Rahul, Deepika Mishra, Kalpana Bansal
Summary: This proof-of-concept study aimed to investigate the microscopic changes in resin penetration characteristics of tooth fragments after different rehydration protocols. The results showed that rehydration with distilled water resulted in the greatest depth and width of resin tags, followed by rehydration in a humidification chamber. Additionally, there were more resin tags in the samples rehydrated with distilled water and humidification compared to the samples with no rehydration.
DENTAL TRAUMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tulshidas S. Patil, Nayan A. Gujarathi, Abhijeet A. Aher, Hemal E. Pachpande, Charu Sharma, Shreesh Ojha, Sameer N. Goyal, Yogeeta O. Agrawal
Summary: Psoriasis is a disease characterized by abnormal differentiation and excessive proliferation of epidermal keratinocytes, severely impacting patients' quality of life. Current treatment options provide only temporary relief with various adverse effects. Nanostructured lipid carriers (NLCs) have emerged as promising nanocarriers for psoriasis treatment due to their superior physicochemical properties. This manuscript provides an overview of psoriasis, its pathophysiology, existing treatment options, and limitations, highlighting the advantages, rationale, and mechanism of NLCs for psoriasis treatment. It also presents various NLC nanoformulations and relevant patents for psoriasis treatment, along with regulatory considerations. NLCs exhibit sustained drug release, the ability to incorporate hydrophobic and hydrophilic drugs, improved skin hydration, penetration, retention, and bioavailability, reduced staining potential, and decreased side effects compared to conventional ointments, indicating a bright future for NLC nanoformulations in psoriasis treatment. However, academic-industry collaboration and stricter regulatory controls are needed for the commercialization of NLC nanoformulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sheikh Azimullah, Richard L. Jayaraj, Mohamed Fizur. Nagoor Meeran, Fakhreya Y. Jalal, Abdu Adem, Shreesh Ojha, Rami Beiram
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons, resulting in motor deficits. The present study evaluated the role of myrcene in preventing the loss of dopaminergic neurons in a rodent model of PD and elucidated the underlying mechanisms.
Review
Nutrition & Dietetics
Shilu Deepa Thomas, Niraj Kumar Jha, Saurabh Kumar Jha, Bassem Sadek, Shreesh Ojha
Summary: Apigenin, a dietary flavonoid, has antioxidant, anti-inflammatory, anticancer, and antibacterial properties. It has shown potential therapeutic effects in the treatment of cardiovascular diseases such as atherosclerosis, stroke, hypertension, myocardial injury, and diabetic cardiomyopathy. This review focuses on the pharmacological mechanisms, therapeutic uses, and potential applications of apigenin in the treatment of cardiovascular disorders. Further research is needed to establish its safety and efficacy and explore its potential as a nutraceutical and therapeutic agent.
Article
Biochemistry & Molecular Biology
Fayez T. Hammad, Loay Lubbad, Suhail Al-Salam, Javed Yasin, Mohamed Fizur Nagoor Meeran, Shreesh Ojha, Waheed F. Hammad
Summary: Both ureteral obstruction and hypertension have significant impacts on kidney functions. Reversible ureteral obstruction in hypertensive rats showed exaggerated alterations in renal functions and other parameters of renal injury compared to normotensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Khatija Ayoob, Seenipandi Arunachalam, Shreesh Ojha, Rami Beiram
Summary: Parkinson's disease (PD) is a movement disorder characterized by the degeneration of dopaminergic neurons in the brain. The etiopathogenesis of PD involves oxidative stress, inflammation, impaired autophagy, accumulation of a-synuclein, and a-Glutamate neurotoxicity. This study investigated the effect of tannic acid (TA) in a rodent model of PD induced by rotenone (ROT), and found that TA can reduce oxidative stress, inhibit inflammation, and protect dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Reshal Suri, Tapas C. Nag, Nikita Mehra, Yub Raj Neupane, Sadat Shafi, Devyani Sharma, Kalicharan Sharma, Yasmin Sultana, Kanchan Kohli
Summary: This study found that chitosan functionalized PLGA nanoparticles can effectively and sustainedly deliver sirolimus to the retina for the treatment of AMD. Compared to plain sirolimus, these nanoparticles provide better protection against retinal degeneration and have no toxic side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shilu Deepa Thomas, Niraj Kumar Jha, Shreesh Ojha, Bassem Sadek
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in social interaction and communication along with repetitive stereotypic behaviors. There are no specific biomarkers for diagnostic screening or treatments available for autistic patients. Genetic disorders such as tuberous sclerosis complex, phosphatase and tensin homolog, and fragile X syndrome are associated with high prevalence of ASD. Preclinical investigations in animal models have revealed irregularities in the PI3K/Akt/mTOR signaling pathway as well as ASD-related behavioral defects. Modulation of the pathway with plant bioactive molecules has shown beneficial evidence in ASD treatment.
Article
Biochemistry & Molecular Biology
Indrani Mukherjee, Subhrajit Biswas, Sunil Singh, Joyeeta Talukdar, Mohammed S. S. Alqahtani, Mohamed Abbas, Tapas Chandra Nag, Asit Ranjan Mridha, Surabhi Gupta, Jai Bhagwan Sharma, Supriya Kumari, Ruby Dhar, Subhradip Karmakar
Summary: The overproduction of ROS has been linked to various human diseases. Monosodium glutamate (MSG), a food additive commonly used in Asian cuisine, has been associated with ROS generation. This study found that MSG exposure influenced trophoblast invasion and differentiation, two critical functions during placenta formation, through increased ROS production. The findings suggest that long-term exposure to MSG may have adverse health effects, compromising important trophoblast functions.
Review
Chemistry, Medicinal
Madhuri Baghel, Kalyani Sakure, Tapan Kumar Giri, Sabyasachi Maiti, Kartik T. Nakhate, Shreesh Ojha, Charu Sharma, Yogeeta Agrawal, Sameer Goyal, Hemant Badwaik
Summary: Natural polysaccharides have excellent biocompatibility and fewer adverse effects, but it is challenging to compare their bioactivities with manufactured synthetics due to their intrinsic physicochemical characteristics. Carboxymethylation of polysaccharides can increase their solubility and bioactivities, but it has limitations that can be overcome through derivatization or grafting. These modifications improve the swelling, flocculation, viscosity, metal absorption properties, and thermosensitivity of natural polysaccharides. Researchers have modified carboxymethylated gums to create better and functionally enhanced polysaccharides. This review explores the impact of molecular modifications on their characteristics and applications.
Article
Ophthalmology
Tapas C. Nag
Summary: This study investigated age-related changes in Muller glial cells in donor human retina and found that these cells undergo osmotic changes, gliosis, and lipid peroxidation with advanced aging. Photoreceptor cells also experience oxidative-nitrosative stress with aging. Muller glial cells respond to oxidative stress through different mechanisms, but their phagocytic potential decreases with aging.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sumit S. Rathod, Yogeeta O. Agrawal, Kartik T. Nakhate, M. F. Nagoor Meeran, Shreesh Ojha, Sameer N. Goyal
Summary: Neuroinflammation is a complex biological process that originates as a protective response in the brain. The distribution of CB1 and CB2 cannabinoid receptors across different brain regions may play important roles in regulating neuroinflammatory processes.
Meeting Abstract
Peripheral Vascular Disease
Khushboo Bisht, Dharam Vir Singh Arya, Vipin Kumar Verma, Zia Abdullah, Ruma Ray, Rajiv Narang, Tapas Chandra Nag, Jagriti Bhatia
JOURNAL OF HYPERTENSION
(2023)