Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Article
Clinical Neurology
Alicia A. Swan, Eamonn Kennedy, Douglas B. Cooper, Megan E. Amuan, Jamie Mayo, David F. Tate, Kangwon Song, Blessen C. Eapen, Anne C. Van Cott, Maria R. Lopez, Mary Jo Pugh
Summary: The study examined the association between comorbidities (PTSD, depression, and/or headache) and polypharmacy with neurobehavioral symptoms among post-9/11 veterans with a history of mild traumatic brain injury (mTBI). The results showed that comorbidity burden and polypharmacy were associated with neurobehavioral symptom distress.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Eli Fried, Uri Balla, Merav Catalogna, Eran Kozer, Adi Oren-Amit, Amir Hadanny, Shai Efrati
Summary: This study aimed to evaluate the prevalence of persistent post-concussion syndrome (PPCS) in children after mild traumatic brain injury (mTBI) and identify high-risk factors. The results showed that 25% of children may suffer from PPCS, but it is often underdiagnosed in the pediatric population. Screening guidelines should be implemented to identify and treat these children in a timely manner.
SCIENTIFIC REPORTS
(2022)
Article
Sport Sciences
Todd W. Lyons, Rebekah Mannix, Ken Tang, Keith Owen Yeates, Gurinder Sangha, Emma C. M. Burns, Darcy Beer, Alexander S. Dubrovsky, Isabelle Gagnon, Jocelyn Gravel, Stephen B. Freedman, William Craig, Kathy Boutis, Martin H. Osmond, Gerard Gioia, Roger Zemek
Summary: This study aimed to assess the occurrence and clustering of post-concussive symptoms in children and identify distinct patient phenotypes based on symptom type and severity. The results showed that post-concussive symptoms occur in distinct clusters and five patient groups were identified based on symptom type and severity.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Review
Clinical Neurology
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Summary: This article reviews recent research on neuromodulation for mild traumatic brain injury (mTBI). It suggests that transcranial magnetic stimulation (TMS) shows promise as a potential treatment strategy for post-concussive symptoms, such as depression and headaches, while transcranial direct current stimulation (tDCS) has more mixed results. Further studies are needed to explore new stimulation protocols, personalized approaches, and the role of placebo effects.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Neurosciences
Eva Keatley, Kathleen Bechtold, Kevin Psoter, Matthew E. Peters, Allen Everett, Vani Rao, Timothy E. Van Meter, Hayley Falk, Frederick K. Korley, Durga Roy
Summary: This study utilized group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild traumatic brain injury (TBI) in the first 6 months after injury. The findings identified four distinct trajectories of recovery, which can be helpful for understanding the natural history of recovery and developing targeted interventions.
Article
Public, Environmental & Occupational Health
Katherine E. Miller, James P. MacDonald, Lindsay Sullivan, Lakshmi Prakruthi Rao Venkata, Junxin Shi, Keith Owen Yeates, Su Chen, Enas Alshaikh, H. Gerry Taylor, Amanda Hautmann, Nicole Asa, Daniel M. Cohen, Thomas L. Pommering, Elaine R. Mardis, Jingzhen Yang, NCH Concuss Res Grp
Summary: This study conducted a long-term assessment of salivary miRNA expression levels in concussed children and found differences in expression levels between children with and without PPCS.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Jessica-Dominique Lecques, Brynna J. K. Kerr, Lyn M. Hillyer, Jing X. Kang, Lindsay E. Robinson, W. L. David
Summary: This study demonstrates the protective effect of n-3 PUFA against mild brain injury, using a weight drop injury model on fat-1 mice and WT counterparts. The fat-1 mice showed significantly lower neurological severity scores and faster neurological restoration compared to WT mice post-injury.
Review
Clinical Neurology
Sepehr Mortaheb, Maria Maddalena Filippini, Jean-Francois Kaux, Jitka Annen, Nicolas Lejeune, Geraldine Martens, Maria Antonia Fuentes Calderon, Steven Laureys, Aurore Thibaut
Summary: This study focused on exploring the use of different neuroimaging modalities in persistent post-concussive symptoms (PCS) after mild traumatic brain injury (mTBI), with functional techniques being the most sensitive tools for evaluating PCS. Functional patterns associated with PCS symptoms typically include decreased anti-correlation between the default mode network and the task positive network, as well as reduced brain activity in specific areas, particularly the prefrontal cortex.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rehabilitation
Linda Fordal, Jonas Stenberg, Grant L. Iverson, Simen B. Saksvik, Migle Karaliute, Anne Vik, Alexander Olsen, Toril Skandsen
