Review: Preclinical Rheumatoid Arthritis: Progress Toward Prevention

B cell signature contributes to the prediction of RA development in patients with arthralgia

(2015) Joyce Lübbers et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-carbamylated Protein Antibodies Are Present Prior to Rheumatoid Arthritis and Are Associated with Its Future Diagnosis

(2015) R. W. Gan et al.   JOURNAL OF RHEUMATOLOGY

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Autoantibodies in Prediction of the Development of Rheumatoid Arthritis Among Healthy Relatives of Patients With the Disease

(2015) Cesar Ramos-Remus et al.   Arthritis & Rheumatology

Predicting the development of clinical arthritis in anti-CCP positive individuals with non-specific musculoskeletal symptoms: a prospective observational cohort study

(2014) C Rakieh et al.   ANNALS OF THE RHEUMATIC DISEASES

Characterising arthralgia in the preclinical phase of rheumatoid arthritis using MRI

(2014) Hanna W van Steenbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation

(2014) A Jimmy Ytterberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Symptom complexes in patients with seropositive arthralgia and in patients newly diagnosed with rheumatoid arthritis: a qualitative exploration of symptom development

(2014) R. J. Stack et al.   RHEUMATOLOGY

Subclinical inflammation on MRI of hand and foot of anticitrullinated peptide antibody–negative arthralgia patients at risk for rheumatoid arthritis

(2014) Hanna W van Steenbergen et al.   ARTHRITIS RESEARCH & THERAPY

Development of anti-citrullinated protein antibody and rheumatoid factor isotypes prior to the onset of rheumatoid arthritis

(2014) Wouter H Bos et al.   ARTHRITIS RESEARCH & THERAPY

Three-Year Clinical Outcome Following Baseline Magnetic Resonance Imaging in Anti-Citrullinated Protein Antibody-Positive Arthralgia Patients: An Exploratory Study

(2014) Yoony Y. J. Gent et al.   Arthritis & Rheumatology

Periodontitis andPorphyromonas gingivalisin Patients With Rheumatoid Arthritis

(2014) Ted R. Mikuls et al.   Arthritis & Rheumatology

MRI of hand and foot joints of patients with anticitrullinated peptide antibody positive arthralgia without clinical arthritis

(2013) Annemarie Krabben et al.   ANNALS OF THE RHEUMATIC DISEASES

The type I IFN signature as a biomarker of preclinical rheumatoid arthritis

(2013) Joyce Lübbers et al.   ANNALS OF THE RHEUMATIC DISEASES

Heightened immune response to autocitrullinatedPorphyromonas gingivalispeptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

(2013) Anne-Marie Quirke et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-Citrullinated Protein Antibodies in Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients

(2013) Lillian Barra et al.   ARTHRITIS AND RHEUMATISM

Review: The Preclinical Phase of Rheumatoid Arthritis: What Is Acknowledged and What Needs to be Assessed?

(2013) H. W. van Steenbergen et al.   ARTHRITIS AND RHEUMATISM

Familial Risks and Heritability of Rheumatoid Arthritis: Role of Rheumatoid Factor/Anti-Citrullinated Protein Antibody Status, Number and Type of Affected Relatives, Sex, and Age

(2013) Thomas Frisell et al.   ARTHRITIS AND RHEUMATISM

Analysis of Fecal Lactobacillus Community Structure in Patients with Early Rheumatoid Arthritis

(2013) Xiaofei Liu et al.   CURRENT MICROBIOLOGY

Influence of periodontal disease, Porphyromonas gingivalisand cigarette smoking on systemic anti-citrullinated peptide antibody titres

(2013) David F. Lappin et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis

(2013) Gudrun Reynisdottir et al.   Arthritis & Rheumatology

Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis

(2013) M. J. H. de Hair et al.   Arthritis & Rheumatology

Smoking and overweight determine the likelihood of developing rheumatoid arthritis

(2012) Maria J H de Hair et al.   ANNALS OF THE RHEUMATIC DISEASES

A prediction rule for the development of arthritis in seropositive arthralgia patients

(2012) Lotte Arwen van de Stadt et al.   ANNALS OF THE RHEUMATIC DISEASES

Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA)

(2012) Jan M Hughes-Austin et al.   ANNALS OF THE RHEUMATIC DISEASES

EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis

(2012) Danielle M Gerlag et al.   ANNALS OF THE RHEUMATIC DISEASES

Porphyromonas gingivalisand disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis

(2012) Ted R. Mikuls et al.   ARTHRITIS AND RHEUMATISM

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis

(2012) Jose U. Scher et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Anti-Carbamylated Protein Antibodies Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis

(2012) Jing Shi et al.   ARTHRITIS AND RHEUMATISM

Salivary IgA antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis

(2012) Anna Svärd et al.   IMMUNOBIOLOGY

Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva

(2012) G. P. Harvey et al.   JOURNAL OF PERIODONTAL RESEARCH

Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients

(2012) K Erciyas et al.   ORAL DISEASES

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease

(2012) Aryeh Fischer et al.   RESPIRATORY MEDICINE

Environmental and Gene-Environment Interactions and Risk of Rheumatoid Arthritis

(2012) Elizabeth W. Karlson et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden

(2011) Lisbeth Ärlestig et al.   ANNALS OF THE RHEUMATIC DISEASES

Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: Findings of a prospective pilot study

(2011) Yoony Y. J. Gent et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?

(2011) M. Kristen Demoruelle et al.   ARTHRITIS AND RHEUMATISM

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

(2011) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modifiable risk factors for RA: prevention, better than cure?

(2011) M. Lahiri et al.   RHEUMATOLOGY

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia

(2010) L. A. van de Stadt et al.   ANNALS OF THE RHEUMATIC DISEASES

Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

Gene expression profiling in autoantibody-positive patients with arthralgia predicts development of arthritis

(2010) Lisa G. M. van Baarsen et al.   ARTHRITIS AND RHEUMATISM

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis

(2010) Natalia Wegner et al.   ARTHRITIS AND RHEUMATISM

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

(2010) A. Hendler et al.   JOURNAL OF DENTAL RESEARCH

Association of Periodontitis With Rheumatoid Arthritis: A Pilot Study

(2010) Addie Dissick et al.   JOURNAL OF PERIODONTOLOGY

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study

(2010) Lotte A van de Stadt et al.   ARTHRITIS RESEARCH & THERAPY

Effect of dexamethasone on autoantibody levels and arthritis development in patients with arthralgia: a randomised trial

(2009) W. H. Bos et al.   ANNALS OF THE RHEUMATIC DISEASES

Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study

(2009) W. H. Bos et al.   ANNALS OF THE RHEUMATIC DISEASES

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES