Article
Plant Sciences
Anbazhakan Kandasamy, Kanakaraj Aruchamy, Praveena Rangasamy, Deepha Varadhaiyan, Chandrasekar Gowri, Tae Hwan Oh, Subramaniyan Ramasundaram, Balasankar Athinarayanan
Summary: This study extracted and identified compounds from Centella asiatica and evaluated its medicinal properties. The extracts from shoot, callus, and cell suspension cultures all contained tannins, flavonoids, terpenoids, saponins, and steroids. The cell suspension culture exhibited the highest antioxidant activity.
Article
Multidisciplinary Sciences
Garland Kgosi More, Jacques Vervoort, Paul Anton Steenkamp, Gerhard Prinsloo
Summary: This study investigates twenty medicinal plants with previously established anti-viral activity against a wild-type RVFV using bio-chemometric and analytical techniques. The aim is to identify common compounds in the plants that contribute to the anti-viral effect. Proton nuclear magnetic resonance (H-1 NMR) spectroscopy and multivariate data analysis (MVDA) were used to characterize metabolite profiles. The study identifies potential metabolites, such as trigonelline and vanillic acid, as well as the presence of hydroxylated fatty acids, which have not been previously reported in all tested plants with high anti-RVFV activity. These findings provide insight into the metabolomic profile of anti-RVFV plant extracts and suggest potential targets for the development of antiviral therapeutic agents.
Article
Agricultural Engineering
Umair Khurshid, Saeed Ahmad, Hammad Saleem, Marya Aziz, Muhammad Asif Wazir, Muhammad Sarfraz, Sirajudheen Anwar, Siddique Akber Ansari, Sarfaraz Ahmed, Adriano Mollica, Mohamad Fawzi Mahomoodally, Nafees Ahemad
Summary: This research explores the phytochemical and biological properties of different polarity solvent extracts of Trianthema triquetra. The methanol extract shows the highest total phenolic and flavonoid content, as well as higher antioxidant capacity. The ethyl-acetate fraction exhibits strong inhibition against certain key enzymes, while the n-butanol and n-hexane extracts show activity against others. PCA analysis confirms the close association between bioactive contents and antioxidant assays.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Rune Slimestad, Amritha Johny, Mette Goul Thomsen, Christian Rene Karlsen, Jan Thomas Rosnes
Summary: The present study evaluated the antimicrobial and antioxidant properties of extracts from nine herb species. The results showed that these herb extracts have potential as natural antimicrobials and antioxidants.
Article
Biochemistry & Molecular Biology
Suvesh Munakarmi, Yamuna Gurau, Juna Shrestha, Prabodh Risal, Ho Sung Park, Geum-Hwa Lee, Yeon Jun Jeong
Summary: Identifying effective biomarker-based phytochemicals from medicinal plants is a promising strategy to protect against liver injury. The combination of Vitis vinifera L. (VE) leaf and Centella asiatica (CE) extract (VCEC) shows synergistic protective effects against CCl4-induced acute liver injury in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jia Hui Wong, Anna M. Barron, Jafri Malin Abdullah
Summary: Centella asiatica, a medicinal plant, has demonstrated anti-inflammatory, neuroprotective, and cognitive benefits which may be harnessed for treating brain aging and neurodegenerative diseases by its mitoprotective and antioxidative effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Bothe Thokchom, Santosh Mallikarjun Bhavi, Megha B. Abbigeri, Arun K. Shettar, Ramesh Babu Yarajarla
Summary: This study demonstrates the green synthesis of carbon dots using Centella asiatica leaves as the carbon source via a fast and cost-effective microwave-assisted method. The synthesized carbon dots exhibited quasi-spherical shape with a size range of 3-6 nm and showed blue fluorescence under UV with a maximum emission wavelength of 460 nm. Furthermore, the Centella asiatica-derived carbon dots displayed antimicrobial, antioxidant, and anti-inflammatory activities, and were found to be safe for in vitro administration.
Article
Food Science & Technology
Abdulhakeem S. Alamri, Hammad Saleem, Irfan Pervaiz, Umair Khurshid, Juwairiya Butt, Tahir Ali Chohan, Majid Alhomrani, Marcello Locatelli, Syafiq Asnawi Zainal Abidin, Yasir Nasser H. Alqahtani, Kannan R. R. Rengasamy, Mohamad Fawzi Mahomoodally
Summary: This study explored the phytochemical profiles of E. suberosa, which is traditionally used to treat ulcers and piles. The methanol and dichloromethane extracts from different parts of the plant were analyzed for their bioactive contents and potential therapeutic effects. The results showed that E. suberosa possesses antioxidant and enzyme inhibition properties, validating its traditional uses and suggesting its potential as a functional food.
Article
Food Science & Technology
Esha Bala, Sanjukta Patra, Siddhartha Singha
Summary: Herbal beverages from Centella asiatica were characterized chemically and found to contain 52 compounds with antioxidant or antiinflammatory effects. The beverages showed reducing capacity and free radical scavenging ability, and could inhibit the growth of gastrointestinal pathogens while promoting the growth of probiotics. These beverages can balance intestinal antioxidant status and maintain microbiota diversity to protect intestinal health.
Article
Chemistry, Applied
Marzieh Taghizadeh, Shabnam Jalili
Summary: The present study evaluates the Centella asiatica ethanolic extract for its phenolic content, flavonoids, flavonols, anthocyanin, antioxidants, and antibacterial activities. The extract contains various phenolic substances and exhibits strong antibacterial activities against certain bacteria. These findings suggest that Centella asiatica has potential applications in cosmetics and pharmaceuticals.
NATURAL PRODUCT RESEARCH
(2023)
Article
Polymer Science
Chi-Wen Kuo, Yi-Fang Chiu, Min-Hua Wu, Ming-Hsien Li, Cheng-Nan Wu, Wan-Sin Chen, Chiung-Hua Huang
Summary: The study prepared gelatin/chitosan (GC) bilayer patches at different temperatures, with the most effective one prepared at -80 degrees C/RT, showing potential for absorbing pus and fluids while inhibiting bacterial growth. The bilayer patches loaded with Cortex Phellodendri amurensis (PA) and Centella asiatica (CA) extracts demonstrated inhibitory effects on P. acnes growth and promotion of skin fibroblast cell viability, suggesting their potential for acne spot treatment.
Article
Chemistry, Inorganic & Nuclear
M. A. Pavan Kumar, D. Suresh, A. H. Sneharani
Summary: The research utilized Gotukola to prepare multifunctional ZnO nanocrystals through solution combustion synthesis, demonstrating excellent photocatalytic activity, antibacterial properties, antidiabetic abilities, and cytotoxic potency. Additionally, the nanoparticles also exhibited strong anticoagulant properties.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Infectious Diseases
Sundaram Muthukrishnan, Paranivasakam Prakathi, Thangavel Sivakumar, Muthu Thiruvengadam, Bindhu Jayaprakash, Venkidasamy Baskar, Maksim Rebezov, Marina Derkho, Gokhan Zengin, Mohammad Ali Shariati
Summary: Endophytic fungi residing in medicinal plants have the potential to produce various bioactive compounds. In this study, three endophytic fungi were isolated from different medicinal plants and their intra- and extracellular products were analyzed. The analysis revealed the presence of bioactive metabolites and phytochemicals, and the extracts exhibited strong antibacterial and antioxidant activity. Molecular docking analysis also suggested the potential anticancer activity of certain compounds. These findings highlight the importance of endophytic fungi in natural drug development and reducing the environmental burden of synthetic drugs.
Article
Pharmacology & Pharmacy
Cameron Ryall, Shuo Chen, Sanjukta Duarah, Jingyuan Wen
Summary: Centella asiatica's active component asiatic acid (AA) has limited penetration capability when delivered as an ointment for wound healing. Researchers have formulated AA-loaded microneedle arrays to bypass the stratum corneum and achieve effective AA delivery, leading to accelerated wound closure.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biotechnology & Applied Microbiology
Sujata Mandal, Tuyelee Das, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Abilash Valsala Gopalakrishnan, Manoj Kumar, Arabinda Radha, Arabinda Ghosh, Nobendu S. Mukerjee, Mahipal Shekhawat, Devendra Kumar Pandey, Abhijit Dey
Summary: In vitro culture of plant cells, tissues, and organs is an eco-friendly biotechnological strategy for producing plant chemicals. This review focuses on increasing the production of triterpenoid saponins in Centella asiatica by using genetic engineering tools and proper strategies. It discusses the roles of different carbon sources, biotic and abiotic elicitors, and plant growth regulators at different growth stages. The study also highlights various techniques such as organogenesis and somatic embryogenesis. The review provides valuable insights into biotechnological interventions for enhancing triterpenoid saponin yield in C. asiatica.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Textiles
Manasee Choudhury, Elancheran Ramakrishnan, Dipali Devi
Summary: Organic extraction of pigmentation constituents from the cocoons of Antheraea assamensis (muga) was conducted using benign solvents, revealing the presence of methyl isoeugenol and isoeugenyl acetate. It is suggested that these compounds may play a role in the coloration of the muga fiber and silk fiber production by the silkworm larva. This study opens up new possibilities for the use of methyl isoeugenol as a potential dyeing material in the textile industry.
JOURNAL OF NATURAL FIBERS
(2021)
Article
Cell Biology
Sima Kumari, Parmeshwar B. Katare, R. Elancheran, Hina L. Nizami, Bugga Paramesha, Sudheer Arava, Partha Pratim Sarma, Roshan Kumar, Dinesh Mahajan, Yashwant Kumar, Rajlakshmi Devi, Sanjay K. Banerjee
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Review
Chemistry, Medicinal
V. L. Maruthanila, Elancheran Ramakrishnan, Mirunalini Sankaran
Summary: Carica papaya is an essential medicinal plant with anticancer activities, containing phenolic compounds like Caffeic acid, Quinic acid and Chlorogenic acid, which play significant roles in cancer prevention and treatment mechanisms.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
U. Vanitha, R. Elancheran, V. Manikandan, S. Kabilan, K. Krishnasamy
Summary: The study focuses on the synthesis and characterization of 3-phenyl-2-thioxoimidazolidin-4-one derivatives and their potential application in breast cancer treatment. Molecular docking and computational studies suggest that these compounds may have promising activity, with further evaluation of their in vitro and in vivo anticancer activities planned for the future.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Medicinal
V. L. Maruthanila, Ramakrishnan Elancheran, Sankaran Mirunalini
Summary: Breast cancer is a major global problem, and current treatment options have side effects. This study identified five bioactive compounds from Carica papaya that may serve as antiestrogens or aromatase inhibitors for treating breast cancer with fewer side effects.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2022)
Article
Chemistry, Inorganic & Nuclear
Aadil A. Ahangar, R. Elancheran, Aijaz A. Dar
Summary: Halogen atoms are commonly found in organic molecules and their functionalization plays a significant role in organic synthesis. This study focuses on the development of halogen functional red tri-halo Schiff bases/Anils and explores the impact of halogen atoms on molecular packing and physicochemical properties.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Swarnali Bhattacharjee, R. Elancheran, Kasturi Dutta, Prashanta Kumar Deb, Rajlakshmi Devi
Summary: This study demonstrates that the extract of Garcinia pedunculata has antioxidant and cardioprotective effects, reducing cardiac hypertrophy and inflammation in experimental animal models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Swarnali Bhattacharjee, Elancheran Ramakrishnan, Prashanta Kumar Deb, Partha Pratim Sarma, Debopriya Choudhury, Senthamaraikannan Kabilan, Rajlakshmi Devi
Summary: This study investigated the impact of three different drying conditions (shade, oven, and traditional sun drying) on the nutritional profile of Garcinia pedunculata (GP) plants, assessed the choice of solvent extraction for maximum phytochemical extraction, and studied their in vitro biological activities and chemical profiling. The results showed that shade-drying preserved the nutritional profile of GP better. Moreover, the shade-dried hydromethanolic extract exhibited higher levels of phenols and flavonoids, as well as better antioxidant and enzyme-inhibitory activities.
PHARMACOGNOSY MAGAZINE
(2023)
Article
Food Science & Technology
Jubanlak Mary Pohsnem, Elancheran Ramakrishnan, Deep Prakash Parasar
Summary: North Eastern India, with its diverse ethnic groups, provides an excellent opportunity for ethno botanical studies. Indigenous and fermented foods are an integral part of the diets of these ethnic tribes. Soybeans, bamboo shoots, and locally available fruits, vegetables, and fish are commonly fermented by the majority of people in North Eastern India. Fermentation of plant and animal materials, as a technology driven by both industrial and life sciences, can lead to significant changes in the health-promoting properties of foods.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2023)
Article
Chemistry, Physical
E. G. Sundararaman, R. Elancheran, M. N. Arumugham
Summary: A new copper complex with distorted square-pyramidal geometry was synthesized and characterized. The complex showed partial intercalation binding mechanism with DNA and demonstrated strong cytotoxic effects against a human hepatocellular carcinoma cell line. It also exhibited effective antibacterial and antifungal properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Umapathy Vanitha, Ramakrishnan Elancheran, Senthamaraikannan Kabilan, Kuppusamy Krishnasamy
Summary: This study used molecular docking to investigate the binding of 1,3,4-thiadiazole derivatives to estrogen receptors. We found that TOH62 and TF62 had the highest binding energies, indicating their potential as lead candidates. Furthermore, the presence of phenolic OH was identified as a key factor in the binding process. Future research will focus on in vitro and in vivo anti-breast cancer evaluations of these compounds.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Article
Neurosciences
Chandana Choudhury Barua, Lipika Buragohain, Farida Rahman, Ramakrishna Elancheran, Hooriyah Rizavi
Summary: The hydroalcoholic extract of Zanthoxylum alatum seeds was found to reduce chronic restraint stress by exerting antioxidant properties and down-regulating genes involved in endoplasmic reticulum stress.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Oncology
Maruthanila Lenin, Elancheran Ramakrishnan, Mirunalini Sankaran
Summary: The study aims to identify new anticancer agents from natural and dietary compounds and suggests that daidzein may be an effective drug for breast cancer.
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Beenita Saikia, Lipika Buragohain, Chandana Barua, Jadav Sarma, Sarojini Tamuli, Dhruba Kalita, Acheenta Barua, Iswar Barua, Ramakrishna Elancheran
Summary: This study explores the effects of petroleum ether extract from Conyza bonariensis leaves on scopolamine-induced amnesia in rats, and suggests that it may be a potential curative drug for the treatment of cognitive impairment.
INDIAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Crystallography
H. A. Arjun, G. N. Anil Kumar, R. Elancheran, S. Kabilan
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2020)
