Article
Neurosciences
Ilaria Piano, Francesca Corsi, Beatrice Polini, Claudia Gargini
Summary: Treatment with naringenin and quercetin can alleviate retinal degeneration by preserving photoreceptor functionality and increasing antioxidant and anti-apoptotic pathways.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching- Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su
Summary: Research found that mitochondrial transplantation can moderately attenuate the degeneration of retinal layers in RCS rats. This result was confirmed through histological examination and OCT measurement of retina thickness. VEP analysis showed that the transmission time of electrical signals after mitochondrial transplantation was similar to the normal value. The results suggest that mitochondrial transplantation can improve the degeneration of photoreceptors in RCS rats and have potential for clinical application.
Article
Cell Biology
Lucie Crouzier, Camille Diez, Elodie M. Richard, Nicolas Cubedo, Clement Barbereau, Mireille Rossel, Thomas Delaunay, Tangui Maurice, Benjamin Delprat
Summary: Retinitis pigmentosa (RP) is a common inherited retinal degeneration disease with no current treatment available. The zebrafish pde6a(Q70X) mutant serves as an ideal model for studying the progression of RP and potential treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yogita Kanan, Sean F. Hackett, Henry T. Hsueh, Mahmood Khan, Laura M. Ensign, Peter A. Campochiaro
Summary: Retinitis pigmentosa (RP) is a genetic disorder that causes rod photoreceptor degeneration and subsequent cone photoreceptor degeneration. Reduced oxygen consumption from the loss of rods leads to retinal hyperoxia and oxidative stress, resulting in cone cell death and degeneration. However, reducing inspired oxygen levels can reduce retinal hyperoxia, preserve cone structure and function, and decrease oxidative damage in animal models of RP.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biology
Duygu Karademir, Vyara Todorova, Lynn J. A. Ebner, Marijana Samardzija, Christian Grimm
Summary: This study utilizes droplet-based single-cell RNA sequencing to investigate the degeneration process in rod and cone photoreceptor cells in an RP mouse model. The results identify early changes in rods and potential early responses in cones, suggesting mechanisms involved in secondary cone degeneration. Furthermore, the study implicates EGR1 as a potential key regulator of early degenerative events in both types of photoreceptor cells.
Article
Biochemistry & Molecular Biology
Yang Liu, Yafang Wang, Yushu Xiao, Xiaomeng Li, Shang Ruan, Xueting Luo, Xiaoling Wan, Fenghua Wang, Xiaodong Sun
Summary: By establishing a CNGA1 knockout mouse model, researchers observed progressive retinal thinning and functional deficits as typical phenotypes for RP, along with degeneration in rods and cones, microglial activation, and oxidative stress damage. RNA-sequencing analysis indicated down-regulated synaptic transmission and phototransduction as early triggers for photoreceptor degeneration. The study contributes to understanding the mechanisms of photoreceptor death during RP progression and provides a novel model for potential therapeutic development.
Article
Ophthalmology
Paul. S. Micevych, Jessica Wong, Hao Zhou, Ruikan. K. Wang, Travis. C. Porco, Joseph Carroll, Austin Roorda, Jacque. L. Duncan
Summary: This study compared cone structure and function between patients with RPGR and USH2A-related retinal degeneration. It found that outer retinal structure and choriocapillaris perfusion were more abnormal in patients with RPGR-related retinal degeneration compared to those with USH2A-related retinal degeneration. However, there were no significant differences in below-normal regional sensitivity between rod-cone degeneration associated with variants in these 2 genes expressed at the photoreceptor-connecting cilium.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalia Martinez-Gil, Oksana Kutsyr, Agustina Noailles, Laura Fernandez-Sanchez, Lorena Vidal, Xavier Sanchez-Saez, Carla Sanchez-Castillo, Pedro Lax, Nicolas Cuenca, Antonio G. Garcia, Victoria Maneu
Summary: P2X7R and P2X4R play important roles in retinal diseases and their expression increases during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Sohair A. Eltony, Heba S. Mohaseb, Amel A. Ahmed, Manal M. Sayed
Summary: This study aimed to investigate the effect of metformin on the retina of the ENU-induced rat model of RP. The results showed that metformin could reduce retinal degeneration and improve the morphology of glia and blood capillaries. This suggests that metformin has a neuroprotective effect on the retina.
