Review
Cell Biology
Yunfei Ma, Guangda Li, Mingwei Yu, Xu Sun, Jiayun Nian, Yu Gao, Xiaoxiao Li, Tongjing Ding, Xiaomin Wang
Summary: The meta-analysis results indicate that thrombocytosis is associated with poor prognosis in lung cancer patients, including poor overall survival, disease-free survival, and progression-free survival. Despite some publication bias, the overall findings remained consistent after bias adjustment, suggesting that thrombocytosis can serve as a predictor of unfavorable outcomes in lung cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo Sang Lee, Hyun Woo Kwon, Seok-Byung Lim, Jin Cheon Kim, Chang Sik Yu, Yong Sang Hong, Tae Won Kim, Minyoung Oh, Sangwon Han, Jae Hwan Oh, Sohyun Park, Tae-Sung Kim, Seok-ki Kim, Hyun Joo Kim, Jae Young Kwak, Ho-Suk Oh, Sungeun Kim, Jung-Myun Kwak, Ji Sung Lee, Jae Seung Kim
Summary: This study developed and validated a prognostic model based on FDG metabolic parameters for predicting recurrence after surgery for colorectal cancer liver metastasis. The model showed good discrimination and calibration in external validation, and can be used for accurate risk stratification in patients with synchronous colorectal cancer liver metastasis.
EUROPEAN RADIOLOGY
(2023)
Review
Hematology
Clemens Stockklausner, C. M. Duffert, H. Cario, R. Knofler, W. Streif, A. E. Kulozik
Summary: The text discusses how secondary thrombocytosis is common in childhood infections and inflammations, while primary hereditary thrombocytosis may be caused by genetic mutations. By increasing knowledge on the molecular mechanisms and clinical complications of these diseases, the WHO and European LeukemiaNet have developed guidelines for the management of adult MPNs.
ANNALS OF HEMATOLOGY
(2021)
Article
Oncology
Zoltan Herold, Magdolna Dank, Magdolna Herold, Peter Nagy, Klara Rosta, Aniko Somogyi
Summary: This study focused on the combined effects of CgA(+) and paraneoplastic thrombocytosis on CRC patient survival, proposing a new subtype of CRC characterized by CgA(+) and distinct pathophysiologies.
Article
Medicine, General & Internal
Gyorgy Herczeg, Aniko Somogyi, Magdolna Herold, Agnes Fodor, Klara Rosta, Magdolna Dank, Zsolt Lang, Zoltan Herold
Summary: This study investigated the survival of colorectal cancer patients and its relationship with type 2 diabetes mellitus (T2DM) and paraneoplastic thrombocytosis. The results showed that the coexistence of T2DM and paraneoplastic thrombocytosis did not further impair the survival of colorectal cancer patients, suggesting that T2DM has no significant effect over paraneoplastic thrombocytosis.
Review
Medicine, Research & Experimental
Yuyan Li, Shuangge Wang, Han Xiao, Fang Lu, Bin Zhang, Tingting Zhou
Summary: Platelets are important in cancer, but their role in leukemia is not well understood. This study shows that platelet count can predict long-term prognosis after chemotherapy in acute myeloid leukemia patients. Additionally, certain platelet-related factors, such as low platelet-to-lymphocyte ratio and mean platelet volume, as well as high platelet distribution width, are associated with poor prognosis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Pathology
Shi-cheng Liu, Le-lan Gong, Feng-chang Huang, Ning Xu, Ke-xin Yang, Xi-hong Liu, Wen-liang Li
Summary: Colorectal cancer (CRC) poses a serious threat to human health and the study identified RNF114 as a potential therapeutic target and biomarker for CRC. High expression of RNF114 was significantly associated with tumor invasion and clinical stage, and promoted cell proliferation, invasion, and metastasis. This study provides new insights into the mechanisms of CRC and offers potential strategies for treatment and diagnosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Ana Fernandez Montes, Vicente Alonso Orduna, Elena Asensio Martinez, Nuria Rodriguez Salas, Esperanza Torres, Diego Cacho Lavin, Rosa Maria Rodriguez Alonso, Esther Falco, Joan Carles Oliva, Lluis Cirera, Jesus Garcia Gomez, Carles Pericay
Summary: This study evaluated the prognostic value of specific KRAS mutation codon locations in metastatic colorectal cancer (mCRC) patients and the survival outcomes in relation to treatment. The results showed that KRAS mutation location can predict survival outcomes and that combination therapy before and after surgery provides survival benefits for patients.
