From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders

Positive reinforcing effect of oxytocin microinjection in the rat central nucleus of amygdala

(2016) K. László et al.   BEHAVIOURAL BRAIN RESEARCH

Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity

(2015) Yusaku Iwasaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys

(2015) James E. Blevins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

(2015) Hamid Meziane et al.   BIOLOGICAL PSYCHIATRY

Oxytocin enables maternal behaviour by balancing cortical inhibition

(2015) Bianca J. Marlin et al.   NATURE

Erratum: Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia

(2015) Na Young Shin et al.   NEUROPSYCHOPHARMACOLOGY

Endocannabinoid signaling mediates oxytocin-driven social reward

(2015) Don Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma oxytocin levels predict social cue recognition in individuals with schizophrenia

(2015) Gregory P. Strauss et al.   SCHIZOPHRENIA RESEARCH

Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism

(2015) Olga Peñagarikano et al.   Science Translational Medicine

Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders

(2014) S.M. Francis et al.   BRAIN RESEARCH

Divergent Effects of Oxytocin Treatment of Obese Diabetic Mice on Adiposity and Diabetes

(2014) Jordi Altirriba et al.   ENDOCRINOLOGY

Intranasal Oxytocin as an Adjunct to Escitalopram in Major Depression

(2014) Gabrielle Scantamburlo et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress

(2014) Amanda J. Myers et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Oxytocin-Augmented Social Cognitive Skills Training in Schizophrenia

(2014) Michael C Davis et al.   NEUROPSYCHOPHARMACOLOGY

A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia

(2014) Clare M. Gibson et al.   SCHIZOPHRENIA RESEARCH

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

Effects of intranasal oxytocin administration on memory for infant cues: Moderation by childhood emotional maltreatment

(2014) Ritu Bhandari et al.   Social Neuroscience

Region Specific Up-Regulation of Oxytocin Receptors in the Opioid Oprm1−/− Mouse Model of Autism

(2014) Valentina Gigliucci et al.   Frontiers in Pediatrics

Oxytocin modulates social interaction but is not essential for sexual behavior in male mice

(2013) Virgínia Meneghini Lazzari et al.   BEHAVIOURAL BRAIN RESEARCH

Clinical features, developmental course, and psychiatric comorbidity of adult autism spectrum disorders

(2013) Giulia Vannucchi et al.   CNS SPECTRUMS

Oxytocin Reduces Reward-Driven Food Intake in Humans

(2013) V. Ott et al.   DIABETES

Long-Term Administration of Intranasal Oxytocin Is a Safe and Promising Therapy for Early Adolescent Boys with Autism Spectrum Disorders

(2013) Masaya Tachibana et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons

(2013) Scott F. Owen et al.   NATURE

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

(2013) Gül Dölen et al.   NATURE

Prosocial effects of oxytocin in two mouse models of autism spectrum disorders

(2013) Brian L. Teng et al.   NEUROPHARMACOLOGY

Chronic and Acute Intranasal Oxytocin Produce Divergent Social Effects in Mice

(2013) Huiping Huang et al.   NEUROPSYCHOPHARMACOLOGY

Repeated intranasal oxytocin administration in early life dysregulates the HPA axis and alters social behavior

(2013) Jean-Loup Rault et al.   PHYSIOLOGY & BEHAVIOR

The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences

(2013) Miranda Olff et al.   PSYCHONEUROENDOCRINOLOGY

Role of oxytocin signaling in the regulation of body weight

(2013) James E. Blevins et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse

(2013) Elizabeth A. D. Hammock   Frontiers in Behavioral Neuroscience

Oxytocin Gene Polymorphisms Influence Human Dopaminergic Function in a Sex-Dependent Manner

(2012) Tiffany M. Love et al.   BIOLOGICAL PSYCHIATRY

Chronic Intranasal Oxytocin Causes Long-Term Impairments in Partner Preference Formation in Male Prairie Voles

(2012) Karen L. Bales et al.   BIOLOGICAL PSYCHIATRY

Long-term oxytocin administration improves social behaviors in a girl with autistic disorder

