Article
Orthopedics
Matthew T. Kingery, Utkarsh Anil, Elyse J. Berlinberg, Andrew J. Clair, Lena Kenny, Eric J. Strauss
Summary: This study evaluates changes in the concentration of proinflammatory and anti-inflammatory synovial fluid cytokines during the period between acute ACL injury and surgical reconstruction. The results show that there are significant decreases in 6 cytokines and significant increases in 2 cytokines between the initial clinical presentation shortly after the injury and the time of surgery 1 month later.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
K. Kumagai, H. Fujimaki, S. Yamada, S. Nejima, J. Matsubara, Y. Inaba
Summary: This study evaluated the effects of high tibial osteotomy (HTO) on knee osteoarthritis using joint markers in synovial fluid. The results showed significant improvement in knee function and structure after surgery, as well as decreased concentrations of joint biomarkers in synovial fluid, indicating an improvement in disease state.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Medicine, General & Internal
Richard T. Meehan, Mary T. Gill, Eric D. Hoffman, Claire M. Coeshott, Manuel D. Galvan, Molly L. Wolf, Isabelle A. Amigues, Liudmila M. Kastsianok, Elizabeth A. Regan, James L. Crooks, Gregory J. Czuczman, Vijaya Knight
Summary: This study aimed to determine if clinical improvement in pain and function after intra-articular hyaluronic acid injections using ultrasound guidance is associated with changes in synovial fluid volume and biomarker proteins at 3 months. The results showed clinical improvements at 12 months, but only one synovial fluid protein biomarker was different at 3 months. Larger studies are needed to identify which synovial fluid biomarkers can predict the greatest benefit from intra-articular therapeutics in individual patients with osteoarthritis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Michael Yayac, Zachary S. Aman, Alexander J. Rondon, Timothy L. Tan, P. Maxwell Courtney, James J. Purtill
Summary: The study identified independent risk factors for developing AKI during total joint arthroplasty and established a predictive model to assist surgeons in reducing this risk. The final predictive model showed excellent performance with a c-statistic of 0.967.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Urology & Nephrology
Meiping Wang, Bo Zhu, Li Jiang, Xuying Luo, Na Wang, Yibing Zhu, Xiuming Xi
Summary: Different trajectories of fluid balance in critically ill patients with acute kidney injury are associated with clinical outcomes. High fluid balance above or below a certain range is associated with increased risk of mortality. A J-shaped relationship was observed between maximum fluid overload and 28-day mortality, with the lowest risk at a maximum FO of 2.8% L/kg.
Review
Critical Care Medicine
Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincon-Gutierrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone
Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.
Article
Orthopedics
U. T. Timur, H. Jahr, J. Anderson, D. C. Green, P. J. Emans, A. Smagul, L. W. van Rhijn, M. J. Peffers, T. J. M. Welting
Summary: This study identified tissue-dependent secreted proteins from intra-articular human knee osteoarthritis tissues, which may serve as novel candidates for osteoarthritis biomarker development on a tissue-specific basis.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Chemistry, Multidisciplinary
Uthpala N. Wijayaratna, Sachindra D. Kiridena, John D. Adams, Caleb J. Behrend, Jeffrey N. Anker
Summary: An implantable sensor has been developed to measure synovial fluid pH for noninvasive early detection and monitoring of hip infections using standard-of-care plain radiography. The sensor shows a linear response and reversibility in the physiologically relevant pH range.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Stefania Kalogera, Mylene P. Jansen, Anne-Christine Bay-Jensen, Peder Frederiksen, Morten A. Karsdal, Christian S. Thudium, Simon C. Mastbergen
Summary: The association between structural changes and pain sensation in osteoarthritis (OA) is still not clear. This study found that some biomarkers were associated with structural outcomes, while most were associated with pain outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Laura Rizzi, Marco Turati, Elena Bresciani, Filippo Maria Anghilieri, Ramona Meanti, Laura Molteni, Massimiliano Piatti, Nicolo Zanchi, Silvia Coco, Francesco Buonanotte, Luca Rigamonti, Giovanni Zatti, Vittorio Locatelli, Robert J. J. Omeljaniuk, Marco Bigoni, Antonio Torsello
Summary: This study investigated the changes in microRNA expression profiles in knee synovial fluid of patients with osteoarthritis (OA) and anterior cruciate ligament (ACL) rupture. The results showed that specific microRNAs were expressed differently in OA and ACL tear samples. These findings may contribute to further research on the mechanisms and treatments of osteoarthritis and ACL rupture.
