Article
Veterinary Sciences
Zamira Gibb, Olga Blanco-Prieto, Diego Bucci
Summary: Mammalian semen is composed of spermatozoa and seminal plasma, with sperm undergoing various physiological processes to fertilize the oocyte. The production and maturation of sperm occur in different internal organs, exposing them to oxidative stress. Antioxidants play a crucial role in protecting sperm and maintaining their fertilizing capacity, deficiencies of which can impact reproductive function.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Nutrition & Dietetics
Mariana S. Diniz, Carina C. Magalhaes, Carolina Tocantins, Luis F. Grilo, Jose Teixeira, Susana P. Pereira
Summary: Chronic diseases, such as gestational diabetes and maternal obesity, during pregnancy can create an adverse intrauterine environment, increasing the risk of chronic diseases in offspring. Mitochondrial dysfunction and oxidative stress are mechanisms by which these conditions program the development of chronic diseases. Maternal antioxidant supplementation with compounds like resveratrol and curcumin may help mitigate metabolic dysfunction and oxidative stress associated with these conditions, potentially reducing the risk of chronic diseases.
Article
Biology
Jake Sawecki, Peter D. D. Dijkstra
Summary: This study provides evidence that organisms protect against oxidative stress during reproduction through dynamic interactions between behavioral and physiological adjustments at different stages. It also highlights the role of parental investment adjustment, such as filial cannibalism, in managing the cost of reproduction and maintaining antioxidant function.
Article
Biochemistry & Molecular Biology
IrantzuADD F. B. Perez-Ruiz, Jose-Ignacio Ruiz-Sanz, Maria-Luisa Hernandez, Rosaura Navarro, Marcos Ferrando, Zaloa Larreategui, Maria-Begona Ruiz-Larrea
Summary: This study provided the first evidence of the presence of mRNAs and proteins of the three members of the PON family in human ovarian granulosa cells, with active secretion of PON1 and PON3 by the cells. Additionally, it was discovered that PON2 mainly localized with mitochondria and the subcellular nucleo-cytoplasmic distribution of PON1 was associated with the cell cycle.
Review
Agriculture, Dairy & Animal Science
Sarah McCoski, Amanda Bradbery, Rodrigo da Silva Marques, Christian Posbergh, Carla Sanford
Summary: Current research on the interaction between maternal nutrition and developmental programming in male offspring primarily focuses on the effects of maternal diet on female offspring, with less attention on male offspring. Poor maternal nutrition can lead to various maladaptive phenotypes in offspring, but the specific outcomes in male offspring remain poorly understood.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress occurs when the production of reactive oxygen or nitrogen species exceeds the capacity of antioxidant systems. It has a significant impact on kidney development and can lead to kidney disease in adulthood. Evaluating biomarkers allows us to assess oxidative stress in fetuses and neonates. Animal models have provided valuable insights into the mechanisms of renal programming related to oxidative stress and interventions to prevent kidney disease. This comprehensive review examines the effects of perinatal oxidative stress on renal programming, the role of antioxidant strategies in kidney disease prevention, and the challenges in translating findings from animal models to clinical practice.
Article
Ecology
Maria Cristina Lorenzi, Franco G. Robles-Guerrero, David Costantini
Summary: Measuring reproductive costs is crucial to understanding sexual conflict and its evolutionary outcomes. In this study, hermaphroditic worms were exposed to different social conditions to measure reproductive costs. It was found that hermaphrodites that invested relatively more in the female function produced fewer eggs but had higher levels of antioxidant protection. This suggests that in the short-term, male competition might be costlier than egg production in terms of regulation of oxidative status.
Review
Chemistry, Multidisciplinary
Jingnan Zhao, Fanfan Guo, Lin Hou, Yongxing Zhao, Pengchao Sun
Summary: Inflammatory diseases are associated with high levels of ROS. Excess ROS leads to the polarization of microphages into the proinflammatory M1 phenotype and causes damage to DNA, proteins, and lipids, worsening the inflammatory response. Scavenging ROS to alleviate oxidative stress has proven to be an effective strategy for reversing inflammation. Inspired by natural antioxidant enzymes, electron transfer-based artificial antioxidant nanozymes have emerged as therapeutic agents for treating inflammatory diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Medicine, General & Internal
Chao Dong, Nai-Jin Zhang, Li-Jun Zhang
Summary: Oxidative stress is closely related to leukemia, affecting its treatment and prognosis. Research is exploring the use of antioxidants in leukemia treatment as an alternative to standard chemotherapy.
CHINESE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Xin Deng, Peng Ouyang, Wei Xu, Erhua Yang, Zhen Bao, Yijing Wu, Jin Gong, Jinghua Pan
Summary: Hepatic ischemia-reperfusion injury (HIRI) is an additional injury to ischemic tissue after hepatic revascularization, and its pathological mechanism is complex. Recent studies have found that the antioxidant treatment of nano selenium can reduce the excessive production of reactive oxygen species (ROS) and play a potential protective role in reducing HIRI.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fleur L. Meulmeester, Jiao Luo, Leon G. Martens, Kevin Mills, Diana van Heemst, Raymond Noordam
Summary: Oxidative stress is a major contributor to lifestyle- and age-related diseases. Antioxidant supplementation has been proposed as a method to delay and improve these diseases, but clinical trials have failed to provide evidence for its benefits. This review discusses recent developments and research techniques in clarifying the controversy surrounding antioxidant supplementation in health and disease.
Review
Biochemistry & Molecular Biology
Minyu Piao, Yan Tu, Naifeng Zhang, Qiyu Diao, Yanliang Bi
Summary: Under current breeding conditions, multiple stressors pose important challenges for animal husbandry in maintaining animal wellbeing. The use of antibiotics in the livestock industry has raised social concerns, necessitating the exploration of alternative technologies and products. Phytogenic extracts offer natural and extensive sources with low residue, pollution-free, and renewable characteristics. They can alleviate various stresses on animals, regulate proinflammatory cytokines, enhance animal immunity, and improve the gastrointestinal microorganism structure, making them a preferred choice for improving animal health.
Review
Nutrition & Dietetics
Kosar Valaei, Shima Taherkhani, Hamid Arazi, Katsuhiko Suzuki
Summary: Reactive oxygen species (ROS) play a crucial role in the pathophysiology of cardiac diseases, leading to cellular and molecular disorders that can result in heart dysfunction. New experimental treatments such as creatine supplementation, omega-3 fatty acids, and others have shown beneficial effects in improving oxidative stress.
Article
Veterinary Sciences
Navid Ghavipanje, Mohammad Hasan Fathi Nasri, Seyyed Homayoun Farhangfar, Seyyed Ehsan Ghiasi, Einar Vargas-Bello-Perez
Summary: Supplementation of either 2 or 4 g/day berberine enhanced antioxidant capacity and immune function of transition goats, improving post-partum performance and mitigating oxidative stress and inflammation during the transition period in dairy goats.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Plant Sciences
Renata Biba, Petra Cvjetko, Mihaela Jakopcic, Bruno Komazec, Mirta Tkalec, Nino Dimitrov, Tajana Begovic, Biljana Balen
Summary: Plastic contamination is a pressing environmental issue due to the increasing production of disposable plastic products. In this study, onion roots were exposed to commercial polystyrene (PS-MPs) and polymethyl methacrylate microparticles (PMMA-MPs) to investigate their effects. The results showed that PS-MPs were more readily taken up by onion roots compared to PMMA-MPs. Both types of microparticles did not induce toxic effects on root growth, and PMMA-MPs even stimulated root growth. Antioxidant enzymes were activated in root cells after exposure to both types of microparticles.
Article
Multidisciplinary Sciences
Cedric Zimmer, Conor C. Taff, Daniel R. Ardia, Alexandra P. Rose, David A. Aborn, L. Scott Johnson, Maren N. Vitousek
SCIENTIFIC REPORTS
(2020)
Article
Biology
Cedric Zimmer, Haley E. Hanson, Derek E. Wildman, Monica Uddin, Lynn B. Martin
Article
Biology
Haley E. Hanson, Cedric Zimmer, Bilal Koussayer, Aaron W. Schrey, J. Dylan Maddox, Lynn B. Martin
Summary: The study reveals that house sparrows with high EP express more TLR4 in various physiological tissues, especially in the blood, compared to those with low EP. Additionally, only females with high EP exhibit reversibility in gene expression. The effect of EP varies between sexes and among tissues.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Behavioral Sciences
Conor C. Taff, Cedric Zimmer, David Scheck, Thomas A. Ryan, Jennifer L. Houtz, Melanie R. Smee, Tory A. Hendry, Maren N. Vitousek
Summary: Signals often covary with physiological and behavioural traits to form an axis of integrated phenotypic variation associated with reproductive performance. Manipulating the expression of social signals can independently impact a suite of integrated traits, ultimately affecting reproductive performance.