(2012) Hirotaka Kosaka et al.   BMC Psychiatry

Intranasal Oxytocin as an Adjunct to Risperidone in Patients with Schizophrenia

(2012) Amirhossein Modabbernia et al.   CNS DRUGS

PLASMA OXYTOCIN IMMUNOREACTIVE PRODUCTS AND RESPONSE TO TRUST IN PATIENTS WITH SOCIAL ANXIETY DISORDER

(2012) Elizabeth A. Hoge et al.   DEPRESSION AND ANXIETY

Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus

(2012) Carlos Dombret et al.   HUMAN MOLECULAR GENETICS

Central Amygdala Metabotropic Glutamate Receptor 5 in the Modulation of Visceral Pain

(2012) L. W. Crock et al.   JOURNAL OF NEUROSCIENCE

Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response

(2012) H. Sophie Knobloch et al.   NEURON

Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure

(2012) Dong Xi et al.   PLoS One

Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males

(2012) Gail A. Alvares et al.   PSYCHONEUROENDOCRINOLOGY

Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics

(2012) Michael Lukas et al.   PSYCHONEUROENDOCRINOLOGY

Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia

(2012) David Feifel et al.   SCHIZOPHRENIA RESEARCH

Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia

(2012) Daimei Sasayama et al.   SCHIZOPHRENIA RESEARCH

Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study

(2012) Christiane Montag et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial

(2012) Evdokia Anagnostou et al.   Molecular Autism

Oxytocin in schizophrenia: a review of evidence for its therapeutic effects.

(2011) Kai MacDonald et al.   ACTA NEUROPSYCHIATRICA

Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment

(2011) Guo Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats

(2011) Gregory J. Morton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications

(2011) Gene J. Blatt et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders

(2011) Mikle South et al.   Autism Research

Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat

(2011) Mario Gil et al.   HORMONES AND BEHAVIOR

Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action

(2011) Oliver J. Bosch et al.   HORMONES AND BEHAVIOR

Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab-Israeli pedigree

(2011) Omri Teltsh et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Oxytocin and bone remodelling: Relationships with neuropituitary hormones, bone status and body composition

(2011) Véronique Breuil et al.   JOINT BONE SPINE

Decreased Nocturnal Oxytocin Levels in Anorexia Nervosa Are Associated With Low Bone Mineral Density and Fat Mass

(2011) Elizabeth A. Lawson et al.   JOURNAL OF CLINICAL PSYCHIATRY

Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder

(2011) Daniel B. Campbell et al.   Journal of Neurodevelopmental Disorders

Neuropeptide Exocytosis Involving Synaptotagmin-4 and Oxytocin in Hypothalamic Programming of Body Weight and Energy Balance

(2011) Guo Zhang et al.   NEURON

Replication and Extension of Association Between Common Genetic Variants in SIM1 and Human Adiposity

(2011) Michael M. Swarbrick et al.   Obesity

Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients

(2011) Maïthe Tauber et al.   Orphanet Journal of Rare Diseases

Mechanisms of the Anti-Obesity Effects of Oxytocin in Diet-Induced Obese Rats

(2011) Nicolas Deblon et al.   PLoS One

Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect

(2011) Joanna Dabrowska et al.   PSYCHONEUROENDOCRINOLOGY

Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia

(2011) Morris B. Goldman et al.   PSYCHOPHARMACOLOGY

Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

(2011) D. Viviani et al.   SCIENCE

Social effects of oxytocin in humans: context and person matter

(2011) Jennifer A. Bartz et al.   TRENDS IN COGNITIVE SCIENCES

Newborn Analgesia Mediated by Oxytocin during Delivery

(2011) Michel Mazzuca et al.   Frontiers in Cellular Neuroscience

Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus

(2010) Dean S. Carson et al.   ADDICTION BIOLOGY

Examining the role of oxytocin in the interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) using a drug discrimination paradigm in the rat

(2010) Jillian H. Broadbear et al.   ADDICTION BIOLOGY

Adjunctive Intranasal Oxytocin Reduces Symptoms in Schizophrenia Patients

(2010) David Feifel et al.   BIOLOGICAL PSYCHIATRY

REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

(2010) Cedric Viero et al.   CNS Neuroscience & Therapeutics

NEONATAL RESPIRATORY DEPRESSION AND DELAY IN DIAGNOSIS IN PRADER-WILLI SYNDROME

(2010) Robert H. Wharton et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Oxytocin-Dopamine Interactions Mediate Variations in Maternal Behavior in the Rat