Review
Biochemistry & Molecular Biology
Davide Allegrini, Raffaele Raimondi, Alfredo Borgia, Tania Sorrentino, Giovanni Montesano, Panos Tsoutsanis, Giuseppe Cancian, Yash Verma, Francesco Paolo De Rosa, Mario R. Romano
Summary: Recent evidence suggests that curcumin may be effective in treating retinal diseases by modulating gene transcription, reducing cell apoptosis, and improving vascular function. However, its limited bioavailability has hindered its use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Geetika Kaur, Nikhlesh K. Singh
Summary: Vision depends on the precise structure and functioning of the retina, and any stress or injury can disrupt it, leading to vision impairment, loss, and blindness. Inflammation plays a crucial role in the development of retinal disorders, such as glaucoma, macular degeneration, diabetic retinopathy, and retinitis pigmentosa. This review provides evidence on the role of inflammation in these disorders and suggests potential therapeutic targets.
NEURAL REGENERATION RESEARCH
(2023)
Review
Medicine, General & Internal
Grazyna Adamus
Summary: Inherited retinal diseases are rare disorders that lead to blindness through various mechanisms including immune responses, gene mutations, and inflammation affecting the death of retinal photoreceptor cells.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Enrica Strettoi, Beatrice Di Marco, Noemi Orsini, Debora Napoli
Summary: This article reviews the plasticity of the retina, finding that it has limited plasticity outside the developmental stage. In contrast, the retina is highly adept at maintaining a stable structure and functional organization. The article also discusses the variable rate of structural plasticity in retinal neurons in different circumstances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hyeonhee Roh, Yanjinsuren Otgondemberel, Jeonghyeon Eom, Daniel Kim, Maesoon Im
Summary: This study investigates the electric response features of retinal ganglion cells (RGCs) in rd8 mice with retinal degeneration caused by Crb1 mutation. The results show that different types of RGCs have different electric response features in the early stage of RP, suggesting the importance of genotype- and RGC type-dependent analyses for retinal prosthetic research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Ophthalmology
Yuhong Chen, Jieqiong Chen, Hong Wang, Yang Yu, Wenqiu Wang, Wenjia Liu, Suqin Yu, Yuanyuan Gong, Huixun Jia, Tong Li, Xiaodong Sun
Summary: The prevalence of outer retinal tubulation (ORT) varies among different inherited retinal diseases (IRDs) phenotypes, with the highest prevalence in Bietti crystalline corneoretinal dystrophy (BCD). The presence of choroidal atrophy and inner nuclear layer (INL) cysts may be associated with an increased risk of ORT formation in patients with IRD.
Article
Immunology
Aaron Glass, Mark Polhemus, Dongliang Wang, Richard G. Jarman, Stephen J. Thomas, Heather Friberg, Jeffrey R. Currier, Matthew Bonaparte, Rafael De la Barra, Michael F. Princiotta, Mark Abbott, Brian Cuzzo, Tifany Machabert, Saranya Sridhar, Timothy P. Endy
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Surgery
Oleh Pankewycz, Engin Onan, Dane Rucker, Dongliang Wang, Angelika Gruessner, Rainer Gruessner, Mark R. Laftavi
CLINICAL TRANSPLANTATION
(2020)
Article
Pathology
Kwun Wah Wen, Peter S. Rabinovitch, Dongliang Wang, Aras N. Mattis, Linda D. Ferrell, Won-Tak Choi
Article
Immunology
Timothy P. Endy, Dongliang Wang, Mark E. Polhemus, Richard G. Jarman, Louis E. Jasper, Greg Gromowski, Leyi Lin, Rafael A. De la Barra, Heather Friberg, Jeffrey R. Currier, Mark Abbott, Lisa Ware, Michelle Klick, Kristopher M. Paolino, Donald C. Blair, Kenneth Eckels, Wiriya Rutvisuttinunt, Stephen J. Thomas
Summary: The study used the challenge virus DENV-1-LVHC to test the safety and performance of prophylaxis and therapeutics in 12 healthy adult volunteers, with positive results suggesting that it may be a suitable model for testing therapeutic and prophylactic products.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Helen Byakwaga, Arturo Barbachano-Guerrero, Dongliang Wang, Shane McAllister, Kamal Naphri, Miriam Laker-Oketta, Conrad Muzoora, Peter W. Hunt, Jeffrey Martin, Christine A. King
Summary: In a study of untreated HIV-infected adults in Uganda, it was found that patients with KS had higher plasma IgE levels, which were associated with the presence and severity of KS. Higher eosinophil counts and plasma interleukin 33 concentrations were also linked to IgE levels, indicating a potential role of IgE-driven atopic inflammation in the pathogenesis of KS. Targeting IgE-mediated mast cell activation could be a novel approach for the treatment or prevention of KS.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, Legal
