Role of DUSP1/MKP1 in tumorigenesis, tumor progression and therapy

Disruption of a regulatory loop between DUSP1 and p53 contributes to hepatocellular carcinoma development and progression

(2015) Pei-Pei Hao et al.   JOURNAL OF HEPATOLOGY

MKP1 phosphatase mediates G1-specific dephosphorylation of H3Serine10P in response to DNA damage

(2015) Ajit K. Sharma et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

MiR-101 targets DUSP1 to regulate the TGF-β secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma

(2015) Xufu Wei et al.   Oncotarget

Evaluation of sorafenib treatment and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: a comparative study using the propensity score matching method

(2015) Kotaro Fukubayashi et al.   Cancer Medicine

Sorafenib for the treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a prospective multicenter cohort study

(2015) Masahito Nakano et al.   Cancer Medicine

Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells

(2014) D. Candas et al.   CANCER RESEARCH

Involvement of MAPK Phosphatase-1 in Dexamethasone-Induced Chemoresistance in Lung Cancer

(2014) Jian Huang et al.   JOURNAL OF CHEMOTHERAPY

DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine

(2014) Fang Liu et al.   PLoS One

Lapatinib plus capecitabine for HER2-positive advanced breast cancer: a multicentre study of Anatolian Society of Medical Oncology (ASMO)

(2013) Bulent Cetin et al.   JOURNAL OF CHEMOTHERAPY

A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis

(2013) Kantima Leelahavanichkul et al.   Molecular Oncology

TGF-β1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death

(2013) J Park et al.   Cell Death & Disease

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK

(2012) Antonio Maraver et al.   CANCER CELL

Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells

(2011) Juan Wang et al.   CELL CYCLE

Target Therapy in HER2-Overexpressing Breast Cancer Patients

(2011) Rosalba Amodio et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Targeted Therapy in Metastatic Breast Cancer: The HER2/neu Oncogene

(2010) Nadia Harbeck et al.   Breast Care

HER2 as a target for breast cancer therapy

(2010) Elda Tagliabue et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

(2010) Christopher J. Staples et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer

(2010) V Moncho-Amor et al.   ONCOGENE

Clinical trials of note

(2009) Carrie Printz   CANCER

MKP1 repression is required for the chemosensitizing effects of NF-κB and PI3K inhibitors to cisplatin in non-small cell lung cancer

(2009) María Cortes-Sempere et al.   CANCER LETTERS

Proinflammatory Mediators Upregulate Snail in Head and Neck Squamous Cell Carcinoma

(2009) M. A. St. John et al.   CLINICAL CANCER RESEARCH

Sorafenib

(2009) Gillian M. Keating et al.   DRUGS

Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors

(2008) Shiro Miura et al.   CANCER

Dual-Specificity Phosphatase 1 Ubiquitination in Extracellular Signal-Regulated Kinase-Mediated Control of Growth in Human Hepatocellular Carcinoma

(2008) D. F. Calvisi et al.   CANCER RESEARCH

Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors

(2008) F. L. Chen et al.   CLINICAL CANCER RESEARCH

Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control

(2008) Diego F. Calvisi et al.   INTERNATIONAL JOURNAL OF CANCER