Summary: This study aimed to examine the trajectories of persistent postconcussion symptoms (PPCS) after mild traumatic brain injury (MTBI) and investigate the factors associated with symptom reporting. The results showed a similar prevalence of moderate to severe PPCS in the MTBI group at 3 and 12 months post-injury. Individual trajectory analysis revealed considerable change in both symptom severity and total scores over time in the MTBI group. In addition, the presence of intracranial lesions was associated with a higher likelihood of improvement. Female gender and personal factors such as reduced employment, pain, poor sleep, low resilience, high neuroticism and pessimism, and a psychiatric history were associated with persistent symptoms. In conclusion, personal factors play an important role in the presence of persistent symptoms during the first year after MTBI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Benedikte a. Madsen, Silje C. R. Fure, Nada Andelic, Daniel Loke, Marianne Lovstad, Cecilie Roe, Emilie Isager Howe
Summary: Approximately 30% of individuals with mild traumatic brain injury (mTBI) experience persistent post-concussion symptoms (PPCS). Personality traits such as neuroticism, openness to experience, and conscientiousness are associated with more severe PPCS and lower return to work (RTW) in patients with mild-to-moderate TBI. However, after controlling for PPCS, personality traits are no longer significantly associated with RTW.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Vivian A. Guedes, Chen Lai, Christina Devoto, Katie A. Edwards, Sara Mithani, Dilorom Sass, Rany Vorn, Bao-Xi Qu, Heather L. Rusch, Carina A. Martin, William C. Walker, Elisabeth A. Wilde, Ramon Diaz-Arrastia, Jessica M. Gill, Kimbra Kenney
Summary: The study found that levels of neurofilament light chain (NfL) were associated with the severity of PTSD symptoms in participants with remote mTBI, and specific miRNAs were also linked to the severity of PTSD symptoms. This suggests possible signaling pathways linked to the development of persistent PTSD symptoms after TBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Linda J. D'Silva, Prabhakar Chalise, Sakher Obaidat, Michael Rippee, Hannes Devos
Summary: The study found that individuals with mTBI performed poorly in dynamic mobility tasks and had higher symptom severity. Dynamic balance deficits were associated with time since concussion, visual function, and symptom severity.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Katie A. Edwards, Kisha Greer, Jacqueline Leete, Chen Lai, Christina Devoto, Bao-Xi Qu, Angela M. Yarnell, Elena Polejaeva, Kristine C. Dell, Matthew L. LoPresti, Peter Walker, Eric M. Wassermann, Walter Carr, James R. Stone, Stephen T. Ahlers, Rany Vorn, Carina Martin, Jessica M. Gill
Summary: The study revealed that tau concentrations in neuronal-derived EVs were significantly elevated in experienced breachers and correlated with neurobehavioral symptoms, while no significant changes were found in NF-L or A beta 42 levels. These findings suggest that tau concentrations in neuronal-derived EVs may be a potential biomarker for neurological effects in individuals with a history of multiple low-level blast exposures.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Michael Dretsch, Joseph Bleiberg, Kathy Williams, Jesus Caban, James Kelly, Geoffrey Grammer, Thomas DeGraba
JOURNAL OF HEAD TRAUMA REHABILITATION
(2016)
Article
Clinical Neurology
F. Jay Haran, Michael N. Dretsch, Joseph Bleiberg
APPLIED NEUROPSYCHOLOGY-ADULT
(2016)
Article
Clinical Neurology
Leonard A. Temme, Paul St Onge, Joseph Bleiberg
FRONTIERS IN NEUROLOGY
(2016)
Article
Critical Care Medicine
James L. Spira, Corinna E. Lathan, Joseph Bleiberg, Jack W. Tsao
JOURNAL OF NEUROTRAUMA
(2014)
Article
Medicine, General & Internal
Andrea S. Vincent, Joseph Bleiberg, Sam Yan, Brian Ivins, Dennis L. Reeves, Karen Schwab, Kirby Gilliland, Robert Schlegel, Deborah Warden
Article
Medicine, General & Internal
Corinna Lathan, James L. Spira, Joseph Bleiberg, Jack Vice, Jack W. Tsao
Article
Neurosciences
Emma B. Roach, Joseph Bleiberg, Corinna E. Lathan, Lawrence Wolpert, Jack W. Tsao, Robert C. Roach
Article
Clinical Neurology
Leonard Temme, Joseph Bleiberg, Dennis Reeves, David L. Still, Dan Levinson, Rebecca Browning
FRONTIERS IN NEUROLOGY
(2013)
Article
Rheumatology
Brian Walitt, Tresa Roebuck-Spencer, Joseph Bleiberg, Gregory Foster, Arthur Weinstein
RHEUMATOLOGY INTERNATIONAL
(2008)
Article
Rheumatology
Brian Walitt, Tresa Roebuck-Spencer, Guiseppe Esposito, Frances Atkins, Joseph Bleiberg, Gregory Foster, Arthur Weinstein
RHEUMATOLOGY INTERNATIONAL
(2007)
Article
Pharmacology & Pharmacy
Jennifer R. Schroeder, John Schmittner, Joseph Bleiberg, David H. Epstein, Mori J. Krantz, Kenzie L. Preston
Article
Medicine, General & Internal
Dennis L. Reeves, Joseph Bleiberg, Tresa Roebuck-Spencer, Alison N. Cernich, Karen Schwab, Brian Ivins, Andres M. Salazar, Sally C. Harvey, Fred H. Brown, Deborah Warden
Article
Rheumatology
Larissa Lapteva, Miroslawa Nowak, Cheryl H. Yarboro, Kazuki Takada, Tresa Roebuck-Spencer, Thomas Weickert, Joseph Bleiberg, Donald Rosenstein, Maryland Pao, Nicholas Patronas, Sonya Steele, Melissa Manzano, Jan Willem C. van der Veen, Peter E. Lipsky, Stefano Marenco, Robert Wesley, Bruce Volpe, Betty Diamond, Gabor G. Illei
ARTHRITIS AND RHEUMATISM
(2006)
Article
Rheumatology
Tresa M. Roebuck-Spencer, Cheryl Yarboro, Miroslawa Nowak, Kazuki Takada, Geneva Jacobs, Larissa Lapteva, Thomas Weickert, Bruce Volpe, Betty Diamond, Gabor Illei, Joseph Bleiberg
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
(2006)