Article
Immunology
Xin Zhang, Sisi Ma, Syeda Iffat Naz, Vaibhav Jain, Erik J. Soderblom, Constantin Aliferis, Virginia Byers Kraus
Summary: The study reveals that extracellular vesicles in synovial fluid carry proteins and surface markers associated with the severity of osteoarthritis, suggesting their potential use as diagnostic biomarkers or therapeutic targets.
CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Priya Kulkarni, Vanshika Srivastava, Kaspar Tootsi, Ali Electricwala, Avinash Kharat, Ramesh Bhonde, Sulev Koks, Aare Martson, Abhay Harsulkar
Summary: Macrophage polarization is a crucial factor in the progression of osteoarthritis. Synovial fluid from OA patients can induce differentiation and polarization of macrophages, providing a proinflammatory microenvironment.
Article
Infectious Diseases
Alina Daciana Elec, Mihai Oltean, Patricia Goldis, Cristina Cismaru, Mihaela Lupse, Adriana Muntean, Florin Ioan Elec
Summary: This study reviewed 42 kidney transplant recipients with COVID-19, finding that antiretrovirals and RDV may increase the risk of renal impairment, but most patients can recover to baseline kidney function after discharge.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
R. Scott Watson, Sue R. Beers, Lisa A. Asaro, Cheryl Burns, Min Jung Koh, Mallory A. Perry, Derek C. Angus, David Wypij, Martha A. Q. Curley
Summary: This study compared the neurocognitive outcomes of children who survived pediatric intensive care unit (PICU) hospitalization for acute respiratory failure with their biological siblings. The results showed that children who survived PICU hospitalization had significantly lower IQ scores, as well as lower scores in nonverbal memory, visuospatial skills, and fine motor control compared to their siblings. However, the magnitude of the difference was small and of uncertain clinical importance.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ichiro Sekiya, Hisako Katano, Nobutake Ozeki
Summary: Research has shown the presence of many MSCs similar to synovial MSCs in the synovial fluid of human OA knees, with their number correlating with the severity of OA. Endogenous MSCs in OA knees have a protective effect, but the limited number may contribute to disease progression. Exogenous synovial MSCs have shown promise in promoting anti-inflammation, lubrication, and cartilage matrix synthesis in OA knees.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Orthopedics
V. Georgopoulos, S. Smith, D. F. McWilliams, M. P. M. Steultjens, A. Williams, A. Price, A. M. Valdes, T. L. Vincent, F. E. Watt, D. A. Walsh
Summary: This study aimed to harmonize patient-reported outcome measures (PROMs) in knee pain due to osteoarthritis or knee trauma using the Patient Acceptable Symptom State scores (PASS) as a criterion. Standardized PROMs showed similar PASS thresholds in group data, but divergent scores within individuals.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Health Care Sciences & Services
Joanna McLaughlin, Joshua Elsey, Ruth Kipping, Amanda Owen-Smith, Andrew Judge, Hugh McLeod
Summary: Commissioning policies in England that restrict access to hip and knee arthroplasty based on patients' body mass index and smoking status are widespread and increasing in prevalence. These policies may result in unequal access to surgery and specialist support for affected patients.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Oncology
Usama M. Ali, Diana R. Withrow, Andrew D. Judge, Puneet Plaha, Sarah C. Darby
Summary: A study in England found an increase in the incidence of primary CNS tumors, mainly due to the greater detection of benign tumors, possibly caused by the increased use of neuroimaging, specifically CT head scans in older adults.
Article
Medicine, General & Internal
Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J. Mark Wilkinson, Andrew Judge
Summary: This study aimed to assess the impact of BMI policies on access to hip replacement surgery in England. The study found that the implementation of BMI policies led to a decrease in surgery rates, while areas without policies saw an increase in rates, exacerbating health inequalities. It is recommended to no longer use BMI policies involving extra waiting time or mandatory BMI thresholds to reduce access to hip replacement surgery.