(2010) Dara K. Shahrokh et al.   ENDOCRINOLOGY

The neurobiology of pair bonding: Insights from a socially monogamous rodent

(2010) Kimberly A. Young et al.   FRONTIERS IN NEUROENDOCRINOLOGY

A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene

(2010) Fabienne Schaller et al.   HUMAN MOLECULAR GENETICS

Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes

(2010) Renan P. Souza et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Chronic Inflammation in Obesity and the Metabolic Syndrome

(2010) Rosário Monteiro et al.   MEDIATORS OF INFLAMMATION

Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder

(2010) Izelle Labuschagne et al.   NEUROPSYCHOPHARMACOLOGY

Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: Genetic and molecular studies

(2010) Katherine E. Tansey et al.   NEUROSCIENCE LETTERS

Promoting social behavior with oxytocin in high-functioning autism spectrum disorders

(2010) E. Andari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain

(2009) Bryce C. Ryan et al.   BEHAVIOURAL BRAIN RESEARCH

Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders

(2009) Adam J. Guastella et al.   BIOLOGICAL PSYCHIATRY

Genomic and epigenetic evidence for oxytocin receptor deficiency in autism

(2009) Simon G Gregory et al.   BMC Medicine

Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusionThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 1 of a 2-part Special Issue).

(2009) Maria Ondrejcakova et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Nesfatin-1-Regulated Oxytocinergic Signaling in the Paraventricular Nucleus Causes Anorexia through a Leptin-Independent Melanocortin Pathway

(2009) Yuko Maejima et al.   Cell Metabolism

Dopamine–oxytocin interactions in penile erection

(2009) T. A. Baskerville et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior

(2009) Heather E. Ross et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

(2009) Nadine Gogolla et al.   Journal of Neurodevelopmental Disorders

Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry

(2009) A. Kiss et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats

(2009) j. qin et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats

(2009) Dean S. Carson et al.   NEUROPHARMACOLOGY

Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence

(2009) B. Pierrehumbert et al.   NEUROSCIENCE

Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats

(2009) Yi Han et al.   NEUROSCIENCE LETTERS

Low Sympathetic Tone and Obese Phenotype in Oxytocin-deficient Mice

(2009) Claudia Camerino   Obesity

Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment

(2009) Saliha Ozsoy et al.   PSYCHIATRY RESEARCH

Oxytocin receptor polymorphisms and adult attachment style in patients with depression

(2009) Barbara Costa et al.   PSYCHONEUROENDOCRINOLOGY

A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder

(2009) Adam J. Guastella et al.   PSYCHONEUROENDOCRINOLOGY

Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration

(2009) G. J. H. Dumont et al.   Social Neuroscience

Genes Controlling Affiliative Behavior as Candidate Genes for Autism

(2008) Carolyn M. Yrigollen et al.   BIOLOGICAL PSYCHIATRY

Oxytocin Levels in Social Anxiety Disorder

(2008) Elizabeth A. Hoge et al.   CNS Neuroscience & Therapeutics

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies

(2008) Kimberly A. Young et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

The Role of Oxytocin in Neuropsychiatric Disorders

(2008) D. Marazziti et al.   CURRENT MEDICINAL CHEMISTRY

Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction

(2008) S. Kasama et al.   EUROPEAN HEART JOURNAL

Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus

(2008) Annegret Blume et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Oxytocin Deficiency Mediates Hyperphagic Obesity ofSim1Haploinsufficient Mice

(2008) Bassil M. Kublaoui et al.   MOLECULAR ENDOCRINOLOGY

Oxytocin receptor-deficient mice developed late-onset obesity

(2008) Yuki Takayanagi et al.   NEUROREPORT

Evidence of Dysregulated Peripheral Oxytocin Release Among Depressed Women

(2008) Jill M. Cyranowski et al.   PSYCHOSOMATIC MEDICINE

Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats

(2007) Chiu-Lung Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits

(2007) Morris Goldman et al.   SCHIZOPHRENIA RESEARCH