Serenella Serinelli, Ponni Arunkumar, Robert Stoppacher, Dongliang Wang, Lorenzo Gitto
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2020)
Article
Oncology
Prashanth Ashok Kumar, Shweta Paulraj, Dongliang Wang, Danning Huang, Abirami Sivapiragasam
Summary: Studies on the timing of initiation of adjuvant chemotherapy (AC) in breast cancer patients have shown controversial results, but starting AC by 31-60 days after surgery appears to have the best survival outcomes, particularly in hormone positive/HER2 negative breast cancer. Delaying the start of AC after surgery can lead to poorer outcomes, emphasizing the importance of timely treatment initiation in breast cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Ophthalmology
Robert W. Weisenthal, Han Y. Yin, Allison R. Jarstad, Dongliang Wang, David D. Verdier
Summary: In the long-term follow-up, DMEK and DSAEK showed comparable levels of BSCVA and patient satisfaction.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Pathology
Nebil Mohammed, Peter S. Rabinovitch, Dongliang Wang, Bence P. Kovari, Aras N. Mattis, Gregory Y. Lauwers, Won-Tak Choi
Summary: Nonampullary duodenal adenomas (NADAs) can develop sporadically or in the context of hereditary syndromes like familial adenomatous polyposis (FAP). Although FAP-related NADAs have distinct clinicopathologic features compared to sporadic NADAs, the majority of both lack the DNA content abnormality typically seen in the adenoma-carcinoma sequence. Adenocarcinoma development is more common in FAP patients with a high adenoma burden, but overall risk of advanced neoplasia may be similar between FAP-related and sporadic NADAs on a per-adenoma basis.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Infectious Diseases
Wesley D. Kufel, Keri A. Mastro, Jeffrey M. Steele, Dongliang Wang, Scott W. Riddell, Kristopher M. Paolino, Stephen J. Thomas
Summary: The study evaluated the impact of a pharmacist-facilitated evidence-based bundle initiative with infectious disease consultation on Staphylococcus aureus bacteremia, showing significant improvements in treatment adherence and clinical outcomes after implementation.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Behavioral Sciences
Shahram Izadyar, Golshan Fahimi, Seyedali Hejazi, Dongliang Wang
Summary: A significant association between atmospheric pressure and the occurrence of nonepileptic seizures was found, whereas no consistent increase in PNES was observed during the full moon phases. The effect of lunar phases on human behavior and neurological disorders such as PNES remains a topic of debate.
EPILEPSY & BEHAVIOR
(2021)
Article
Statistics & Probability
Xin Yang, Alan D. Hutson, Dongliang Wang
Summary: In this study, a theoretically optimal method for combining different types of summary information is proposed to obtain less biased and more flexible pooled estimates. The method has appropriate coverage probabilities for confidence intervals, which are theoretically justified and verified by simulation studies. The BLUE method is illustrated through a real data application.
JOURNAL OF APPLIED STATISTICS
(2022)
Article
Pathology
Christopher J. Bowman, Ruth Zhang, Dana Balitzer, Dongliang Wang, Peter S. Rabinovitch, Bence P. Kovari, Aras N. Mattis, Sanjay Kakar, Gregory Y. Lauwers, Won-Tak Choi
Summary: Endoscopic therapy is standard care for Barrett's esophagus patients with high-grade dysplasia or intramucosal adenocarcinoma. DNA content abnormality and treatment with EMR alone are significant risk factors for persistent/recurrent HGD/IMC or EAC, as identified through this study.
Article
Multidisciplinary Sciences
Dongliang Wang, Xueya Cai
Summary: The study proposes two novel tuning parameters for estimating the ROC curve through Bernstein polynomial smoothing, which is shown to be uniformly more efficient than the empirical ROC estimator and competitive with eleven other existing smooth ROC estimators in terms of mean integrated square errors.
Article
Endocrinology & Metabolism
Paula M. Trief, Seth C. Kalichman, Dongliang Wang, Kimberly L. Drews, Barbara J. Anderson, Jane D. Bulger, Ruth S. Weinstock
Summary: This study aimed to assess the prevalence and factors associated with medication adherence in young adults with youth-onset type 2 diabetes. The results showed low medication adherence and poor glycemic control in these patients. Female gender, non-Hispanic Black ethnicity, and lack of healthcare coverage were associated with lower medication adherence. Interventions are needed to improve medication adherence in this vulnerable group.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