Article
Oncology
Gustavo C. L. Gossling, Marcio F. Chedid, Fernando S. Pereira, Rafaela K. da Silva, Leonardo B. Andrade, Nicolas Peruzzo, Mauricio G. Saueressig, Gilberto Schwartsmann, Aparna R. Parikh
Summary: This study aimed to identify clinicopathological and molecular features associated with progression-free survival (PFS) and overall survival (OS) after pulmonary metastasectomy for metastatic colorectal cancer. The findings suggest that disease-free interval, synchronous presentation, and number and size of lesions are significant prognostic factors for OS, while presenting with more than one lesion is predictive for PFS but not for OS.
Article
Hematology
Pierre Laporte, Marie Tuffigo, Anne Ryman, Mathieu Fiore, Etienne Riviere, Chloe James, Alexandre Guy
Summary: The study aimed to evaluate the performance of VWF:GPIbR with HemosIL VWF:RCo Werfen versus VWF:RCo in patients with thrombocytosis in the context of MPNs and in patients with secondary thrombocytosis.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Oncology
Doyoun Kim, Jae-Hoon Lee, Eun-Suk Cho, Su-Jin Shin, Hye Sun Lee, Hwa-Hee Koh, Kang Young Lee, Jeonghyun Kang
Summary: Combining preoperative and postoperative ALBI scores is an independent prognostic factor for the overall survival of patients with colorectal cancer (CRC), and it shows superior predictive power compared to using preoperative or postoperative scores alone.
CANCER RESEARCH AND TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Igor Lopes dos Santos, Karlla Greick Batista Dias Penna, Megmar Aparecida dos Santos Carneiro, Larisse Silva Dalla Libera, Jessica Enocencio Porto Ramos, Vera Aparecida Saddi
Summary: Colorectal cancer patients' tissue miRs expression show significant associations with prognostic factors, including oncogenic miRs like miR-21 and tumor suppressor miRs like miR-126, which have significant impacts on the survival and relapse risk of CRC patients.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park
Summary: The study aimed to investigate the prognostic factors for overall survival in patients who had undergone pulmonary metastasectomy for colorectal cancer. It found that pulmonary metastasectomy provided long-term survival for patients, with female sex, distally located colorectal cancer, and high-volume hospital centers being positive prognostic factors for survival.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Medicine, General & Internal
Xiaolong Sun, Xu Wang, Guang Dong, Zhenyu Zhao, Jibo Song
Summary: This study aimed to detect the expression level of miR-383-5p in CRC patients following chemotherapy and its influence on prognosis. The serum levels of miR-383-5p in CRC patients before and after chemotherapy were measured using RT-PCR. Cox hazard analysis showed that the level of miR-383-5p was closely related to differentiation, TNM staging, lymphatic metastasis, and vascular infiltration in CRC. High level of miR-383-5p was favorable for overall survival in CRC.
Review
Gastroenterology & Hepatology
Jia-Min Zhou, Lu Wang, An-Rong Mao
Summary: Repeat hepatectomy is a safe and effective treatment option for patients with resectable recurrent colorectal liver metastases (CRLM). Prognostic factors such as R0 resection, carcinoembryonic antigen level, presence of extrahepatic disease, disease-free interval, number and size of hepatic lesions, blood transfusion requirement, and adjuvant chemotherapy play a role in determining the outcomes. Multimodal approach involving aggressive chemotherapy and repeat hepatectomy might be preferred for early recurrent CRLM.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