Article
Orthopedics
Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn, Antonella Delmestri, Lindsay K. K. Smith, Andrew Judge, Sarah R. R. Kingsbury, Martin H. H. Stone, Philip G. G. Conaghan
Summary: Follow-up visits after primary hip or knee replacement surgery have been recommended, but their benefits have not been specifically examined. This study found that patients attending follow-up visits had a higher risk of revision surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Hasan R. Mohammad, Andrew Judge, David W. Murray
Summary: The study examined the performance of cemented and cementless UKRs in different BMI groups. It found that higher-BMI groups had higher revision rates for cemented UKRs, but not for cementless UKRs. Cementless fixation was associated with reduced long-term revision rates and lower risks of aseptic loosening and pain in the obese group.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Geriatrics & Gerontology
Samuel Hawley, Dominic Inman, Celia L. Gregson, Michael Whitehouse, Antony Johansen, Andrew Judge
Summary: This study aims to identify risk factors and examine associations with returning home or recovery of mobility among hip fracture patients who have normal preoperative cognition. The results show that patients with postoperative delirium are less likely to return home or regain outdoor mobility. Multiple factors, including deficits in preoperative cognition and malnutrition, increase the risk of delirium, while the use of preoperative nerve blocks reduces the risk. Understanding the importance of preventing postoperative delirium and identifying high-risk patients can potentially improve outcomes for hip fracture patients.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Orthopedics
Hasan Raza Mohammad, Andrew Judge, Christopher Dodd, David Murray
Summary: This study assessed the effects of pre and post-operative activity levels on cementless Unicompartmental Knee Replacement (UKR), and found that increasing post-operative activity did not increase revision rates but was associated with better post-operative function. Therefore, activity should not be restricted before or after cementless UKR.
Article
Medicine, General & Internal
Tim Jones, Chris Penfold, Maria Theresa Redaniel, Emily Eyles, Tim Keen, Andrew Elliott, Ashley W. Blom, Andrew Judge
Summary: This study aims to investigate the impact of temporarily cancelling elective surgery in winter 2017 on the trends in primary hip and knee replacement at a major NHS Trust. The study also explores whether there are lessons to be learned about efficient surgery provision. The results showed a sustained reduction in knee replacements, a decrease in the proportion of deprived people having knee replacements, and an increase in average age and comorbidity for both types of surgery.
Article
Medicine, General & Internal
Erik Lenguerrand, Yoav Ben-Shlomo, Amar Rangan, Andrew Beswick, Michael R. Whitehouse, Kevin Deere, Adrian Sayers, Ashley W. Blom, Andrew Judge
Summary: This study examined the provision of primary hip and knee replacement surgery in the United Kingdom, specifically focusing on social inequalities in access to these procedures. The findings indicate that there have been persistent socioeconomic disparities in the provision of joint replacement surgery over the past decade. The authors emphasize the need for healthcare providers to address and reduce these unwarranted variations in access.
Article
Orthopedics
Hasan R. Mohammad, Karen Barker, Andrew Judge, David W. Murray
Summary: A matched study was performed to compare the periprosthetic fracture rates after TKR and UKR. The fracture rate after UKR was approximately twice as high as that after TKR within the first 3 months postoperatively. However, over the first 10 years, the cumulative fracture rate after TKR was almost twice as high as that after UKR. Fracture rates after both UKR and TKR were higher in women, patients aged 75 or older, and patients with normal weight.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Medicine, General & Internal
Karen D. Coulman, Ruta Margelyte, Tim Jones, Jane M. Blazeby, John Macleod, Amanda Owen-Smith, Helen Parretti, Richard Welbourn, Maria Theresa Redaniel, Andy Judge
Summary: Between 2007 and 2020, only a small percentage of the primary care population eligible for WM referral or bariatric surgery based on national guidelines actually received either. Higher BMI and GP practice region showed the strongest associations with both outcomes. Regional disparities may indicate variations in the commissioning and provision of WM services nationwide.
Article
Orthopedics
R. J. Holleyman, S. S. Jameson, M. Reed, R. M. D. Meek, V. Khanduja, A. Hamer, A. Judge, T. Board
Summary: This study examines the annual volume variation of revision hip arthroplasty (RHA) performed by consultant surgeons nationally and the rate at which new consultants accrue RHA experience. The majority of RHAs are performed by higher-volume surgeons, and there is a significant variation in RHA volumes by indication, day of the week, and between consultants nationally. The low rate of RHA experience accrual by new consultants has important implications for establishing an experienced RHA consultant workforce.
BONE & JOINT JOURNAL
(2023)
Article
Health Care Sciences & Services
Tim Dong, Shubhra Sinha, Ben Zhai, Daniel P. Fudulu, Jeremy Chan, Pradeep Narayan, Andy Judge, Massimo Caputo, Arnaldo Dimagli, Umberto Benedetto, Gianni D. Angelini
Summary: This study combines EuroSCORE I and EuroSCORE II data using ensemble learning methods to predict cardiac surgery risk. The results show that both homogeneous and heterogeneous machine learning ensembles perform better than dynamic model averaging ensembles.
Review
Orthopedics
Amir Abdelmalek, Samuel Haines, Baha John Tadros, Jonathan T. Evans, Andrew Judge
Summary: This study aimed to compare the reoperation rates between arthroscopic treatment and open arthrotomy for native shoulder septic arthritis. The results showed a higher reoperation rate in arthroscopy compared to arthrotomy, indicating a need for higher quality evidence.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)