Article
Dentistry, Oral Surgery & Medicine
Ezgi Yuceer-Cetiner, Nilufer Ozkan, Mehmet Emin Onger, Mustafa Yavuz Gulbahar, Metehan Keskin
Summary: This study compared different graft materials for reconstructing mandibular bone defects, finding that a combination of autograft and xenograft was more effective than using either alone or leaving the defects empty. Immunohistochemical and stereological results support the adoption of the induced membrane technique in humans for small segmental mandibular defect reconstruction.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Critical Care Medicine
Hening Sun, Charles Godbout, Gareth Ryan, Graeme Hoit, James Higgins, Emil H. Schemitsch, Aaron Nauth
Summary: The study compared two bone grafting procedures in rat models of induced membrane technique (IMT), revealing significantly improved healing outcomes in the second group. This suggests that the revised bone grafting method plays a key role in enhancing healing outcomes and establishing a reliable rat model for IMT.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Review
Orthopedics
Yi Lu, Chih-Yang Lai, Po-Ju Lai, Yi-Hsun Yu
Summary: This systematic review and meta-analysis of the induced membrane technique (IMT) in femoral defects found that external fixation in the second-stage surgery was associated with a higher risk of post-procedural bone graft infection, while age over 65 years increased the risk of final non-union status. Shorter union time was related to impregnated antibiotics in the spacer, the use of all-autologous grafts, and the application of intramedullary nails as the second-stage fixation method.
ORTHOPAEDIC SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Rene D. Verboket, Nicolas Soehling, Myriam Heilani, Charlotte Fremdling, Alexander Schaible, Katrin Schroeder, Jan C. Brune, Ingo Marzi, Dirk Henrich
Summary: The Masquelet technique is a two-stage procedure used to treat large bone defects. This study tested the effectiveness of demineralized bone matrix and bone marrow mononuclear cells as membrane fillings, and found that they cannot replicate the good results of this material in large, non-membrane coated bone defects. However, they do support the maturation of new bone tissue locally.
Article
Orthopedics
Takahiro Niikura, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Yoshitada Sakai, Tomoo Itoh, Ryosuke Kuroda
Summary: Factors such as sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement were found to have no significant impact on the vascularization of the induced membrane (IM). However, the vascularization of IM was reduced in patients who underwent free flap surgery compared to those who did not.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cell Biology
Nicolas Soehling, Myriam Heilani, Charlotte Fremdling, Alexander Schaible, Katrin Schroeder, Jan C. Brune, Volker Eras, Christoph Nau, Ingo Marzi, Dirk Henrich, Rene D. Verboket
Summary: The classic two-stage masquelet technique is effective for treating large bone defects. Using decellularized dermis membrane (DCD) can save one surgery. It is also possible to use granular demineralized bone matrix (g-DBM) or fibrous demineralized bone matrix (f-DBM) instead of syngeneic cancellous bone (SCB) for defect filling.
Review
Engineering, Biomedical
Benjamin Dalisson, Baptiste Charbonnier, Ahmed Aoude, Mirko Gilardino, Edward Harvey, Nicholas Makhoul, Jake Barralet
Summary: This review article discusses different strategies for repairing massive segmental bone defects and explores emerging potential replacements for the standard treatment of fibular transplantation with a blood supply. The review highlights the importance of considering more basic approaches in bone repair and challenges the assumption that mimicry is necessary for success in repair strategies.
ACTA BIOMATERIALIA
(2021)
Article
Medicine, General & Internal
Yang Yang, Wei Zhang, Shuanji Ou, Changpeng Xu, Yong Qi, Xiangyang Ma
Summary: Through a retrospective study, it was found that the induced membrane technique (IMT) has a good effect in treating infected tibial bone defect. This technique involves a 2-stage surgery to reconstruct the bone defects of the limbs. The study results showed that bone union was achieved in all cases, and there was good recovery of joint function.
Article
Medicine, General & Internal
Zeng-Bing Liu, Qiang Li, Wen-Xia Liu, Xin-Hai Li, Kai Ma, Yu-Bao Huo, Jin-Guang Wang, Qing-He Wang, Ya-Dong Yu
Summary: This study investigated the clinical effects of the modified Masquelet technique and the Kirschner wire external fixation-assisted autologous bone transplantation technique in treating segmental metacarpophalangeal bone defects. The improved Masquelet technique showed better postoperative outcomes and fewer complications compared to the external fixation group.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Critical Care Medicine
Kyohei Takase, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryo Yoshikawa, Yuya Yamamoto, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura
Summary: This study aimed to investigate the effects of low-intensity pulsed ultrasound (LIPUS) on the osteogenic differentiation of human induced membrane-derived cells (IMCs). The results showed that LIPUS significantly enhanced the osteogenic capability of IMCs and upregulated the expression of bone formation-related genes. Therefore, LIPUS can be utilized as an additional tool to enhance the healing process of the Masquelet technique.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Review
Medicine, General & Internal
Shih-Heng Sun, Wen-Wen Tsai, Sz-Iuan Shiu, Chih-Hui Chen
Summary: The aim of this study was to evaluate the efficacy of induced membrane technique (IMT) and analyze the impact of patient factors and surgical parameters on bone union and complication rates. The study included 78 trials with a total of 3840 patients managed with IMT. Results showed that delaying the timing of the second stage to 6 to 8 weeks after the first stage and using bone cement with antibiotics can improve outcomes. The study also found that concerns about postoperative infection should not deter the use of internal fixation.
Article
Critical Care Medicine
Kai Wang, Fandong Gao, Yuanshu Zhang, Beichen Dai, Xujie Yan, Xuchen He, Dong Mao, Yongjun Rui
Summary: There is inhomogeneity in induced membrane activity during bone graft growth after Masquelet technique. The number and maturation of vessels in the proximal region of the induced membrane at the bone defect site are higher than those in the distal region, and the expression of growth factors is higher.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Orthopedics
Takahiro Niikura, Takahiro Oda, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Tomoo Itoh, Ryosuke Kuroda
Summary: This study confirmed the presence of osteoinductive factors BMP-4, 6, 7, and 9 in IM harvested from patients, indicating the effectiveness of the Masquelet technique in healing large bone defects.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Critical Care Medicine
Cesar Angel Pesciallo, German Garabano, Tamara Dainotto, Glenda Ernst
Summary: The study aimed to describe the outcomes of using induced membrane technique with a high proportion of allograft (up to 64%) to treat infected femoral and tibial segmental bone defects, showing similar union and failure rates compared to series with lower allograft proportions.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Critical Care Medicine
J. Frese, A. P. Schulz, B. Kowald, U. -j. Gerlach, K. -h. Frosch, R. Schoop
Summary: The Masquelet technique is a surgical procedure for bone defect reconstruction, involving the use of a cement spacer and bone graft. This study retrospectively analyzed data from 171 patients treated with the Masquelet technique, and found that factors such as defect size, treatment methods, and microbiological results can influence treatment outcomes. The results showed that defects larger than 62 mm have lower chances of achieving full weight bearing, suggesting that this size can be considered a critical defect size for the Masquelet technique based on the data.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)