Article
Behavioral Sciences
Cedric Zimmer, Haley E. Hanson, Lynn B. Martin
Summary: The study found that in house sparrows, adult birds with low stress-induced FKBP5 expression exhibit higher HPA flexibility, greater exploratory disposition, and are better at maintaining body mass under stressful conditions.
HORMONES AND BEHAVIOR
(2021)
Article
Biology
Conor C. Taff, Cedric Zimmer, Thomas A. Ryan, David Chang van Oordt, David A. Aborn, Daniel R. Ardia, L. Scott Johnson, Alexandra P. Rose, Maren N. Vitousek
Summary: Animals respond to sudden challenges with coordinated physiological and behavioral responses. The relationship between corticosterone and glucose regulation varies between different individuals and within populations. A strong response in corticosterone does not necessarily indicate a strong response in glucose.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Cedric Zimmer, H. Arthur Woods, Lynn B. Martin
Summary: Information theory is underutilized in stress endocrinology, despite its importance in understanding the information content of hormones. The free energy principle from neuroscience could provide insights into how hormones like glucocorticoids encode information and how cells respond to them. Further research is needed to explore these ideas and potential applications.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Ornithology
Mary J. Woodruff, Cedric Zimmer, Daniel R. Ardia, Maren N. Vitousek, Kimberly A. Rosvall
Summary: Climate change is impacting our planet, and understanding the effects on wild birds' thermal tolerance is limited. Through studying Tree Swallows (Tachycineta bicolor), researchers found natural variation in heat shock protein (HSP) gene expression among different tissues and populations. The brain tissues consistently showed higher HSP gene expression compared to the pectoral muscle. Additionally, populations in southern regions exhibited higher neural HSP gene expression than those in northern regions.
Article
Ecology
Maren N. Vitousek, Jennifer L. Houtz, Monique A. Pipkin, David A. Chang van Oordt, Kelly K. Hallinger, Jennifer J. Uehling, Cedric Zimmer, Conor C. Taff
Summary: As global climate changes, many species are at risk due to shifting thermal regimes. The ability to cope with cold is crucial for populations facing more frequent or extreme cold. Experiments have shown that extreme cold or rapid temperature declines usually result in an increase in stress hormones in captive animals. However, it is unclear whether free-living adults, who may better handle cold effects, show a similar response to ecologically relevant thermal challenges. The effects of cold on sensitivity to future challenges and the long-term consequences are not well understood.
FUNCTIONAL ECOLOGY
(2022)
Article
Multidisciplinary Sciences
Elisabetta Versace, Paola Sgado, Julia George, Jasmine L. Loveland, Joseph Ward, Peter Thorpe, Lars Juhl Jensen, Karen A. Spencer, Silvia Paracchini, Giorgio Vallortigara
Summary: The study reveals a transient effect of light exposure on gene expression related to lateralisation, with downregulation of the sensitive-period mediator gene DIO2 in the right retina. No significant differences were found in gene expression between the right and left telencephalon. Gene networks associated with lateralisation were connected to vascularisation, cell motility, and extracellular matrix.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Blanca Jimeno, Cedric Zimmer
Summary: This study discusses the regulatory mechanisms of the hypothalamic-pituitary-adrenal axis in response to environmental changes, particularly emphasizing the role of glucocorticoid receptors. The study suggests that the expression of glucocorticoid receptors is crucial for the ability to respond to environmental changes and the regulation and dynamics of glucocorticoids.
