Article
Environmental Sciences
Abdullah Aslan, Muhammed Ismail Can, Ozlem Gok, Seda Beyaz, Gozde Parlak, Ibrahim Hanifi Ozercan
Summary: The study demonstrated that royal jelly has protective effects on muscle tissue against fluoride-induced damage, reducing the levels of damage and inflammatory responses caused by fluoride exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Urology & Nephrology
Qiang Wan, Jiabao Zhou, Yansheng Wu, Liqiang Shi, Weiwei Liu, Jiaoying Ou, Jiandong Gao
Summary: TNF-alpha may play an important role in podocyte injury and apoptosis in IgA nephropathy through the apoptotic death receptor pathway.
Article
Integrative & Complementary Medicine
Wen-Ya Su, Ying Li, Xuan Chen, Xin Li, Heng Wei, Zhi Liu, Qiong Shen, Chen Chen, Ying-Ping Wang, Wei Li
Summary: This study evaluates the ameliorative effects of ginsenoside Rh1 on obesity-linked diabetic nephropathy induced by high fat diet and streptozotocin. The results suggest that G-Rh1 shows potential in improving treatment of DN.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Aminah G. Alotaibi, Jia Li, Nigel J. Gooderham
Summary: The study revealed that the inflammation mediator TNF-alpha can enhance DNA damage induced by BaP and PhIP in colon cancer epithelial cells, without affecting the gene expression levels of the AhR signaling pathways. Additionally, functional p53 suppresses TNF-alpha-induced DNA damage, while the JNK signaling pathway plays a crucial role in this process.
Article
Cell & Tissue Engineering
Shuangyue Li, Huai Guan, Yan Zhang, Sheng Li, Kaixin Li, Shuhai Hu, Enjun Zuo, Cong Zhang, Xin Zhang, Guanyu Gong, Ruoyu Wang, Fengyuan Piao
Summary: The study demonstrated that BMSCs promote remyelination in the spinal cord of HD-exposed rats via the TNF alpha/RelB-Hes1 pathway, presenting novel insights for evaluating and further exploring the therapeutic effect of BMSCs on demyelinating neurodegenerative diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Wenhui Zhu, Ming Chen, Yang Wang, Yao Chen, Yonggang Zhang, Yan Wang, Peng Liu, Ping Li
Summary: This study reveals the mechanism by which morroniside affects renal lipid deposition in diabetic nephropathy, regulating lipid metabolism by inhibiting the NF-κB/TNF-α/SREBP1c signaling pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Mine Kokturk
Summary: Dyes have adverse effects on the aquatic environment and aquatic life, but limited research has been done on their toxic properties. This study found that the textile dye RG-GR has sublethal toxicity on zebrafish embryos and larvae, affecting their morphological development and biochemical parameters.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Applied
Diana Del Juncal-Guzman, Marilena Antunes-Ricardo, Jorge A. Sanchez-Burgos, Sonia G. Sayago-Ayerdi, Janet A. Gutierrez-Uribe
Summary: Phenolic compounds can modulate the immune response, and UV-C irradiation is commonly used in fresh-foods for minimal processing. The study evaluated the effect of intestinal and fermented fractions of non-irradiated and irradiated pineapple snack-bars on the production of nitric oxide, interleukin 6, cyclooxygenase 2, and tumor necrosis factor-alpha in mice macrophages. The results showed that IF of NIPB and IPB had a significant immunomodulatory effect, particularly on the production of TNF-alpha.
Article
Cell Biology
Xiaoliu Li, Jing Zhang, Qiang Wang, Lian Xiang, Jing Dong
Summary: This study aimed to investigate the expression of IL-11 in ischemic stroke patients and its correlation with rehabilitation training and prognosis. The results showed that patients in the rehabilitation training group had higher serum IL-11 levels and better prognosis compared to the control group. Serum IL-11 levels were found to be potential diagnostic biomarkers for poor prognosis in ischemic stroke patients. These findings suggest that IL-11, NIHSS score, and rehabilitation training are important factors for predicting the prognosis of ischemic stroke patients.
MEDIATORS OF INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Jessica W. Luzwick, Eszter Dombi, Rebecca A. Boisvert, Sunetra Roy, Soyoung Park, Selvi Kunnimalaiyaan, Steffi Goffart, Detlev Schindler, Katharina Schlacher
Summary: The Fanconi anemia suppressor genes in mitochondria protect mtDNA replication forks, while degradation by MRE11 nuclease leads to loss of nascent mtDNA. Unlike nuclear DNA replication fork stability, mitochondrial replication fork protection does not require pathway activation, revealing a separation between the two stability pathways.
Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Alice Santos-Silva, Luis Belo
Summary: Chronic kidney disease is a global public health problem with high morbidity and mortality. Inflammation and inflammatory mediators, such as tumor necrosis factor-related biomarkers, play a role in the development and progression of CKD. Tumor necrosis factor receptors 1 and 2 have been associated with changes in kidney function and injury, and could potentially serve as biomarkers for CKD prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elisa Rossi, Alexandre Kauskot, Francois Saller, Elisa Frezza, Sonia Poirault-Chassac, Anna Lokajczyk, Pierre Bourdoncle, Bruno Saubamea, Pascale Gaussem, Miguel Pericacho, Regis Bobe, Christilla Bachelot-Loza, Samuela Pasquali, Carmelo Bernabeu, David M. Smadja
Summary: Endoglin (Eng) is a transmembrane glycoprotein involved in adhesion and angiogenesis of endothelial cells. Mutations in Eng may lead to vessel abnormalities. Studies have shown that silencing of Eng affects endothelial cell proliferation and permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Dongsheng Cheng, Rulian Liang, Baorui Huang, Jiasheng Hou, Jianyong Yin, Ting Zhao, Lu Zhou, Rui Wu, Youcun Qian, Feng Wang
Summary: This study demonstrated that TNF-alpha inhibition can reduce tubular injury in diabetic rats by suppressing the expression of the NLRP3 inflammasome, offering potential protective effects against tubulointerstitial injury in diabetic nephropathy.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Immunology
Anqi Lin, Hongman Zhang, Hui Meng, Ze Deng, Tianqi Gu, Peng Luo, Jian Zhang
Summary: This research indicates that TNFα-MT may serve as a potential clinical biomarker for predicting the efficacy and prognosis of NSCLC patients receiving ICIs. TNFα-MT is associated with high immunogenicity and infiltration of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)