HORMONES AND BEHAVIOR
(2022)
Letter
Biology
Lynn B. Martin, Cedric Zimmer
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Behavioral Sciences
Cedric Zimmer, Conor C. Taff, Daniel R. Ardia, Kimberly A. Rosvall, Christine Kallenberg, Alexandra B. Bentz, Audrey R. Taylor, L. Scott Johnson, Maren N. Vitousek
Summary: This study compares gene expression in female tree swallows from different breeding environments and finds that the expression of glucocorticoid and mineralocorticoid receptors in the hypothalamus varies among populations. The variation in circulating glucocorticoids predicts differences in gene expression, suggesting a combination of local adaptation and phenotypic plasticity in the stress response. The results highlight the importance of considering regulatory traits in the evolutionary study of stress response.
HORMONES AND BEHAVIOR
(2023)
Article
Biology
Elizabeth Sheldon, Cedric Zimmer, Haley Hanson, Bilal Koussayer, Aaron Schrey, Darrys Reese, Paul Wigley, Amy L. Wedley, Lynn B. Martin
Summary: Animals moving into new areas face novel challenges, including pathogen exposure. DNA methylation regulates plasticity by affecting gene expression. Non-native house sparrows with high epigenetic potential (EP) in the promoter of a key microbial surveillance gene, Toll-like receptor 4 (TLR4), were better able to resist pathogenic infection.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Behavioral Sciences
Jessica Harvey-Carroll, Tyler J. Stevenson, Karen A. Spencer
Summary: Maternal signals play a crucial role in shaping embryonic development and post-natal phenotypes. RNA deposition is one method of maternal signaling, and it is believed to transmit circadian rhythms to offspring. However, the extent to which maternal developmental conditions influence maternal circadian gene transcripts and early embryonic gene transcription remains unclear.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sang Hyuck Lee, Mi Ae Kim, Young Chang Sohn
Summary: This study characterized the CCAP signaling system in Pacific abalone and revealed its relationship with the calcium/PKC and cAMP/PKA signal transduction pathways. It provides new insights into the evolutionary origins of the NPS and OT/VP signaling systems in protostomes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Hanna Scheuffele, Erica V. Todd, John A. Donald, Timothy D. Clark
Summary: Global warming is causing an increase in extreme weather events, affecting ecosystems and the behavior of ectotherms. More research is needed to understand the impact of diurnal thermal variability and improve climate change predictions.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jaakko Haverinen, Ahmed Badr, Markus Eskelinen, Matti Vornanen
Summary: The acclimatization of certain ectothermic vertebrates to winter conditions involves reduced energy consumption, achieved through decreased movement activity, depression of cellular functions, or switching to anaerobic energy production. This study on crucian carp showed that winter-acclimatized fish exhibited lower metabolic rates and a shift to anaerobic energy production during anoxia. Winter dormancy in crucian carp is achieved through active reduction of energy consumption, a slowed metabolic rate, and a direct response to oxygen absence.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Maria Cruz Sueiro, Cynthia A. Awruch, Gustavo M. Somoza, Walter S. Svagelj, Maria G. Palacios
Summary: According to life-history theory, there might be different immunological strategies between reproductive and non-reproductive periods due to limited resources. Our study on two sympatric marine fish species, rockfish and sandperch, found that reproductive individuals showed lower immune function, but higher levels of natural antibodies in rockfish females, compared to their non-reproductive counterparts. On the other hand, reproductively active sandperch males showed lower levels of natural antibodies and higher neutrophil to lymphocyte ratio and spleen index compared to non-reproductive males. The study highlights the species-specific patterns of immunity and the potential influence of resource limitation and abiotic factors on immune trade-offs in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
James B. Cummins, Dane A. Crossley II
Summary: This study focuses on cardiovascular development in altricial bird species, which has been less studied compared to precocial species. The researchers investigated the cholinergic and adrenergic receptor mediated control of arterial blood pressure and heart rate in the neotropic cormorant. The findings suggest that both cholinergic and adrenergic tone play a role in cardiovascular regulation in embryonic birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ru Xia, Hong-Kang Liu, Xi-Feng Liu, Xin Deng, Chuan-Jie Qin, Yuan-Fa He, Shi-Mei Lin, Yong-Jun Chen
Summary: This study cloned the genes encoding glucokinase and glucose-6-phosphatase catalytic subunit in largemouth bass, revealing their distribution and transcriptional regulation. The results showed that the functions of G6pc and Gck in LMB were highly conserved in evolution, and the interconversion of glucose and G6P in the liver was well regulated at the transcript level under high starch diet, but a futile cycle was induced after a glucose load.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)